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List of works by Sergey Leikin

Abnormal type I collagen post-translational modification and crosslinking in a cyclophilin B KO mouse model of recessive osteogenesis imperfecta

scientific article

Absence of FKBP10 in recessive type XI osteogenesis imperfecta leads to diminished collagen cross-linking and reduced collagen deposition in extracellular matrix.

scientific article

Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta.

scientific article published on 21 July 2016

COL1 C-propeptide cleavage site mutations cause high bone mass osteogenesis imperfecta.

scientific article

Carcinomas contain a matrix metalloproteinase-resistant isoform of type I collagen exerting selective support to invasion

scientific article

Changes in thermal stability and microunfolding pattern of collagen helix resulting from the loss of alpha2(I) chain in osteogenesis imperfecta murine

scientific article published in August 2003

Chaperoning osteogenesis: new protein-folding disease paradigms.

scientific article

Collagen degradation by tumor-associated trypsins.

scientific article published on 28 March 2013

DNA Double Helices Recognize Mutual Sequence Homology in a Protein Free Environment

article

Defective C-propeptides of the proalpha2(I) chain of type I procollagen impede molecular assembly and result in osteogenesis imperfecta

scientific article

Deficiency of CRTAP in non-lethal recessive osteogenesis imperfecta reduces collagen deposition into matrix.

scientific article published on 19 October 2011

Deficient degradation of homotrimeric type I collagen, α1(I)3 glomerulopathy in oim mice ⬇️

scientific article published on July 31, 2011

Direct observation of azimuthal correlations between DNA in hydrated aggregates

scientific article published on 29 September 2005

Electrostatic braiding and homologous pairing of DNA double helices.

scientific article

Evidence of biomechanical and collagen heterogeneity in uterine fibroids

article

Fluctuations and interactions of semi-flexible polyelectrolytes in columnar assemblies

scientific article

Helical structure determines different susceptibilities of dsDNA, dsRNA, and tsDNA to counterion-induced condensation.

scientific article published on May 2013

Interactions of inorganic phosphate and sulfate anions with collagen

scientific article published on 01 November 2004

Kuskokwim syndrome, a recessive congenital contracture disorder, extends the phenotype of FKBP10 mutations.

scientific article published on 08 July 2013

Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding

scientific article

MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta.

scientific article published on 06 July 2016

Makings of a brittle bone: Unexpected lessons from a low protein diet study of a mouse OI model

scientific article published on 30 March 2016

Molecular mechanism of alpha 1(I)-osteogenesis imperfecta/Ehlers-Danlos syndrome: unfolding of an N-anchor domain at the N-terminal end of the type I collagen triple helix

scientific article published on 5 January 2006

Molecular mechanism of type I collagen homotrimer resistance to mammalian collagenases.

scientific article

Mutations Near Amino End of α1(I) Collagen Cause Combined Osteogenesis Imperfecta/Ehlers-Danlos Syndrome by Interference with N-propeptide Processing

scientific article published in Journal of Biological Chemistry

Mutations in WNT1 cause different forms of bone fragility

scientific article

Osteoblast Malfunction Caused by Cell Stress Response to Procollagen Misfolding in α2(I)-G610C Mouse Model of Osteogenesis Imperfecta.

scientific article published on March 2016

Procollagen triple helix assembly: an unconventional chaperone-assisted folding paradigm

scientific article

Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta

scientific article

Pulse-chase analysis of procollagen biosynthesis by azidohomoalanine labeling.

scientific article

Raman spectral evidence for hydration forces between collagen triple helices ⬇️

scientific article published on October 14, 1997

Selective retention and degradation of molecules with a single mutant alpha1(I) chain in the Brtl IV mouse model of OI

scientific journal article

Signatures of DNA flexibility, interactions and sequence-related structural variations in classical X-ray diffraction patterns.

scientific article

Structural heterogeneity of type I collagen triple helix and its role in osteogenesis imperfecta.

scientific article published on 11 December 2007

Structure, stability and interactions of type I collagen with GLY349-CYS substitution in alpha 1(I) chain in a murine Osteogenesis Imperfecta model

scientific article published in May 2004

Substitution of murine type I collagen A1 3-hydroxylation site alters matrix structure but does not recapitulate osteogenesis imperfecta bone dysplasia

scientific article published on 26 February 2020

Substitutions for arginine at position 780 in triple helical domain of the α1(I) chain alter folding of the type I procollagen molecule and cause osteogenesis imperfecta

scientific article published on 10 July 2018

Sugars and Polyols Inhibit Fibrillogenesis of Type I Collagen by Disrupting Hydrogen-Bonded Water Bridges between the Helices ⬇️

scientific article published on August 25, 1998

Symmetry Laws for Interaction between Helical Macromolecules ⬇️

scientific article published on November 1, 1998

The chaperone activity of 4PBA ameliorates the skeletal phenotype of Chihuahua, a zebrafish model for dominant osteogenesis imperfecta

scientific article published on 5 May 2017

Torsional deformation of double helix in interaction and aggregation of DNA

scientific article published on 01 May 2004

Undulations enhance the effect of helical structure on DNA interactions.

scientific article

Variable bone fragility associated with an Amish COL1A2 variant and a knock-in mouse model

scientific article

Y-position cysteine substitution in type I collagen (alpha1(I) R888C/p.R1066C) is associated with osteogenesis imperfecta/Ehlers-Danlos syndrome phenotype.

scientific article

Zebrafish Collagen Type I: Molecular and Biochemical Characterization of the Major Structural Protein in Bone and Skin.

scientific article published on 15 February 2016

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