List of works - Stefano Costanzi

2- and 8-alkynyl-9-ethyladenines: Synthesis and biological activity at human and rat adenosine receptors

scientific article published on 17 March 2005

2- and 8-alkynyladenosines: conformational studies and docking to human adenosine A3 receptor can explain their different biological behavior

scientific article published in January 2003

2-ClATP exerts anti-tumoural actions not mediated by P2 receptors in neuronal and glial cell lines.

scientific article published in February 2004

2-Phenylhydroxypropynyladenosine derivatives as high potent agonists at A2B adenosine receptor subtype

scientific article published in May 2003

3'-deoxyribofuranose derivatives of 1-deaza and 3-deaza-adenosine and their activity as adenosine deaminase inhibitors

scientific article published in April 2001

4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y6 receptor.

scientific article published in May 2013

A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).

scientific article published on 16 February 2006

A missense mutation in the seven-transmembrane domain of the human Ca2+ receptor converts a negative allosteric modulator into a positive allosteric modulator

scientific article published on 30 May 2006

A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists

scientific article

A2B adenosine receptor agonists: synthesis and biological evaluation of 2-phenylhydroxypropynyl adenosine and NECA derivatives

scientific article published in January 2004

A2B adenosine receptor blockade inhibits growth of prostate cancer cells.

scientific article

Action of nucleosides and nucleotides at 7 transmembrane-spanning receptors

scientific article published on January 2006

Activation of the P2Y1 receptor induces apoptosis and inhibits proliferation of prostate cancer cells.

scientific article

Adenine and deazaadenine nucleoside and deoxynucleoside analogues: inhibition of viral replication of sheep MVV (in vitro model for HIV) and bovine BHV-1

scientific article (publication date: September 2002)

Adenosine deaminase: functional implications and different classes of inhibitors

scientific article

Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library

scientific article

Application of Monte Carlo-based receptor ensemble docking to virtual screening for GPCR ligands

scientific article published in January 2013

Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.

scientific article

Atomistic insights into rhodopsin activation from a dynamic model

scientific article published on 12 July 2008

Computational Drug Target Screening through Protein Interaction Profiles

scientific article

Computational studies to predict or explain G protein coupled receptor polypharmacology

scientific article

Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors

scientific article

Coupling of 2,6-disubstituted purines to ribose-modified sugars

scientific article published in April 2001

Deaza- and deoxyadenosine derivatives: synthesis and inhibition of animal viruses as human infection models.

scientific article published in May 2003

Defining the nucleotide binding sites of P2Y receptors using rhodopsin-based homology modeling

scientific article published on 01 July 2006

Delineation of the molecular mechanisms of nucleoside recognition by cytidine deaminase through virtual screening.

scientific article

Design and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality.

scientific article

Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.

scientific article

Docking-based virtual screening for ligands of G protein-coupled receptors: not only crystal structures but also in silico models.

scientific article

Effects of 5'-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors.

scientific article published in April 2005

Facilitating adverse drug event detection in pharmacovigilance databases using molecular structure similarity: application to rhabdomyolysis.

scientific article published on 21 September 2011

Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier

scientific article

Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation

scientific article

Hepatocyte growth factor and transforming growth factor β1 ratio at baseline can predict early response to cyclophosphamide in systemic lupus erythematosus nephritis

article

Homology modeling of a Class A GPCR in the inactive conformation: A quantitative analysis of the correlation between model/template sequence identity and model accuracy

scientific article published on 4 October 2016

Homology modeling of class a G protein-coupled receptors

scientific article

Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.

scientific article published on December 2005

Human cytidine deaminase: a biochemical characterization of its naturally occurring variants

scientific article published on 29 October 2013

Human cytidine deaminase: a three-dimensional homology model of a tetrameric metallo-enzyme inferred from the crystal structure of a distantly related dimeric homologue

scientific article

Human cytidine deaminase: understanding the catalytic mechanism

scientific article

In silico analysis of the binding of agonists and blockers to the β2-adrenergic receptor.

scientific article

In silico screening for agonists and blockers of the β(2) adrenergic receptor: implications of inactive and activated state structures

scientific article published on 14 December 2011

Influence of the Structural Accuracy of Homology Models on Their Applicability to Docking-Based Virtual Screening: The β2 Adrenergic Receptor as a Case Study

scientific article published on 01 July 2019

Intersubunit interactions in human cytidine deaminase

scientific article

Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor.

scientific article

Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands

scientific article published on 16 May 2008

Ligand and structure-based models for the prediction of ligand-receptor affinities and virtual screenings: Development and application to the beta(2)-adrenergic receptor

scientific article

Modeling G protein-coupled receptors and their interactions with ligands

scientific article published on 15 February 2013

Modeling G protein-coupled receptors in complex with biased agonists

scientific article published on 02 May 2014

Modulation of apoptosis in human lymphocytes by adenosine analogues

scientific article published on 01 September 1998

Molecular evolution of the transmembrane domains of G protein-coupled receptors

scientific article

Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate

scientific article

Molecular recognition at adenine nucleotide (P2) receptors in platelets.

scientific article published on April 2005

Molecular recognition at purine and pyrimidine nucleotide (P2) receptors.

scientific article published in January 2004

Molecular structure of P2Y receptors: mutagenesis, modeling, and chemical probes ⬇️

scientific article published on September 12, 2012

N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands

scientific article (publication date: 18 July 2002)

N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor

scientific article

Nerve Agents: What They Are, How They Work, How to Counter Them

scientific article published on 25 April 2018

New Insights for Drug Design from the X-Ray Crystallographic Structures of G-Protein-Coupled Receptors ⬇️

scientific article published on June 13, 2012

New substituted 9-alkylpurines as adenosine receptor ligands

scientific article

Novel structural and functional insights into M3 muscarinic receptor dimer/oligomer formation

scientific article published on 16 October 2013

Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors ⬇️

scientific article

On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor.

scientific article published on 29 April 2008

P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring

scientific article published on 12 June 2007

Pharmacochemistry of the platelet purinergic receptors.

scientific article

Probing GPCR structure: adenosine and P2Y nucleotide receptors

scientific article published on January 2013

Purine and deazapurine nucleosides: synthetic approaches, molecular modelling and biological activity

scientific article published in March 2003

Purine nucleosides bearing 1-alkynyl chains as adenosine receptor agonists

scientific article (publication date: 2002)

Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor

scientific article

Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors

scientific article

Ring opening reactions: synthesis of AICAR analogs as potential antimetabolite agents

scientific article

Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects.

scientific article published on 2 April 2008

Structural Basis of M3 Muscarinic Receptor Dimer/Oligomer Formation ⬇️

scientific article published on June 17, 2011

Structural aspects of M₃ muscarinic acetylcholine receptor dimer formation and activation

scientific article published on 26 October 2011

Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines.

scientific article published on 13 October 2009

Supporting the fight against the proliferation of chemical weapons through cheminformatics

scientific article published in 2022

Synthesis and Adenosine Deaminase Inhibitory Activity of 3′-Deoxy-1-deazaadenosines

scholarly article by Rosaria Volpini et al published 15 December 1999 in Helvetica Chimica Acta

Synthesis and adenosine receptor affinity and potency of 8-alkynyl derivatives of adenosine

scientific article published in April 2001

Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists

scientific article published on August 1998

Synthetic procedure for the preparation of novel potent and selective A3 adenosine receptor radioligands

scientific article published in April 2001

Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation.

scientific article published on 08 December 2008

Understanding the structural and functional differences between mouse thyrotropin-releasing hormone receptors 1 and 2

scientific article published on 01 May 2008

Unraveling the structure and function of G protein-coupled receptors through NMR spectroscopy.

scientific article

Virtual screening leads to the discovery of novel non-nucleotide P2Y₁ receptor antagonists.

scientific article

List of works by Stefano Costanzi

2- and 8-alkynyl-9-ethyladenines: Synthesis and biological activity at human and rat adenosine receptors

2- and 8-alkynyladenosines: conformational studies and docking to human adenosine A3 receptor can explain their different biological behavior

2-ClATP exerts anti-tumoural actions not mediated by P2 receptors in neuronal and glial cell lines.

2-Phenylhydroxypropynyladenosine derivatives as high potent agonists at A2B adenosine receptor subtype

3'-deoxyribofuranose derivatives of 1-deaza and 3-deaza-adenosine and their activity as adenosine deaminase inhibitors

4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y6 receptor.

A low molecular weight agonist signals by binding to the transmembrane domain of thyroid-stimulating hormone receptor (TSHR) and luteinizing hormone/chorionic gonadotropin receptor (LHCGR).

A missense mutation in the seven-transmembrane domain of the human Ca2+ receptor converts a negative allosteric modulator into a positive allosteric modulator

A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonists

A2B adenosine receptor agonists: synthesis and biological evaluation of 2-phenylhydroxypropynyl adenosine and NECA derivatives

A2B adenosine receptor blockade inhibits growth of prostate cancer cells.

Action of nucleosides and nucleotides at 7 transmembrane-spanning receptors

Activation of the P2Y1 receptor induces apoptosis and inhibits proliferation of prostate cancer cells.

Adenine and deazaadenine nucleoside and deoxynucleoside analogues: inhibition of viral replication of sheep MVV (in vitro model for HIV) and bovine BHV-1

Adenosine deaminase: functional implications and different classes of inhibitors

Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library

Application of Monte Carlo-based receptor ensemble docking to virtual screening for GPCR ligands

Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.

Atomistic insights into rhodopsin activation from a dynamic model

Computational Drug Target Screening through Protein Interaction Profiles

Computational studies to predict or explain G protein coupled receptor polypharmacology

Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors

Coupling of 2,6-disubstituted purines to ribose-modified sugars

Deaza- and deoxyadenosine derivatives: synthesis and inhibition of animal viruses as human infection models.

Defining the nucleotide binding sites of P2Y receptors using rhodopsin-based homology modeling

Delineation of the molecular mechanisms of nucleoside recognition by cytidine deaminase through virtual screening.

Design and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality.

Development of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.

Docking-based virtual screening for ligands of G protein-coupled receptors: not only crystal structures but also in silico models.

Effects of 5'-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors.

Facilitating adverse drug event detection in pharmacovigilance databases using molecular structure similarity: application to rhabdomyolysis.

Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier

Gigantism and acromegaly due to Xq26 microduplications and GPR101 mutation

Hepatocyte growth factor and transforming growth factor β1 ratio at baseline can predict early response to cyclophosphamide in systemic lupus erythematosus nephritis

Homology modeling of a Class A GPCR in the inactive conformation: A quantitative analysis of the correlation between model/template sequence identity and model accuracy

Homology modeling of class a G protein-coupled receptors

Human P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.

Human cytidine deaminase: a biochemical characterization of its naturally occurring variants

Human cytidine deaminase: a three-dimensional homology model of a tetrameric metallo-enzyme inferred from the crystal structure of a distantly related dimeric homologue

Human cytidine deaminase: understanding the catalytic mechanism

In silico analysis of the binding of agonists and blockers to the β2-adrenergic receptor.

In silico screening for agonists and blockers of the β(2) adrenergic receptor: implications of inactive and activated state structures

Influence of the Structural Accuracy of Homology Models on Their Applicability to Docking-Based Virtual Screening: The β2 Adrenergic Receptor as a Case Study

Intersubunit interactions in human cytidine deaminase

Introduction of alkynyl chains on C-8 of adenosine led to very selective antagonists of the A(3) adenosine receptor.

Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands

Ligand and structure-based models for the prediction of ligand-receptor affinities and virtual screenings: Development and application to the beta(2)-adrenergic receptor

Modeling G protein-coupled receptors and their interactions with ligands

Modeling G protein-coupled receptors in complex with biased agonists

Modulation of apoptosis in human lymphocytes by adenosine analogues

Molecular evolution of the transmembrane domains of G protein-coupled receptors

Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate

Molecular recognition at adenine nucleotide (P2) receptors in platelets.

Molecular recognition at purine and pyrimidine nucleotide (P2) receptors.

Molecular structure of P2Y receptors: mutagenesis, modeling, and chemical probes ⬇️

N(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligands

N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor

Nerve Agents: What They Are, How They Work, How to Counter Them

New Insights for Drug Design from the X-Ray Crystallographic Structures of G-Protein-Coupled Receptors ⬇️

New substituted 9-alkylpurines as adenosine receptor ligands

Novel structural and functional insights into M3 muscarinic receptor dimer/oligomer formation

Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors ⬇️

On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor.

P2Y1 antagonists: combining receptor-based modeling and QSAR for a quantitative prediction of the biological activity based on consensus scoring

Pharmacochemistry of the platelet purinergic receptors.

Probing GPCR structure: adenosine and P2Y nucleotide receptors

Purine and deazapurine nucleosides: synthetic approaches, molecular modelling and biological activity

Purine nucleosides bearing 1-alkynyl chains as adenosine receptor agonists

Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor

Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors

Ring opening reactions: synthesis of AICAR analogs as potential antimetabolite agents

Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects.

Structural Basis of M3 Muscarinic Receptor Dimer/Oligomer Formation ⬇️

Structural aspects of M₃ muscarinic acetylcholine receptor dimer formation and activation

Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines.

Supporting the fight against the proliferation of chemical weapons through cheminformatics

Synthesis and Adenosine Deaminase Inhibitory Activity of 3′-Deoxy-1-deazaadenosines

Synthesis and adenosine receptor affinity and potency of 8-alkynyl derivatives of adenosine

Synthesis and biological activity of a new series of N6-arylcarbamoyl, 2-(Ar)alkynyl-N6-arylcarbamoyl, and N6-carboxamido derivatives of adenosine-5'-N-ethyluronamide as A1 and A3 adenosine receptor agonists