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List of works by Moosa Mohammadi

A Conserved Allosteric Pathway in Tyrosine Kinase Regulation

scientific article published on 13 June 2019

A G protein-coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23

scientific article published on 05 September 2019

A Molecular Brake in the Kinase Hinge Region Regulates the Activity of Receptor Tyrosine Kinases

scientific article

A crystallographic snapshot of tyrosine trans-phosphorylation in action

scientific article

A homozygous missense mutation in human KLOTHO causes severe tumoral calcinosis

scientific article published in September 2007

A novel fibroblast growth factor-1 ligand with reduced heparin binding protects the heart against ischemia-reperfusion injury in the presence of heparin co-administration

scientific article published on 7 September 2017

A protein canyon in the FGF-FGF receptor dimer selects from an à la carte menu of heparan sulfate motifs

scientific article

A single amino acid substitution in the activation loop defines the decoy characteristic of VEGFR-1/FLT-1

scientific article

A threshold model for receptor tyrosine kinase signaling specificity and cell fate determination.

scientific article

A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1 ⬇️

scientific article published on October 1, 1991

Aggregation-induced activation of the epidermal growth factor receptor protein tyrosine kinase

scientific article published on August 1993

Analysis of mutations in fibroblast growth factor (FGF) and a pathogenic mutation in FGF receptor (FGFR) provides direct evidence for the symmetric two-end model for FGFR dimerization

scientific article

Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23

scientific article

Arterial klotho expression and FGF23 effects on vascular calcification and function

scientific article

Autoregulatory mechanisms in protein-tyrosine kinases

scientific article published on May 1998

BetaKlotho is required for metabolic activity of fibroblast growth factor 21

scientific article

Biochemical analysis of pathogenic ligand-dependent FGFR2 mutations suggests distinct pathophysiological mechanisms for craniofacial and limb abnormalities

scientific article

Circulating FGF21 is liver derived and enhances glucose uptake during refeeding and overfeeding.

scientific article

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases ⬇️

scientific article published on April 5, 1991

Compositional analysis of heparin/heparan sulfate interacting with fibroblast growth factor.fibroblast growth factor receptor complexes

scientific article

Congenital hypogonadotropic hypogonadism with split hand/foot malformation: a clinical entity with a high frequency of FGFR1 mutations.

scientific article published on 13 November 2014

Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor

scientific article

Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Analysis of Pathogenic Gain-of-Function Mutations

scientific article

Crystal Structure of a Fibroblast Growth Factor Homologous Factor (FHF) Defines a Conserved Surface on FHFs for Binding and Modulation of Voltage-gated Sodium Channels

scientific article

Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.

scientific article

Crystal structure of fibroblast growth factor 9 reveals regions implicated in dimerization and autoinhibition

scientific article

Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

scientific article

Curtailing FGF19's mitogenicity by suppressing its receptor dimerization ability

scientific article published on 03 November 2020

DFG-out mode of inhibition by an irreversible type-1 inhibitor capable of overcoming gate-keeper mutations in FGF receptors

scientific article

Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice

scientific article

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors

scientific article

Different tyrosine autophosphorylation requirements in fibroblast growth factor receptor-1 mediate urokinase-type plasminogen activator induction and mitogenesis

scientific article published on January 1999

Differential interactions of FGFs with heparan sulfate control gradient formation and branching morphogenesis

scientific article

Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism

scientific article

Elucidation of a four-site allosteric network in fibroblast growth factor receptor tyrosine kinases

scientific article published on 06 February 2017

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21

scientific article (publication date: June 2007)

Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

scientific article (publication date: 18 September 2014)

Erratum: Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer

scientific article published in Nature

Exploring mechanisms of FGF signalling through the lens of structural biology ⬇️

scientific article published on February 13, 2013

FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis

scientific article

FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response

scientific article

FGF21 mediates alcohol-induced adipose tissue lipolysis by activation of systemic release of catecholamine in mice

scientific article published on 19 June 2015

FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2-SGK1 signaling pathway

scientific article published on 27 May 2012

FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2–SGK1 signaling pathway

FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1.

scientific article

FGF23 promotes renal calcium reabsorption through the TRPV5 channel

scientific journal article

FGF23 regulates renal sodium handling and blood pressure

article by O. Andrukhova et al published December 2012 in Bone

FGF23-induced hypophosphatemia persists in Hyp mice deficient in the WNT coreceptor Lrp6.

scientific article published on 3 May 2013

Fibroblast Growth Factor Binding Protein 3 (FGFBP3) impacts carbohydrate and lipid metabolism

scientific article published in Scientific Reports

Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs

scientific article

Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism

scientific article published on 24 July 2017

Fibroblast growth factor 21 deficiency exacerbates chronic alcohol-induced hepatic steatosis and injury

scientific article published on 08 August 2016

Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.

scientific article published on 6 February 2012

Fibulin-1 Binds to Fibroblast Growth Factor 8 with High Affinity: EFFECTS ON EMBRYO SURVIVAL.

scientific article published on 8 July 2016

Frequency of Impaired Fibroblast Growth Factor Receptor 1 Signaling as a Cause of Normosmic Idiopathic Hypogonadotropic Hypogonadism.

scientific article published in December 2009

Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes

scientific article

Generation of recombinant cytoplasmic domain of epidermal growth factor receptor with intrinsic protein tyrosine kinase activity

scientific article published on April 1990

Genetic overlap in Kallmann syndrome, combined pituitary hormone deficiency, and septo-optic dysplasia

scientific article published on 8 February 2012

Genetic testing facilitates prepubertal diagnosis of congenital hypogonadotropic hypogonadism.

scientific article published on 14 February 2017

Graded levels of FGF protein span the midbrain and can instruct graded induction and repression of neural mapping labels

scientific article

Grb2, a double-edged sword of receptor tyrosine kinase signaling

scientific article published on 6 November 2012

Hedgehogs like it sweet, too.

scholarly article

Homodimerization Controls the Fibroblast Growth Factor 9 Subfamily's Receptor Binding and Heparan Sulfate-Dependent Diffusion in the Extracellular Matrix

scientific article

Identification of phosphopeptides by MALDI Q-TOF MS in positive and negative ion modes after methyl esterification

scientific article published on 7 March 2005

Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction

scientific article

Impaired FGF signaling contributes to cleft lip and palate

scientific article

Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism ⬇️

scientific article published on 09 October 2009

In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis

scientific article published on 03 October 2008

Induction of urokinase-type plasminogen activator by fibroblast growth factor (FGF)-2 is dependent on expression of FGF receptors and does not require activation of phospholipase Cgamma1

scientific article published in Journal of Biological Chemistry

Influence of heparin mimetics on assembly of the FGF.FGFR4 signaling complex.

scientific article published on 14 June 2010

Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia

scientific article published on 26 February 2018

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21.

scientific article published on July 2008

Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity

scientific article

Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.

scientific article published on June 1994

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

scientific article

KLB, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism

scientific article published on 28 July 2017

Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly

scientific article published in April 2004

Klotho coreceptors inhibit signaling by paracrine fibroblast growth factor 8 subfamily ligands

scientific article

Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma

scientific article

Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation

scientific article published on 20 January 2020

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

scientific article

Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology

scientific article

Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism

scientific article

Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes

scientific article

Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism

scholarly article

Nonsense mutations in FGF8 gene causing different degrees of human gonadotropin-releasing deficiency.

scientific article published on 12 May 2010

Paracrine-endocrine FGF chimeras as potent therapeutics for metabolic diseases

scientific article published on 17 October 2019

Parathyroid-specific deletion of Klotho unravels a novel calcineurin-dependent FGF23 signaling pathway that regulates PTH secretion

scientific article

Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1

scientific article

Point mutation in FGF receptor eliminates phosphatidylinositol hydrolysis without affecting mitogenesis

scientific article

Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells

scientific article

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

scientific article published on 11 July 2011

Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity

scientific article published on 12 November 2003

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family

scientific article

Reduced activation of RAF-1 and MAP kinase by a fibroblast growth factor receptor mutant deficient in stimulation of phosphatidylinositol hydrolysis

scientific article published on March 1995

Regulation of Receptor Binding Specificity of FGF9 by an Autoinhibitory Homodimerization

scientific article

Regulation of serum 1,25(OH)2 vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4

scientific journal article

Research resource: Comprehensive expression atlas of the fibroblast growth factor system in adult mouse.

scientific article

Role of SH2-containing proteins in cellular signaling by receptor tyrosine kinases

scientific article published on January 1, 1992

SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma

scientific article

SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors.

scientific article published on August 2000

Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes

scientific article

Somatic FGF9 mutations in colorectal and endometrial carcinomas associated with membranous beta-catenin

scientific article published on March 2008

Structural Biology of the FGF7 Subfamily

scientific article published on 12 February 2019

Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation

scientific article

Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors

scientific article

Structural basis by which alternative splicing modulates the organizer activity of FGF8 in the brain

scientific article

Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome

scientific article

Structural basis for fibroblast growth factor receptor activation

scientific article

Structure-based mutational analyses in FGF7 identify new residues involved in specific interaction with FGFR2IIIb

scientific article published on September 2003

The FGF family: biology, pathophysiology and therapy

scientific article published on March 2009

The alternatively spliced acid box region plays a key role in FGF receptor autoinhibition

scientific article

The demonstration of αKlotho deficiency in human chronic kidney disease with a novel synthetic antibody

scientific article

The parathyroid is a target organ for FGF23 in rats

scientific journal article

The structural biology of the FGF19 subfamily

scientific article published on January 2012

Therapeutic Effects of FGF23 c-tail Fc in a Murine Preclinical Model of X-Linked Hypophosphatemia Via the Selective Modulation of Phosphate Reabsorption

scientific article published on 10 June 2017

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

scientific article

Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ

scientific article published on 9 December 2015

Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ

scholarly article by Zhifeng Huang published in January 2016

Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

scientific article published on 30 January 2014

Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability

scientific article

Understanding the molecular basis of Apert syndrome

scientific article

Urothelial tumor initiation requires deregulation of multiple signaling pathways: implications in target-based therapies

scientific article

α-Klotho is a non-enzymatic molecular scaffold for FGF23 hormone signalling

scientific article published on 17 January 2018

β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue.

scientific article

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