List of works - Marc Fransen

A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathway

scientific article

A cost-effective approach to microporate mammalian cells with the Neon Transfection System

scientific article published on 27 August 2014

A mouse model for Zellweger syndrome

scientific journal article

Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis

scientific article

Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay

scientific article

Antioxidant cytoprotection by peroxisomal peroxiredoxin-5.

scientific article published on 13 March 2015

Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b

scientific article

Cyclophilin D: a therapeutic target to counteract reactive oxygen species-mediated damage in neurodegenerative disease?

scientific article published on 28 November 2012

Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting

scientific article published on 24 May 2019

Differential distribution of peroxisomal proteins points to specific roles of peroxisomes in the murine retina

scientific article published on 02 January 2019

Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.

scientific article

Farnesylation of Pex19p is not essential for peroxisome biogenesis in yeast and mammalian cells.

scientific article published on July 2006

Fibroblast studies documenting a case of peroxisomal 2-methylacyl-CoA racemase deficiency: possible link between racemase deficiency and malabsorption and vitamin K deficiency.

scientific article published in August 2001

Functional characterization of two missense mutations in Pex5p - C11S and N526K

scientific article published on 29 April 2007

Functional peroxisomes are required for β-cell integrity in mice

scientific article published on 08 February 2019

Further characterization of the human peroxisomal C-terminal targeting signal protein import receptor

scientific article published on 01 December 1996

Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver. Relationship between the different dehydrogenases and evidence that fatty acids and the C27 bile acids di- and tri-hydroxycoprostanic acids are metabolized

scientific article published on 01 September 1996

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

HaloTag as a tool to investigate peroxisome dynamics in cultured mammalian cells.

scientific article

How peroxisomes arise.

scientific article

Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii

scientific article

Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor

scientific journal article

Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import ⬇️

scientific article published on July 7, 1998

Identification of a novel PEX14 mutation in Zellweger syndrome.

scientific article

Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase

scientific article

Import of peroxisomal membrane proteins: the interplay of Pex3p- and Pex19p-mediated interactions.

scientific article published on 26 September 2006

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

scientific article published on 3 March 2011

KillerRed as a Tool to Study the Cellular Responses to Peroxisome-Derived Oxidative Stress.

scientific article

Large-scale purification and further characterization of rat pristanoyl-CoA oxidase

scientific journal article

Mammalian peroxisomal acyl-CoA oxidases. I. Molecular characterization of rat pristanoyl-CoA oxidase

scientific article published on 01 December 1996

Mammalian peroxisomal acyl-CoA oxidases. II. Molecular characterization of rat trihydroxycoprostanoyl-CoA oxidase

scientific article published on 01 December 1996

Mammalian peroxisomal acyl-CoA oxidases. III. Molecular characterization of human branched chain fatty acyl-CoA oxidase

scientific article

Membrane topologies of PEX13 and PEX14 provide new insights on the mechanism of protein import into peroxisomes

scientific article published on 28 November 2018

Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation

scientific article published on 20 November 2014

Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation

scientific article published on 26 March 2020

Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome

scientific article

Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase

scientific journal article

PEX5 Protein Binds Monomeric Catalase Blocking Its Tetramerization and Releases It upon Binding the N-terminal Domain of PEX14 ⬇️

scientific article published on October 5, 2011

PEX5, the shuttling import receptor for peroxisomal matrix proteins, is a redox-sensitive protein

scientific article published on 31 October 2013

Peroxisomal Dysfunction and Oxidative Stress in Neurodegenerative Disease: A Bidirectional Crosstalk

scientific article published on 01 January 2020

Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease

scientific article published on 26 July 2019

Peroxisomal metabolism and oxidative stress.

scientific article published on 09 August 2013

Peroxisome biogenesis in mammalian cells: The impact of genes and environment.

scientific article published on 21 August 2015

Peroxisome dynamics in cultured mammalian cells.

scientific article published on 4 August 2009

Peroxisomes and Cellular Oxidant/Antioxidant Balance: Protein Redox Modifications and Impact on Inter-organelle Communication

scientific article published on 01 January 2018

Peroxisomes are signaling platforms for antiviral innate immunity

scientific article

Peroxisomes as Modulators of Cellular Protein Thiol Oxidation: A New Model System.

scientific article

Peroxisomes in zebrafish: distribution pattern and knockdown studies

scientific article published on 17 June 2010

Pex11pbeta-mediated growth and division of mammalian peroxisomes follows a maturation pathway

scientific article published on 20 July 2010

Pex5p, the peroxisomal cycling receptor, is a monomeric non-globular protein.

scientific article published on 2 May 2005

Potential limitations in the use of KillerRed for fluorescence microscopy ⬇️

scientific article published on November 17, 2011

Potential role for Pex19p in assembly of PTS-receptor docking complexes

scientific article (publication date: 26 March 2004)

Presence of small GTP-binding proteins in the peroxisomal membrane

scientific article published on August 10, 1992

Properties of the ubiquitin-pex5p thiol ester conjugate.

scientific article

Quantitative Monitoring of Subcellular Redox Dynamics in Living Mammalian Cells Using RoGFP2-Based Probes.

scientific article

Redox Signaling from and to Peroxisomes: Progress, Challenges and Prospects

scientific article published on 13 February 2018

Redox interplay between mitochondria and peroxisomes

scientific article

Role of peroxisomes in ROS/RNS-metabolism: implications for human disease.

scientific article published on 09 December 2011

Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6.

scientific article published on 17 August 2009

The 80 kDa cytosolic protein that binds the C-terminal part of rat acyl-CoA oxidase is not a peroxisomal import receptor but a prolyl-endopeptidase

scientific article published on 01 November 1994

The N-terminal half of the peroxisomal cycling receptor Pex5p is a natively unfolded domain.

scientific article published on 19 December 2005

The Peroxisome-Mitochondria Connection: How and Why?

scientific article

The cytosolic domain of PEX3, a protein involved in the biogenesis of peroxisomes, binds membrane lipids

scientific article

The difference in recognition of terminal tripeptides as peroxisomal targeting signal 1 between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it.

scientific article

The import competence of a peroxisomal membrane protein is determined by Pex19p before the docking step.

scientific article published on 15 September 2006

The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress

scientific article published on 28 July 2017

The peroxisomal protein import machinery displays a preference for monomeric substrates.

scientific article published on April 2015

The visualization of peroxisomal proteins containing a C-terminal targeting sequence on western blot by using the biotinylated PTS1-receptor

scientific article published in November 1996

Trypanosoma brucei glycosomal ABC transporters: identification and membrane targeting.

scientific article published on March 2006

Ubiquitination of mammalian Pex5p, the peroxisomal import receptor.

scientific article

List of works by Marc Fransen

A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated protein import pathway

A cost-effective approach to microporate mammalian cells with the Neon Transfection System

A mouse model for Zellweger syndrome

Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis

Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay

Antioxidant cytoprotection by peroxisomal peroxiredoxin-5.

Comparison of the PTS1- and Rab8b-binding properties of Pex5p and Pex5Rp/TRIP8b

Cyclophilin D: a therapeutic target to counteract reactive oxygen species-mediated damage in neurodegenerative disease?

Deciphering the potential involvement of PXMP2 and PEX11B in hydrogen peroxide permeation across the peroxisomal membrane reveals a role for PEX11B in protein sorting

Differential distribution of peroxisomal proteins points to specific roles of peroxisomes in the murine retina

Export-deficient monoubiquitinated PEX5 triggers peroxisome removal in SV40 large T antigen-transformed mouse embryonic fibroblasts.

Farnesylation of Pex19p is not essential for peroxisome biogenesis in yeast and mammalian cells.

Fibroblast studies documenting a case of peroxisomal 2-methylacyl-CoA racemase deficiency: possible link between racemase deficiency and malabsorption and vitamin K deficiency.

Functional characterization of two missense mutations in Pex5p - C11S and N526K

Functional peroxisomes are required for β-cell integrity in mice

Further characterization of the human peroxisomal C-terminal targeting signal protein import receptor

Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver. Relationship between the different dehydrogenases and evidence that fatty acids and the C27 bile acids di- and tri-hydroxycoprostanic acids are metabolized

Guidelines for the use and interpretation of assays for monitoring autophagy

HaloTag as a tool to investigate peroxisome dynamics in cultured mammalian cells.

How peroxisomes arise.

Identification and characterization of human PMP34, a protein closely related to the peroxisomal integral membrane protein PMP47 of Candida boidinii

Identification and characterization of the putative human peroxisomal C-terminal targeting signal import receptor

Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import ⬇️

Identification of a novel PEX14 mutation in Zellweger syndrome.

Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase

Import of peroxisomal membrane proteins: the interplay of Pex3p- and Pex19p-mediated interactions.

Intraperoxisomal redox balance in mammalian cells: oxidative stress and interorganellar cross-talk

KillerRed as a Tool to Study the Cellular Responses to Peroxisome-Derived Oxidative Stress.

Large-scale purification and further characterization of rat pristanoyl-CoA oxidase

Mammalian peroxisomal acyl-CoA oxidases. I. Molecular characterization of rat pristanoyl-CoA oxidase

Mammalian peroxisomal acyl-CoA oxidases. II. Molecular characterization of rat trihydroxycoprostanoyl-CoA oxidase

Mammalian peroxisomal acyl-CoA oxidases. III. Molecular characterization of human branched chain fatty acyl-CoA oxidase

Membrane topologies of PEX13 and PEX14 provide new insights on the mechanism of protein import into peroxisomes

Mitochondria in peroxisome-deficient hepatocytes exhibit impaired respiration, depleted DNA, and PGC-1α independent proliferation

Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation

Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome

Molecular cloning and further characterization of rat peroxisomal trihydroxycoprostanoyl-CoA oxidase

PEX5 Protein Binds Monomeric Catalase Blocking Its Tetramerization and Releases It upon Binding the N-terminal Domain of PEX14 ⬇️

PEX5, the shuttling import receptor for peroxisomal matrix proteins, is a redox-sensitive protein

Peroxisomal Dysfunction and Oxidative Stress in Neurodegenerative Disease: A Bidirectional Crosstalk

Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease

Peroxisomal metabolism and oxidative stress.

Peroxisome biogenesis in mammalian cells: The impact of genes and environment.

Peroxisome dynamics in cultured mammalian cells.

Peroxisomes and Cellular Oxidant/Antioxidant Balance: Protein Redox Modifications and Impact on Inter-organelle Communication

Peroxisomes are signaling platforms for antiviral innate immunity

Peroxisomes as Modulators of Cellular Protein Thiol Oxidation: A New Model System.

Peroxisomes in zebrafish: distribution pattern and knockdown studies

Pex11pbeta-mediated growth and division of mammalian peroxisomes follows a maturation pathway

Pex5p, the peroxisomal cycling receptor, is a monomeric non-globular protein.

Potential limitations in the use of KillerRed for fluorescence microscopy ⬇️

Potential role for Pex19p in assembly of PTS-receptor docking complexes

Presence of small GTP-binding proteins in the peroxisomal membrane

Properties of the ubiquitin-pex5p thiol ester conjugate.

Quantitative Monitoring of Subcellular Redox Dynamics in Living Mammalian Cells Using RoGFP2-Based Probes.

Redox Signaling from and to Peroxisomes: Progress, Challenges and Prospects

Redox interplay between mitochondria and peroxisomes

Role of peroxisomes in ROS/RNS-metabolism: implications for human disease.

Small G proteins in peroxisome biogenesis: the potential involvement of ADP-ribosylation factor 6.

The 80 kDa cytosolic protein that binds the C-terminal part of rat acyl-CoA oxidase is not a peroxisomal import receptor but a prolyl-endopeptidase

The N-terminal half of the peroxisomal cycling receptor Pex5p is a natively unfolded domain.

The Peroxisome-Mitochondria Connection: How and Why?

The cytosolic domain of PEX3, a protein involved in the biogenesis of peroxisomes, binds membrane lipids

The difference in recognition of terminal tripeptides as peroxisomal targeting signal 1 between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it.

The import competence of a peroxisomal membrane protein is determined by Pex19p before the docking step.

The peroxisomal import receptor PEX5 functions as a stress sensor, retaining catalase in the cytosol in times of oxidative stress

The peroxisomal protein import machinery displays a preference for monomeric substrates.

The visualization of peroxisomal proteins containing a C-terminal targeting sequence on western blot by using the biotinylated PTS1-receptor

Trypanosoma brucei glycosomal ABC transporters: identification and membrane targeting.

Ubiquitination of mammalian Pex5p, the peroxisomal import receptor.