List of works by David A. Fidock

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

scientific article

A Breathprint for Malaria: New Opportunities for Non-Interventional Diagnostics and Mosquito Traps?

scientific article published on 3 February 2018

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

scientific article

A Worldwide Map of Plasmodium falciparum K13-Propeller Polymorphisms.

scientific article

A broad analysis of resistance development in the malaria parasite

scientific article published on 15 June 2016

A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.

scientific article published on 9 June 2005

A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assay

scientific article (publication date: April 2017)

A key role for lipoic acid synthesis during Plasmodium liver stage development

scientific article published on 05 April 2013

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

scientific article

A method for rapid genetic integration into Plasmodium falciparum utilizing mycobacteriophage Bxb1 integrase

scientific article published on January 2010

A molecular marker for chloroquine-resistant falciparum malaria

scientific article

A novel multiple-stage antimalarial agent that inhibits protein synthesis

scientific article (publication date: 18 June 2015)

A phase 1, placebo controlled, randomised, single ascending dose study and a volunteer infection study to characterize the safety, pharmacokinetics and antimalarial activity of the Plasmodium phosphatidylinositol 4-kinase inhibitor MMV390048

scientific article published on 02 April 2020

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

scientific article (publication date: 6 March 2017)

A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype-genotype association study

scientific article

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

scientific article published on 24 May 2017

A ubiquitous Plasmodium protein displays a unique surface labeling pattern in sporozoites

scientific article

A var gene promoter implicated in severe malaria nucleates silencing and is regulated by 3' untranslated region and intronic cis-elements

scientific article published on 20 May 2009

Accelerated evolution and spread of multidrug-resistant Plasmodium falciparum takes down the latest first-line antimalarial drug in southeast Asia

scientific article published on 22 July 2019

Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt

scientific article

Advances in understanding the genetic basis of antimalarial drug resistance

scientific article published in August 2007

Allelic modifications of the cg2 and cg1 genes do not alter the chloroquine response of drug-resistant Plasmodium falciparum

scientific article published on September 2000

Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum

scientific article published on January 2002

An integrated strategy for efficient vector construction and multi-gene expression in Plasmodium falciparum

scientific article published on 26 October 2013

Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria

scientific article published on 22 April 2020

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

article

Antimalarial drug discovery: efficacy models for compound screening

scientific article published on June 2004

Antimalarial drug discovery: progress and approaches

scientific article published on 31 August 2023

Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic

scientific article

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

scientific article

Arresting malaria parasite egress from infected red blood cells.

scientific article published in March 2008

Artemisinin Action and Resistance in Plasmodium falciparum

scientific article published in September 2016

Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model

scientific article published on 19 November 2018

Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria

scientific article published in December 2009

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum's intra-erythrocytic metabolic program to enhance survival

scientific article published on 22 January 2021

Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity

scientific article published on August 2017

Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter

scientific article published on 20 May 2015

Blocking Plasmodium Development in Mosquitoes: A Powerful New Approach for Expanding Malaria Control Efforts

scientific article published on 01 October 2019

CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs

scientific article

CRISPR-mediated genome editing of Plasmodium falciparum malaria parasites.

scientific article

Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages

article

Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages.

scientific article

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling

scientific article

Characterization of a PRL protein tyrosine phosphatase from Plasmodium falciparum

scientific article (publication date: March 2008)

Characterization of the ATG8-conjugation system in 2 Plasmodium species with special focus on the liver stage: possible linkage between the apicoplastic and autophagic systems?

scientific article

Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets

scientific article

Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations

scientific article

Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter.

scientific article published on 17 June 2003

Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms.

scientific article published on 25 September 2006

Cloning and characterization of a novel Plasmodium falciparum sporozoite surface antigen, STARP

scientific article (publication date: April 1994)

Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum

scientific article published on 22 February 2016

Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery

scientific article published on 05 December 2019

Comparative 3D genome organization in apicomplexan parasites

scientific article published on 05 February 2019

Conservation of a novel vacuolar transporter in Plasmodium species and its central role in chloroquine resistance of P. falciparum

scientific article

Conservation of the Plasmodium falciparum sporozoite surface protein gene, STARP, in field isolates and distinct species of Plasmodium

scientific article published in October 1994

Construction of Plasmodium falciparum lambda cDNA libraries

scientific article

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.

scientific article published on 25 May 2016

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

scientific article published on 06 June 2019

Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone

scientific article published on 03 May 2019

Cycloguanil and its parent compound proguanil demonstrate distinct activities against Plasmodium falciparum malaria parasites transformed with human dihydrofolate reductase

scientific article published on December 1998

DNA repair mechanisms and their biological roles in the malaria parasite Plasmodium falciparum

scientific article

Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin

scientific article published on 11 July 2006

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors

scientific article published on 29 August 2018

Defining the role of PfCRT in Plasmodium falciparum chloroquine resistance

scientific article

Degrees of chloroquine resistance in Plasmodium - is the redox system involved?

scientific article

Developmental arrest of the human malaria parasite Plasmodium falciparum within the mosquito midgut via CTRP gene disruption

scientific article (publication date: April 2000)

Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum

scientific article published on April 2007

Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT.

scientific article

Discovery of novel inhibitors targeting enoyl-acyl carrier protein reductase in Plasmodium falciparum by structure-based virtual screening

scientific article published on 26 April 2007

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay

scientific article published on 13 December 2013

Disruption of Plasmodium falciparum chitinase markedly impairs parasite invasion of mosquito midgut ⬇️

scientific article

Disruption of a Plasmodium falciparum gene linked to male sexual development causes early arrest in gametocytogenesis

scientific article (publication date: 15 November 2005)

Disruption of the C-terminal region of EBA-175 in the Dd2/Nm clone of Plasmodium falciparum does not affect erythrocyte invasion

scientific article published in September 2000

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

scientific article

Drug discovery: Chemical diversity targets malaria

scientific article

Drug discovery: Priming the antimalarial pipeline

scientific article published in May 2010

Drug resistance-associated pfCRT mutations confer decreased Plasmodium falciparum digestive vacuolar pH.

scientific article published on January 2004

Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

scientific article

Editing the Plasmodium vivax genome, using zinc-finger nucleases

scientific article

Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum.

scientific article published on 15 December 2006

Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase

scientific article

Elucidating Mechanisms of Drug-Resistant Plasmodium falciparum

scientific article published on 01 July 2019

Emergence and clonal expansion of in vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda

scientific article published on 03 August 2020

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

scientific article published in Nature Communications

Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria"

scientific article published on 24 October 2018

Erratum to “Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4′-Substituted triclosan derivatives” [Bioorg. Med. Chem. Lett. 15 (2005) 524

article

Erratum: Efficient site-specific integration in Plasmodium falciparum chromosomes mediated by mycobacteriophage Bxb1 integrase

scientific article published in September 2006

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

scientific article published in Scientific Reports

Evidence for a Central Role for PfCRT in Conferring Plasmodium falciparum Resistance to Diverse Antimalarial Agents

scientific article (publication date: 24 September 2004)

Evidence for a pfcrt-associated chloroquine efflux system in the human malarial parasite Plasmodium falciparum

scientific article published on July 2005

Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria.

scientific article published on 27 April 2001

Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent model.

scientific article published on 21 October 2013

Evidence of a Mild Mutator Phenotype in Cambodian Plasmodium falciparum Malaria Parasites

scientific article

Evidence that mutant PfCRT facilitates the transmission to mosquitoes of chloroquine-treated Plasmodium gametocytes

scientific article

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

scientific article

Evolution of a unique Plasmodium falciparum chloroquine-resistance phenotype in association with pfcrt polymorphism in Papua New Guinea and South America

scientific article

First evidence of pfcrt mutant Plasmodium falciparum in Madagascar

scientific article

Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites

scientific article

Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters

scientific article published on 11 September 2019

Genetic disruption of the Plasmodium falciparum digestive vacuole plasmepsins demonstrates their functional redundancy

scientific article published on 18 October 2004

Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum

scientific article published on 22 June 2006

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum

scientific article published on 06 September 2009

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

scientific article published on 23 September 2020

Genome projects, genetic analysis, and the changing landscape of malaria research

scientific article

Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1

scientific article published on 21 December 2015

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness

scientific article published on 30 April 2019

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.

scientific article published on 18 May 2016

Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity

scientific article published on 14 August 2017

How can we identify parasite genes that underlie antimalarial drug resistance?

scientific article published on January 2011

Hydrogen peroxide dynamics in subcellular compartments of malaria parasites using genetically encoded redox probes.

scientific article

Identification and mechanistic understanding of dihydroorotate dehydrogenase point mutations in Plasmodium falciparum that confer in vitro resistance to the clinical candidate DSM265

scientific article published on 13 November 2018

Identification of MMV malaria box inhibitors of plasmodium falciparum early-stage gametocytes using a luciferase-based high-throughput assay

scientific article

Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum

scientific article

Identification of a role for the PfEMP1 semi-conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells

scientific article

Identification of conserved antigenic components for a cytotoxic T lymphocyte-inducing vaccine against malaria

scientific article published in April 1995

Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches

scientific article

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

scientific article (publication date: 9 December 2011)

In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei

scientific article published on 19 October 2011

In vitro and in vivo activity of solithromycin (CEM-101) against Plasmodium species

scientific article published on 14 November 2011

In vitro efficacy, resistance selection, and structural modeling studies implicate the malarial parasite apicoplast as the target of azithromycin

scientific article (publication date: 26 January 2007)

In vitro evaluations of antimalarial drugs and their relevance to clinical outcomes

scientific article published on April 2008

In vivo and in vitro antimalarial properties of azithromycin-chloroquine combinations that include the resistance reversal agent amlodipine

scientific article published on 4 April 2011

In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa

scientific article published on March 2009

Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity

scientific article published on 16 April 2020

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13

scientific article published on 20 April 2020

Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance

scientific article published on 21 June 2010

KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission

scientific article

Local emergence in Amazonia of Plasmodium falciparum k13 C580Y mutants associated with in vitro artemisinin resistance

scientific article published on 12 May 2020

Loss of malarial susceptibility to artemisinin in Thailand

scientific article published on 5 April 2012

Luciferase-Based, High-Throughput Assay for Screening and Profiling Transmission-Blocking Compounds against Plasmodium falciparum Gametocytes

scientific article published on 19 January 2016

ML238: An Antimalarial Small Molecule of a Unique Structural Class

Malaria's missing number: calculating the human component of R0 by a within-host mechanistic model of Plasmodium falciparum infection and transmission

scientific article

Malaria: progress, perils, and prospects for eradication

scientific article

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

scientific article published in January 2018

Microbiology. Eliminating malaria

scientific article published on June 2013

Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families

scientific article

Modeling within-host effects of drugs on Plasmodium falciparum transmission and prospects for malaria elimination

scientific article published on 23 January 2014

Molecular Markers of Plasmodium Resistance to Antimalarials

Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria

scientific article published on 01 September 2020

Multicolor bioluminescence boosts malaria research: quantitative dual-color assay and single-cell imaging in Plasmodium falciparum parasites

scientific article

Mutations conferring drug resistance in malaria parasite drug transporters Pgh1 and PfCRT do not affect steady-state vacuolar Ca2+.

scientific article

Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance

scientific article (publication date: October 2000)

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities

scientific article

N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds

scientific article published on 21 July 2014

No evidence of decreased artemisinin efficacy in a high-transmission malaria setting in Mali

scientific article published in July 2012

Novel diaryl ureas with efficacy in a mouse model of malaria.

scientific article published on 20 December 2012

Nucleotide sequence of the F41 fimbriae subunit gene in Escherichia coli B41.

scientific article

Oleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic target

scientific article published on 3 September 2009

Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond

scientific article (publication date: July 2016)

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials

scientific article published on 01 December 2018

Origin of robustness in generating drug-resistant malaria parasites

scientific article

P. falciparum CG2, linked to chloroquine resistance, does not resemble Na+/H+ exchangers

scientific article published on August 1998

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

scientific article published on 14 April 2020

Parasite-induced ER stress response in hepatocytes facilitates Plasmodium liver stage infection

scientific article

Perspectives: The missing pieces

scientific article published on 25 April 2012

PfCRT and its role in antimalarial drug resistance

scientific article (publication date: November 2012)

PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.

scientific article published on 31 August 2006

Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites

scientific article

Plasmodium falciparum In Vitro Drug Resistance Selections and Gene Editing

scientific article published on 01 January 2019

Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro

scientific article

Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motif

scientific article (publication date: June 2008)

Plasmodium falciparum liver stage antigen-1 is well conserved and contains potent B and T cell determinants.

scientific article published in July 1994

Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission

scientific article published on 21 October 2013

Plasmodium falciparum resistance to piperaquine driven by PfCRT

scientific article published on 01 November 2019

Plasmodium falciparum sporozoite invasion is inhibited by naturally acquired or experimentally induced polyclonal antibodies to the STARP antigen

scientific article

Plasmodium falciparum: generation of a cDNA library enriched in sporozoite-specific transcripts by directional tag subtractive hybridization.

scientific article

Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor

scientific article published on 24 March 2020

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

scientific article published on 20 April 2022

Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials

scientific article published on 04 March 2020

Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE

scientific article (publication date: June 2009)

Production of stage-specific Plasmodium falciparum cDNA libraries using subtractive hybridization

scientific article

Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum

scientific article published in September 2015

Protein Degradation Systems as Antimalarial Therapeutic Targets

scientific article

Pyronaridine-Artesunate Shows Promise as an Effective and Well-Tolerated Treatment for Artemisinin-Resistant Plasmodium falciparum Malaria

scientific article published on 28 June 2019

Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue

scientific article published on 31 October 2011

Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum

scientific article

Recent clinical and molecular insights into emerging artemisinin resistance in Plasmodium falciparum

scientific article published in December 2011

Recent highlights in antimalarial drug resistance and chemotherapy research

scientific article published on 18 October 2008

Recent insights into fatty acid acquisition and metabolism in malarial parasites

scientific article published on 25 March 2010

Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors

scientific article

Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study

scientific article

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum

scientific article published on 20 January 2009

Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases

scientific article published on 26 August 2012

Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum

scientific article published on 14 March 2013

Spiroindolones, a potent compound class for the treatment of malaria

scientific article

Stable integration and comparison of hGrx1-roGFP2 and sfroGFP2 redox probes in the malaria parasite Plasmodium falciparum

scientific article published on 06 September 2018

Stage-dependent localization of a novel gene product of the malaria parasite, Plasmodium falciparum

scientific article (publication date: 13 July 2001)

Structural elucidation of the specificity of the antibacterial agent triclosan for malarial enoyl acyl carrier protein reductase

scientific article published on 12 April 2002

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT

scientific article published on 27 November 2019

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors

scientific article published on 09 May 2019

Substrate and Inhibitor Specificity of the Plasmodium berghei Equilibrative Nucleoside Transporter Type 1

scientific article published on 05 April 2016

Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum

scientific article

Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate

scientific article

Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives.

scientific article published on 8 February 2006

Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives.

scientific article published on 29 September 2005

Taking Charge: Feeding Malaria via Anion Channels

scientific article

Targeting Plasmodium PI(4)K to eliminate malaria

scientific article (publication date: 12 December 2013)

Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance

scientific article (publication date: April 2015)

Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data

scientific article (publication date: 6 June 2003)

The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites

scientific article published on 23 January 2020

The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial Parasites

scientific article published on 11 December 2008

The Mu subunit of Plasmodium falciparum clathrin-associated adaptor protein 2 modulates in vitro parasite response to artemisinin and quinine

scientific article (publication date: May 2015)

The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites

scientific article

The chitinase PfCHT1 from the human malaria parasite Plasmodium falciparum lacks proenzyme and chitin-binding domains and displays unique substrate preferences

scientific article (publication date: 23 November 1999)

The longin domain regulates the steady-state dynamics of Sec22 in Plasmodium falciparum

scientific article (publication date: September 2009)

The selectable marker human dihydrofolate reductase enables sequential genetic manipulation of the Plasmodium berghei genome.

scientific article published in March 2000

Transformation with human dihydrofolate reductase renders malaria parasites insensitive to WR99210 but does not affect the intrinsic activity of proguanil

scientific article (publication date: 30 September 1997)

Transfusion of stored blood impairs host defenses against Gram-negative pathogens in mice

scientific article published on 19 May 2014

Transporters involved in resistance to antimalarial drugs.

scientific article

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

scientific article

Tricks in Plasmodium's molecular repertoire--escaping 3'UTR excision-based conditional silencing of the chloroquine resistance transporter gene

scientific article

Triclosan is minimally effective in rodent malaria models

scientific article published in January 2011

Turning the tide: targeting PfCRT to combat drug-resistant P. falciparum?

scientific article published on 01 May 2020

Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes

scientific article (publication date: May 2014)

UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

scientific article published on 27 August 2018

UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

scientific article (publication date: 19 September 2016)

UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells

scientific article published on 10 June 2013

Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum

scientific article

Using genetic methods to define the targets of compounds with antimalarial activity

scientific article

Vesicular ATPase-overexpressing cells determine the distribution of malaria parasite oocysts on the midguts of mosquitoes.

scientific article published on April 1999

X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy

scientific article

Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites

scientific article published on 30 January 2015

pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum

scientific article published on August 2005

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