Search filters

List of works by Rudi Beyaert

99mTc-labelled S-HYNIC certolizumab pegol in rheumatoid arthritis and spondyloarthritis patients: a biodistribution and dosimetry study

scientific article published on 12 December 2016

A Founder Mutation Disrupts NF-κB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation

scientific article published on 31 October 2018

A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions

scientific article

A Two-Step Activation Mechanism of MALT1 Paracaspase ⬇️

scientific article published on March 15, 2012

A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

scientific article published on 21 October 2019

A novel link between Lck, Bak expression and chemosensitivity.

scientific article

A novel type of deubiquitinating enzyme

scientific article (publication date: 20 June 2003)

A role for hnRNP C1/C2 and Unr in internal initiation of translation during mitosis

scientific article

A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation

scientific article published in Scientific Reports

A universal role for MyD88 in TLR/IL-1R-mediated signaling

scientific article

A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

scientific article published on 14 August 2011

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection

scientific article

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection

scientific article published on 27 January 2016

A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes

scientific article

A20 Restrains Thymic Regulatory T Cell Development.

scientific article published on 25 August 2017

A20 and CYLD do not share significant overlapping functions during B cell development and activation

scientific article published on 21 September 2012

A20 controls intestinal homeostasis through cell-specific activities

scientific article published on 30 September 2014

A20 deletion in T cells modulates acute graft-versus-host disease in mice

scientific article published on 22 August 2017

A20 in inflammation and autoimmunity

scientific article

A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis

scientific article published on 22 August 2016

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

scientific article

A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions

scientific article

A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins

scientific article

A20, an inhibitor of cell death, self-associates by its zinc finger domain

scientific article

A20-deficient mast cells exacerbate inflammatory responses in vivo

scientific article published on 14 January 2014

A20: attractive without showing cleavage

scientific article published on 30 May 2014

A20: central gatekeeper in inflammation and immunity

scientific article

ABINs inhibit EGF receptor-mediated NF-kappaB activation and growth of EGF receptor-overexpressing tumour cells

scientific article

ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling

scientific article published on 27 February 2009

Abin1

Abin2

Abscisic Acid as Pathogen Effector and Immune Regulator

scientific article published on 19 April 2017

Adenoviral gene transfer of ABIN-1 protects mice from TNF/galactosamine-induced acute liver failure and lethality

scientific article published in August 2005

Adenoviral gene transfer of the NF-kappa B inhibitory protein ABIN-1 decreases allergic airway inflammation in a murine asthma model

scientific article published on 18 February 2005

Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome

scientific article published on October 1999

An E3 ubiquitin ligase-independent role of LUBAC.

scientific article

Ancient Origin of the CARD-Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions.

scientific article

Anti-endotoxic activity and structural basis for human MD-2·TLR4 antagonism of tetraacylated lipid A mimetics based on βGlcN(1↔1)αGlcN scaffold

scientific article

Antiinflammatory Properties of a Plant-Derived Nonsteroidal, Dissociated Glucocorticoid Receptor Modulator in Experimental Autoimmune Encephalomyelitis.

scientific article

Antiinflammatory properties of a plant-derived nonsteroidal, dissociated glucocorticoid receptor modulator in experimental autoimmune encephalomyelitis

scientific article

Apoptosis induced by gamma irradiation in peripheral blood mononuclear cells is not mediated by cytochrome-c release and only partially involves caspase-3-like proteases

scientific article published in January 1999

Apoptosis of hematopoietic cells induced by growth factor withdrawal is associated with caspase-9 mediated cleavage of Raf-1.

scientific article published on February 2005

Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated?

scientific article published on 18 March 2008

Aspergillus fumigatus Recognition by Dendritic Cells Negatively Regulates Allergic Lung Inflammation Through a TLR2/MyD88 Pathway

scientific article published on 24 September 2020

Attenuated Expression of A20 Markedly Increases the Efficacy of Double-Stranded RNA-Activated Dendritic Cells As an Anti-Cancer Vaccine

scientific article published on 01 January 2009

Author Correction: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation

scientific article published on 20 November 2019

B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice

scientific journal article

CARD14-Mediated Activation of Paracaspase MALT1 in Keratinocytes: Implications for Psoriasis

scientific article published on 8 December 2016

CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different

scientific article published on 31 March 2017

Cancer risk in immune-mediated inflammatory diseases (IMID).

scientific article published on 29 August 2013

Casein kinase-1 phosphorylates the p75 tumor necrosis factor receptor and negatively regulates tumor necrosis factor signaling for apoptosis

scientific article

Caspase-1 targets the TLR adaptor Mal at a crucial TIR-domain interaction site

scientific article

Caspase-11 gene expression in response to lipopolysaccharide and interferon-gamma requires nuclear factor-kappa B and signal transducer and activator of transcription (STAT) 1.

scientific article published on 26 August 2002

Caspase-11 mediates ischemia-induced astrocyte death: involvement of endoplasmic reticulum stress and C/EBP homologous protein

scientific article published in April 2010

Caspases are not localized in mitochondria during life or death

scientific article published in November 2002

Cathepsin B-mediated activation of the proinflammatory caspase-11.

scientific article published in October 1998

Cell death induction by receptors of the TNF family: towards a molecular understanding.

scientific article published on June 1997

Cellular expression of A20 and ABIN-3 in response to Toll-like receptor-4 stimulation

scientific article published in January 2009

Characterization of an intravenous lipopolysaccharide inflammation model in broiler chickens.

scientific article published on October 2009

Characterization of seven murine caspase family members

scientific article published in February 1997

Chemical synthesis of Burkholderia Lipid A modified with glycosyl phosphodiester-linked 4-amino-4-deoxy-β-L-arabinose and its immunomodulatory potential

scientific article published on 28 January 2015

Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases

scientific article published on 01 March 2020

Cleavage by MALT1 induces cytosolic release of A20.

scientific article published on 20 September 2010

Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor

scientific article (publication date: 2 May 1997)

Cleavage of transcription factor SP1 by caspases during anti-IgM-induced B-cell apoptosis

scientific article published on April 1999

Correction: A20 () Deficiency in Myeloid Cells Protects against Influenza A Virus Infection

Correction: Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

scientific article published on 01 June 2020

Cytotoxic activity of tumor necrosis factor is inhibited by amiloride derivatives without involvement of the Na+/H+ antiporter

scientific article published in February 1990

Death receptor signalling in central nervous system inflammation and demyelination

scientific article published on 13 October 2011

Defining the combinatorial space of PKC::CARD-CC signal transduction nodes

scientific article published on 13 August 2020

Deletion of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 in Mouse T Cells Protects Against Development of Autoimmune Arthritis but Leads to Spontaneous Osteoporosis

scientific article published on 09 November 2019

Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase

scientific article

Development of αGlcN(1↔1)αMan-based lipid A mimetics as a novel class of potent Toll-like receptor 4 agonists

scientific article published on 25 September 2014

Dexamethasone alters messenger RNA levels but not synthesis of collagens, fibronectin, or laminin by cultured rat fat-storing cells

scientific article published on 01 June 1996

Dichotomous function of IL-33 in health and disease: From biology to clinical implications

scientific article published on 5 January 2018

Differential activation of phospholipases during necrosis or apoptosis: A comparative study using tumor necrosis factor and anti-Fas antibodies

scholarly article by Dirk De Valck published in December 1998

Differential activation of phospholipases during necrosis or apoptosis: a comparative study using tumor necrosis factor and anti-Fas antibodies

scientific article published in December 1998

Differential involvement of caspases in apoptosis of myeloid leukemic cells induced by chemotherapy versus growth factor withdrawal

scientific journal article

Differential role of calcium in tumour necrosis factor-mediated apoptosis and secretion of granulocyte-macrophage colony-stimulating factor in a T cell hybridoma.

scientific article

Disaccharide-Based Anionic Amphiphiles as Potent Inhibitors of Lipopolysaccharide-Induced Inflammation

scholarly article by Alessio Borio et al published 23 October 2018 in ChemMedChem

Disaccharide-based Anionic Amphiphiles as Potent Inhibitors of LPS-induced Inflammation

Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome

scientific article published on 01 June 2020

Emerging Role of Ubiquitination in Antiviral RIG-I Signaling ⬇️

scientific article published on March 1, 2012

Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation.

scientific article published in December 2001

Endoplasmic reticulum chaperone gp96 is essential for infection with vesicular stomatitis virus

scientific article

Engineering a Minimal 1185 Bp Cloning Vector from a Puc18 Plasmid Backbone with an Extended Multiple Cloning Site

Engineering a Minimal Cloning Vector from a pUC18 Plasmid Backbone with an Extended Multiple Cloning Site

Engineering a minimal cloning vector from a pUC18 plasmid backbone with an extended multiple cloning site

scientific article published on 24 May 2019

Enhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b+ myelopoiesis

scientific article

Enterocyte death and intestinal barrier maintenance in homeostasis and disease

scientific article published on 06 July 2011

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis

scientific article

Erratum: Corrigendum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

scholarly article by Ezra Aksoy et al published August 2013 in Nature Immunology

Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB.

scientific article published on 10 December 2007

Expression, biological activities and mechanisms of action of A20 (TNFAIP3).

scientific article published on 03 July 2010

Farm dust and endotoxin protect against allergy through A20 induction in lung epithelial cells

scientific article published on September 2015

Fragility can be a good thing in cancer

scientific article published on 01 January 2020

Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members

scientific article

Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions

scientific article (publication date: June 2001)

GC Content of Early Metazoan Genes and Its Impact on Gene Expression Levels in Mammalian Cell Lines.

scientific article

Gene cloning and structure - function relationship of cytokines such as TNF and interleukins

article

Genetic relationships between A20/TNFAIP3, chronic inflammation and autoimmune disease

scientific article

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice

scientific article published on 25 June 2018

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

article by Daniel J Klionsky et al published January 2021 in Autophagy

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

scientific article published on 01 October 2019

Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: effects on liver homeostasis and beyond.

scientific article published on 12 April 2007

High-fat nutrition reduces hepatic damage following exposure to bacterial DNA and hemorrhagic shock

scientific article published on 08 November 2008

Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives

scientific article published in September 1990

How Good Roommates Can Protect against Microbial Sepsis

scientific article published on 01 March 2018

IL ‐33 signalling contributes to pollutant‐induced allergic airway inflammation

scientific article published on 19 September 2018

IL-17 Signaling Triggers Degradation of the Constitutive NF-κB Inhibitor ABIN-1

scientific article published on 01 September 2017

IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice.

scientific article

IL-33trap is a novel IL-33-neutralizing biologic that inhibits allergic airway inflammation.

scientific article published on 13 March 2019

Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2

scientific article (publication date: 10 August 2001)

Identification of interaction sites for dimerization and adapter recruitment in Toll/interleukin-1 receptor (TIR) domain of Toll-like receptor 4.

scientific article published on 2 December 2011

Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies-T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study.

scientific article

In macrophages, caspase-1 activation by SopE and the type III secretion system-1 of S. typhimurium can proceed in the absence of flagellin

scientific article

Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications

scholarly article by Jens Staal & Rudi Beyaert published 29 August 2018 in Cells

Inflammatory Properties and Adjuvant Potential of Synthetic Glycolipids Homologous to Mycolate Esters of the Cell Wall of Mycobacterium tuberculosis.

scientific article

Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation

scientific article

Inhibition by glucocorticoids of tumor necrosis factor-mediated cytotoxicity. Evidence against lipocortin involvement.

scientific article published in March 1990

Inhibition of NF-kappaB activation by the histone deacetylase inhibitor 4-Me2N-BAVAH induces an early G1 cell cycle arrest in primary hepatocytes

scientific article

Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor.

scientific article published on May 1998

Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4

scientific journal article

Interleukin-1α controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.

scientific article

Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites

scientific article published on August 2015

Isolation and characterization of two novel A20-like proteins

scientific article

IκB kinase ε (IKKε): a therapeutic target in inflammation and cancer

scientific article published on 17 January 2013

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

scientific article published on 13 May 2011

LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation

scientific article

Laboratory mice with a wild microbiota generate strong allergic immune responses

scientific article published on 29 September 2023

Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome

scientific article

Linear ubiquitination in NF-κB signaling and inflammation: What we do understand and what we do not.

scientific article published on 20 July 2011

Lipid A structural characterization from the LPS of the Siberian psychro-tolerant Psychrobacter arcticus 273-4 grown at low temperature

scientific article published on 20 August 2018

Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex

scientific article published on 14 August 2018

Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression

scientific article published on July 1991

Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF). Evidence for a role of the TNF receptor-associated death domain protein

scientific article

Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity

scientific article published on 12 September 2020

MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner

scientific article published on 14 August 2019

MALT1 cleaves the E3 ubiquitin ligase HOIL-1 in activated T cells, generating a dominant negative inhibitor of LUBAC-induced NF-κB signaling

scientific article

MALT1 is not alone after all: identification of novel paracaspases

scientific article

MALT1 targeting suppresses CARD14-induced psoriatic dermatitis in mice

scientific article published on 28 April 2020

MALT1--a universal soldier: multiple strategies to ensure NF-κB activation and target gene expression

scientific article published on 21 May 2015

MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging

scientific article published on 01 October 2019

MAPPIT (mammalian protein-protein interaction trap) analysis of early steps in toll-like receptor signalling

scientific article published in January 2009

MAPPIT analysis of TLR adaptor complexes

scientific journal article

Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes.

scientific article published on 24 August 2006

Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function

MicroRNA let-7 modulates the immune response to Mycobacterium tuberculosis infection via control of A20, an inhibitor of the NF-κB pathway.

scientific article published on 12 February 2015

Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasis

scientific article published on 18 October 2018

Molecular mechanisms of tumor necrosis factor-induced cytotoxicity. What we do understand and what we do not.

scientific article published on February 1994

Monitoring Ubiquitin-Coated Bacteria via Confocal Microscopy

scientific article

MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression

scientific article published in July 2003

NF-κB Activation by Tumor Necrosis Factor and Interleukin-1

article published in 2003

NF-κB as an emerging target in atopy

scholarly article by Rudi Beyaert published June 1999 in Expert Opinion on Therapeutic Targets

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20.

scientific article published on 22 August 2016

Negative regulation of NF-κB and its involvement in rheumatoid arthritis

scientific article published on 31 May 2011

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

scientific article

Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling

scientific article published on 29 September 2009

Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling.

scientific article

No ubiquitin anchors and fully RIGged

scientific article published in June 2012

Non-apoptotic functions of caspase-8.

scientific article published on 06 August 2008

Non-specific effects of methyl ketone peptide inhibitors of caspases

scientific article published on January 1999

Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties

scientific article published in Scientific Reports

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

scientific article published on 02 September 2013

Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease.

scientific article published on October 2003

Oligodendrocyte-specific FADD deletion protects mice from autoimmune-mediated demyelination

scientific article published on 10 November 2010

Optineurin deficiency in mice is associated with increased sensitivity to Salmonella but does not affect proinflammatory NF-κB signaling

scientific article published on 17 December 2015

Overexpression of the nuclear factor kappaB inhibitor A20 is neurotoxic after an excitotoxic injury to the immature rat brain

scientific article

Paracaspase MALT1 deficiency protects mice from autoimmune-mediated demyelination

scientific article published on 11 February 2013

Patterns, Receptors, and Signals: Regulation of Phagosome Maturation

scientific article

Pellino proteins are more than scaffold proteins in TLR/IL-1R signalling: a role as novel RING E3-ubiquitin-ligases

scientific article

Pellino proteins: novel players in TLR and IL-1R signalling

scientific article published on May 2007

Perinatal Activation of the Interleukin-33 Pathway Promotes Type 2 Immunity in the Developing Lung.

scientific article published on 5 December 2016

Pharmacodynamics of tepoxalin, sodium-salicylate and ketoprofen in an intravenous lipopolysaccharide inflammation model in broiler chickens.

scientific article published on December 2010

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis.

scientific article

Phytohormones: Multifunctional nutraceuticals against metabolic syndrome and comorbid diseases

scientific article published on 20 February 2020

Priming IKKβ kinase for action.

scientific article published in October 2014

Prolonged exposure to IL-1beta and IFNgamma induces necrosis of L929 tumor cells via a p38MAPK/NF-kappaB/NO-dependent mechanism

scientific article published on 4 February 2008

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme

scientific article

Psoriasis Plays a Wild CARD

scholarly article by Elien Van Nuffel published in September 2018

Receptor proximal kinases in NF-κB signaling as potential therapeutic targets in cancer and inflammation

scientific article

Reduced tumour necrosis factor-induced cytotoxicity by inhibitors of the arachidonic acid metabolism

scientific article

Regulation of NF-κB signaling by caspases and MALT1 paracaspase

scientific article

Regulation of TNF-induced NF-κB activation by different cytoplasmic ubiquitination events

scientific article published on October 2011

Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88

scientific article (publication date: 19 March 2002)

Regulation of macrophage motility by the water channel aquaporin-1: crucial role of M0/M2 phenotype switch

scientific article

Regulation of the cell-cycle-dependent internal ribosome entry site of the PITSLRE protein kinase: roles of Unr (upstream of N-ras) protein and phosphorylated translation initiation factor eIF-2alpha

scientific article published on January 2005

Resistance to tumor necrosis factor (TNF) cytotoxicity by autocrine TNF production is independent of intracellular signaling pathways

scientific article

Reversion of autoimmune lymphoproliferative syndrome with an antimalarial drug: preliminary results of a clinical cohort study and molecular observations

scientific article (publication date: April 2002)

Role of Toll-like receptors in pathogen recognition.

scientific article published on October 2003

Role of the Bacterial Type VI Secretion System in the Modulation of Mammalian Host Cell Immunity

scientific article published on January 2015

SHP works a double shift to control TLR signaling ⬇️

scientific article published on July 19, 2011

ST2 as checkpoint target for colorectal cancer immunotherapy

scientific article published on 07 May 2020

Sensing of viral infection and activation of innate immunity by toll-like receptor 3

scientific article

Sensitization of tnf-induced apoptosis with polyamine synthesis inhibitors in different human and murine tumour cell lines

scientific article published on June 1998

Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas.

scientific article published in January 2002

Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors

scientific article published on 13 July 2020

Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation

scientific article

Spatiotemporal changes of the phagosomal proteome in dendritic cells in response to LPS stimulation

scientific article published on 26 February 2019

Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8.

scientific article

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

scientific article published on 3 April 2017

Structure and function of the Type III secretion system of Pseudomonas aeruginosa

scientific article published on December 2012

Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists.

scientific article published in March 2018

Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1

scientific journal article

Synergistic induction of interleukin-6 by tumor necrosis factor and lithium chloride in mice: possible role in the triggering and exacerbation of psoriasis by lithium treatment

scientific article published in August 1992

Synthetic glycan-based TLR4 agonists targeting caspase-4/11 for the development of adjuvants and immunotherapeutics.

scientific article

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20

scientific article

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1.

scientific article

TAX1BP1, a ubiquitin-binding adaptor protein in innate immunity and beyond

scientific article published on 04 May 2011

TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C

scientific article published on 7 February 2022

TLR-4, IL-1R and TNF-R signaling to NF-kappaB: variations on a common theme

scientific article published on October 2008

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile

scientific article published on 10 June 2019

TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation

scientific article

TRAF1 is a TNF inducible regulator of NF-kappaB activation

scientific article published in October 1999

TRAF2 multitasking in TNF receptor-induced signaling to NF-κB, MAP kinases and cell death

scientific article published on 15 March 2016

TRAF2 plays a dual role in NF-kappaB-dependent gene activation by mediating the TNF-induced activation of p38 MAPK and IkappaB kinase pathways.

scientific article published on March 1998

Taking the STING Out of Sepsis?

scientific article published on 01 April 2020

Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad?

scientific article

Targeting Rac1 by the Yersinia effector protein YopE inhibits caspase-1-mediated maturation and release of interleukin-1beta

scientific article published on April 2004

Targeting the EGF receptor ectodomain in the context of cancer

scientific article

The CARD-CC/Bcl10/paracaspase signaling complex is functionally conserved since the last common ancestor of planulozoa

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling.

scientific article published on 26 January 2018

The IL-33/ST2 axis is crucial in type 2 airway responses induced by Staphylococcus aureus-derived serine protease-like protein D.

scientific article published on 19 May 2017

The PDGF-BB-SOX7 axis-modulated IL-33 in pericytes and stromal cells promotes metastasis through tumour-associated macrophages

scientific article published on 6 May 2016

The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase-1 mediated IL-1beta maturation.

scientific article published on 10 December 2007

The Pseudomonas aeruginosa type III secretion system has an exotoxin S/T/Y independent pathogenic role during acute lung infection

scientific article

The S. Typhimurium effector SopE induces caspase-1 activation in stromal cells to initiate gut inflammation

scientific article published in August 2009

The biology of A20-binding inhibitors of NF-kappaB activation (ABINs).

scientific article

The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide

scientific article published on 4 April 2001

The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6

scientific article

The influence of age and repeated lipopolysaccharide administration on body temperature and the concentration of interleukin-6 and IgM antibodies against lipopolysaccharide in broiler chickens.

scientific article published in February 2008

The kinase NIK as a therapeutic target in multiple myeloma

scientific article published on 05 January 2011

The multifaceted role of the E3 ubiquitin ligase HOIL-1: beyond linear ubiquitination

scientific article published on July 2015

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.

scientific article

The paracaspase MALT1 mediates CARD14-induced signaling in keratinocytes

scientific journal article

The polypyrimidine tract-binding protein stimulates HIF-1alpha IRES-mediated translation during hypoxia

scientific article

The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells

scientific article

The ubiquitin editing enzyme A20 (TNFAIP3) is upregulated during permanent middle cerebral artery occlusion but does not influence disease outcome

scientific article published on 7 March 2013

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

scientific article published on 28 July 2009

The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity.

scientific article published on 30 June 2011

The yeast three-hybrid system as a tool to study caspases

scientific article published in January 2004

The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN

scientific article

The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases

scientific journal article

Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9.

scientific article

Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo

scientific article

Toll-like Receptor 4 Engagement on Dendritic Cells Restrains Phago-Lysosome Fusion and Promotes Cross-Presentation of Antigens

scientific article published on December 2015

Trabid epigenetically drives expression of IL-12 and IL-23.

scientific article published in February 2016

Translational control of eukaryotic gene expression

scientific article published on July 2009

Tumor Necrosis Factor and Lymphotoxin

Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche

scientific article published in 2022

Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells.

scientific article

Tumour-necrosis-factor-mediated cytotoxicity is correlated with phospholipase-A2 activity, but not with arachidonic acid release per se.

scientific article published on January 1991

Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities

scientific article published on 16 March 2020

Two tumour necrosis factor receptors: structure and function.

scientific article published in October 1995

UNR translation can be driven by an IRES element that is negatively regulated by polypyrimidine tract binding protein

scientific article

Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins

scientific article

Ubiquitin: tool and target for intracellular NF-kappaB inhibitors.

scientific article published on 18 September 2006

Ubiquitination and phosphorylation of the CARD11-BCL10-MALT1 signalosome in T cells

scientific article published on 01 December 2018

Unusual Lipid A from a Cold-Adapted Bacterium: Detailed Structural Characterization

scientific article published on 26 June 2017

Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients.

scientific article

Use of the yeast three-hybrid system as a tool to study caspases

scientific article published in October 1998

XEDAR activates the non-canonical NF-κB pathway

scientific article published on 7 August 2015

Yeast two-hybrid screening for proteins interacting with the anti-apoptotic protein A20.

scientific article published in January 2004

Yeast two-hybrid: State of the art ⬇️

scientific article published on October 4, 1999

Yolk Sac Macrophages, Fetal Liver, and Adult Monocytes Can Colonize an Empty Niche and Develop into Functional Tissue-Resident Macrophages

scientific article

ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

scientific article published on 28 June 2021

Zinc inhibits lethal inflammatory shock by preventing microbe-induced interferon signature in intestinal epithelium

scientific article published on 11 September 2020

Paulina is supported by:

About Paulina

Help