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List of works by Miguel C. Seabra

A general role for Rab27a in secretory cells

scientific article

A novel statin-mediated "prenylation block-and-release" assay provides insight into the membrane targeting mechanisms of small GTPases

scientific article

A practical diagnostic test for choroideremia

scientific article

A role for Na+,K+-ATPase α1 in regulating Rab27a localisation on melanosomes

scientific article

Adeno-associated virus 8-mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models

scientific article

An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue

scientific article published in January 2012

Analysis and preparation of stable complexes between Rab GTPases, Rab escort protein, and Rab geranylgeranyl transferase

scientific article published in January 2002

Are prenyl groups on proteins sticky fingers or greasy handles?

scientific article

Armus is a Rac1 effector that inactivates Rab7 and regulates E-cadherin degradation

scientific article

Bacteria and Protozoa Differentially Modulate the Expression of Rab Proteins ⬇️

scientific article published on July 20, 2012

Clinical utility gene card for: choroideremia.

scientific article published on 21 August 2013

Cloning, mapping and characterization of the human RAB27A gene.

scientific article

Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium

scientific article

Correction: A Role for Na+,K+-ATPase α1 in Regulating Rab27a Localisation on Melanosomes

scientific article published on 3 February 2016

Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux

scientific article

Deficient geranylgeranylation of Ram/Rab27 in choroideremia.

scientific article

Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics

scientific article published on 01 April 2019

ER-associated protein degradation is a common mechanism underpinning numerous monogenic diseases including Robinow syndrome

scientific article published on 27 July 2005

Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis

scientific article

Evolution of the Rab family of small GTP-binding proteins

scientific article (publication date: 2 November 2001)

Expression of OA1 limits the fusion of a subset of MVBs with lysosomes - a mechanism potentially involved in the initial biogenesis of melanosomes

scientific article published on 4 September 2013

Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome

scientific article

Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome

Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome.

scientific article published in October 2002

GTPase activity of Rab5 acts as a timer for endocytic membrane fusion

scientific article published in Nature

Gene therapy for choroideremia: in vitro rescue mediated by recombinant adenovirus

scientific article published in April 2003

Host PI(3,5)P2 activity is required for Plasmodium berghei growth during liver stage infection

scientific article

Host cell autophagy contributes to Plasmodium liver development

scientific article published on 24 September 2015

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

scientific article

Impaired prenylation of Rab GTPases in the gunmetal mouse causes defects in bone cell function.

scientific article

Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia

scientific article

Isoprenylcysteine carboxyl methyltransferase deficiency in mice

scientific article

Mechanism of Rab Geranylgeranylation: Formation of the Catalytic Ternary Complex ⬇️

scientific article published on September 8, 1998

Melanin Transferred to Keratinocytes Resides in Nondegradative Endocytic Compartments

scientific article published on 23 October 2017

Melanin processing by keratinocytes: A non‐microbial type of host‐pathogen interaction?

scientific article published on 01 April 2019

Melanosome maturation defect in Rab38-deficient retinal pigment epithelium results in instability of immature melanosomes during transient melanogenesis

scientific article

Melanosomes on the move: a model to understand organelle dynamics.

scientific article published on October 2011

Membrane Association and Targeting of Prenylated Ras-like GTPases ⬇️

scientific article published on March 1, 1998

Membrane targeting of Rab GTPases is influenced by the prenylation motif

scientific article

MicroRNA-Containing T-Regulatory-Cell-Derived Exosomes Suppress Pathogenic T Helper 1 Cells.

scientific article

Mouse genetic corneal disease resulting from transgenic insertional mutagenesis

scientific article published on March 2004

Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases

scientific article

Multiple regions contribute to membrane targeting of Rab GTPases

scientific article

Myosin Va acts in concert with Rab27a and MyRIP to regulate acute von-Willebrand factor release from endothelial cells

scientific article published on 5 August 2011

Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport.

scientific article published on 21 March 2009

NOX2 Controls Phagosomal pH to Regulate Antigen Processing during Crosspresentation by Dendritic Cells

Novel functions for Rab GTPases in multiple aspects of tumour progression ⬇️

scientific article published on December 1, 2012

Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a.

scientific article

Phagosome maturation during endosome interaction revealed by partial rhodopsin processing in retinal pigment epithelium

scientific article

Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo

scientific article published in September 2005

Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease).

scientific article

Portugal's research funding is secure

journal article; published in Nature on 2014-03-19

Prenylation Assays for Small GTPases

scientific article published on January 1, 1998

Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease.

scientific article published in June 2001

Preparation of recombinant Rab geranylgeranyltransferase and Rab escort proteins

scientific article published on January 1995

Protein prenyltransferases

scientific article (publication date: 8 March 1996)

PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils

scientific article

Rab GTPase regulation of bacteria and protozoa phagocytosis occurs through the modulation of phagocytic receptor surface expression

scientific article published in Scientific Reports

Rab GTPases containing a CAAX motif are processed post-geranylgeranylation by proteolysis and methylation

scientific article published on 18 November 2006

Rab GTPases, intracellular traffic and disease.

scientific article

Rab and Arf proteins in genetic diseases

scientific article

Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A

scientific article

Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys ⬇️

scientific article published on July 15, 1992

Rab geranylgeranylation occurs preferentially via the pre-formed REP-RGGT complex and is regulated by geranylgeranyl pyrophosphate

scientific article published on October 2008

Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis

scientific article published on 18 October 2013

Rab1a and Rab5a preferentially bind to binary lipid compositions with higher stored curvature elastic energy

scientific article

Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli

scientific article published on 4 October 2017

Rab27a Targeting to Melanosomes Requires Nucleotide Exchange but Not Effector Binding ⬇️

scientific article published on June 15, 2011

Rab27a and Rab27b control different steps of the exosome secretion pathway

scientific article

Rab27a and melanosomes: a model to investigate the membrane targeting of Rabs.

scientific article published on December 2012

Rab27a is required for regulated secretion in cytotoxic T lymphocytes

scientific article published on February 2001

Rab27a regulates phagosomal pH and NADPH oxidase recruitment to dendritic cell phagosomes

scientific article published on 11 March 2007

Rab27a supports exosome-dependent and -independent mechanisms that modify the tumor microenvironment and can promote tumor progression

scientific article published on 3 August 2012

Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment

scientific article

Rab27b regulates mast cell granule dynamics and secretion

scientific article

Rab27b regulates number and secretion of platelet dense granules

scholarly article

Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes

scientific article

Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models.

scientific article

Rapid multilabel detection of geranylgeranylated proteins by using bioorthogonal ligation chemistry

scientific article

Regulation of melanosome number, shape and movement in the zebrafish retinal pigment epithelium by OA1 and PMEL.

scientific article published on 17 February 2015

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial.

scientific article

Retinal pigment epithelium defects accelerate photoreceptor degeneration in cell type-specific knockout mouse models of choroideremia

scientific article

Rod disc renewal occurs by evagination of the ciliary plasma membrane that makes cadherin-based contacts with the inner segment

scientific article published on 14 December 2015

Single prenyl-binding site on protein prenyl transferases ⬇️

scientific article published on October 13, 1998

Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria.

scientific article

Symmetric arrangement of mitochondria:plasma membrane contacts between adjacent photoreceptor cells regulated by Opa1

scientific article published on 22 June 2020

Synthesis, stereochemistry and SAR of a series of minodronate analogues as RGGT inhibitors

scientific article

The gunmetal mouse reveals Rab geranylgeranyl transferase to be the major molecular target of phosphonocarboxylate analogues of bisphosphonates

scientific article published on 21 March 2011

The host endocytic pathway is essential for Plasmodium berghei late liver stage development

scientific article published on 3 August 2012

The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes

scientific journal article

The mammalian Rab family of small GTPases: definition of family and subfamily sequence motifs suggests a mechanism for functional specificity in the Ras superfamily

scientific article published in August 2000

The melanosome as a model to study organelle motility in mammals

scientific article published on April 2004

The melanosome: membrane dynamics in black and white

scientific article

The role of Rab27a in the regulation of melanosome distribution within retinal pigment epithelial cells

scientific journal article

The secretory small GTPase Rab27B as a marker for breast cancer progression

scientific article

The ternary Rab27a-Myrip-Myosin VIIa complex regulates melanosome motility in the retinal pigment epithelium

scientific article

Thematic review series: lipid posttranslational modifications. geranylgeranylation of Rab GTPases.

scientific article

Thousands of rab GTPases for the cell biologist

scientific article

Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease

scientific article published on 22 September 2008

cDNA cloning and chromosomal localization of the genes encoding the alpha- and beta-subunits of human Rab geranylgeranyl transferase: the 3' end of the alpha-subunit gene overlaps with the transglutaminase 1 gene promoter

scientific article published in December 1996

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