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List of works by Nicolas L. Young

A mixed integer linear optimization framework for the identification and quantification of targeted post-translational modifications of highly modified proteins using multiplexed electron transfer dissociation tandem mass spectrometry

scientific article published on 07 August 2009

A novel approach for untargeted post-translational modification identification using integer linear optimization and tandem mass spectrometry.

scientific article

AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia

scientific article published on 01 December 2019

Asymmetrically modified nucleosomes

scientific article

Characterization of SETD3 methyltransferase mediated protein methionine methylation

scientific article published on 05 June 2020

Chemical inhibition of prometastatic lysyl-tRNA synthetase-laminin receptor interaction.

scientific article

Collective mass spectrometry approaches reveal broad and combinatorial modification of high mobility group protein A1a.

scientific article published on 28 January 2010

Control of Hexamerization, Assembly, and Excluded Strand Specificity for the Sulfolobus solfataricus MCM Helicase

scientific article published on 19 September 2018

DNA Interactions Probed by Hydrogen-Deuterium Exchange (HDX) Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Confirm External Binding Sites on the Minichromosomal Maintenance (MCM) Helicase

scientific article published on 04 April 2016

Early butyrate induced acetylation of histone H4 is proteoform specific and linked to methylation state

scientific article published on 07 August 2018

Epitope mapping of 7S cashew antigen in complex with antibody by solution-phase H/D exchange monitored by FT-ICR mass spectrometry

scientific article published on June 2015

Heterochromatin protein 1 is extensively decorated with histone code-like post-translational modifications

scientific article

High throughput characterization of combinatorial histone codes

scientific article published on 04 August 2009

High-Throughput Quantitative Top-Down Proteomics: Histone H4

scientific article published on 18 November 2019

Histone Deacetylase 9 Deficiency Protects against Effector T Cell-mediated Systemic Autoimmunity ⬇️

scientific article published on June 27, 2011

Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells.

scientific article published on February 2009

How many human proteoforms are there?

scientific article published in February 2018

Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry

scientific article published on 19 August 2020

Label-Free Relative Quantitation of Isobaric and Isomeric Human Histone H2A and H2B Variants by Fourier Transform Ion Cyclotron Resonance Top-Down MS/MS.

scientific article published on 18 July 2016

Mapping the contact surfaces in the Lamin A:AIMP3 complex by hydrogen/deuterium exchange FT-ICR mass spectrometry.

scientific article published on 10 August 2017

Method to site-specifically identify and quantitate carbonyl end products of protein oxidation using oxidation-dependent element coded affinity tags (O-ECAT) and nanoliquid chromatography Fourier transform mass spectrometry

scientific article published in March 2006

Methylation of H2AR29 is a novel repressive PRMT6 target

scientific article

Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.

scientific article

Middle-Down Characterization of the Cell Cycle Dependence of Histone H4 Post-Translational Modifications and Proteoforms.

scientific article published on 17 April 2018

Nucleotide-induced conformational changes of tetradecameric GroEL mapped by H/D exchange monitored by FT-ICR mass spectrometry

scientific article published on 13 February 2013

One-Pot Quantitative Top- and Middle-Down Analysis of GluC-Digested Histone H4

scientific article published on 30 May 2019

One-pot shotgun quantitative mass spectrometry characterization of histones

scientific article

Paired single residue-transposed Lys-N and Lys-C digestions for label-free identification of N-terminal and C-terminal MS/MS peptide product ions: ultrahigh resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spect

scientific article

Protected amine labels: a versatile molecular scaffold for multiplexed nominal mass and sub-Da isotopologue quantitative proteomic reagents.

scientific article published on 05 February 2014

Proteomic Interrogation of Human Chromatin ⬇️

scientific article published on September 14, 2011

Quantitative Mass Spectrometry Reveals that Intact Histone H1 Phosphorylations are Variant Specific and Exhibit Single Molecule Hierarchical Dependence

scientific article published on 24 July 2015

Quantitative proteomic approaches to studying histone modifications.

scientific article

Rapid screening for potential epitopes reactive with a polycolonal antibody by solution-phase H/D exchange monitored by FT-ICR mass spectrometry

scientific article published on 17 May 2013

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

scientific article

Structure of a pentameric virion-associated fiber with a potential role in Orsay virus entry to host cells

scientific article

Systems-wide proteomic characterization of combinatorial post-translational modification patterns

scientific article published on February 2010

The N-terminal Domain of Escherichia coli Assimilatory NADPH-Sulfite Reductase Hemoprotein Is an Oligomerization Domain That Mediates Holoenzyme Assembly.

scientific article published on 18 June 2015

The first pilot project of the consortium for top-down proteomics: a status report

scientific article

The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance.

scientific article published on 7 June 2018

The significance, development and progress of high-throughput combinatorial histone code analysis

scientific article published on 04 August 2010

Ultrahigh-resolution Fourier transform ion cyclotron resonance mass spectrometry and tandem mass spectrometry for peptide de novo amino acid sequencing for a seven-protein mixture by paired single-residue transposed Lys-N and Lys-C digestion

scientific article published on 4 November 2016

Ultraviolet photodissociation enhances top-down mass spectrometry as demonstrated on green fluorescent protein variants

scientific article published on 24 April 2014

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