List of works - Peer-Hendrik Kuhn

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein

scientific article

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

scientific article published on 30 July 2010

Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10.

scientific article

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

scientific article published on 24 August 2012

Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies

scientific article published on 29 July 2016

F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion.

scientific article published on 9 December 2010

Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).

scientific article

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

scientific article

Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease

scientific article published on 17 March 2016

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase

scientific article published on 15 January 2013

Integration of innate into adaptive immune responses in ZAP-70-positive chronic lymphocytic leukemia.

scientific article published on 27 October 2015

Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo

scientific article

Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains

scientific article

Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments

scientific article published in December 2012

Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration

scientific article

Paired High-Content Analysis of Prostate Cancer Cells in Bone Marrow and Blood Characterizes Increased Androgen Receptor Expression in Tumor Cell Clusters

scientific article published on 4 October 2016

QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis

scientific article published on 31 May 2013

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

scientific article published on 16 February 2007

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

scientific article

Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways

scientific article

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

scientific article

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.

scientific article published on 05 October 2016

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation

scientific article

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

scientific article

TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons

scientific article published on 12 September 2016

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

scientific article

The Fibrin Matrix Regulates Angiogenic Responses within the Hemostatic Microenvironment through Biochemical Control

scientific article

The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity

scientific article

Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex

scientific article

γ-Secretase directly sheds the survival receptor BCMA from plasma cells

scientific article published on 11 June 2015

List of works by Peer-Hendrik Kuhn

A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons

Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10.

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein-specific antibodies

F-spondin regulates neuronal survival through activation of disabled-1 in the chicken ciliary ganglion.

Foamy virus envelope protein is a substrate for signal peptide peptidase-like 3 (SPPL3).

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease

Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase

Integration of innate into adaptive immune responses in ZAP-70-positive chronic lymphocytic leukemia.

Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo

Label-free quantitative analysis of the membrane proteome of Bace1 protease knock-out zebrafish brains

Loss of PAFAH1B2 reduces amyloid-β generation by promoting the degradation of amyloid precursor protein C-terminal fragments

Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration

Paired High-Content Analysis of Prostate Cancer Cells in Bone Marrow and Blood Characterizes Increased Androgen Receptor Expression in Tumor Cell Clusters

QARIP: a web server for quantitative proteomic analysis of regulated intramembrane proteolysis

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase

SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production

Secretome analysis identifies novel signal Peptide peptidase-like 3 (Sppl3) substrates and reveals a role of Sppl3 in multiple Golgi glycosylation pathways

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

Seizure protein 6 and its homolog seizure 6-like protein are physiological substrates of BACE1 in neurons.

Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 (SPPL3) regulates cellular N-glycosylation

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

The Fibrin Matrix Regulates Angiogenic Responses within the Hemostatic Microenvironment through Biochemical Control

The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity

Transmembrane protein 147 (TMEM147) is a novel component of the Nicalin-NOMO protein complex

γ-Secretase directly sheds the survival receptor BCMA from plasma cells