List of works - Tony Tiganis

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

scientific article published in August 2017

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

scientific article published in September 2017

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

scientific article published on 01 December 2019

A novel mechanism for imatinib mesylate (STI571) resistance in CML cell line KT-1: role of TC-PTP in modulating signals downstream from the BCR-ABL fusion protein

scientific article

Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells

scientific article published on 19 March 2019

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

article

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

scientific article published on 21 May 2009

Approaches to the Identification of Protein Tyrosine Phosphatase Substrates

Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97

scientific article (publication date: 22 August 1997)

Casein kinase II beta-subunit inhibits the activity of the catalytic alpha-subunit in the absence of salt

scientific article published on December 1993

Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus

scientific article published on 07 December 2018

Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1

scientific article published on 28 August 2018

Cellular stress regulates the nucleocytoplasmic distribution of the protein-tyrosine phosphatase TCPTP.

scientific article published on 30 July 2001

Characterization of PTPN2 and its use as a biomarker

scientific article published on 30 August 2013

Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase

scientific article published on 5 April 2001

Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP

scientific journal article

Crystallization of importin α, the nuclear-import receptor

scientific article published on 01 February 1999

DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression.

scientific article

Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

scientific article

Differential SKIP expression in PTEN-deficient glioblastoma regulates cellular proliferation and migration

scientific article published on 22 September 2014

Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase

scientific article

Differential regulation of protein tyrosine kinase signaling by Dock and the PTP61F variants

scientific article

Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling

scientific article published in October 2011

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance

scientific article published on 13 October 2011

Erratum to: Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice

scientific article published on 01 December 2016

Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456-2465

scientific article published on 11 January 2019

Functional and morphological changes induced by tunicamycin in dividing and confluent endothelial cells

scientific article published on 01 February 1992

Glucocorticoids stimulate hepatic and renal catecholamine inactivation by direct rapid induction of the dopamine sulfotransferase Sult1d1.

scientific article published on 4 December 2009

Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2

scientific article

Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice

scientific article published on 15 September 2016

High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage

scientific article published on 11 March 2014

Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase

scientific article published on 25 June 2012

Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes

scientific article published on 15 October 2011

Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets

scientific article published on 2 March 2015

Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells

scientific article published in June 2003

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

scientific article

Insert Regions in Domain X of the Casein Kinase II Catalytic Subunit

scientific article published in 2008

Insulin action in the brain: Roles in energy and glucose homeostasis

scientific article published on 31 July 2017

Insulin regulates POMC neuronal plasticity to control glucose metabolism

article by Garron T. Dodd et al published 19 September 2018 in eLife

Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

scientific article published on 01 September 2019

Isolation and Characterization of Mouse Intrahepatic Lymphocytes by Flow Cytometry

scientific article published in January 2018

Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

scientific article published on 01 January 2019

Leptin and insulin act on POMC neurons to promote the browning of white fat.

scientific article published on January 2015

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

scientific article published on 25 October 2018

PTP1B and TCPTP in CNS Signaling and Energy Balance

PTP1B and TCPTP – nonredundant phosphatases in insulin signaling and glucose homeostasis ⬇️

scientific article published on April 18, 2012

PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling

scientific article published on 20 August 2008

PTPN2 attenuates T-cell lymphopenia-induced proliferation

scientific article published in Nature Communications

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

scientific article published on 05 December 2019

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.

scientific article published on 10 August 2017

PTPN2 restrains CD8+ T cell responses after antigen cross-presentation for the maintenance of peripheral tolerance in mice

article

PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity

scientific article published on 19 September 2016

PTPN2: a tumor suppressor you want deleted?

scientific article published on 10 October 2017

Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice

scientific article

Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis

scientific article

Persistent Leptin Signaling in the Arcuate Nucleus Impairs Hypothalamic Insulin Signaling and Glucose Homeostasis in Obese Mice

scientific article published on 16 April 2019

Phosphorylation at the cyclin-dependent kinases site (Thr85) of parathyroid hormone-related protein negatively regulates its nuclear localization

scientific article published on June 1999

Pioneer of Eph biology and therapeutics: Martin Lackmann (1956-2014).

scientific article published on 17 November 2014

Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

scientific article published on October 2015

Protein kinase CK2: biphasic kinetics with peptide substrates

scientific article published in January 1996

Protein tyrosine phosphatase function: the substrate perspective

scientific article published on February 2007

Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization

scientific article

Protein tyrosine phosphatases: dephosphorylating the epidermal growth factor receptor

scientific article

RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State

scientific article

Reactive oxygen species and insulin resistance: the good, the bad and the ugly ⬇️

scientific article published on December 14, 2010

Reactive oxygen species enhance insulin sensitivity

scientific article

Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity

scientific article published on 11 February 2019

Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1.

scientific article published on 27 March 2009

Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP

scientific article

Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.

scientific article

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response

scientific article

Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase

scientific article

Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton

scientific article

Special Issue - Signalling. Introduction: Frontiers in cell signalling

scientific article published in 2013

Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice.

scientific article

Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity

scientific article published on November 1994

Synapsins as major neuronal Ca2+/S100A1-interacting proteins

scientific article published in 1999

T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice

scientific article

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

scientific article published in December 2011

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

scientific article published in November 2015

T-Cell-Specific PTPN2 Deficiency in NOD Mice Accelerates the Development of Type 1 Diabetes and Autoimmune Comorbidities

scientific article published on 01 April 2019

T-cell protein tyrosine phosphatase attenuates STAT3 and insulin signaling in the liver to regulate gluconeogenesis ⬇️

scientific journal article

T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6

scientific article

TCPTP Regulates Insulin Signaling in AgRP Neurons to Coordinate Glucose Metabolism With Feeding

scientific article published on 30 April 2018

TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers.

scientific article published on 19 November 2012

The Akt kinase signals directly to endothelial nitric oxide synthase

scientific journal article

The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis

scientific article published on August 2015

The Noncatalytic C-terminal Segment of the T Cell Protein Tyrosine Phosphatase Regulates Activity via an Intramolecular Mechanism

scientific article published in Journal of Biological Chemistry

The Role of TCPTP in Cancer

The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis

scientific article published on June 2004

The nucleus- and endoplasmic reticulum-targeted forms of protein tyrosine phosphatase 61F regulate Drosophila growth, life span, and fecundity

scientific article published on 22 January 2013

The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor.

scientific article

The protein-tyrosine phosphatase TCPTP regulates epidermal growth factor receptor-mediated and phosphatidylinositol 3-kinase-dependent signaling

scientific article (publication date: 24 September 1999)

The role of liver fructose-1,6-bisphosphatase in regulating appetite and adiposity.

scientific article

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

scientific article published on 14 October 2010

The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane

scientific article

Torso-Like Is a Component of the Hemolymph and Regulates the Insulin Signalling Pathway in Drosophila

scientific article published on 13 February 2018

List of works by Tony Tiganis

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

A novel mechanism for imatinib mesylate (STI571) resistance in CML cell line KT-1: role of TC-PTP in modulating signals downstream from the BCR-ABL fusion protein

Activation of naïve CD4+ T cells re-tunes STAT1 signaling to deliver unique cytokine responses in memory CD4+ T cells

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

Approaches to the Identification of Protein Tyrosine Phosphatase Substrates

Association of the T-cell protein tyrosine phosphatase with nuclear import factor p97

Casein kinase II beta-subunit inhibits the activity of the catalytic alpha-subunit in the absence of salt

Celastrol Promotes Weight Loss in Diet-Induced Obesity by Inhibiting the Protein Tyrosine Phosphatases PTP1B and TCPTP in the Hypothalamus

Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1

Cellular stress regulates the nucleocytoplasmic distribution of the protein-tyrosine phosphatase TCPTP.

Characterization of PTPN2 and its use as a biomarker

Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase

Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP

Crystallization of importin α, the nuclear-import receptor

DNA replication stalling attenuates tyrosine kinase signaling to suppress S phase progression.

Development of "substrate-trapping" mutants to identify physiological substrates of protein tyrosine phosphatases

Differential SKIP expression in PTEN-deficient glioblastoma regulates cellular proliferation and migration

Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase

Differential regulation of protein tyrosine kinase signaling by Dock and the PTP61F variants

Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling

Elevated Hypothalamic TCPTP in Obesity Contributes to Cellular Leptin Resistance

Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance

Erratum to: Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice

Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456-2465

Functional and morphological changes induced by tunicamycin in dividing and confluent endothelial cells

Glucocorticoids stimulate hepatic and renal catecholamine inactivation by direct rapid induction of the dopamine sulfotransferase Sult1d1.

Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2

Hepatocyte glutathione peroxidase-1 deficiency improves hepatic glucose metabolism and decreases steatohepatitis in mice

High-fat-fed obese glutathione peroxidase 1-deficient mice exhibit defective insulin secretion but protection from hepatic steatosis and liver damage

Identification and functional characterization of protein kinase A phosphorylation sites in the major lipolytic protein, adipose triglyceride lipase

Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes

Inactivation of Protein Tyrosine Phosphatases Enhances Interferon Signaling in Pancreatic Islets

Inhibition of phosphatidylinositol 3-kinase signaling negates the growth advantage imparted by a mutant epidermal growth factor receptor on human glioblastoma cells

Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

Insert Regions in Domain X of the Casein Kinase II Catalytic Subunit

Insulin action in the brain: Roles in energy and glucose homeostasis

Insulin regulates POMC neuronal plasticity to control glucose metabolism

Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

Isolation and Characterization of Mouse Intrahepatic Lymphocytes by Flow Cytometry

Leptin Signaling in the Arcuate Nucleus Reduces Insulin's Capacity to Suppress Hepatic Glucose Production in Obese Mice

Leptin and insulin act on POMC neurons to promote the browning of white fat.

Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

PTP1B and TCPTP in CNS Signaling and Energy Balance

PTP1B and TCPTP – nonredundant phosphatases in insulin signaling and glucose homeostasis ⬇️

PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling

PTPN2 attenuates T-cell lymphopenia-induced proliferation

PTPN2 phosphatase deletion in T cells promotes anti-tumour immunity and CAR T-cell efficacy in solid tumours

PTPN2 regulates T cell lineage commitment and αβ versus γδ specification.

PTPN2 restrains CD8+ T cell responses after antigen cross-presentation for the maintenance of peripheral tolerance in mice

PTPN2-deficiency exacerbates T follicular helper cell and B cell responses and promotes the development of autoimmunity

PTPN2: a tumor suppressor you want deleted?

Pancreatic T cell protein-tyrosine phosphatase deficiency affects beta cell function in mice

Pancreatic T cell protein-tyrosine phosphatase deficiency ameliorates cerulein-induced acute pancreatitis

Persistent Leptin Signaling in the Arcuate Nucleus Impairs Hypothalamic Insulin Signaling and Glucose Homeostasis in Obese Mice

Phosphorylation at the cyclin-dependent kinases site (Thr85) of parathyroid hormone-related protein negatively regulates its nuclear localization

Pioneer of Eph biology and therapeutics: Martin Lackmann (1956-2014).

Protein Tyrosine Phosphatases in Hypothalamic Insulin and Leptin Signaling

Protein kinase CK2: biphasic kinetics with peptide substrates

Protein tyrosine phosphatase function: the substrate perspective

Protein tyrosine phosphatase hPTPN20a is targeted to sites of actin polymerization

Protein tyrosine phosphatases: dephosphorylating the epidermal growth factor receptor

RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State

Reactive oxygen species and insulin resistance: the good, the bad and the ugly ⬇️

Reactive oxygen species enhance insulin sensitivity

Reduced expression of phosphatase PTPN2 promotes pathogenic conversion of Tregs in autoimmunity

Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1.

Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP

Regulation of insulin signaling through reversible oxidation of the protein-tyrosine phosphatases TC45 and PTP1B.

Reversed T Cell Receptor Docking on a Major Histocompatibility Class I Complex Limits Involvement in the Immune Response

Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase

Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton

Special Issue - Signalling. Introduction: Frontiers in cell signalling

Strain-dependent differences in bone development, myeloid hyperplasia, morbidity and mortality in ptpn2-deficient mice.

Substrate and pseudosubstrate interactions with protein kinases: determinants of specificity

Synapsins as major neuronal Ca2+/S100A1-interacting proteins

T cell protein tyrosine phosphatase (TCPTP) deficiency in muscle does not alter insulin signalling and glucose homeostasis in mice