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List of works by Kiaran Kirk

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

scientific article

1H-NMR metabolite profiles of different strains of Plasmodium falciparum

scientific article

A 4-cyano-3-methylisoquinoline inhibitor of Plasmodium falciparum growth targets the sodium efflux pump PfATP4

scientific article published on 16 July 2019

A biotin derivative blocks parasite induced novel permeation pathways in Plasmodium falciparum-infected erythrocytes

scientific article published in November 2003

A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites

scientific article

A female gametocyte-specific ABC transporter plays a role in lipid metabolism in the malaria parasite

scientific article (publication date: 8 September 2014)

A high-sensitivity HPLC assay for measuring intracellular Na(+) and K(+) and its application to Plasmodium falciparum infected erythrocytes

scientific article

A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum

scientific article (publication date: 31 March 2015)

A polymorphic drug pump in the malaria parasite

scientific article published in November 2008

A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT.

scientific article published on 22 February 2011

A surface transporter family conveys the trypanosome differentiation signal

scientific article

A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites

scientific article published on 29 April 2008

Acid extrusion from the intraerythrocytic malaria parasite is not via a Na(+)/H(+) exchanger

scientific article published on 15 July 2008

Acidification of the malaria parasite's digestive vacuole by a H+-ATPase and a H+-pyrophosphatase.

scientific article published on 8 November 2002

An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum

scientific article

Anthracene-polyamine conjugates inhibit in vitro proliferation of intraerythrocytic Plasmodium falciparum parasites

scientific article published on April 2013

Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes

scientific article published on September 2004

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase

scientific article

Biochemical characterization and chemical inhibition of PfATP4-associated Na-ATPase activity in membranes

scientific article published in Journal of Biological Chemistry

CJ-15,801, a fungal natural product, inhibits the intraerythrocytic stage of Plasmodium falciparum in vitro via an effect on pantothenic acid utilisation

scientific article published in May 2005

Cationic amino acid transporters play key roles in the survival and transmission of apicomplexan parasites

scientific article (publication date: 16 February 2017)

Cell Swelling Induced by the Antimalarial KAE609 (Cipargamin) and Other PfATP4-Associated Antimalarials

scholarly article by Adelaide S M Dennis et al published June 2018 in Antimicrobial Agents and Chemotherapy

Cell volume control in the Plasmodium-infected erythrocyte

scientific article published in January 2004

Channels and transporters as drug targets in the Plasmodium-infected erythrocyte

scientific article published on February 2004

Characterization of the apicomplexan amino acid transporter (ApiAT) family inToxoplasma gondii

Chemical activation of a high-affinity glutamate transporter in human erythrocytes and its implications for malaria-parasite-induced glutamate uptake

scientific article

Chloroquine resistance and the pH of the malaria parasite's digestive vacuole.

scientific article published on December 2001

Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole

scientific article published on 13 October 2008

Chloroquine transport via the malaria parasite's chloroquine resistance transporter

scientific article (publication date: 25 September 2009)

Choline uptake into the malaria parasite is energized by the membrane potential

scientific article

Coenzyme A biosynthesis: an antimicrobial drug target

scientific article published on January 2008

Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance

scientific article

Degrees of chloroquine resistance in Plasmodium - is the redox system involved?

scientific article

Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT.

scientific article

Diverse antimalarials from whole-cell phenotypic screens disrupt malaria parasite ion and volume homeostasis.

scientific article

Diverse chemotypes disrupt ion homeostasis in the Malaria parasite

scientific article

Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter

scientific article

Efflux of a range of antimalarial drugs and 'chloroquine resistance reversers' from the digestive vacuole in malaria parasites with mutant PfCRT.

scientific article published on 28 June 2010

Electrophysiological studies of malaria parasite-infected erythrocytes: current status

scientific article published on 9 January 2007

Evidence for the involvement of Plasmodium falciparum proteins in the formation of new permeability pathways in the erythrocyte membrane

scientific article published in April 2006

Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite

scientific article published on 20 June 2007

Functional properties and physiological roles of organic solute channels ⬇️

scientific article published on January 1, 1998

Furosemide analogues as potent inhibitors of the new permeability pathways of Plasmodium falciparum-infected human erythrocytes

scientific article published in February 2004

Glutathione export from human erythrocytes and Plasmodium falciparum malaria parasites

scientific article published in December 2012

Human dihydrofolate reductase influences the sensitivity of the malaria parasite Plasmodium falciparum to ketotifen - A cautionary tale in screening transgenic parasites

scientific article published on 22 September 2016

Inhibition of hexose transport and abrogation of pH homeostasis in the intraerythrocytic malaria parasite by an O-3-hexose derivative

scientific article published in July 2004

Ion Regulation in the Malaria Parasite

scientific article

Loss of pH control in Plasmodium falciparum parasites subjected to oxidative stress

scientific article

Measuring Solute Transport in Toxoplasma gondii Parasites

scientific article published on 01 January 2020

Membrane transport in the malaria parasite and its host erythrocyte

scientific article published on January 2014

Membrane transport proteins of the malaria parasite

scientific article published in October 2009

Metabolite profiling of the intraerythrocytic malaria parasite Plasmodium falciparum by (1)H NMR spectroscopy

scientific article

Methionine transport in the malaria parasite Plasmodium falciparum

scientific article published on 17 September 2010

Mice deficient in the putative phospholipid flippase ATP11C exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span.

scientific article

Molecular approaches to malaria.

scientific article published in November 2004

Mutations in pfmdr1 modulate the sensitivity of Plasmodium falciparum to the intrinsic antiplasmodial activity of verapamil

scientific article

Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials

scientific article (publication date: 13 February 2013)

Na+ extrusion imposes an acid load on the intraerythrocytic malaria parasite

scientific article

Na+-dependent acid efflux from P. falciparum: PfNHE or residual nigericin?

scientific article published in 2009

Of malaria, metabolism and membrane transport

scientific article

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

scientific article (publication date: July 2016)

Osmotic swelling activates two pathways for K+ efflux in a rat hepatoma cell line

scientific article published on January 2004

PfNT2, a permease of the equilibrative nucleoside transporter family in the endoplasmic reticulum of Plasmodium falciparum

scientific article (publication date: 2 July 2010)

Plasmodium falciparum culture: the benefits of shaking

scientific article

Polyamine uptake by the intraerythrocytic malaria parasite, Plasmodium falciparum

scientific article published on 2 August 2012

Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite

scientific article

Purine nucleobase transport in the intraerythrocytic malaria parasite.

scientific article

Purine salvage pathways in the intraerythrocytic malaria parasite Plasmodium falciparum

scientific article published on 20 June 2008

Purine uptake in Plasmodium: transport versus metabolism.

scientific article published on 5 May 2009

Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

scientific article

Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum

scientific article

Saquinavir inhibits the malaria parasite's chloroquine resistance transporter.

scientific article

Sequestration and metabolism of host cell arginine by the intraerythrocytic malaria parasite Plasmodium falciparum

scientific article

Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite

scientific article (publication date: 5 October 2006)

Swelling-activated Organic Osmolyte Channels ⬇️

scientific article published on July 1, 1997

Targeting nutrient uptake mechanisms in Plasmodium

scientific article published on January 2007

The 'permeome' of the malaria parasite: an overview of the membrane transport proteins of Plasmodium falciparum

scientific article

The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens

scientific article (publication date: February 2017)

The NMR 'split peak effect' in cell suspensions: Historical perspective, explanation and applications.

scientific article published on 7 November 2017

The Plasmodium falciparum-infected red blood cell

scientific article published in June 2011

The malaria parasite cation ATPase PfATP4 and its role in the mechanism of action of a new arsenal of antimalarial drugs

scientific article

The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily

scientific article (publication date: October 2004)

The membrane potential of the intraerythrocytic malaria parasite Plasmodium falciparum

scientific article published on 20 November 2003

The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance

scientific article published on 21 February 2006

The role of P2Y1 purinergic receptors and cytosolic Ca2+ in hypotonically activated osmolyte efflux from a rat hepatoma cell line

scientific article published on 22 July 2002

The tyrosine transporter of Toxoplasma gondii is a member of the newly defined apicomplexan amino acid transporter (ApiAT) family

scientific article published on 11 February 2019

Transport of nucleosides across the Plasmodium falciparum parasite plasma membrane has characteristics of PfENT1

scientific article (publication date: May 2006)

Transport of the essential nutrient isoleucine in human erythrocytes infected with the malaria parasite Plasmodium falciparum

scientific article published on 17 October 2006

pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum

scientific article

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