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List of works by Mauro Modesti

A human XRCC4-XLF complex bridges DNA

scientific article

Alkyltransferase-like protein (eATL) prevents mismatch repair-mediated toxicity induced by O6-alkylguanine adducts in Escherichia coli.

scientific article

BTN3A is a prognosis marker and a promising target for Vγ9Vδ2 T cells based-immunotherapy in pancreatic ductal adenocarcinoma (PDAC).

scientific article published on 21 September 2017

Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization

scientific article

Counting RAD51 proteins disassembling from nucleoprotein filaments under tension.

scientific article

Crystal structure of human XLF: a twist in nonhomologous DNA end-joining

scientific article

Crystal structure of the Xrcc4 DNA repair protein and implications for end joining

scientific article

DNA repair: spot(light)s on chromatin.

scientific article

DNA-binding and strand-annealing activities of human Mre11: implications for its roles in DNA double-strand break repair pathways

scientific article published on March 2001

Dissecting elastic heterogeneity along DNA molecules coated partly with Rad51 using concurrent fluorescence microscopy and optical tweezers

scientific article

Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex

scientific article published on 12 July 2021

Domain swapping between FEN-1 and XPG defines regions in XPG that mediate nucleotide excision repair activity and substrate specificity.

scientific article published on 22 April 2007

Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4

scientific article

Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques.

scientific article

ExoMeg1: a new exonuclease from metagenomic library.

scientific article published on 27 January 2016

Experimental phase diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence

scientific article published on February 2015

Fluorescent Human RAD51 Reveals Multiple Nucleation Sites and Filament Segments Tightly Associated along a Single DNA Molecule

article by Mauro Modesti et al published May 2007 in Structure

Fluorescent Labeling of Proteins

scientific article

Fluorescent labeling of proteins.

scientific article published in January 2011

Fungal BRCA2 ortholog Brh2 brings 5' end strand invasion back on stage

scientific article published on 01 November 2009

Homologous recombination in real time: DNA strand exchange by RecA.

scientific article published in May 2008

Human RAD52 Captures and Holds DNA Strands, Increases DNA Flexibility, and Prevents Melting of Duplex DNA: Implications for DNA Recombination

scientific article published on March 2017

Human RPA activates BLM's bidirectional DNA unwinding from a nick

scientific article published on 26 February 2020

Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function

scientific article

Lipid-based passivation in nanofluidics

scientific article

Mutational phospho-mimicry reveals a regulatory role for the XRCC4 and XLF C-terminal tails in modulating DNA bridging during classical non-homologous end joining

scientific article

N-terminal constraint activates the catalytic subunit of the DNA-dependent protein kinase in the absence of DNA or Ku.

scientific article published on 13 December 2011

PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF.

scientific article published in October 2016

Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase

scientific article

Plugged into the Ku-DNA hub: The NHEJ network

scientific article published on 06 March 2019

Probing physical properties of a DNA-protein complex using nanofluidic channels.

scientific article

RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination

scientific article published in November 2007

RADX Modulates RAD51 Activity to Control Replication Fork Protection

scientific article published on 01 July 2018

Rab6 regulates transport and targeting of exocytotic carriers

scientific article published on August 2007

Rad52 and Ku bind to different DNA structures produced early in double-strand break repair

scientific article

Real-time assembly and disassembly of human RAD51 filaments on individual DNA molecules

scientific article

Reconstitution of anaphase DNA bridge recognition and disjunction

scientific article published on 03 September 2018

Revealing the competition between peeled ssDNA, melting bubbles, and S-DNA during DNA overstretching using fluorescence microscopy

scientific article published on 19 February 2013

Sequential role of RAD51 paralog complexes in replication fork remodeling and restart

scientific article published on 15 July 2020

Single-molecule views on homologous recombination.

scientific article published on 09 September 2013

Sliding sleeves of XRCC4-XLF bridge DNA and connect fragments of broken DNA.

scientific article published on 20 July 2016

Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4

scientific article

Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface.

scientific article published on 11 March 2016

Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive

scientific article

The bacterial alkyltransferase-like (eATL) protein protects mammalian cells against methylating agent-induced toxicity

scientific article

The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks

scientific article published on 12 October 2006

Two distinct conformational states define the interaction of human RAD51-ATP with single-stranded DNA.

scientific article published on 5 March 2018

Unraveling the structure of DNA during overstretching by using multicolor, single-molecule fluorescence imaging

scientific article

V(D)J recombination: links to transposition and double-strand break repair.

scientific article

Visualization and quantification of nascent RAD51 filament formation at single-monomer resolution

scientific article

Visualizing the Nonhomogeneous Structure of RAD51 Filaments Using Nanofluidic Channels.

scientific article published in August 2016

XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining

scientific article published on 05 October 2018

XRCC4's interaction with XLF is required for coding (but not signal) end joining

scientific article

XRCC4/XLF Interaction Is Variably Required for DNA Repair and Is Not Required for Ligase IV Stimulation

scientific article published on 22 June 2015

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