List of works - David J. Stephens

A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function

scientific article published on 07 September 2021

A role for Tctex-1 (DYNLT1) in controlling primary cilium length

scientific article published on 22 June 2011

A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment

scientific article published on 01 February 2003

A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2.

scientific article published on 17 September 2013

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

scientific article

Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity.

scientific article published on June 2017

Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated Degradation.

scientific article

Biogenesis of ER-to-Golgi transport carriers: complex roles of COPII in ER export.

scientific article published on February 2004

Bioimaging has been a cornerstone of cell biology and developmental biology research

scientific article published on 12 September 2009

COPII-dependent ER export in animal cells: adaptation and control for diverse cargo

scientific article published on 18 June 2018

Cargo loading at the ER ⬇️

scientific article published on November 1, 2010

Cell biology: Collagen secretion explained

scientific article published on 22 February 2012

Cep126 is required for pericentriolar satellite localisation to the centrosome and for primary cilium formation

scientific article

Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis

scientific article published on 09 August 2013

Characterization of human Sec16B: indications of specialized, non-redundant functions ⬇️

scientific article published on August 30, 2011

Coupling of ER exit to microtubules through direct interaction of COPII with dynactin

scientific article

Cytoplasmic dynein-2 at a glance

scientific article published on 30 March 2020

De novo formation, fusion and fission of mammalian COPII-coated endoplasmic reticulum exit sites

scientific article

Developing pathways to clarify pathogenicity of unclassified variants in Osteogenesis Imperfecta genetic analysis

scientific article published on 30 September 2019

Differential effects of a GTP-restricted mutant of Sar1p on segregation of cargo during export from the endoplasmic reticulum

scientific article published in July 2004

Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin

scientific article (publication date: 15 October 1999)

Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function

scientific article published on 16 October 2018

ER exit sites--localization and control of COPII vesicle formation

scientific article published on 20 October 2009

ER-to-Golgi Transport: A Sizeable Problem

scientific article published on 17 October 2019

ER-to-Golgi trafficking of procollagen in the absence of large carriers

scientific article published on 26 December 2018

ER-to-Golgi transport: form and formation of vesicular and tubular carriers.

scientific article

Early stages of retinal development depend on Sec13 function

scientific article published on 10 January 2013

Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development.

scientific article published on 19 August 2008

Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion

scientific article published on 13 February 2012

Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells

scientific article published on 9 August 2010

Functional coupling of microtubules to membranes – implications for membrane structure and dynamics ⬇️

scientific article published on June 26, 2012

Giantin is required for intracellular N-terminal processing of type I procollagen

scientific article published on 04 May 2021

Giantin-knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression.

scientific article

In vivo dynamics of the F-actin-binding protein neurabin-II

scientific journal article

Inhibition of the interaction between tyrosine-based motifs and the medium chain subunit of the AP-2 adaptor complex by specific tyrphostins

scientific article published on 01 October 1998

Insulin dependent tyrosine phosphorylation of the tyrosine internalisation motif of TGN38 creates a specific SH2 domain binding site ⬇️

scientific article published on October 13, 1997

Insulin promotes Rip11 accumulation at the plasma membrane by inhibiting a dynamin- and PI3-kinase-dependent, but Akt-independent, internalisation event

scientific article

Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells.

scientific article

Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport.

scientific article published on 9 August 2008

LG186: An inhibitor of GBF1 function that causes Golgi disassembly in human and canine cells

scientific article published on 15 October 2010

Meeting report--Imaging membrane dynamics, 14-17 September, Royal Holloway--University of London, UK

scientific article published on 07 February 2007

Membrane contact sites--an interesting species, an interesting mix.

scientific article published on 5 April 2013

Microtubule motors mediate endosomal sorting by maintaining functional domain organization

scientific article

Microtubule plus-end loading of p150(Glued) is mediated by EB1 and CLIP-170 but is not required for intracellular membrane traffic in mammalian cells.

scientific article

Nordihydroguaiaretic acid affects multiple dynein-dynactin functions in interphase and mitotic cells.

scientific article published on 14 November 2006

Opposing microtubule motors control motility, morphology and cargo segregation during ER-to-Golgi transport

scientific article

Optimising the precision for localising fluorescent proteins in living cells by 2D Gaussian fitting of digital images: application to COPII-coated endoplasmic reticulum exit sites.

scientific article

Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.

scientific article

P4HB recurrent missense mutation causing Cole-Carpenter syndrome.

scientific article published on 20 December 2017

PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport

scientific article

Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor

scientific article

Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex

scientific article published on 26 September 2019

RNA interference approaches to examine Golgi function in animal cell culture

scientific article published on January 2013

Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control.

scientific article published on 11 April 2018

Role of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomes

scientific article

SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment

scientific article

Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells

scientific article

Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis

scientific article

Secretory cargo regulates the turnover of COPII subunits at single ER exit sites

scientific article published in January 2006

Specific functions of BIG1 and BIG2 in endomembrane organization

scientific article

Specificity of cytoplasmic dynein subunits in discrete membrane-trafficking steps

scientific article published on 22 April 2009

Subunit composition of the human cytoplasmic dynein-2 complex

scientific journal article

TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion

scientific article published on 11 May 2016

The Golgi matrix protein giantin is required for normal cilia function in zebrafish.

scientific article published on 25 May 2017

The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis

scientific article published on 13 December 2013

The many ways to cross the plasma membrane.

scholarly article

The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network

scientific article

The role of motor proteins in endosomal sorting

scientific article published on October 2011

The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network.

scientific article published on September 2008

Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction.

scientific article published on January 1997

List of works by David J. Stephens

A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function

A role for Tctex-1 (DYNLT1) in controlling primary cilium length

A role for glycogen synthase kinase-3 in mitotic spindle dynamics and chromosome alignment

A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2.

Analysis of GTPase-activating proteins: Rab1 and Rab43 are key Rabs required to maintain a functional Golgi complex in human cells

Assembly, Secretory Pathway Trafficking, and Surface Delivery of Kainate Receptors Is Regulated by Neuronal Activity.

Bap31 is an itinerant protein that moves between the peripheral endoplasmic reticulum (ER) and a juxtanuclear compartment related to ER-associated Degradation.

Biogenesis of ER-to-Golgi transport carriers: complex roles of COPII in ER export.

Bioimaging has been a cornerstone of cell biology and developmental biology research

COPII-dependent ER export in animal cells: adaptation and control for diverse cargo

Cargo loading at the ER ⬇️

Cell biology: Collagen secretion explained

Cep126 is required for pericentriolar satellite localisation to the centrosome and for primary cilium formation

Characteristic phenotypes associated with congenital dyserythropoietic anemia (type II) manifest at different stages of erythropoiesis

Characterization of human Sec16B: indications of specialized, non-redundant functions ⬇️

Coupling of ER exit to microtubules through direct interaction of COPII with dynactin

Cytoplasmic dynein-2 at a glance

De novo formation, fusion and fission of mammalian COPII-coated endoplasmic reticulum exit sites

Developing pathways to clarify pathogenicity of unclassified variants in Osteogenesis Imperfecta genetic analysis

Differential effects of a GTP-restricted mutant of Sar1p on segregation of cargo during export from the endoplasmic reticulum

Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin

Dynein-2 intermediate chains play crucial but distinct roles in primary cilia formation and function

ER exit sites--localization and control of COPII vesicle formation

ER-to-Golgi Transport: A Sizeable Problem

ER-to-Golgi trafficking of procollagen in the absence of large carriers

ER-to-Golgi transport: form and formation of vesicular and tubular carriers.

Early stages of retinal development depend on Sec13 function

Efficient coupling of Sec23-Sec24 to Sec13-Sec31 drives COPII-dependent collagen secretion and is essential for normal craniofacial development.

Epithelial organization and cyst lumen expansion require efficient Sec13-Sec31-driven secretion

Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells

Functional coupling of microtubules to membranes – implications for membrane structure and dynamics ⬇️

Giantin is required for intracellular N-terminal processing of type I procollagen

Giantin-knockout models reveal a feedback loop between Golgi function and glycosyltransferase expression.

In vivo dynamics of the F-actin-binding protein neurabin-II

Inhibition of the interaction between tyrosine-based motifs and the medium chain subunit of the AP-2 adaptor complex by specific tyrphostins

Insulin dependent tyrosine phosphorylation of the tyrosine internalisation motif of TGN38 creates a specific SH2 domain binding site ⬇️

Insulin promotes Rip11 accumulation at the plasma membrane by inhibiting a dynamin- and PI3-kinase-dependent, but Akt-independent, internalisation event

Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells.

Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport.

LG186: An inhibitor of GBF1 function that causes Golgi disassembly in human and canine cells

Meeting report--Imaging membrane dynamics, 14-17 September, Royal Holloway--University of London, UK

Membrane contact sites--an interesting species, an interesting mix.

Microtubule motors mediate endosomal sorting by maintaining functional domain organization

Microtubule plus-end loading of p150(Glued) is mediated by EB1 and CLIP-170 but is not required for intracellular membrane traffic in mammalian cells.

Nordihydroguaiaretic acid affects multiple dynein-dynactin functions in interphase and mitotic cells.

Opposing microtubule motors control motility, morphology and cargo segregation during ER-to-Golgi transport

Optimising the precision for localising fluorescent proteins in living cells by 2D Gaussian fitting of digital images: application to COPII-coated endoplasmic reticulum exit sites.

Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER.

P4HB recurrent missense mutation causing Cole-Carpenter syndrome.

PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport

Phosphatidylinositol 4-kinase is required for endosomal trafficking and degradation of the EGF receptor

Planar Cell Polarity Effector Proteins Inturned and Fuzzy Form a Rab23 GEF Complex

RNA interference approaches to examine Golgi function in animal cell culture

Regulator of calcineurin-2 is a centriolar protein with a role in cilia length control.

Role of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomes

SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment

Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells

Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis

Secretory cargo regulates the turnover of COPII subunits at single ER exit sites

Specific functions of BIG1 and BIG2 in endomembrane organization

Specificity of cytoplasmic dynein subunits in discrete membrane-trafficking steps

Subunit composition of the human cytoplasmic dynein-2 complex

TFG Promotes Organization of Transitional ER and Efficient Collagen Secretion

The Golgi matrix protein giantin is required for normal cilia function in zebrafish.

The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis

The many ways to cross the plasma membrane.

The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network

The role of motor proteins in endosomal sorting

The secretion inhibitor Exo2 perturbs trafficking of Shiga toxin between endosomes and the trans-Golgi network.

Tumor necrosis factor-alpha-induced insulin resistance in 3T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction.