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List of works by Marcel Spaargaren

A loss-of-adhesion CRISPR-Cas9 screening platform to identify cell adhesion-regulatory proteins and signaling pathways

scientific article published on 19 April 2022

Antibody-induced activation of the epidermal growth factor receptor tyrosine kinase requires the presence of detergent

scientific article published on September 1990

Antibody-induced dimerization activates the epidermal growth factor receptor tyrosine kinase

scientific article published on January 1991

Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor.

scientific article

BTK inhibitors in chronic lymphocytic leukemia: a glimpse to the future

scientific article

Bruton's Tyrosine Kinase and Phospholipase Cγ2 Mediate Chemokine-Controlled B Cell Migration and Homing

scientific article published on 01 January 2007

CD44 expression in intestinal epithelium and colorectal cancer is independent of p53 status

scientific article

Cell surface proteoglycan syndecan-1 mediates hepatocyte growth factor binding and promotes Met signaling in multiple myeloma

scientific article published on 01 February 2002

Characterization and identification of an epidermal-growth-factor-activated phospholipase A2.

scientific article published on October 1992

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal Tumorigenesis

article

Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936.

scientific article published on December 2003

Differential interaction of the ras family GTP-binding proteins H-Ras, Rap1A, and R-Ras with the putative effector molecules Raf kinase and Ral-guanine nucleotide exchange factor

scientific article

Diffuse large B cell lymphomas relapsing in the CNS lack oncogenic MYD88 and CD79B mutations

scientific article published on 12 December 2014

Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival.

scientific article published on 6 April 2011

Egress of CD19(+)CD5(+) cells into peripheral blood following treatment with the Bruton tyrosine kinase inhibitor ibrutinib in mantle cell lymphoma patients

scientific article

Epidermal growth factor (EGF) induces serine phosphorylation-dependent activation and calcium-dependent translocation of the cytosolic phospholipase A2.

scientific article published on August 1995

EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations.

scientific article published on 24 August 2012

Expression of c-Met and heparan-sulfate proteoglycan forms of CD44 in colorectal cancer

scientific article published in November 2000

FOXP1 directly represses transcription of proapoptotic genes and cooperates with NF-κB to promote survival of human B cells

scientific article

Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac.

scientific article

Follicular dendritic cells catalyze hepatocyte growth factor (HGF) activation in the germinal center microenvironment by secreting the serine protease HGF activator

scientific article published in September 2005

Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma.

scientific article

Heparan Sulfate-modified CD44 Promotes Hepatocyte Growth Factor/Scatter Factor-induced Signal Transduction through the Receptor Tyrosine Kinase c-Met

scientific article published in Journal of Biological Chemistry

Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation.

scientific article

Heparan sulfate proteoglycans in the control of B cell development and the pathogenesis of multiple myeloma

scientific article

Hepatocyte growth factor triggers signaling cascades mediating vascular smooth muscle cell migration

scientific article published in October 2002

High prevalence of oncogenic MYD88 and CD79B mutations in diffuse large B-cell lymphomas presenting at immune-privileged sites

scientific article published on 6 September 2013

High prevalence of oncogenic MYD88 and CD79B mutations in primary testicular diffuse large B-cell lymphoma

scientific article published on 20 November 2013

Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1

scientific article

Ibrutinib and idelalisib synergistically target BCR-controlled adhesion in MCL and CLL: a rationale for combination therapy

scientific article published on April 2015

Ibrutinib and idelalisib target B cell receptor- but not CXCL12/CXCR4-controlled integrin-mediated adhesion in Waldenström macroglobulinemia

scientific article published on 3 December 2015

Ibrutinib for AML? Check CD117 (KIT)!

scientific article

Identification of the SRC-family tyrosine kinase HCK as a therapeutic target in mantle cell lymphoma

scientific article published on 26 June 2020

Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap

scientific article

Illegitimate WNT pathway activation by beta-catenin mutation or autocrine stimulation in T-cell malignancies.

scientific article published in September 2008

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

scientific article

Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase

scientific article published on 5 March 2010

Instant conditional transgenesis in the mouse hematopoietic compartment

scientific article published on 13 September 2008

Interaction of Epidermal growth factor receptors with the cytoskeleton is related to receptor clustering

Lymphoma dissemination: the other face of lymphocyte homing

scientific article published on 26 July 2007

Lymphoma spread? Target CD47-SIRP !

MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms

scientific article published on 14 July 2017

Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator

scientific article

N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation

scientific article published on 9 August 2011

Primary follicular lymphoma of the small intestine: alpha4beta7 expression and immunoglobulin configuration suggest an origin from local antigen-experienced B cells

scientific article published on January 2003

R-Ras alters Ca2+ homeostasis by increasing the Ca2+ leak across the endoplasmic reticular membrane.

scientific article published on 13 February 2003

Rab5 induces Rac-independent lamellipodia formation and cell migration

scientific article

RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein.

scientific article published on July 1996

Regulation of cytokine signaling by B cell antigen receptor and CD40-controlled expression of heparan sulfate proteoglycans

scientific article published on October 2000

Signal transduction by Ras-like GTPases: a potential target for anticancer drugs

scientific article published on January 1995

Significantly improved PCR-based clonality testing in B-cell malignancies by use of multiple immunoglobulin gene targets. Report of the BIOMED-2 Concerted Action BHM4-CT98-3936.

scientific article published on 14 December 2006

Stem cell CD44v isoforms promote intestinal cancer formation in Apc(min) mice downstream of Wnt signaling

scientific article published on 14 January 2013

Stimulated plasmacytoid dendritic cells impair human T-cell development

scientific article published on 17 August 2006

Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins

scientific article published on 6 December 2017

Targeting EXT1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma.

scientific article

Targeting cell adhesion and homing as strategy to cure Waldenström's macroglobulinemia

scientific article published on June 2016

The B cell antigen receptor controls AP-1 and NFAT activity through Ras-mediated activation of Ral.

scientific article published on February 2007

The B cell antigen receptor controls integrin activity through Btk and PLCgamma2.

scientific article published on 10 November 2003

The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas

scientific article published on 22 July 2010

The Ras-related protein R-ras interacts directly with Raf-1 in a GTP-dependent manner

scientific article published on June 1994

The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia

scientific article

The forkhead transcription factor FOXP1 represses human plasma cell differentiation

scientific article published on 19 August 2015

The hepatocyte growth factor/Met pathway controls proliferation and apoptosis in multiple myeloma.

scientific article published in April 2003

The hepatocyte growth factor/Met pathway in development, tumorigenesis, and B-cell differentiation.

scientific article

The hypoxia target adrenomedullin is aberrantly expressed in multiple myeloma and promotes angiogenesis.

scientific article published on 12 March 2013

The pan phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor SAR245409 (voxtalisib/XL765) blocks survival, adhesion and proliferation of primary chronic lymphocytic leukemia cells.

scientific article published on 4 September 2015

The small FOXP1 isoform predominantly expressed in activated B cell-like diffuse large B-cell lymphoma and full-length FOXP1 exert similar oncogenic and transcriptional activity in human B cells

scientific article published on December 2016

The small GTPase Ral mediates SDF-1-induced migration of B cells and multiple myeloma cells

scientific article published on 28 January 2008

Tipping the balance: toward rational combination therapies to overcome venetoclax resistance in mantle cell lymphoma

scientific article published in 2022

Transcriptional silencing of the Wnt-antagonist DKK1 by promoter methylation is associated with enhanced Wnt signaling in advanced multiple myeloma

scientific article

Tubular epithelial syndecan-1 maintains renal function in murine ischemia/reperfusion and human transplantation

scientific article published on 11 January 2012

Tubulointerstitial heparan sulfate proteoglycan changes in human renal diseases correlate with leukocyte influx and proteinuria.

scientific article published on 21 November 2007

WNT signaling controls expression of pro-apoptotic BOK and BAX in intestinal cancer

scientific article published on 22 December 2010

c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination

scientific article (publication date: October 2002)

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