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List of works by Ralph Witzgall

A mammalian expression vector for the expression of GAL4 fusion proteins with an epitope tag and histidine tail

scientific article published on December 1994

A polycystin-2 protein with modified channel properties leads to an increased diameter of renal tubules and to renal cysts

scientific article published on 23 August 2021

A truncated polycystin-2 protein causes polycystic kidney disease and retinal degeneration in transgenic rats

scientific article published on 30 August 2006

Advanced electron microscopic techniques provide a deeper insight into the peculiar features of podocytes

scientific article

Altered expression pattern of polycystin-2 in acute and chronic renal tubular diseases

scientific journal article

An endocytosis defect as a possible cause of proteinuria in polycystic kidney disease

scientific article published on 01 February 2001

Are renal proximal tubular epithelial cells constantly prepared for an emergency? Focus on "the proliferation capacity of the renal proximal tubule involves the bulk of differentiated epithelial cells"

scientific article published on 17 October 2007

Biodistribution of quantum dots in the kidney after intravenous injection

scientific article published on May 2014

Ca2+-dependent conformational changes in a C-terminal cytosolic domain of polycystin-2.

scientific article

Calmodulin-dependent activation of the epithelial calcium-dependent chloride channel TMEM16A

scientific article published on 29 November 2010

Cerebral localization and regulation of the cell volume-sensitive serum- and glucocorticoid-dependent kinase SGK1.

scientific article published on 9 November 2001

Cytosolic phospholipase A2 (PLA2), but not secretory PLA2, potentiates hydrogen peroxide cytotoxicity in kidney epithelial cells

scientific article published on August 1996

Differentiation and cell polarity during renal cyst formation in the Han:SPRD (cy/+) rat, a model for ADPKD.

scientific article published in September 1997

Doxycycline accelerates renal cyst growth and fibrosis in the pcy/pcy mouse model of type 3 nephronophthisis, a form of recessive polycystic kidney disease

scientific article published on 21 April 2009

ER-localized bestrophin 1 activates Ca2+-dependent ion channels TMEM16A and SK4 possibly by acting as a counterion channel.

scientific article published on 13 October 2009

Expression of clusterin in Crohn's disease of the terminal ileum

scientific article published on 01 July 2001

Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules.

scientific article published on August 1997

Genomic structure and chromosomal location of the rat gene encoding the zinc finger transcription factor Kid-1.

scientific article published in March 1994

How are podocytes affected in nail-patella syndrome?

scientific article published on 6 February 2008

Identification and characterization of polycystin-2, the PKD2 gene product

scientific article

Impaired endocytosis may represent an obstacle to gene therapy in polycystic kidney disease

scientific article

Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance

scientific article published on 2 January 2015

Intravital Imaging Reveals Angiotensin II-Induced Transcytosis of Albumin by Podocytes.

scientific article published on 26 June 2015

Kid-1 expression is high in differentiated renal proximal tubule cells and suppressed in cyst epithelia.

scientific article published on December 1998

Kid-1, a kidney transcription factor

scientific article published on 01 May 1995

Kidney podocytes as specific targets for cyclo(RGDfC)-modified nanoparticles.

scientific article published on 8 August 2012

LMX1B is essential for the maintenance of differentiated podocytes in adult kidneys

scientific article

Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia

scientific journal article

Lack of connexin 40 causes displacement of renin-producing cells from afferent arterioles to the extraglomerular mesangium

scientific article published on 28 February 2007

Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells.

scientific article

Missense mutation in sterile alpha motif of novel protein SamCystin is associated with polycystic kidney disease in (cy/+) rat.

scientific article

Mistargeting of peroxisomal EHHADH and inherited renal Fanconi's syndrome

scientific article

Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.

scientific article

Mutations of the Uromodulin gene in MCKD type 2 patients cluster in exon 4, which encodes three EGF-like domains

scientific article published in November 2003

NMR-assignments of a cytosolic domain of the C-terminus of polycystin-2

scientific article

Nail-patella syndrome

scientific article published on 05 July 2017

Natriuretic Peptide Receptor Guanylyl Cyclase-A in Podocytes is Renoprotective but Dispensable for Physiologic Renal Function

scientific article published on 6 May 2016

New developments in the field of cystic kidney diseases.

scientific article

Nonspecific cation current associated with native polycystin-2 in HEK-293 cells.

scientific article published on 5 January 2006

Novel role for polycystin-1 in modulating cell proliferation through calcium oscillations in kidney cells

scientific article published on 15 April 2008

PIGEA-14, a novel coiled-coil protein affecting the intracellular distribution of polycystin-2

scientific article

Phospholipase A(2) and Lipids as Potential Modulators of c-Raf-1 Kinase

scientific article published on 01 April 1996

Phosphorylation of C-terminal polycystin-2 influences the interaction with PIGEA14: a QCM study based on solid supported membranes

scientific article published on 6 July 2013

Photochemically Active Fluorophore-DNA/RNA Conjugates for Cellular Imaging of Nucleic Acids by Readout in Electron Microscopy

scientific article published on 21 June 2013

Polycystic kidney disease--a tale of calcium channels and the actin cytoskeleton

scientific article published on 01 July 2001

Polycystin-1 promotes PKCalpha-mediated NF-kappaB activation in kidney cells

scientific article published on 18 September 2006

Polycystin-2 takes different routes to the somatic and ciliary plasma membrane

scientific article published on 14 February 2011

Polycystin-2--an intracellular or plasma membrane channel?

scientific article

Quantifying the interaction of the C-terminal regions of polycystin-2 and polycystin-1 attached to a lipid bilayer by means of QCM

scientific article published on 11 February 2010

Regulation of clusterin expression following spinal cord injury

scientific article published on 01 November 2001

Renal osmotic stress-induced cotransporter: expression in the newborn, adult and post-ischemic rat kidney

scientific article published in December 1997

Renal phenotype in heterozygous Lmx1b knockout mice (Lmx1b+/-) after unilateral nephrectomy

scientific article published on 27 July 2007

Role of transcription factors in podocytes

scientific article published on 06 June 2007

Soluble interleukin-2 receptors inhibit interleukin 2-dependent proliferation and cytotoxicity: explanation for diminished natural killer cell activity in cutaneous T-cell lymphomas in vivo?

scientific article published on January 1992

TRPP2 channel regulation

scientific article

The Krüppel-associated box (KRAB)-zinc finger protein Kid-1 and the Wilms' tumor protein WT1, two transcriptional repressor proteins, bind to heteroduplex DNA

scientific article published on 01 October 1997

The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression.

scientific article

The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes

scientific article

The calcium-activated chloride channel Anoctamin 1 contributes to the regulation of renal function

scientific article published on 29 January 2014

The human polycystin-2 protein represents an integral membrane protein with six membrane-spanning domains and intracellular N- and C-termini ⬇️

scientific article published on January 15, 2011

The podocyte-specific inactivation of Lmx1b, Ldb1 and E2a yields new insight into a transcriptional network in podocytes

scientific article published on 18 January 2007

The proximal tubule phenotype and its disruption in acute renal failure and polycystic kidney disease

scientific article published in January 1999

The rat pkd2 protein assumes distinct subcellular distributions in different organs

scientific article published on December 1999

The swelling-activated chloride channel ClC-2, the chloride channel ClC-3, and ClC-5, a chloride channel mutated in kidney stone disease, are expressed in distinct subpopulations of renal epithelial cells

scientific article published on February 1998

Up-regulation of the human serum and glucocorticoid-dependent kinase 1 in glomerulonephritis

scientific article published in January 2002

Use of the tetracycline system for inducible protein synthesis in the kidney

scientific article published in August 2003

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