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List of works by Christof Fellmann

A computational algorithm to predict shRNA potency.

scientific article

A pipeline for the generation of shRNA transgenic mice

scientific article published on 02 February 2012

An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance

scientific article

An optimized microRNA backbone for effective single-copy RNAi

scientific article

Author Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

scientific article published on 01 July 2019

CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification

scientific article published on 01 January 2019

Cancer-specific loss of <i>TERT</i> activation sensitizes glioblastoma to DNA damage

scientific article published on 01 March 2021

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

scientific article published on 20 May 2019

Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs

scientific article published on 09 May 2019

Cornerstones of CRISPR-Cas in drug discovery and therapy

scientific article published on 23 December 2016

Development of siRNA payloads to target KRAS-mutant cancer

scientific article

Differential Effector Engagement by Oncogenic KRAS.

scientific article published in February 2018

Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors

scientific article

Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner

scientific article published on 01 September 2018

Extension of the crRNA enhances Cpf1 gene editing in vitro and in vivo

scientific article published in Nature Communications

Functional identification of optimized RNAi triggers using a massively parallel sensor assay

scientific article

HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase

scientific article published in June 2010

MAP kinase and autophagy pathways cooperate to maintain RAS mutant cancer cell survival

article by Chih-Shia Lee et al published 1 February 2019 in Proceedings of the National Academy of Sciences of the United States of America

MYC Drives Pten/Trp53-Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2.

scientific article published on 31 March 2015

PI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay

scientific article published on 12 May 2021

Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes

scientific article published on 10 March 2020

Prediction of potent shRNAs with a sequential classification algorithm

scientific article

Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch

scientific article

Stable RNA interference rules for silencing

scientific article published on January 2014

Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a

scientific article published on 09 August 2019

Systematic discovery of natural CRISPR-Cas12a inhibitors

scientific article

Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy

scientific article published on 4 January 2012

Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi

scientific article

Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma

scientific article

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