Search filters

List of works by Owen J Sansom

53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy.

scientific article published on 23 April 2007

A FAK-PI-3K-mTOR axis is required for Wnt-Myc driven intestinal regeneration and tumorigenesis.

scientific article published on 15 January 2011

A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer

scientific article published on 04 November 2019

A RAC-GEF network critical for early intestinal tumourigenesis

scientific article published on 04 January 2021

A Rac1-independent role for P-Rex1 in melanoblasts

scientific article published on 30 July 2014

A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

scientific article published in October 2017

A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis

scientific article published on October 2016

A caveolin-dependent and PI3K/AKT-independent role of PTEN in β-catenin transcriptional activity

scientific article published on 26 August 2015

A complex secretory program orchestrated by the inflammasome controls paracrine senescence

scientific article

A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine

scientific article

A new tumour suppressor enters the network of intestinal progenitor cell homeostasis ⬇️

scientific article published on April 17, 2012

A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model

scientific article

A role for mismatch repair in control of DNA ploidy following DNA damage

scientific article published on April 2001

ADF and Cofilin1 Control Actin Stress Fibers, Nuclear Integrity, and Cell Survival

scientific article published on 19 November 2015

AKT regulates NPM dependent ARF localization and p53mut stability in tumors

scientific article

AKT/mTORC2 Inhibition Activates FOXO1 Function in CLL Cells Reducing B-Cell Receptor-Mediated Survival

scientific article published on 17 December 2018

APC as a master regulator of intestinal homeostasis and transformation: from flies to vertebrates.

scientific article published on 8 September 2009

Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche

scientific article published on December 2014

Absolute requirement for STAT3 function in small-intestine crypt stem cell survival

scientific article published on 3 June 2011

Accepting from the best donor; analysis of long-lifetime donor fluorescent protein pairings to optimise dynamic FLIM-based FRET experiments

scientific article published on 2 January 2018

Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D-driven Pancreatic Tumorigenesis.

scientific article published on 31 May 2017

Activated mutant NRas(Q61K) drives aberrant melanocyte signaling, survival, and invasiveness via a Rac1-dependent mechanism

scientific article

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.

scientific article

Activation of PP2A and inhibition of mTOR synergistically reduce MYC signaling and decrease tumor growth in pancreatic ductal adenocarcinoma

scientific article published on 02 November 2018

Activation of Wnt signalling promotes development of dysplasia in Barrett's oesophagus

article

Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis

scientific article

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

scientific article

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation

scientific article

Advanced intravital subcellular imaging reveals vital three-dimensional signalling events driving cancer cell behaviour and drug responses in live tissue

scientific article published on 28 June 2013

Advances in mouse models of prostate cancer

scientific article published on 09 June 2008

An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth

scientific article

An efficient and robust MRI-guided radiotherapy planning approach for targeting abdominal organs and tumours in the mouse

scientific article

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity

scientific article published on 16 October 2017

Analyzing tumor suppressor activities in the murine small intestine.

scientific article

Apc and p53 interaction in DNA damage and genomic instability in hepatocytes

scientific article

Apc deficiency predisposes to renal carcinoma in the mouse

Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo

scientific article

Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer

scientific article (publication date: May 2007)

Author Correction: Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

scientific article published on 26 March 2019

Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling

scientific article published on 04 December 2011

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver

scholarly article

BCL-XL is crucial for progression through the adenoma-to-carcinoma sequence of colorectal cancer

scientific article published on 11 June 2021

Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling

scientific article

Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells

scientific journal article

Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas

scientific article published on 11 March 2019

C-Myc is a critical mediator of the phenotypes of Apc loss in the intestine

scientific article published on July 2008

CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan

scientific article published on 12 August 2019

CRISPR activation screen in mice identifies novel membrane proteins enhancing pulmonary metastatic colonisation

scientific article published on 23 March 2021

CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype

scientific article published in May 2018

CXCR2 Inhibition Profoundly Suppresses Metastases and Augments Immunotherapy in Pancreatic Ductal Adenocarcinoma

scientific article

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells.

scientific article

CXCR2 inhibition in pancreatic cancer: opportunities for immunotherapy?

CXCR2 inhibition suppresses acute and chronic pancreatic inflammation

scientific article published on 4 June 2015

Calcium signalling links MYC to NUAK1.

scientific article published on 6 November 2017

Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis

scientific article published on 01 November 2018

Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis

scientific article

Cell lineage tracing reveals a biliary origin of intrahepatic cholangiocarcinoma

scientific article published on 5 December 2013

Chk1 is essential for chemical carcinogen-induced mouse skin tumorigenesis.

scientific article published in August 2011

Colon contradictions: NF-κB signaling in intestinal tumorigenesis

scientific article published on December 2015

Colorectal Tumors Require NUAK1 for Protection from Oxidative Stress

scientific article published on 2 March 2018

Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis

scientific article

Correction: Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.

scientific article published on 10 March 2017

Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine.

scientific article published on 5 February 2009

Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease

scientific article

Crypt stem cells as the cells-of-origin of intestinal cancer

scientific article

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine

scientific article published on 9 June 2005

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss

scientific article published on 24 August 2010

Dasatinib inhibits mammary tumour development in a genetically engineered mouse model

scientific article published on August 2013

Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma

scientific article published on 17 March 2010

Deficiency of Mbd2 attenuates Wnt signaling

scientific journal article

Deficiency of Mbd2 suppresses intestinal tumorigenesis

Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice

scientific journal article

Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models

scientific article published on 23 August 2017

Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol.

scientific article published on 23 August 2010

Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice

scientific article published in December 1999

E-cadherin can limit the transforming properties of activating β-catenin mutations

scientific article published on 3 August 2015

E2f1-3 switch from activators in progenitor cells to repressors in differentiating cells

scientific article published in December 2009

Efficient Deletion of NormalBrca2-Deficient Intestinal Epithelium by Poly(ADP-Ribose) Polymerase Inhibition Models Potential Prophylactic Therapy

article

Efficient Wnt mediated intestinal hyperproliferation requires the cyclin D2-CDK4/6 complex

scientific article published on 2 February 2011

Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine.

scientific article

Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo

scientific article published on 28 February 2014

Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

scientific article

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

scientific article

Eukaryotic Elongation Factor 2 Kinase Activity Is Required for the Phenotypes of the Rpl24 Mouse

scientific article published in 2022

Evaluating data integrity in ribosome footprinting datasets through modelled polysome profiles

scientific article published in 2022

Exploiting inflammation for therapeutic gain in pancreatic cancer

scientific article

Exploring molecular genetics of bladder cancer: lessons learned from mouse models ⬇️

scientific article published on March 15, 2012

Expression of KOC, S100P, mesothelin and MUC1 in pancreatico-biliary adenocarcinomas: development and utility of a potential diagnostic immunohistochemistry panel

scientific article

Expression of R-spondin1 in ApcMin/+ Mice Reduces Growth of Intestinal Adenomas by Altering Wnt and TGFB Signaling

scientific article published on 14 September 2020

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

scientific article published on 24 January 2020

FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells

scientific article

FGFR3 mutation increases bladder tumourigenesis by suppressing acute inflammation

scientific article published on 19 September 2018

FLIM-FRET imaging in vivo reveals 3D-environment spatially regulates RhoGTPase activity during cancer cell invasion

scientific article

Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis

scientific article

Fascin 1 is transiently expressed in mouse melanoblasts during development and promotes migration and proliferation

scientific article

Fascin expression is increased in metastatic lesions but does not correlate with progression nor outcome in melanoma

article

Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes

scientific article

Fem1b antigen in the stool of ApcMin mice as a biomarker of early Wnt signaling activation in intestinal neoplasia

scientific article published on 16 October 2010

Fem1b, a proapoptotic protein, mediates proteasome inhibitor-induced apoptosis of human colon cancer cells

scientific article

Fibroblast growth factor receptor 3 activation plays a causative role in urothelial cancer pathogenesis in cooperation with Pten loss in mice

scientific article published on 31 March 2014

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

scientific article published on August 2010

Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells.

scientific article

Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells

scientific article

Functional exploration of colorectal cancer genomes using Drosophila

scientific article published on 29 November 2016

Functions of TAp63 and p53 in restraining the development of metastatic cancer.

scientific article published on 22 July 2013

GEMMs as preclinical models for testing pancreatic cancer therapies

scientific article

GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine

scientific article published on 30 July 2018

Gemcitabine-Induced TIMP1 Attenuates Therapy Response and Promotes Tumor Growth and Liver Metastasis in Pancreatic Cancer

scientific article published in August 2017

Genetic Screens Identify a Context-Specific PI3K/p27Kip1 Node Driving Extrahepatic Biliary Cancer

scientific article published on 01 December 2021

Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids

scientific article published on 07 March 2017

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

scientific article

Genomic analyses identify molecular subtypes of pancreatic cancer

scientific article published on 24 February 2016

Global increase of p16INK4a in APC-deficient mouse liver drives clonal growth of p16INK4a-negative tumors.

scientific article published on 30 September 2014

HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer

scientific article

HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia

scientific article

HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation

scientific article published on 21 December 2016

Hepatic progenitor cells of biliary origin with liver repopulation capacity

scientific article

Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background

Hypermutation In Pancreatic Cancer

scientific article

Hypoxic cancer–associated fibroblasts increase NCBP2-AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling

scientific article published on 05 February 2019

IP-10/CXCL10 induction in human pancreatic cancer stroma influences lymphocytes recruitment and correlates with poor survival.

scientific article

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth

scientific article published on 26 March 2018

Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib

scientific article published on 5 December 2006

Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.

scientific article

Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma

scientific article published on 25 August 2016

Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten-Deficient Mouse Model of Prostate Carcinogenesis.

scientific article published on 17 May 2017

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

scientific journal article

Inducible progenitor-derived Wingless regulates adult midgut regeneration inDrosophila ⬇️

scientific article published on September 4, 2012

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

scientific article

Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference With CD44v6 Signaling.

scientific article published on 24 October 2015

Integrated β-catenin, BMP, PTEN, and Notch signalling patterns the nephron

scientific article

Integrin signalling regulates YAP and TAZ to control skin homeostasis

scientific article published on 17 March 2016

Intestinal Stem Cell Dynamics: A Story of Mice and Humans

scholarly article by Michael C. Hodder et al published June 2018 in Cell Stem Cell

Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.

scientific article published on 14 July 2017

Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties

scientific article

Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer

scientific article published on 7 June 2013

Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue

scientific article published on 22 December 2015

Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer.

scientific article

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder.

scientific article published on 18 April 2011

Kaiso-deficient mice show resistance to intestinal cancer

scientific article

LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest

scientific article published on 06 May 2010

Large variety in a panel of human colon cancer organoids in response to EZH2 inhibition

scientific article published on 13 September 2016

Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas

scientific article published on 17 November 2021

Lgr5 joins the club of gastric stem cell markers in the corpus

scientific article published in June 2017

Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism.

scientific article published on 5 March 2009

Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine

scientific article

Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut

scientific article

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

scientific article

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

scholarly article

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

scientific journal article

Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

scientific article published in Nature Communications

Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.

scientific article published on 19 April 2018

Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival.

scientific article published on 18 March 2016

Loss of TGF-β signaling drives cSCC from skin stem cells - More evidence

scientific article published on 18 November 2016

Luminal iron levels govern intestinal tumorigenesis after Apc loss in vivo

scientific article published on 9 August 2012

MBD2 deficiency does not accelerate p53 mediated lymphomagenesis

scientific article

MBD2 is required for correct spatial gene expression in the gut.

scientific article published on 12 March 2007

MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR.

scientific article

MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine

scientific journal article

MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer

scientific article published on 05 July 2021

MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression

scientific article published on 16 December 2020

MYC Is a Major Determinant of Mitotic Cell Fate

scientific article published in July 2015

MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.

scientific article

MYC‐y mice: From tumour initiation to therapeutic targeting of endogenous MYC ⬇️

scientific article published on 08 March 2013

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.

scientific article

Mannose impairs tumour growth and enhances chemotherapy

scientific article published in Nature

Markedly enhanced colon tumorigenesis in Apc(Min) mice lacking glutathione S-transferase Pi.

scientific article

Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.

scientific article published on 30 March 2018

Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer

scientific article published on May 2007

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal

scientific article (publication date: October 2014)

Methods to assess Myc function in intestinal homeostasis, regeneration, and tumorigenesis

scientific article published in January 2013

MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus.

scientific article

MicroRNA Molecular Profiles Associated with Diagnosis, Clinicopathologic Criteria, and Overall Survival in Patients with Resectable Pancreatic Ductal Adenocarcinoma

scientific article published on 23 November 2011

MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer

scientific article published on April 2014

Microenvironmental cues in cancer stemness

scientific article published on 01 October 2018

Microtubule stress modifies intra-nuclear location of Msh2 in mouse embryonic fibroblasts.

scientific article published on 15 May 2004

Modulating the therapeutic response of tumours to dietary serine and glycine starvation

scientific article

More, more, more: downregulation of a MK5-FoxO3a-mir34b/c pathway further increases c-Myc levels in colorectal cancer

scientific article published in February 2011

Mouse models of intestinal cancer

scientific article

Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner

scientific journal article

Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.

scientific article

Mutant p53 drives invasion by promoting integrin recycling

scientific article

Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer

scientific article

Mutant p53 enhances MET trafficking and signalling to drive cell scattering and invasion

scientific article

Mutant p53-associated myosin-X upregulation promotes breast cancer invasion and metastasis.

scientific article

Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells

scientific article published on 9 November 2016

Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis

scientific article published on 17 November 2007

Mutations in Apc and p53 synergize to promote mammary neoplasia.

scientific article

Myc deletion rescues Apc deficiency in the small intestine

scientific journal article

Myc heterozygosity attenuates the phenotypes of APC deficiency in the small intestine.

scientific article

Neutrophils: Homing in on the myeloid mechanisms of metastasis.

scientific article published on 18 December 2017

Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy

scientific article published on 14 August 2013

Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut

scientific article published in December 2012

Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis

scientific article published on 01 May 2019

Non-canonical HIF-1 stabilization is essential for intestinal tumorigenesis

Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

scientific article published on 23 January 2020

Notch3 drives development and progression of cholangiocarcinoma.

scientific article published on 10 October 2016

Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

scientific article published on 08 June 2021

Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine

scientific article published on 17 December 2015

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

scientific article

PD-L1 blockade enhances response of pancreatic ductal adenocarcinoma to radiotherapy

scientific article published on 8 December 2016

PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine

scientific article published in November 2004

PPARdelta status and mismatch repair mediated neoplasia in the mouse intestine.

scientific article published on 3 May 2006

PROX1 promotes metabolic adaptation and fuels outgrowth of Wnt(high) metastatic colon cancer cells

scientific article published on 18 September 2014

PTEN deficiency permits the formation of pancreatic cancer in the absence of autophagy

scientific article

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers.

scientific article

Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion

scientific article

Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors

scientific article published on 20 November 2018

R-spondin Is More Than Just Wnt's Sidekick

scientific article published in June 2017

RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways

scientific article published on 20 April 2021

RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes

scientific article published on 07 March 2019

RALB GTPase: a critical regulator of DR5 expression and TRAIL sensitivity in KRAS mutant colorectal cancer

scientific article published on 29 October 2020

ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation

scientific article published on 09 May 2013

Rab25 and CLIC3 collaborate to promote integrin recycling from late endosomes/lysosomes and drive cancer progression.

scientific article

Rac1 drives intestinal stem cell proliferation and regeneration

scientific article published on 12 August 2013

Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression

scientific article

Rac1 in the driver’s seat for melanoma

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc

scientific article published on 5 September 2006

Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis ⬇️

scientific article

Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis.

scientific article published on 4 December 2015

Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation.

scientific article published on 12 April 2013

RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis

scientific article published on 25 July 2016

Reserve stem cells: Differentiated cells reprogram to fuel repair, metaplasia, and neoplasia in the adult gastrointestinal tract

scientific article

Responding to R-spondin: slit2 potentiates intestinal regeneration.

scientific article

Role of Wnt Signalling in Advanced Prostate Cancer

scientific article

Runx2 contributes to the regenerative potential of the mammary epithelium

scientific article

SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis

scientific article published on 31 May 2012

STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.

scientific article published on 29 May 2018

Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1.

scientific article published on 10 January 2013

Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation.

scientific article published on 28 July 2015

Single cell tracking reveals that Msh2 is a key component of an early-acting DNA damage-activated G2 checkpoint

scientific article

Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer

scientific article published on 29 June 2016

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

scientific article

Spatiotemporal regulation of liver development by the Wnt/β-catenin pathway.

scientific article published on 9 February 2018

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

scientific article published in February 2010

Sprouty2 loss-induced IL6 drives castration-resistant prostate cancer through scavenger receptor B1.

scientific article

Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression

scientific article published on 22 February 2013

Stem vs non-stem cell origin of colorectal cancer.

scientific article published on 25 June 2015

Subversion of Niche-Signalling Pathways in Colorectal Cancer: What Makes and Breaks the Intestinal Stem Cell

scientific article published on 28 February 2021

Systems level expression correlation of Ras GTPase regulators

scientific article published on 15 August 2018

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence

scientific article published on 01 August 2018

TGFβ pathway limits dedifferentiation following WNT and MAPK pathway activation to suppress intestinal tumourigenesis

scientific article published on 16 June 2017

TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells

scientific article

TIGAR is required for efficient intestinal regeneration and tumorigenesis

scientific journal article

Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer

scientific article published on 28 October 2017

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

scientific article published on 08 October 2020

Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer

scientific article published on May 2015

Targeting mTOR dependency in pancreatic cancer

scientific article

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy.

scientific article published on 15 June 2015

The APC network regulates the removal of mutated cells from colonic crypts.

scientific article published on 27 March 2014

The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines

scientific article published on 20 July 2016

The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs

scientific article (publication date: December 2009)

The Initiator Methionine tRNA Drives Secretion of Type II Collagen from Stromal Fibroblasts to Promote Tumor Growth and Angiogenesis

scientific article published on 2 March 2016

The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers

scientific article published on 12 June 2012

The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues

scientific article published on 13 March 2014

The Wae to repair: prostaglandin E2 (PGE2) triggers intestinal wound repair

scientific article published on 8 December 2016

The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice

scientific article published in August 2002

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

scientific article published on 07 January 2021

The in vivo function of TIGAR, a p53 target gene that regulates glucose metabolism.

scientific article

The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma

scientific article published on 19 August 2016

The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy

scientific article published on 30 July 2019

The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively

scientific article

The pathogenesis of mesothelioma is driven by a dysregulated translatome

scientific article published on 13 August 2021

The pro-apoptotic K-Ras 4A proto-oncoprotein does not affect tumorigenesis in the ApcMin/+ mouse small intestine.

scientific article

The right time, the right place: will targeting human cancer-associated mutations to the mouse provide the perfect preclinical model? ⬇️

scientific article published on February 2012

The role of MIZ-1 in MYC-dependent tumorigenesis

scientific article

The role of mTOR-mediated signals during haemopoiesis and lineage commitment

scientific article published in 2018

The role of murine models of prostate cancer in drug target discovery and validation ⬇️

scientific article published on August 1, 2009

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

scientific article published on 31 January 2017

Tiam1-Rac signaling counteracts Eg5 during bipolar spindle assembly to facilitate chromosome congression

scientific article published on 25 March 2010

Timing Is Everything: Brca2 and p53 Mutations in Pancreatic Cancer

scientific article published on 23 February 2011

Tissue-specific tumour suppression by APC.

scientific article published on January 2009

Today's research: tomorrow's therapies

scientific article published in July 2010

Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging

scientific article published in 2022

Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

scientific article published in April 2017

Translating the molecular hallmarks of colorectal cancer to patient therapies: an interview with Owen Sansom

scientific article published on August 2014

Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase

scientific article

WNT signaling drives cholangiocarcinoma growth and can be pharmacologically inhibited

scientific article

Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells.

scientific article published on 19 March 2018

Wnt signalling and its role in stem cell-driven intestinal regeneration and hyperplasia

scientific article published on 22 April 2011

Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers

scientific article published on 12 September 2016

Wnt/Myc interactions in intestinal cancer: partners in crime

scientific article published on 07 August 2011

c-Src drives intestinal regeneration and transformation

scientific article

mTORC1 activity is essential for erythropoiesis and B cell lineage commitment

scientific article published on 15 November 2019

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

scientific article

mTORC2 Signaling Drives the Development and Progression of Pancreatic Cancer

scientific article published on 6 October 2016

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

scientific article

p53 mutation and loss have different effects on tumourigenesis in a novel mouse model of pleomorphic rhabdomyosarcoma

scientific article published in October 2010

p53 status determines the role of autophagy in pancreatic tumour development

scientific article published on 4 December 2013

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

scientific article published on 16 November 2010

β-Catenin activation synergizes with PTEN loss to cause bladder cancer formation.

scientific article

Paulina is supported by:

About Paulina

Help