List of works - Alan R. Clarke

129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal

scientific article published in April 1994

53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy

scientific article published on 23 April 2007

A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine

scientific article

A role for mismatch repair in control of DNA ploidy following DNA damage

scientific article published on April 2001

Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation.

scientific article

Absence of p53 delays apoptotic photoreceptor cell death in the rds mouse

scientific article published in September 1998

Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest.

scientific article

Absolute requirement for STAT3 function in small-intestine crypt stem cell survival

scientific article published on 3 June 2011

Animal models and the molecular pathology of cancer

scientific article published on February 1997

Apc and p53 interaction in DNA damage and genomic instability in hepatocytes

scientific article

Apc deficiency predisposes to renal carcinoma in the mouse

Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo

scientific article

Apoptosis induced by γ-irradiation, but not CD4 ligation, of peripheral T lymphocytesin vivo is p53-dependent

scientific article published on 01 February 1997

Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer

scientific article (publication date: May 2007)

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver

scholarly article

Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells

scientific journal article

Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner

scientific article

Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine

scientific article (publication date: July 2014)

Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes

scientific article published in July 2002

Caspase-dependent proteolytic cleavage of STAT3alpha in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines

scientific article published on 12 February 2007

Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation

scientific article published on 26 January 2009

Cited1 deficiency suppresses intestinal tumorigenesis.

scientific article

Conditional disruption of Axin1 leads to development of liver tumors in mice

scientific article published on 6 September 2012

Controlling the stem cell compartment and regeneration in vivo: the role of pluripotency pathways

scientific article published on January 2012

Cre-loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases

article

Crypt stem cells as the cells-of-origin of intestinal cancer

scientific article

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine

scientific article published on 9 June 2005

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss

scientific article published on 24 August 2010

DNA damage-induced apoptosis: insights from the mouse.

scientific article published in December 2004

Deficiency of Mbd2 attenuates Wnt signaling

scientific journal article

Deficiency of Mbd2 suppresses intestinal tumorigenesis

Dual inhibition of epidermal growth factor and insulin-like 1 growth factor receptors reduce intestinal adenoma burden in the Apcmin/+ mouse ⬇️

scientific article published on August 2, 2011

E-cadherin can limit the transforming properties of activating β-catenin mutations

scientific article published on 3 August 2015

Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis

scientific article published on 9 December 2011

Efficient BLG-Cre mediated gene deletion in the mammary gland

scientific article published in September 1998

Efficient Deletion of NormalBrca2-Deficient Intestinal Epithelium by Poly(ADP-Ribose) Polymerase Inhibition Models Potential Prophylactic Therapy

article

Elevated expression of exogenous Rad51 leads to identical increases in gene-targeting frequency in murine embryonic stem (ES) cells with both functional and dysfunctional p53 genes

article

Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

scientific article

Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice

scientific article

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

scientific article

Epithelial-specific loss of PTEN results in colorectal juvenile polyp formation and invasive cancer.

scientific article

Expanding the p53 toolkit: A new platform for rapid engineering of the p53 locus in vivo ⬇️

scientific article published on July 15, 2011

Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis

scientific article

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

scientific article published on August 2010

Gene manipulation through the use of small interfering RNA (siRNA): from in vitro to in vivo applications.

scientific article published on 20 March 2007

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

scientific article

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

article

Glutathione and p53 independently mediate responses against oxidative stress in ES cells

scientific article published on January 2002

Hepatic progenitor cells of biliary origin with liver repopulation capacity

scientific article

Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background

High-frequency developmental abnormalities in p53-deficient mice.

scientific article published in August 1995

In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system ⬇️

scientific article published on April 2, 2012

Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.

scientific article

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

scientific journal article

Intestinal homeostasis and neoplasia studied using conditional transgenesis.

scientific article published on April 2007

Intestinal renin-angiotensin system is stimulated after deletion of Lkb1.

scientific article published on 3 August 2011

KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes

scientific article published on 6 October 2014

Kaiso-deficient mice show resistance to intestinal cancer

scientific article

LKB1 loss of function studied in vivo

scientific article published on 15 January 2011

Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism.

scientific article published on 5 March 2009

Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder

scientific article

Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine

scientific article

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

scientific article

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

scholarly article

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

scientific journal article

Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine

scientific article published on August 2010

Low frequency ultrasonic propagation through fibre reinforced, polymer composites

scientific article published in May 2002

MBD2 deficiency does not accelerate p53 mediated lymphomagenesis

scientific article

MBD2 is required for correct spatial gene expression in the gut.

scientific article published on 12 March 2007

MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR.

scientific article

MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine

scientific journal article

Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.

scientific article published on 30 March 2018

Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer

scientific article published on May 2007

Milk composition and lactation of beta-casein-deficient mice.

scientific article published on June 1994

Mouse models with modified p53 sequences to study cancer and ageing.

scientific article

Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner

scientific journal article

Murine genetic models of human disease

scientific article published on June 1994

Murine models of intestinal cancer: recent advances.

scientific article published on 21 March 2007

Murine models of neoplasia: functional analysis of the tumour suppressor genes Rb-1 and p53.

scientific article published on June 1995

Myc deletion rescues Apc deficiency in the small intestine

scientific journal article

New approaches for modelling cancer mechanisms in the mouse.

scientific article

Normal stem cells in cancer prone epithelial tissues.

scientific article published on 06 January 2009

OncomiRdbB: a comprehensive database of microRNAs and their targets in breast cancer

scientific article published on 15 January 2014

Origin and maintenance of the intestinal cancer stem cell

scientific article published on April 2011

PPARdelta status and Apc-mediated tumourigenesis in the mouse intestine

scientific article published in November 2004

PPARdelta status and mismatch repair mediated neoplasia in the mouse intestine.

scientific article published on 3 May 2006

PTEN loss and KRAS activation cooperate in murine biliary tract malignancies

scientific article

PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine

scientific article

Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.

scientific article

Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC).

scientific article published on 31 August 2013

Puma: Mauling the Intestinal Crypt

scientific article published on 01 June 2008

Purine analogues kill resting lymphocytes by p53-dependent and -independent mechanisms

scientific article

RNA Interference Using c-Myc-Conjugated Nanoparticles Suppresses Breast and Colorectal Cancer Models.

scientific article

Rapid loss of intestinal crypts upon conditional deletion of the Wnt/Tcf-4 target gene c-Myc

scientific article published on 5 September 2006

Rectal epithelial cell mitosis and expression of macrophage migration inhibitory factor are increased 3 years after Roux-en-Y gastric bypass (RYGB) for morbid obesity: implications for long-term neoplastic risk following RYGB

scientific article published on 08 February 2011

Single cell tracking reveals that Msh2 is a key component of an early-acting DNA damage-activated G2 checkpoint

scientific article

Studying the consequences of immediate loss of gene function in the intestine: APC

article

Successful targeting of the mouse cystic fibrosis transmembrane conductance regulator gene in embryonal stem cells

article

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.

scientific article

T cell receptor δ gene mutant mice: Independent generation of αβ T cells and programmed rearrangements of γδ TCR genes

article

The Human Preprotachykinin-A Gene Promoter Has Been Highly Conserved and Can Drive Human-like Marker Gene Expression in the Adult Mouse CNS

article

The Roles of the Methyl-CpG Binding Proteins in Cancer ⬇️

scientific article published on June 1, 2011

The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice

scientific article published in August 2002

The biology of mitochondrial disease.

scientific article

The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis.

scientific article

The wt1-heterozygous mouse; a model to study the development of glomerular sclerosis

scientific article published in August 2003

Transcription factor PROX1 induces colon cancer progression by promoting the transition from benign to highly dysplastic phenotype

scientific article

Transgenic approaches to cancer biology

scientific article published on December 1993

What are the best routes to effectively model human colorectal cancer?

scientific article published on 20 February 2013

Wnt-cadherin connections in normal and neoplastic mammary epithelium.

scientific article published on October 2003

Wnt-driven intestinal tumourigenesis is suppressed by Chk1 deficiency but enhanced by conditional haploinsufficiency

scientific article

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium

scientific article

p53 mediates a default programme of mammary gland involution in the absence of STAT3

scientific article published on 01 April 2005

p53-independent DNA repair and cell cycle arrest in embryonic stem cells

scientific article published on April 1998

β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

scientific article

List of works by Alan R. Clarke

129/Ola mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal

53BP1 deficiency in intestinal enterocytes does not alter the immediate response to ionizing radiation, but leads to increased nuclear area consistent with polyploidy

A limited role for p53 in modulating the immediate phenotype of Apc loss in the intestine

A role for mismatch repair in control of DNA ploidy following DNA damage

Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation.

Absence of p53 delays apoptotic photoreceptor cell death in the rds mouse

Absence of p53 in Clara cells favours multinucleation and loss of cell cycle arrest.

Absolute requirement for STAT3 function in small-intestine crypt stem cell survival

Animal models and the molecular pathology of cancer

Apc and p53 interaction in DNA damage and genomic instability in hepatocytes

Apc deficiency predisposes to renal carcinoma in the mouse

Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo

Apoptosis induced by γ-irradiation, but not CD4 ligation, of peripheral T lymphocytesin vivo is p53-dependent

Aspirin activates the NF-kappaB signalling pathway and induces apoptosis in intestinal neoplasia in two in vivo models of human colorectal cancer

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver

Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells

Brg1 is required for stem cell maintenance in the murine intestinal epithelium in a tissue-specific manner

Brg1 loss attenuates aberrant wnt-signalling and prevents wnt-dependent tumourigenesis in the murine small intestine

Carcinogen-induced pancreatic lesions in the mouse: effect of Smad4 and Apc genotypes

Caspase-dependent proteolytic cleavage of STAT3alpha in ES cells, in mammary glands undergoing forced involution and in breast cancer cell lines

Chk1 deficiency in the mouse small intestine results in p53-independent crypt death and subsequent intestinal compensation

Cited1 deficiency suppresses intestinal tumorigenesis.

Conditional disruption of Axin1 leads to development of liver tumors in mice

Controlling the stem cell compartment and regeneration in vivo: the role of pluripotency pathways

Cre-loxP mediated control of PrP to study transmissible spongiform encephalopathy diseases

Crypt stem cells as the cells-of-origin of intestinal cancer

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss

DNA damage-induced apoptosis: insights from the mouse.

Deficiency of Mbd2 attenuates Wnt signaling

Deficiency of Mbd2 suppresses intestinal tumorigenesis

Dual inhibition of epidermal growth factor and insulin-like 1 growth factor receptors reduce intestinal adenoma burden in the Apcmin/+ mouse ⬇️

E-cadherin can limit the transforming properties of activating β-catenin mutations

Effects of Wnt3A and mechanical load on cartilage chondrocyte homeostasis

Efficient BLG-Cre mediated gene deletion in the mammary gland

Efficient Deletion of NormalBrca2-Deficient Intestinal Epithelium by Poly(ADP-Ribose) Polymerase Inhibition Models Potential Prophylactic Therapy

Elevated expression of exogenous Rad51 leads to identical increases in gene-targeting frequency in murine embryonic stem (ES) cells with both functional and dysfunctional p53 genes

Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice.

Entopic overexpression of Ascl2 does not accelerate tumourigenesis in ApcMin mice

Epithelial Pten is dispensable for intestinal homeostasis but suppresses adenoma development and progression after Apc mutation

Epithelial-specific loss of PTEN results in colorectal juvenile polyp formation and invasive cancer.

Expanding the p53 toolkit: A new platform for rapid engineering of the p53 locus in vivo ⬇️

Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

Gene manipulation through the use of small interfering RNA (siRNA): from in vitro to in vivo applications.

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

Glutathione and p53 independently mediate responses against oxidative stress in ES cells

Hepatic progenitor cells of biliary origin with liver repopulation capacity

Heterozygosity for p53 promotes microsatellite instability and tumorigenesis on a Msh2 deficient background

High-frequency developmental abnormalities in p53-deficient mice.

In vivo and in vitro models for the therapeutic targeting of Wnt signaling using a Tet-OΔN89β-catenin system ⬇️

Inactivation of Apc perturbs mammary development, but only directly results in acanthoma in the context of Tcf-1 deficiency.

Inducible Cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of beta-catenin

Intestinal homeostasis and neoplasia studied using conditional transgenesis.

Intestinal renin-angiotensin system is stimulated after deletion of Lkb1.

KAISO, a critical regulator of p53-mediated transcription of CDKN1A and apoptotic genes

Kaiso-deficient mice show resistance to intestinal cancer

LKB1 loss of function studied in vivo

Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism.

Lkb1 and Pten synergise to suppress mTOR-mediated tumorigenesis and epithelial-mesenchymal transition in the mouse bladder

Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

Loss of Indian Hedgehog activates multiple aspects of a wound healing response in the mouse intestine

Low frequency ultrasonic propagation through fibre reinforced, polymer composites

MBD2 deficiency does not accelerate p53 mediated lymphomagenesis

MBD2 is required for correct spatial gene expression in the gut.

MBD4 deficiency does not increase mutation or accelerate tumorigenesis in mice lacking MMR.

MBD4 deficiency reduces the apoptotic response to DNA-damaging agents in the murine small intestine

Mbd2 enables tumourigenesis within the intestine while preventing tumour-promoting inflammation.

Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer

Milk composition and lactation of beta-casein-deficient mice.

Mouse models with modified p53 sequences to study cancer and ageing.

Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner

Murine genetic models of human disease

Murine models of intestinal cancer: recent advances.

Murine models of neoplasia: functional analysis of the tumour suppressor genes Rb-1 and p53.