List of works - Tomas Majtan

Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone

scientific article published on 10 October 2008

Behavior, body composition, and vascular phenotype of homocystinuric mice on methionine-restricted diet or enzyme replacement therapy

scientific article published on 26 August 2019

Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase

scientific article published on 6 September 2017

CBS update: Structure, CBS replacement therapy, and H2S production

Classical homocystinuria: From cystathionine beta-synthase deficiency to novel enzyme therapies

scientific article published on 16 December 2019

Cobalt cystathionine β-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif

scientific article published on 11 April 2011

Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine β-synthases

scientific article published on 17 January 2013

Conformational properties of nine purified cystathionine β-synthase mutants

scientific article

Correction to Conformational Properties of Nine Purified Cystathionine β-Synthase Mutants

scientific article published on 27 June 2012

Crystal structure of cystathionine β-synthase from honeybee Apis mellifera.

scientific article

Cystathionine-β-Synthase: Molecular Regulation and Pharmacological Inhibition

scientific article published on 30 April 2020

DEER distance measurement between a spin label and a native FAD semiquinone in electron transfer flavoprotein.

scientific article

DNA microarrays--techniques and applications in microbial systems.

scientific article

Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases

scientific article

Effect of cobalt on Escherichia coli metabolism and metalloporphyrin formation

scientific article

Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes

scientific article published in August 2010

Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthase

scientific article published on 31 July 2012

Electron transfer flavoprotein domain II orientation monitored using double electron-electron resonance between an enzymatically reduced, native FAD cofactor, and spin labels

scientific article

Engineering and Characterization of an Enzyme Replacement Therapy for Classical Homocystinuria

scientific article

Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria

scientific article published on 19 December 2017

Enzyme replacement prevents neonatal death, liver damage, and osteoporosis in murine homocystinuria

scientific article published on 16 August 2017

Enzyme replacement therapy prevents loss of bone and fat mass in murine homocystinuria.

scientific article

Enzyme replacement with PEGylated cystathionine β-synthase ameliorates homocystinuria in murine model.

scientific article

Fir honeydew honey flavonoids inhibit TNF-α-induced MMP-9 expression in human keratinocytes: a new action of honey in wound healing

scientific article published on 28 June 2013

Folding and activity of mutant cystathionine β-synthase depends on the position and nature of the purification tag: characterization of the R266K CBS mutant

scientific article published on 8 February 2012

Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM

scientific article

Hypermethioninemia Leads to Fatal Bleeding and Increased Mortality in a Transgenic I278T Mouse Model of Homocystinuria

scientific article published on 24 July 2020

Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe

scientific article published on 19 March 2013

Import of TAT-conjugated propionyl-CoA carboxylase using models of propionic acidemia

scientific article

Inherited disorders of sulfur amino acid metabolism: recent advances in therapy

scientific article published on 13 October 2020

Interplay of Enzyme Therapy and Dietary Management of Murine Homocystinuria

scientific article published on 22 September 2020

Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine: Potential approach to pharmacological chaperone therapy for homocystinuria

scientific article published on 20 January 2016

Long-term uninterrupted enzyme replacement therapy prevents liver disease in murine model of severe homocystinuria

scientific article published on 05 July 2020

Marine natural products as inhibitors of cystathionine beta-synthase activity

scientific article published on 14 January 2015

Oligomeric status of human cystathionine beta-synthase modulates AdoMet binding.

scientific article published on 14 November 2016

Pharmacokinetics and pharmacodynamics of PEGylated truncated human cystathionine beta-synthase for treatment of homocystinuria

scientific article published on 8 March 2018

Potential Pharmacological Chaperones for Cystathionine Beta-Synthase-Deficient Homocystinuria

scientific article published on 10 November 2017

Purification and characterization of cystathionine β-synthase bearing a cobalt protoporphyrin.

scientific article

Purification, crystallization and preliminary crystallographic analysis of human cystathionine β-synthase.

scientific article

Purification, crystallization and preliminary crystallographic analysis of the catalytic core of cystathionine β-synthase from Saccharomyces cerevisiae.

scientific article published on 19 February 2014

Purification, crystallization and preliminary crystallographic analysis of the full-length cystathionine β-synthase from Apis mellifera

scientific article

Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes

scientific article

Structural basis of regulation and oligomerization of human cystathionine -synthase, the central enzyme of transsulfuration

scientific article

Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine

scientific article

Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future Directions

scientific article published on March 2016

The role of surface electrostatics on the stability, function and regulation of human cystathionine β-synthase, a complex multidomain and oligomeric protein

scientific article

Transcriptional profiling of bacteriophage BFK20: coexpression interrogated by "guilt-by-association" algorithm

scientific article published on 17 October 2006

List of works by Tomas Majtan

Active cystathionine beta-synthase can be expressed in heme-free systems in the presence of metal-substituted porphyrins or a chemical chaperone

Behavior, body composition, and vascular phenotype of homocystinuric mice on methionine-restricted diet or enzyme replacement therapy

Biogenesis of Hydrogen Sulfide and Thioethers by Cystathionine Beta-Synthase

CBS update: Structure, CBS replacement therapy, and H2S production

Classical homocystinuria: From cystathionine beta-synthase deficiency to novel enzyme therapies

Cobalt cystathionine β-synthase: a cobalt-substituted heme protein with a unique thiolate ligation motif

Comparative study of enzyme activity and heme reactivity in Drosophila melanogaster and Homo sapiens cystathionine β-synthases

Conformational properties of nine purified cystathionine β-synthase mutants

Correction to Conformational Properties of Nine Purified Cystathionine β-Synthase Mutants

Crystal structure of cystathionine β-synthase from honeybee Apis mellifera.

Cystathionine-β-Synthase: Molecular Regulation and Pharmacological Inhibition

DEER distance measurement between a spin label and a native FAD semiquinone in electron transfer flavoprotein.

DNA microarrays--techniques and applications in microbial systems.

Domain organization, catalysis and regulation of eukaryotic cystathionine beta-synthases

Effect of cobalt on Escherichia coli metabolism and metalloporphyrin formation

Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes

Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthase

Electron transfer flavoprotein domain II orientation monitored using double electron-electron resonance between an enzymatically reduced, native FAD cofactor, and spin labels

Engineering and Characterization of an Enzyme Replacement Therapy for Classical Homocystinuria

Enzyme Replacement Therapy Ameliorates Multiple Symptoms of Murine Homocystinuria

Enzyme replacement prevents neonatal death, liver damage, and osteoporosis in murine homocystinuria

Enzyme replacement therapy prevents loss of bone and fat mass in murine homocystinuria.

Enzyme replacement with PEGylated cystathionine β-synthase ameliorates homocystinuria in murine model.

Fir honeydew honey flavonoids inhibit TNF-α-induced MMP-9 expression in human keratinocytes: a new action of honey in wound healing

Folding and activity of mutant cystathionine β-synthase depends on the position and nature of the purification tag: characterization of the R266K CBS mutant

Human cystathionine β-synthase (CBS) contains two classes of binding sites for S-adenosylmethionine (SAM): complex regulation of CBS activity and stability by SAM

Hypermethioninemia Leads to Fatal Bleeding and Increased Mortality in a Transgenic I278T Mouse Model of Homocystinuria

Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe

Import of TAT-conjugated propionyl-CoA carboxylase using models of propionic acidemia

Inherited disorders of sulfur amino acid metabolism: recent advances in therapy

Interplay of Enzyme Therapy and Dietary Management of Murine Homocystinuria

Kinetic stability of cystathionine beta-synthase can be modulated by structural analogs of S-adenosylmethionine: Potential approach to pharmacological chaperone therapy for homocystinuria

Long-term uninterrupted enzyme replacement therapy prevents liver disease in murine model of severe homocystinuria

Marine natural products as inhibitors of cystathionine beta-synthase activity

Oligomeric status of human cystathionine beta-synthase modulates AdoMet binding.

Pharmacokinetics and pharmacodynamics of PEGylated truncated human cystathionine beta-synthase for treatment of homocystinuria

Potential Pharmacological Chaperones for Cystathionine Beta-Synthase-Deficient Homocystinuria

Purification and characterization of cystathionine β-synthase bearing a cobalt protoporphyrin.

Purification, crystallization and preliminary crystallographic analysis of human cystathionine β-synthase.

Purification, crystallization and preliminary crystallographic analysis of the catalytic core of cystathionine β-synthase from Saccharomyces cerevisiae.

Purification, crystallization and preliminary crystallographic analysis of the full-length cystathionine β-synthase from Apis mellifera

Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes

Structural basis of regulation and oligomerization of human cystathionine -synthase, the central enzyme of transsulfuration

Structural insight into the molecular mechanism of allosteric activation of human cystathionine β-synthase by S-adenosylmethionine

Targeting Cystathionine Beta-Synthase Misfolding in Homocystinuria by Small Ligands: State of the Art and Future Directions

The role of surface electrostatics on the stability, function and regulation of human cystathionine β-synthase, a complex multidomain and oligomeric protein

Transcriptional profiling of bacteriophage BFK20: coexpression interrogated by "guilt-by-association" algorithm