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List of works by Gerd Mikus

A follow-up report on potential drug interactions with clementines: Two single case experiments show no effect on CYP3A-dependent midazolam clearance

scientific article published on 21 March 2019

A nanogram dose of the CYP3A probe substrate midazolam to evaluate drug interactions.

scientific article published on 8 February 2013

A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer.

scientific article published on 16 January 2018

Absolute Bioavailability of Microdosed Midazolam After Buccal Administration Is Dependent on Buccal Exposure Time

scientific article published on 25 September 2020

Acute and painful exacerbation of RLS and PLM induced by opioid interaction - withdrawal syndrome

scientific article published on 27 May 2017

Acute haemodynamic effects of i.v. nitrendipine in healthy subjects.

scientific article published in January 1991

An in vitro experiment on the interaction of charcoal or wheat bran with 11-nor-9-carboxy-Δ9-tetrahydrocannabinol and its glucuronide

article published in 2013

Analysis of the CYP2D6 gene mutations and their consequences for enzyme function in a West African population

article

Anti-angiogenic activity of VXM01, an oral T-cell vaccine against VEGF receptor 2, in patients with advanced pancreatic cancer: A randomized, placebo-controlled, phase 1 trial.

scientific article published on 16 March 2015

Anticoagulant effects of idraparinux after termination of therapy for prevention of recurrent venous thromboembolism: observations from the van Gogh trials

scientific article published on June 2008

Application of a microdosed cocktail of 3 oral factor Xa inhibitors to study drug-drug interactions with different perpetrator drugs

scientific article published on 11 March 2020

Application of microdosed intravenous omeprazole to determine hepatic CYP2C19 activity

scientific article published on 25 November 2020

Aprepitant, granisetron, and dexamethasone for prevention of chemotherapy-induced nausea and vomiting after high-dose melphalan in autologous transplantation for multiple myeloma: results of a randomized, placebo-controlled phase III trial

scientific article published on 15 September 2014

Arzneimittelinteraktionen

scientific article published on 01 March 2010

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

Association of the CYP3A5 A6986G (CYP3A5*3) polymorphism with saquinavir pharmacokinetics

scientific article published on October 2004

Autoinhibitory properties of the parent but not of the N-oxide metabolite contribute to infusion rate-dependent voriconazole pharmacokinetics.

scientific article published on 29 March 2017

CYP2C19 genotype is a major factor contributing to the highly variable pharmacokinetics of voriconazole

scientific article

CYP2C9 polymorphism is not a major determinant of bosentan exposure in healthy volunteers.

scientific article

CYP3A activity: towards dose adaptation to the individual.

scientific article published on 7 March 2016

Calcium balance during calcitriol and paricalcitol administration in healthy humans.

scientific article published in March 2008

Calcium load during administration of calcium carbonate or sevelamer in individuals with normal renal function

scientific article published on 3 April 2008

Candida infections in the elderly

scientific article published in January 2013

Cardiovascular effects of (R)- and (S)-verapamil and racemic verapamil in humans: a placebo-controlled study

Chronopharmacology of intravenous and oral modified release verapamil.

scientific article

Clarithromycin substantially increases steady-state bosentan exposure in healthy volunteers

scientific article published on January 2014

Clementine juice has the potential for drug interactions - In vitro comparison with grapefruit and mandarin juice

scientific article published on 24 November 2016

Codeine o-demethylation: Rat strain differences and the effects of inhibitors

scientific article published on 01 March 1991

Combinations of QTc-prolonging drugs: towards disentangling pharmacokinetic and pharmacodynamic effects in their potentially additive nature

scientific article published on 28 August 2017

Combined oral prolonged-release oxycodone and naloxone in opioid-induced bowel dysfunction: review of efficacy and safety data in the treatment of patients experiencing chronic pain

scientific article

Comparative Bioavailability of the Microemulsion Formulation of Cyclosporine (Neoral) With a Generic Dispersion Formulation (Cicloral) in Young Healthy Male Volunteers

scientific article published on 01 June 2006

Composite midazolam and 1'-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activity

scientific article published on 08 August 2020

Concentration effect relationship of CYP3A inhibition by ritonavir in humans.

scientific article published on 9 June 2013

Contribution of CYP2C19 and CYP3A4 to the formation of the active nortilidine from the prodrug tilidine

scientific article

Contribution of dihydrocodeine and dihydromorphine to analgesia following dihydrocodeine administration in man: a PK-PD modelling analysis

scientific article

Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction

scientific article published on July 2003

Contribution of oxycodone and its metabolites to the analgesic effect

Contribution of oxycodone and its metabolites to the overall analgesic effect after oxycodone administration

scientific article published on 14 March 2013

Correction to: Drug-Drug Interactions with Direct Oral Anticoagulants

scientific article published on 30 October 2020

Correction to: Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review.

scientific article published on 24 November 2017

Cytochrome P450 enzyme-mediated drug metabolism at exposure to acute hypoxia (corresponding to an altitude of 4,500 m).

scientific article published on 4 February 2005

Cytochrome P450-3A phenotyping using midazolam is not altered by OATP1B1 polymorphisms

scientific article published on 28 February 2013

Daily honey consumption does not change CYP3A activity in humans

scientific article

Deceptive argumentation against diagnostic microdosing of anticancer drugs

article published in 2014

Determining the time course of CYP3A inhibition by potent reversible and irreversible CYP3A inhibitors using A limited sampling strategy

scientific article published on 21 September 2011

Diclofenac does not interact with codeine metabolism in vivo: a study in healthy volunteers

scientific article

Dihydrocodeine: a new opioid substrate for the polymorphic CYP2D6 in humans

scientific article published on October 1995

Dopamine infusion in healthy subjects and critically ill patients.

scientific article

Dose-Dependent Bioavailability and CYP3A Inhibition Contribute to Non-Linear Pharmacokinetics of Voriconazole.

scientific article published on 28 May 2016

Dose-dependent increase of saquinavir bioavailability by the pharmaceutic aid cremophor EL

scientific article published on June 2002

Double-blind, placebo-controlled first in human study to investigate an oral vaccine aimed to elicit an immune reaction against the VEGF-Receptor 2 in patients with stage IV and locally advanced pancreatic cancer

scientific article

Drug interaction of efavirenz and midazolam: efavirenz activates the CYP3A-mediated midazolam 1'-hydroxylation in vitro

scientific article published on 12 March 2012

Drug therapy information: a service provided by clinical pharmacologists for physicians in private practice and hospitals

scientific article published on 01 September 1998

Drug-Drug Interactions with Direct Oral Anticoagulants

scientific article published on 11 March 2020

Efavirenz treatment and false-positive results in benzodiazepine screening tests.

scientific article published in June 2009

Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype*

scientific article published on 01 April 1997

Effect of simultaneous induction and inhibition of CYP3A by St John's Wort and ritonavir on CYP3A activity

scientific article published on 18 November 2009

Effect of the CYP3A inhibitor ketoconazole on the PXR-mediated induction of CYP3A activity

scientific article published on 12 September 2012

Effects and risks associated with novel psychoactive substances: mislabeling and sale as bath salts, spice, and research chemicals

scientific article published on February 2014

Efficacy of methylene blue monotherapy in semi-immune adults with uncomplicated falciparum malaria: a controlled trial in Burkina Faso

scientific article published on 29 March 2010

Electrospray tandem mass spectroscopic characterisation of 18 antiretroviral drugs and simultaneous quantification of 12 antiretrovirals in plasma

scientific article published on 01 January 2007

Enantioselective gallopamil protein binding

scholarly article by Annette S. Gross et al published 1993 in Chirality

Enantioselective quantitation of the ecstasy compound (R)- and (S)-N-ethyl-3,4-methylenedioxyamphetamine and its major metabolites in human plasma and urine

scientific article published in August 2003

Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism

scientific article published on 01 February 1994

European Pain Federation position paper on appropriate opioid use in chronic pain management.

scientific article

Fentanyl pharmacokinetics is not dependent on hepatic uptake by organic anion-transporting polypeptide 1B1 in human beings

scientific article published on 6 April 2013

First-in-human application of the novel hepatitis B and hepatitis D virus entry inhibitor myrcludex B.

scientific article

Fluconazole dosing in continuous veno-venous haemofiltration (CVVHF): need for a high daily dose of 800 mg.

scientific article published on 25 November 2005

Fluctuation effects in an epidemic model

scientific article

Frequency of the SLCO1B1 388A>G and the 521T>C polymorphism in Tanzania genotyped by a new LightCycler®-based method

scientific article

Gabapentin Enhances the Analgesic Effect of Morphine in Healthy Volunteers

scientific article published on 01 July 2000

Genetically determined differences in drug metabolism as a risk factor in drug toxicity

scientific article published on December 1, 1992

High absolute bioavailability of methylene blue given as an aqueous oral formulation

scientific article published on 23 September 2008

Higher chlorzoxazone clearance in obese children compared with nonobese peers

scientific article published on 03 June 2018

Highly sensitive determination of saquinavir in biological samples using liquid chromatography-tandem mass spectrometry

scientific article

Highly sensitive gas chromatographic-tandem mass spectrometric method for the determination of morphine and codeine in serum and urine in the femtomolar range

scientific article

Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake

scientific article published on January 1996

Impact of quinidine on plasma and cerebrospinal fluid concentrations of codeine and morphine after codeine intake

scholarly article by S. H. Sindrup et al published March 1996 in European Journal of Clinical Pharmacology

In Vivo CYP3A Activity in Palliative Care Patients: Study Protocol for a Single Arm Prospective Trial.

scientific article published on 12 January 2018

In vitro characterization of the human cytochrome P-450 involved in polymorphic oxidation of propafenone

scientific article published on 01 January 1989

In vitro identification of the cytochrome P450 isozymes involved in the N-demethylation of the active opioid metabolite nortilidine to bisnortilidine

scientific article

In vitro inhibition of human UGT isoforms by ritonavir and cobicistat

scientific article published on 11 September 2017

In vitro interaction of codeine and diclofenac.

scientific article

In vitro metabolism of the opioid tilidine and interaction of tilidine and nortilidine with CYP3A4, CYP2C19, and CYP2D6.

scientific article published on 31 May 2008

Induction of voriconazole metabolism by rifampin in a patient with acute myeloid leukemia: importance of interdisciplinary communication to prevent treatment errors with complex medications.

scientific article published on 2 July 2007

Influence of CYP2D6 Genetics on Opioid Kinetics, Metabolism and Response

article

Influence of St. Johnâ s wort on the steadystate pharmacokinetics and metabolism of bosentan

scientific article published on 01 April 2014

Inhibition of human cytochromes P450 in vitro by ritonavir and cobicistat.

scientific article published on 29 September 2017

Inhibition of the active principle of the weak opioid tilidine by the triazole antifungal voriconazole

scientific article

Interaction of ambrisentan with clarithromycin and its modulation by polymorphic SLCO1B1.

scientific article published on 9 June 2013

Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action

scientific article published on 01 June 1990

Intracellular vorinostat accumulation and its relationship to histone deacetylase activity in soft tissue sarcoma patients

scientific article published on 13 June 2017

Is there a genetic factor in flecainide toxicity?

scientific article published in November 1988

Isotopically labelled paroxetine standard allows for definite structure elucidation of the paroxetine tandem mass spectrum

scientific article published on 01 August 2018

Kinetics and dynamics of the peripheral neurokinin-1 receptor antagonist SLV317 in healthy individuals

scientific article published on April 2006

Lack of a clinically significant interaction of grapefruit juice with ambrisentan and bosentan in healthy adults

scientific article published on November 2014

Long elimination half-life of idraparinux may explain major bleeding and recurrent events of patients from the van Gogh trials

scientific article published on 27 February 2008

Loss of analgesic effect of morphine due to coadministration of rifampin

scientific article published on 01 August 1997

Management von chronischem Schmerz mit retardiertem Tilidin

Meeting the challenges of opioid-induced constipation in chronic pain management - a novel approach

scientific article published on 28 October 2008

Methadone against cancer: Lost in translation

Methylene blue for malaria in Africa: results from a dose-finding study in combination with chloroquine

scientific article published in 2006

Microdosed Cocktail of Three Oral Factor Xa Inhibitors to Evaluate Drug-Drug Interactions with Potential Perpetrator Drugs

scientific article published on 01 September 2019

Microdosed midazolam for the determination of cytochrome P450 3A activity: Development and clinical evaluation of a buccal film

scientific article published on 16 May 2019

Midazolam microdose to determine systemic and pre-systemic metabolic CYP3A activity in humans

scientific article

Midazolam microdosing applied in early clinical development for drug-drug interaction assessment

scientific article published on 20 May 2020

Misleading results of screening for illicit drugs during efavirenz treatment

scientific article published in June 2007

Modulators of very low voriconazole concentrations in routine therapeutic drug monitoring.

scientific article

Monitoring of lopinavir and ritonavir in peripheral blood mononuclear cells, plasma, and ultrafiltrate using a selective and highly sensitive LC/MS/MS assay

scientific article published on 11 December 2006

Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide

scientific article

Morphine-related metabolites differentially activate adenylyl cyclase isozymes after acute and chronic administration.

scientific article published in March 2000

Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study.

scientific article

No Alteration Of Cyp3a4 Activity After Major Hepatectomy In The Early Postoperative Period - A Prospective Before-After Study

scientific article published on 12 May 2020

No Increased Risk of Ketoconazole Toxicity in Drug-Drug Interaction Studies.

scientific article

No alteration of voriconazole concentration by plasmapheresis in a critically ill patient

article

No evidence for induction of ABC transporters in peripheral blood mononuclear cells in humans after 14 days of efavirenz treatment.

scientific article

Normal CYP3A activity during arsenic trioxide therapy

scientific article published on 16 April 2014

Novel insights into the complex pharmacokinetics of voriconazole: a review of its metabolism

scientific article published on 16 August 2019

OC-10 Anticoagulant effects after termination of therapy using once weekly subcutaneous injections of idraparinux in patients with acute venous thromboembolism

Obesity‐induced CYP2E1 activity in children

scientific article published on 09 December 2018

Opposite effects of short-term and long-term St John's wort intake on voriconazole pharmacokinetics

scientific article published in July 2005

Oral Yohimbine as a New Probe Drug to Predict CYP2D6 Activity: Results of a Fixed-Sequence Phase I Trial

scientific article published on 15 February 2020

P-glycoprotein modulation by the designer drugs methylenedioxymethamphetamine, methylenedioxyethylamphetamine and paramethoxyamphetamine

scientific article published in December 2003

Perspectives on Model-Informed Precision Dosing in the Digital Health Era: Challenges, Opportunities, and Recommendations

scientific article published on 17 October 2020

Pharmacogenomics of the triazole antifungal agent voriconazole

scientific article published on June 2011

Pharmacokinetic and pharmaceutic interaction between digoxin and Cremophor RH40.

scientific article published in May 2003

Pharmacokinetic and pharmacodynamic analysis of enteric-coated mycophenolate sodium: limited sampling strategies and clinical outcome in renal transplant patients.

scientific article

Pharmacokinetic interaction of chloroquine and methylene blue combination against malaria

scientific article published on 13 October 2004

Pharmacokinetic interaction of intravenous fentanyl with ketoconazole

scientific article

Pharmacokinetic modelling of morphine, morphine-3-glucuronide and morphine-6-glucuronide in plasma and cerebrospinal fluid of neurosurgical patients after short-term infusion of morphine

scientific article published on December 2002

Pharmacokinetics and metabolism of quinidine in extensive and poor metabolisers of sparteine

scientific article published on 01 January 1986

Pharmacokinetics and pharmacodynamics of R- and S-gallopamil during multiple dosing

scientific article

Pharmacokinetics and pharmacodynamics of the enantiomers of gallopamil

scientific article published on 01 June 1997

Pharmacokinetics and pharmacodynamics of the enantiomers of gallopamil

Pharmacokinetics and the pharmacodynamic action of midazolam in young and elderly patients undergoing tooth extraction

scientific article published in May 1998

Pharmacokinetics of (+)-, (-)- and (+/-)-verapamil after intravenous administration

scientific article published on April 1984

Pharmacokinetics of 11-nor-9-Carboxy-Δ9-Tetrahydrocannabinol (CTHC) After Intravenous Administration of CTHC in Healthy Human Subjects

Pharmacokinetics of Fentanyl and Its Derivatives in Children: A Comprehensive Review.

scientific article

Pharmacokinetics of a netilmicin loading dose on the first postnatal day in preterm neonates with very low gestational age.

scientific article published on 25 July 2006

Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing

scientific article

Pharmacokinetics of midazolam in relation to polymorphic sparteine oxidation

scientific article published in November 1986

Pharmacokinetics of morphine and its glucuronides following intravenous administration of morphine in patients undergoing continuous ambulatory peritoneal dialysis

scientific article published on 01 April 1999

Pharmacokinetics of oral and intravenous rifampicin during chronic administration

article

Pharmacokinetics of sulfobutylether-beta-cyclodextrin and voriconazole in patients with end-stage renal failure during treatment with two hemodialysis systems and hemodiafiltration

scientific article

Pharmacokinetics, bioavailability, metabolism and acute and chronic antihypertensive effects of nitrendipine in patients with chronic renal failure and moderate to severe hypertension.

scientific article

Pharmacokinetics, metabolism and bioavailability of the triazole antifungal agent voriconazole in relation to CYP2C19 genotype

scientific article

Pharmacological treatment of constipation in palliative care

scientific article published on June 2013

Potent cytochrome P450 2C19 genotype–related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir

scientific article published on 03 July 2006

Pre-systemic Elimination of Tilidine: Localization and Consequences for the Formation of the Active Metabolite Nortilidine

Primary and secondary oxidative metabolism of dextromethorphan

scientific article published on 01 February 1993

Probes and Cocktails for Drug-Drug Interaction Evaluation: The Future Is Microdosing?

scientific article published on 12 February 2019

Prolonged sedation of lorazepam due to absent UGT2B4/2B7 glucuronidation.

scientific article

Proposal of a Safe and Effective Study Design for CYP3A-Mediated Drug-Drug Interactions

scientific article published on 21 May 2020

Proposal of a new limited sampling strategy to predict CYP3A activity using a partial AUC of midazolam

scientific article published on 3 August 2010

Quantification of cationic anti-malaria agent methylene blue in different human biological matrices using cation exchange chromatography coupled to tandem mass spectrometry

scientific article published on 26 January 2008

Quantification of femtomolar concentrations of the CYP3A substrate midazolam and its main metabolite 1'-hydroxymidazolam in human plasma using ultra performance liquid chromatography coupled to tandem mass spectrometry.

scientific article published on 15 January 2012

Quantitative low-volume assay for simultaneous determination of fentanyl, norfentanyl, and minor metabolites in human plasma and urine by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

scientific article

Rapid, highly sensitive method for the determination of morphine and its metabolites in body fluids by liquid chromatography-mass spectrometry

article by Gerhard Schänzle et al published 8 January 1999 in Biomedical applications

Real-world complexity of atrial fibrillation treatment with oral anticoagulants: design and interpretation of pharmacoepidemiological studies.

scientific article published on 21 July 2017

Reduced exposure variability of the CYP3A substrate simvastatin by dose individualization to CYP3A activity

scientific article published on 31 August 2013

Reduction in non-glomerular renal clearance of the caffeine metabolite 1-methylxanthine by probenecid

scientific article published on 01 August 2007

Reduction of saquinavir exposure by coadministration of loperamide: a two-way pharmacokinetic interaction

scientific article published in January 2004

Relative contribution of morphine and morphine-6-glucuronide to the analgesic effect after morphine administration.

scientific article

Relevance of deficient CYP2D6 in opiate dependence

scientific article published on 01 December 1998

Renal Safety and Pharmacokinetics of Ibandronate in Multiple Myeloma Patients With or Without Impaired Renal Function

scholarly article by Raoul Bergner et al published August 2007 in The Journal of Clinical Pharmacology

Reply

Response to "can CYP3A activity be evaluated for drug interaction using a nanogram dose of probe drug?": evaluation of CYP3A activity with microdoses of midazolam.

scientific article published on 6 February 2014

Ritonavir increases loperamide plasma concentrations without evidence for P-glycoprotein involvement

scientific article published in November 2001

Rivaroxaban and macitentan can be co-administered without dose adjustment but the combination of rivaroxaban and St. John´s Wort should be avoided

scientific article published on 11 October 2018

Safety of the combination of chloroquine and methylene blue in healthy adult men with G6PD deficiency from rural Burkina Faso

scientific article published on January 2005

Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841]

scientific article

Safety of voriconazole in a patient with CYP2C9*2/CYP2C9*2 genotype.

scientific article published in September 2006

Same incidence of adverse drug events after codeine administration irrespective of the genetically determined differences in morphine formation

scientific article published on May 1998

Semisimultaneous Midazolam Administration to Evaluate the Time Course of CYP3A Activation by a Single Oral Dose of Efavirenz

scientific article published on 14 February 2017

Significant pharmacokinetic and pharmacodynamic interaction of warfarin with the NO-independent sGC activator HMR1766.

scientific article published in January 2007

Simultaneous determination of dihydrocodeine and dihydromorphine in serum by gas chromatography-tandem mass spectrometry

scientific article published on 01 January 1995

Simultaneous determination of hypericin and hyperforin in human plasma with liquid chromatography-tandem mass spectrometry

scientific article published in December 2004

Simultaneous determination of loperamide and its desmethylated metabolites in plasma and urine by high-performance liquid chromatography — Atmospheric-pressure lonization mass spectrometry

Simultaneous phenotyping of CYP2E1 and CYP3A using oral chlorzoxazone and midazolam microdoses

scientific article published on 09 August 2019

St. John's wort treatment in women bears risks beyond pharmacokinetic drug interactions

scientific article

Steady-state pharmacokinetics and metabolism of voriconazole in patients.

scientific article published on 13 June 2013

Stereoselectivity in cardiovascular and biochemical action of calcium antagonists: Studies with the enantiomers of the dihydropyridine nitrendipine*

scientific article published on 01 January 1995

Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers

scientific article published on July 2004

Systemic exposure of topical erythromycin in comparison to oral administration and the effect on cytochrome P450 3A4 activity

scientific article

Telemetrie

The CYTONOX trial.

scientific article published on May 2016

The NK₁ receptor antagonist aprepitant does not alter the pharmacokinetics of high-dose melphalan chemotherapy in patients with multiple myeloma.

scientific article

The NTCP-inhibitor Myrcludex B: Effects on Bile Acid Disposition and Tenofovir Pharmacokinetics.

scientific article published on 24 May 2017

The effect of induction of CYP3A4 by St John's wort on ambrisentan plasma pharmacokinetics in volunteers of known CYP2C19 genotype

scientific article

The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans.

scientific article

The influence of the sparteine/debrisoquin phenotype on the disposition of flecainide

scientific article published on 01 May 1989

The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes

scientific article

The urinary disposition of intravenously administered 11-nor-9-carboxy-delta-9-tetrahydrocannabinol in humans

scientific article

Treatment of life-threatening multiresistant staphylococcal and enterococcal infections in patients with end-stage renal failure with quinupristin/dalfopristin: preliminary report

scientific article published in October 2002

Treatment with rilpivirine does not alter plasma concentrations of the CYP3A substrates tadalafil and midazolam in humans.

scientific article published on May 2016

Ultra-sensitive and selective quantification of endothelin-1 in human plasma using ultra-performance liquid chromatography coupled to tandem mass spectrometry

scientific article published on 29 April 2017

Ultrasensitive quantification of the CYP2E1 probe chlorzoxazone and its main metabolite 6-hydroxychlorzoxazone in human plasma using ultra performance liquid chromatography coupled to tandem mass spectrometry after chlorzoxazone microdosing.

scientific article published on 31 May 2016

Understanding variability with voriconazole using a population pharmacokinetic approach: implications for optimal dosing

scientific article published on 18 February 2014

Unerwünschte Arzneimittelwirkungen (UAW) und Arzneimittel-Interaktionen – Definition und Einteilung

Unerwünschte Wirkungen und Wechselwirkungen in der Analgetikatherapie

Urine Drug Testing for Oxycodone and Its Metabolites as a Tool for Drug–Drug Interactions?

Use of Fentanyl in Adolescents with Clinically Severe Obesity Undergoing Bariatric Surgery: A Pilot Study

scientific article

Use of microdose phenotyping to individualise dosing of patients

scientific article published on 30 April 2015

Use of pseudoracemic nitrendipine to elucidate the metabolic steps responsible for stereoselective disposition of nitrendipine enantiomers ⬇️

scientific article published on January 1, 1992

Vorinostat in refractory soft tissue sarcomas - Results of a multi-centre phase II trial of the German Soft Tissue Sarcoma and Bone Tumour Working Group (AIO).

scientific article

What, if all alerts were specific - estimating the potential impact on drug interaction alert burden

scientific article published on 13 January 2014

Who is a 'healthy subject'?-consensus results on pivotal eligibility criteria for clinical trials

scientific article published on 07 January 2017

[Clinical relevance of drug metabolism polymorphisms]

scientific article published in September 2000

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