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List of works by Andrés Aguilera

A Meiotic Checkpoint Alters Repair Partner Bias to Permit Inter-sister Repair of Persistent DSBs

article

A genome-wide function of THSC/TREX-2 at active genes prevents transcription-replication collisions

scientific article published on 7 October 2014

A new connection of mRNP biogenesis and export with transcription-coupled repair

scientific article

A new role for Rrm3 in repair of replication-born DNA breakage by sister chromatid recombination

scientific article

A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors.

scientific article published on 8 April 2011

A novel class of mRNA-containing cytoplasmic granules are produced in response to UV-irradiation

scientific article published on 03 September 2008

A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination.

scientific article

A novel yeast mutation, rad52-L89F, causes a specific defect in Rad51-independent recombination that correlates with a reduced ability of Rad52-L89F to interact with Rad59.

scientific article published on September 2004

A reduction in RNA polymerase II initiation rate suppresses hyper-recombination and transcription-elongation impairment of THO mutants

scientific article published on 06 August 2008

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II

scientific article

AID induces double-strand breaks at immunoglobulin switch regions and c-MYC causing chromosomal translocations in yeast THO mutants

scientific article

Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex

scholarly article

An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination.

scientific article

Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor

scientific article published on 7 February 2012

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.

scientific article published in June 2014

BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair‡

scientific article published on 26 February 2021

Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleus

scientific article published on 22 April 2008

CDK targets Sae2 to control DNA-end resection and homologous recombination

scientific article

Causes of genome instability

scientific article published on 31 July 2013

Characterization of two highly similar Rad51 homologs of Physcomitrella patens

scientific article published in February 2002

Chromosomal translocations caused by either pol32-dependent or pol32-independent triparental break-induced replication

scientific article published on 3 August 2009

Cleavage factor I links transcription termination to DNA damage response and genome integrity maintenance in Saccharomyces cerevisiae

scientific article

Competing roles of DNA end resection and non-homologous end joining functions in the repair of replication-born double-strand breaks by sister-chromatid recombination.

scientific article

Complex Chromosomal Rearrangements Mediated by Break-Induced Replication Involve Structure-Selective Endonucleases ⬇️

scientific article published on September 27, 2012

Control of cross-over by single-strand DNA resection

scientific article published in August 2003

Control of the function of the transcription and repair factor TFIIH by the action of the cochaperone Ydj1.

scientific article

Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions

scientific article published on 15 March 2018

Coordinated Activity of Y Family TLS Polymerases and EXO1 Protects Non-S Phase Cells from UV-Induced Cytotoxic Lesions

scientific article published on 01 April 2018

Coordinated control of replication and transcription by a SAPK protects genomic integrity.

scientific article

Correction for Muñoz-Galván et al., "Distinct Roles of Mus81, Yen1, Slx1-Slx4, and Rad1 Nucleases in the Repair of Replication-Born Double-Strand Breaks by Sister Chromatid Exchange"

scientific article published on 16 May 2017

Correction: The Caenorhabditis elegans THO Complex Is Required for the Mitotic Cell Cycle and Development.

scientific article published on 21 July 2016

Cotranscriptional mRNP assembly: from the DNA to the nuclear pore

scientific article

Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination ⬇️

scientific article published on September 1, 2003

DNA repair in mammalian cells: DNA double-strand break repair: how to fix a broken relationship.

scientific article

DNA repair: From molecular mechanism to human disease

scientific article published on 01 August 2006

DNA-RNA hybrids: the risks of DNA breakage during transcription

scientific article

Deletion of the phosphoglucose isomerase structural gene makes growth and sporulation glucose dependent in Saccharomyces cerevisiae

scientific article

Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability

scientific article published on 01 August 2019

Detection of DNA-RNA Hybrids In Vivo

scientific article published in January 2018

Different genetic requirements for repair of replication-born double-strand breaks by sister-chromatid recombination and break-induced replication

scientific article published on 28 September 2007

Different physiological relevance of yeast THO/TREX subunits in gene expression and genome integrity

scientific article

Differential effect of the overexpression of Rad2/XPG family endonucleases on genome integrity in yeast and human cells

scientific article published on 3 July 2017

Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

scientific article

Differential intrachromosomal hyper-recombination phenotype of spt4 and spt6 mutants of S. cerevisiae

scientific article

Distinct roles of Mus81, Yen1, Slx1-Slx4, and Rad1 nucleases in the repair of replication-born double-strand breaks by sister chromatid exchange

scientific article

Double-strand breaks arising by replication through a nick are repaired by cohesin-dependent sister-chromatid exchange.

scientific article

Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability

scientific article published on 10 September 2019

Epigenetic features of human telomeres.

scientific article published on 18 January 2018

Ethanol-sensitive mutants of Saccharomyces cerevisiae

scientific article published on 01 January 1986

Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening

scientific article

FANCD2 Facilitates Replication through Common Fragile Sites.

scientific article

Gene gating at nuclear pores prevents the formation of R loops

scientific article published on 11 December 2017

Genetic and Molecular Analysis of Mitotic Recombination in Saccharomyces cerevisiae

scientific article published on 01 January 2011

Genetic evidence for different RAD52-dependent intrachromosomal recombination pathways in Saccharomyces cerevisiae

article

Genetic stability and DNA rearrangements associated with a 2 × 1.1-Kb perfect palindrome in Escherichia coli

scientific article published on 01 October 1998

Genome instability and transcription elongation impairment in human cells depleted of THO/TREX

scientific article

Genome instability: a mechanistic view of its causes and consequences

scientific article

Genome-wide analysis of factors affecting transcription elongation and DNA repair: a new role for PAF and Ccr4-not in transcription-coupled repair.

scientific article

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles

scientific article published on 24 June 2011

Guidelines and recommendations on yeast cell death nomenclature.

scientific article published in January 2018

Guidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathways

scientific article published on 07 January 2019

Harmful DNA:RNA hybrids are formed in cis and in a Rad51-independent manner

scientific article published on 04 August 2020

Harmful R-loops are prevented via different cell cycle-specific mechanisms

scientific article published on 22 July 2021

High levels of chromosome instability in polyploids of Saccharomyces cerevisiae

scientific article published on 01 August 1990

High-Resolution Mapping of Homologous Recombination Events in rad3 Hyper-Recombination Mutants in Yeast

scientific article

Histone H3K56 acetylation, Rad52, and non-DNA repair factors control double-strand break repair choice with the sister chromatid

scientific journal article

Histone Mutants Separate R Loop Formation from Genome Instability Induction

scientific article published in June 2017

Histone deacetylases facilitate the accurate repair of broken forks

scientific article published on 13 January 2020

Homologous recombination and Mus81 promote replication completion in response to replication fork blockage

scientific article published on 17 May 2020

How to exchange your partner. Workshop on recombination mechanisms and the maintenance of genomic stability

scientific article published on 15 December 2006

Hpr1 is preferentially required for transcription of either long or G+C-rich DNA sequences in Saccharomyces cerevisiae.

scientific article published on October 2001

Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability.

scientific article

Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability

article published in the Proceedings of the National Academy of Sciences of the United States of America

Impairment of replication fork progression mediates RNA polII transcription-associated recombination

scientific article published on 3 March 2005

Impairment of transcription elongation by R-loops in vitro

scientific article published on 25 June 2007

Increase in incidence of chromosome instability and non-conservative recombination between repeats in Saccharomyces cerevisiae hpr1? strains

scientific article published on 01 October 1994

Instability of Saccharomyces cerevisiae heterokaryons

scientific article published on 01 July 1984

Interdependence between Transcription and mRNP Processing and Export, and Its Impact on Genetic Stability

scientific article published on 01 June 2005

Interdependence of the rad50 hook and globular domain functions

scientific article published on 15 January 2015

Isolation and molecular analysis of the phosphoglucose isomerase structural gene of Saccharomyces cerevisiae

scientific article

Methods to study transcription-coupled repair in chromatin

scientific article published in January 2015

Mitotic gene conversion of large DNA heterologies in Saccharomyces cerevisiae

article

Molecular analysis of RGP1, a new yeast gene required for proper mitotic growth

scientific article published on February 1990

Molecular evidence for a positive role of Spt4 in transcription elongation

scientific article

Molecular evidence indicating that the yeast PAF complex is required for transcription elongation

scientific article

Molecular evidence that the eukaryotic THO/TREX complex is required for efficient transcription elongation

scientific article published on 18 July 2003

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts.

scientific article published on 25 January 2018

Mutations suppressing the effects of a deletion of the Phosphoglucose isomerase gene PGI1 in Saccharomyces cerevisiae

article

Nab2 functions in the metabolism of RNA driven by polymerases II and III.

scientific article

Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism

scientific article

New clues to understand the role of THO and other functionally related factors in mRNP biogenesis

scientific article published on 20 December 2011

New in-vivo cloning methods by homologous recombination in yeast

scientific article published on 01 February 1994

New suppressors of THO mutations identify Thp3 (Ypr045c)-Csn12 as a protein complex involved in transcription elongation

scientific article

Npl3, a new link between RNA-binding proteins and the maintenance of genome integrity.

scientific article published on 2 April 2014

Nucleotide sequence and characterization of temperature-sensitive pol1 mutants of Saccharomyces cerevisiae

scientific article published on 01 May 1990

Origin matters: spontaneous DNA-RNA hybrids do not form in trans as a source of genome instability

scientific article published on 23 October 2020

Partial depletion of histone H4 increases homologous recombination-mediated genetic instability

scientific article published on February 2005

Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability

scientific article published on 25 September 2017

Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression

scientific article published in 2015

R Loops: From Physiological to Pathological Roles

scientific article published on 10 October 2019

R Loops: From Transcription Byproducts to Threats to Genome Stability ⬇️

scientific article published on April 27, 2012

R loops are linked to histone H3 S10 phosphorylation and chromatin condensation

scientific article

R loops: new modulators of genome dynamics and function

scientific article published on 15 September 2015

R-Loops as Promoters of Antisense Transcription

scientific article published on 01 November 2019

R-loop mediated transcription-associated recombination in trf4Δ mutants reveals new links between RNA surveillance and genome integrity

scientific article

R-loops cause replication impairment and genome instability during meiosis

scientific article

R-loops do not accumulate in transcription-defective hpr1-101 mutants: implications for the functional role of THO/TREX.

scientific article published on 18 May 2009

RNA polymerase II contributes to preventing transcription-mediated replication fork stalls

scientific article published in December 2014

Recombination between DNA repeats in yeast hpr1delta cells is linked to transcription elongation

scientific article published on May 1997

Relationship between G+C content, ORF-length and mRNA concentration in Saccharomyces cerevisiae

scientific article

Relationship between growth, fermentation, and respiration rates inSaccharomyces cerevisiae: A study based on the analysis of the yield Ypx

scientific article published on 01 July 1988

Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex

scientific article published on April 2006

Replication stress and cancer

scientific article

Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system.

scientific article published on 20 April 2015

Role of mitochondria in ethanol tolerance of Saccharomyces cerevisiae

scientific article published on 01 September 1985

Roles of human POLD1 and POLD3 in genome stability

scientific article published on 15 December 2016

Rpd3L and Hda1 histone deacetylases facilitate repair of broken forks by promoting sister chromatid cohesion

scientific article published on 15 November 2019

Sem1 is a functional component of the nuclear pore complex-associated messenger RNA export machinery

scientific article published on 16 March 2009

Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination.

scientific article

Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle

scientific article published on 16 February 2020

Stimulation of direct-repeat recombination by RNA polymerase III transcription.

scientific article published on 24 January 2009

TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage

scientific article published on 10 December 2020

TREX is a conserved complex coupling transcription with messenger RNA export

scientific article

The Antitumor Drugs Trabectedin and Lurbinectedin Induce Transcription-Dependent Replication Stress and Genome Instability

scientific article published on 14 December 2018

The Caenorhabditis elegans THO complex is required for the mitotic cell cycle and development

scientific article

The DNA damage response acts as a safeguard against harmful DNA-RNA hybrids of different origins

scientific article published on 24 July 2019

The Dot1 histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination in Saccharomyces cerevisiae

scientific article

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

scientific article published on 19 November 2015

The Npl3 hnRNP prevents R-loop-mediated transcription-replication conflicts and genome instability

scientific article published on November 2013

The Nup84 complex coordinates the DNA damage response to warrant genome integrity

scientific article published on 01 May 2019

The Rad50 coiled-coil domain is indispensable for Mre11 complex functions

scientific article

The Role of Replication-Associated Repair Factors on R-Loops

scientific article published on 27 June 2017

The S-phase checkpoint is required to respond to R-loops accumulated in THO mutants

scientific article published on 3 August 2009

The Smc5/6 complex regulates the yeast Mph1 helicase at RNA-DNA hybrid-mediated DNA damage

scientific article published on 27 December 2017

The THO complex as a key mRNP biogenesis factor in development and cell differentiation

scientific article published on 28 January 2010

The THP1-SAC3-SUS1-CDC31 complex works in transcription elongation-mRNA export preventing RNA-mediated genome instability.

scientific article

The absence of the yeast chromatin assembly factor Asf1 increases genomic instability and sister chromatid exchange

scientific article

The connection between transcription and genomic instability

scientific article

The interface between transcription and mRNP export: from THO to THSC/TREX-2.

scientific article published on 19 June 2010

The need to regulate replication fork speed.

scientific article

The phosphofructokinase genes of yeast evolved from two duplication events

scientific article published on May 1989

The rem mutations in the ATP-binding groove of the Rad3/XPD helicase lead to Xeroderma pigmentosum-Cockayne syndrome-like phenotypes

scientific article published on 11 December 2014

The replication checkpoint protects fork stability by releasing transcribed genes from nuclear pores.

scientific article published on July 2011

The stress-activated protein kinase Hog1 mediates S phase delay in response to osmostress

scientific article published on 28 May 2009

The yeast THO complex and mRNA export factors link RNA metabolism with transcription and genome instability

scientific article

The yeast and human FACT chromatin-reorganizing complexes solve R-loop-mediated transcription-replication conflicts

scientific article

Tho1, a novel hnRNP, and Sub2 provide alternative pathways for mRNP biogenesis in yeast THO mutants

scientific article

Topological constraints impair RNA polymerase II transcription and causes instability of plasmid-borne convergent genes ⬇️

scientific article published on October 13, 2011

Transcription and recombination: when RNA meets DNA.

scientific article published on August 2014

Transcription as a Threat to Genome Integrity

scientific article published on 24 March 2016

Transcription at the proximity of the nuclear pore: a role for the THP1-SAC3-SUS1-CDC31 (THSC) complex

scientific article published on 08 April 2009

Transcription coupled repair at the interface between transcription elongation and mRNP biogenesis ⬇️

scientific article published on 06 October 2012

Transcription-associated genome instability

scientific article published on 18 April 2013

Transcription-coupled nucleotide excision repair factors promote R-loop-induced genome instability

scientific article

Transcription-mediated replication hindrance: a major driver of genome instability

scientific article published on 23 May 2019

Transcription-replication conflicts: how they occur and how they are resolved

scientific article

What causes an RNA-DNA hybrid to compromise genome integrity?

scientific article published on 08 July 2019

Yeast Sen1 helicase protects the genome from transcription-associated instability.

scientific article

Yeast pol4 promotes tel1-regulated chromosomal translocations

scientific article

Yra1-bound RNA-DNA hybrids cause orientation-independent transcription-replication collisions and telomere instability

scientific article published on 28 June 2018

Zim17/Tim15 links mitochondrial iron-sulfur cluster biosynthesis to nuclear genome stability

scientific article published on 21 April 2011

mRNA processing and genomic instability

scientific article published on 01 September 2005

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