List of works - Thomas A Hughes

Affimer Tagged Cubosomes: Targeting of Carcinoembryonic Antigen Expressing Colorectal Cancer Cells Using <i>In Vitro</i> and <i>In Vivo</i> Models

scientific article published on 23 February 2022

Analysis of Functional Domains of the Host Cell Factor Involved in VP16 Complex Formation

scientific article published in Journal of Biological Chemistry

CEA-targeted nanoparticles allow specific in vivo fluorescent imaging of colorectal cancer models ⬇️

scientific article

CIP2A expression predicts recurrences of tamoxifen-treated breast cancer ⬇️

scientific article published in October 2017

Carcinoembryonic antigen is the preferred biomarker for in vivo colorectal cancer targeting. ⬇️

scientific article published on 15 January 2013

Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy ⬇️

scientific article

Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours

scientific article published on 21 July 2012

Circulating tumour cells in breast cancer: Prognostic indicators, metastatic intermediates, or irrelevant bystanders? (Review).

scientific article

Clinical importance of estrogen receptor beta isoforms in breast cancer

scientific article published on 10 November 2008

Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity

scientific article published on 14 April 2009

Cross-talk between pRb/E2F and Wnt/beta-catenin pathways: E2F1 induces axin2 leading to repression of Wnt signalling and to increased cell death

scientific journal article

Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

scientific article

Differential Expression of MicroRNAs in Breast Cancers from Four Different Ethnicities ⬇️

scientific article published on 23 May 2018

Differential regulation of oestrogen receptor β isoforms by 5' untranslated regions in cancer

scientific article published on January 2010

Down-Regulation of miR-92 in Breast Epithelial Cells and in Normal but Not Tumour Fibroblasts Contributes to Breast Carcinogenesis ⬇️

scientific article published on 5 October 2015

E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation

scientific article

ER-Negative Breast Cancer Is Highly Responsive to Cholesterol Metabolite Signalling

scientific article published on 01 November 2019

Epithelial-mesenchymal interactions in breast cancer: evidence for a role of nuclear localized β-catenin in carcinoma-associated fibroblasts

scientific article published in October 2011

Estrogen receptor regulation: don’t forget translation

Estrogen receptor {beta}1 expression is regulated by miR-92 in breast cancer

scientific article

Expression of axin2 is regulated by the alternative 5'-untranslated regions of its mRNA

scientific article

Expression of oestrogen receptor beta isoforms is regulated by transcriptional and post-transcriptional mechanisms

scientific article

Expression of phosphorylated eIF4E-binding protein 1, but not of eIF4E itself, predicts survival in male breast cancer ⬇️

scientific article published on 09 June 2016

Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer

scientific article published on 26 December 2019

Identification of candidate mediators of chemoresponse in breast cancer through therapy-driven selection of somatic variants

scientific article published on 30 July 2020

In situ and invasive lobular neoplasia of the breast.

scientific article published on January 2008

Inhibiting ABCG2 could potentially enhance the efficacy of hypericin-mediated photodynamic therapy in spheroidal cell models of colorectal cancer ⬇️

scholarly article by M. Ibrahim Khot et al published September 2018 in Photodiagnosis and Photodynamic Therapy

Intra-operative tumour detection and staging in colorectal cancer surgery

scientific article published on September 2012

Investigation of immunoregulatory mechanisms relating to poor surgical wound healing and breast cancer recurrence

scientific article published on 13 May 2008

Levels of different subtypes of tumour-infiltrating lymphocytes correlate with each other, with matched circulating lymphocytes, and with survival in breast cancer

scientific article published on 23 June 2020

Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer ⬇️

scientific article published on 26 January 2016

Mathematical and biological modelling of RNA secondary structure and its effects on gene expression

scientific article published in March 2006

Metal-shell nanocapsules for the delivery of cancer drugs

scientific article published on 05 December 2019

MiR-19b non-canonical binding is directed by HuR and confers chemosensitivity through regulation of P-glycoprotein in breast cancer ⬇️

scientific article published on 31 August 2018

MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion

scientific article

MicroRNA-222 reprogrammed cancer-associated fibroblasts enhance growth and metastasis of breast cancer

scientific article published on 04 September 2019

MicroRNA-92 targets the 3' untranslated region of ERβ1 mRNA and post-transcriptionally regulates its expression in breast cancer.

scientific article published on 18 May 2010

Mimosine Arrests the Cell Cycle after Cells Enter S-Phase

Neoadjuvant Endocrine Therapy in Breast Cancer Upregulates the Cytotoxic Drug Pump ABCG2 /BCRP, and May Lead to Resistance to Subsequent Chemotherapy ⬇️

Neoadjuvant chemotherapy induces expression levels of breast cancer resistance protein that predict disease-free survival in breast cancer

scientific article (publication date: 2013)

Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients

scientific article published in August 2008

PSMD9 expression predicts radiotherapy response in breast cancer ⬇️

scientific article

Perioperative Reductions in Circulating Lymphocyte Levels Predict Wound Complications After Excisional Breast Cancer Surgery

scientific article published on 01 February 2011

Phytosterols Inhibit Side-Chain Oxysterol Mediated Activation of LXR in Breast Cancer Cells

scientific article published on 02 July 2019

Prediction of clinical outcome in glioblastoma using a biologically relevant nine-microRNA signature ⬇️

scientific article published on 28 November 2014

Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation.

scientific article

Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer.

scientific article

Regulation of estrogen receptor beta by 5' untranslated regions in breast carcinogenesis

scientific article published on 13 May 2008

Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region

scientific article published on 25 September 2013

Regulation of gene expression by alternative untranslated regions

scientific article

Regulatory RNAs: Have mRNA Untranslated Regions Joined the Party?

article by Thomas A Hughes & Pamela F Jones published 20 May 2008 in PLOS MEDICINE

Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer

scientific article

Stromal fibroblasts with nuclear β-catenin are present within breast tumours and increase proliferation and invasion of epithelial breast cancer cells

scientific article published on 13 May 2008

Surgery induced immunosuppression

scientific article published on 16 September 2010

Targeting glucose metabolism: an emerging concept for anticancer therapy

scientific article published on December 2011

The roles of microRNAs in sarcomas

scientific article published on 23 May 2012

List of works by Thomas A Hughes

Affimer Tagged Cubosomes: Targeting of Carcinoembryonic Antigen Expressing Colorectal Cancer Cells Using <i>In Vitro</i> and <i>In Vivo</i> Models

Analysis of Functional Domains of the Host Cell Factor Involved in VP16 Complex Formation

CEA-targeted nanoparticles allow specific in vivo fluorescent imaging of colorectal cancer models ⬇️

CIP2A expression predicts recurrences of tamoxifen-treated breast cancer ⬇️

Carcinoembryonic antigen is the preferred biomarker for in vivo colorectal cancer targeting. ⬇️

Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy ⬇️

Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours

Circulating tumour cells in breast cancer: Prognostic indicators, metastatic intermediates, or irrelevant bystanders? (Review).

Clinical importance of estrogen receptor beta isoforms in breast cancer

Combined analysis of eIF4E and 4E-binding protein expression predicts breast cancer survival and estimates eIF4E activity

Cross-talk between pRb/E2F and Wnt/beta-catenin pathways: E2F1 induces axin2 leading to repression of Wnt signalling and to increased cell death

Dichloroacetate induces apoptosis and cell-cycle arrest in colorectal cancer cells

Differential Expression of MicroRNAs in Breast Cancers from Four Different Ethnicities ⬇️

Differential regulation of oestrogen receptor β isoforms by 5' untranslated regions in cancer

Down-Regulation of miR-92 in Breast Epithelial Cells and in Normal but Not Tumour Fibroblasts Contributes to Breast Carcinogenesis ⬇️

E2F1 up-regulates the expression of the tumour suppressor axin2 both by activation of transcription and by mRNA stabilisation

ER-Negative Breast Cancer Is Highly Responsive to Cholesterol Metabolite Signalling

Epithelial-mesenchymal interactions in breast cancer: evidence for a role of nuclear localized β-catenin in carcinoma-associated fibroblasts

Estrogen receptor regulation: don’t forget translation

Estrogen receptor {beta}1 expression is regulated by miR-92 in breast cancer

Expression of axin2 is regulated by the alternative 5'-untranslated regions of its mRNA

Expression of oestrogen receptor beta isoforms is regulated by transcriptional and post-transcriptional mechanisms

Expression of phosphorylated eIF4E-binding protein 1, but not of eIF4E itself, predicts survival in male breast cancer ⬇️

Genomic and Expression Analyses Define MUC17 and PCNX1 as Predictors of Chemotherapy Response in Breast Cancer

Identification of candidate mediators of chemoresponse in breast cancer through therapy-driven selection of somatic variants

In situ and invasive lobular neoplasia of the breast.

Inhibiting ABCG2 could potentially enhance the efficacy of hypericin-mediated photodynamic therapy in spheroidal cell models of colorectal cancer ⬇️

Intra-operative tumour detection and staging in colorectal cancer surgery

Investigation of immunoregulatory mechanisms relating to poor surgical wound healing and breast cancer recurrence

Levels of different subtypes of tumour-infiltrating lymphocytes correlate with each other, with matched circulating lymphocytes, and with survival in breast cancer

Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer ⬇️

Mathematical and biological modelling of RNA secondary structure and its effects on gene expression

Metal-shell nanocapsules for the delivery of cancer drugs

MiR-19b non-canonical binding is directed by HuR and confers chemosensitivity through regulation of P-glycoprotein in breast cancer ⬇️

MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion

MicroRNA-222 reprogrammed cancer-associated fibroblasts enhance growth and metastasis of breast cancer

MicroRNA-92 targets the 3' untranslated region of ERβ1 mRNA and post-transcriptionally regulates its expression in breast cancer.

Mimosine Arrests the Cell Cycle after Cells Enter S-Phase

Neoadjuvant Endocrine Therapy in Breast Cancer Upregulates the Cytotoxic Drug Pump ABCG2 /BCRP, and May Lead to Resistance to Subsequent Chemotherapy ⬇️

Neoadjuvant chemotherapy induces expression levels of breast cancer resistance protein that predict disease-free survival in breast cancer

Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients

PSMD9 expression predicts radiotherapy response in breast cancer ⬇️

Perioperative Reductions in Circulating Lymphocyte Levels Predict Wound Complications After Excisional Breast Cancer Surgery

Phytosterols Inhibit Side-Chain Oxysterol Mediated Activation of LXR in Breast Cancer Cells

Prediction of clinical outcome in glioblastoma using a biologically relevant nine-microRNA signature ⬇️

Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation.

Regulation of axin2 expression at the levels of transcription, translation and protein stability in lung and colon cancer.

Regulation of estrogen receptor beta by 5' untranslated regions in breast carcinogenesis

Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region

Regulation of gene expression by alternative untranslated regions

Regulatory RNAs: Have mRNA Untranslated Regions Joined the Party?

Response to mTOR inhibition: activity of eIF4E predicts sensitivity in cell lines and acquired changes in eIF4E regulation in breast cancer

Stromal fibroblasts with nuclear β-catenin are present within breast tumours and increase proliferation and invasion of epithelial breast cancer cells

Surgery induced immunosuppression

Targeting glucose metabolism: an emerging concept for anticancer therapy

The roles of microRNAs in sarcomas