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List of works by Hiroyuki Sorimachi

A catalytic subunit of calpain possesses full proteolytic activity

scientific article published on 01 January 1995

A novel aspect of calpain activation

scientific article published on 01 August 1998

A simple purification and fluorescent assay method of the poliovirus 3C protease searching for specific inhibitors

scientific article published on 01 February 2000

Ablation of the p16(INK4a) tumour suppressor reverses ageing phenotypes of klotho mice

scientific article published on 29 April 2015

Amino acid sequence alignment of vertebrate CAPN3/calpain-3/p94.

scientific article published on 4 October 2015

An eccentric calpain, CAPN3/p94/calpain-3

scientific article

Arachidonate metabolites affect the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein.

scientific article published in April 1995

Aspergillus oryzae palBory encodes a calpain-like protease: homology to Emericella nidulans PalB and conservation of functional regions

scientific article published on 01 January 1999

Association and dissociation of the calcium-binding domains of calpain by Ca2+

scientific article published on 01 April 1999

Autolysis of calpain large subunit inducing irreversible dissociation of stoichiometric heterodimer of calpain

scientific article published on 01 April 2000

Both the conserved and the unique gene structure of stomach-specific calpains reveal processes of calpain gene evolution

scientific article published on 01 September 2001

C/EBPα Is Required for Proteolytic Cleavage of Cyclin A by Calpain 3 in Myeloid Precursor Cells

scientific article published in Journal of Biological Chemistry

Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense ⬇️

scientific article published on July 29, 2010

Calpain and pathology in view of structure-function relationships

scientific article published on July 2003

Calpain chronicle—an enzyme family under multidisciplinary characterization ⬇️

scientific article published on January 1, 2011

Calpain cleavage prediction using multiple kernel learning.

scientific article

Calpain dissociates into subunits in the presence of calcium ions

scientific article published on 01 March 1995

Calpain research for drug discovery: challenges and potential

scientific article published on 11 November 2016

Calpain system regulates the differentiation of adult primitive mesenchymal ST-13 adipocytes

scientific article published on 20 July 2006

Calpain-6 confers atherogenicity to macrophages by dysregulating pre-mRNA splicing

scientific article published on 15 August 2016

Calpain-6 deficiency promotes skeletal muscle development and regeneration

scientific article (publication date: 2013)

Calpain-6, a microtubule-stabilizing protein, regulates Rac1 activity and cell motility through interaction with GEF-H1 ⬇️

scientific article published on March 15, 2011

Calpain: novel family members, activation, and physiologic function

scientific article

Calpains: an elaborate proteolytic system

scientific article published on 16 August 2011

Characterization of a human digestive tract-specific calpain, nCL-4, expressed in the baculovirus system.

scientific article

Comparative structures of the apopolysialoglycoproteins from unfertilized and fertilized eggs of salmonid fishes

scientific article published on 01 September 1988

Constitutive activation of the pH-responsive Rim101 pathway in yeast mutants defective in late steps of the MVB/ESCRT pathway

scientific article published on November 2005

Conventional protein kinase C (PKC)-alpha and novel PKC epsilon, but not -delta, increase the secretion of an N-terminal fragment of Alzheimer's disease amyloid precursor protein from PKC cDNA transfected 3Y1 fibroblasts

scientific article published on May 1995

Crystal structure of neoculin: insights into its sweetness and taste-modifying activity.

scientific article published on 29 March 2006

Crystallization and preliminary X-ray analysis of recombinant full-length human m-calpain

scientific article (publication date: 2000)

Degradation of fodrin by m-calpain in fibroblasts adhering to fibrillar collagen I gel

scientific article published on 01 December 2004

Distinct kinetics of subunit autolysis in mammalian m-calpain activation.

scientific article

Does the severity of the LGMD2A phenotype in compound heterozygotes depend on the combination of mutations?

scientific article published on 01 November 2011

Domain II of m-calpain is a Ca(2+)-dependent cysteine protease

scientific article

Domain III of calpain is a ca2+-regulated phospholipid-binding domain

scientific article published on 01 February 2001

Effect of artificial (CTG) repeat expansion on the expression of myotonin protein kinase (MtPK) in COS-1 cells

scientific article published on March 1996

Effect of preslaughter feed withdrawal period on longissimus tenderness and the expression of calpains in the ovine

scientific article published in April 2001

Efficient expression and purification of recombinant human m-calpain using an Escherichia coli expression system at low temperature.

scientific article

Efficient expression and purification of recombinant human μ-calpain using an Escherichia coli expression system

scientific article published on 21 June 2013

Expanded CTG repeats in myotonin protein kinase suppresses myogenic differentiation

scientific article

Expanding members and roles of the calpain superfamily and their genetically modified animals

scientific article published on January 2010

Expression of a novel human myotonin protein kinase (MtPK) cDNA clone which encodes a protein with a thymopoietin-like domain in COS cells.

scientific article

Extracellular production of neoculin, a sweet-tasting heterodimeric protein with taste-modifying activity, by Aspergillus oryzae.

scientific article published on May 2006

Flexibility analysis and structure comparison of two crystal forms of calcium-free human m-calpain

scientific article published in September 2002

Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular dystrophy type 2A

scientific article

Functional evolution of duplicated odorant-binding protein genes, Obp57d and Obp57e, in Drosophila

scientific article

Identification of a third ubiquitous calpain species--chicken muscle expresses four distinct calpains

scientific article

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain

scientific article

Immunocytochemical localization of a full-length myotonin protein kinase in rat L6 myoblasts

scientific article published on November 1996

Impact of genetic insights into calpain biology

scientific article published on 24 May 2011

Induction and myofibrillar targeting of CARP, and suppression of the Nkx2.5 pathway in the MDM mouse with impaired titin-based signaling

scientific journal article

Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly

scientific article

Intravitreal injection or topical eye-drop application of a μ-calpain C2L domain peptide protects against photoreceptor cell death in Royal College of Surgeons' rats, a model of retinitis pigmentosa.

scientific article published on 3 August 2012

Involvement of calpain-7 in epidermal growth factor receptor degradation via the endosomal sorting pathway

scientific article

Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IkappaBalpha/nuclear factor kappaB pathway perturbation in mice.

scientific article

MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss

scientific article

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

scientific article

Metabolism of amyloid precursor protein in COS cells transfected with a beta-secretase candidate

scientific article published on July 2000

Molecular Cloning and Characterization of a Novel Tissue-Specific Calpain Predominantly Expressed in the Digestive Tract ⬇️

scientific article published on February 1, 1998

Molecular cloning and characterization of cDNAs for the mu-type large subunit and the small subunit of chicken calpain

scientific article published on November 1997

Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB.

scientific article

Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis

scientific article

Muscle-specific calpain, p94, interacts with the extreme C-terminal region of connectin, a unique region flanked by two immunoglobulin C2 motifs.

scientific article

Muscle-specific calpain-3 is phosphorylated in its unique insertion region for enrichment in a myofibril fraction.

scientific article published on 24 September 2014

Mutation of potential N-linked glycosylation sites in the Alzheimer's disease amyloid precursor protein (APP).

scientific article published in December 1996

Myogenic stage, sarcomere length, and protease activity modulate localization of muscle-specific calpain

scientific article

Myopathy phenotype of transgenic mice expressing active site-mutated inactive p94 skeletal muscle-specific calpain, the gene product responsible for limb girdle muscular dystrophy type 2A

scientific article published on 01 May 2000

Neoculin as a new taste-modifying protein occurring in the fruit of Curculigo latifolia

scientific article

New era of calpain research. Discovery of tissue-specific calpains

scientific article published on April 1994

Newly identified exons encoding novel variants of p94/calpain 3 are expressed ubiquitously and overlap the alpha-glucosidase C gene

scientific article published on 01 December 2003

Non-proteolytic functions of calpain-3 in sarcoplasmic reticulum in skeletal muscles.

scientific article

Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region

scientific article published on 26 July 2006

Organization and primary sequence of multiple genes coding for the apopolysialoglycoproteins of rainbow trout

scientific article published on 01 January 1990

Overexpression of myotonic dystrophy protein kinase in C2C12 myogenic culture involved in the expression of ferritin heavy chain and interleukin-1alpha mRNAs

scientific article published on 01 August 1999

PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.

scientific article published on 21 May 2013

Possible functions of p94 in connectin-mediated signaling pathways in skeletal muscle cells

scientific article published on 01 January 2005

Possible regulation of the conventional calpain system by skeletal muscle-specific calpain, p94/calpain 3.

scientific article published in November 2003

Predictions of Cleavability of Calpain Proteolysis by Quantitative Structure-Activity Relationship Analysis Using Newly Determined Cleavage Sites and Catalytic Efficiencies of an Oligopeptide Array

scientific article

Primary sequences of rat mu-calpain large and small subunits are, respectively, moderately and highly similar to those of human

scientific article published in November 1996

Processing and secretion of Alzheimer's disease amyloid precursor protein.

scientific article published in November 1994

Proteasome inhibitors induce the association of Alzheimer's amyloid precursor protein with Hsc73.

scientific article

Regulation and physiological roles of the calpain system in muscular disorders

scientific article

Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy

scientific article published on February 2014

Sequence comparison among muscle-specific calpain, p94, and calpain subunits

scientific article published on 01 November 1992

Single-cell chemical lysis method for analyses of intracellular molecules using an array of picoliter-scale microwells

scientific article published in December 2008

Stable expression of calpain 3 from a muscle transgene in vivo: immature muscle in transgenic mice suggests a role for calpain 3 in muscle maturation.

scientific article

Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP.

scientific article published on 13 February 2006

Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains

scientific article published on 23 July 2007

Structural Basis for Possible Calcium-Induced Activation Mechanisms of Calpains

scholarly article by David Reverter published in January 2001

Structure and physiological functions of ubiquitous and tissue-specific calpain species. Muscle-specific calpain, p94, interacts with connectin/titin

scientific article

Structure and physiology of calpain, an enigmatic protease

scientific article published on 01 April 1998

Suppressed disassembly of autolyzing p94/CAPN3 by N2A connectin/titin in a genetic reporter system.

scientific article

Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation

scientific article published on 22 November 2006

The N- and C-terminal autolytic fragments of CAPN3/p94/calpain-3 restore proteolytic activity by intermolecular complementation.

scientific article

The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity

scientific article

The deletion of the C-terminal tail and addition of an endoplasmic reticulum targeting signal to Alzheimer's amyloid precursor protein change its localization, secretion, and intracellular proteolysis

scientific article published on December 1998

The importance of conserved amino acid residues in p94 protease sub-domain IIb and the IS2 region for constitutive autolysis

scientific article published on 05 February 2008

The protease activity of a calpain-like cysteine protease in Saccharomyces cerevisiae is required for alkaline adaptation and sporulation.

scientific article

The structure of calcium-free human m-calpain: implications for calcium activation and function

scientific article (publication date: August 2001)

The structure of calpain.

scientific article

The titin cDNA sequence and partial genomic sequences: Insights into the molecular genetics, cell biology and physiology of the titin filament system

article

Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cells

scientific article

Tissue- and cell type-specific expression of mRNAs for four types of inositol phospholipid-specific phospholipase C.

scientific article published on October 1989

Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin: implications for the nature of vertebrate Z-discs

scientific article published on 01 August 1997

Understanding the substrate specificity of conventional calpains.

scientific article published on September 2012

Up-regulation of dystrophin mRNA by exposure to dibutyryl cAMP in the C2C12 muscle cell line

scientific article published on May 1995

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