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List of works by Gordon S. Lynch

AMPK-independent pathways regulate skeletal muscle fatty acid oxidation.

scientific article published on 9 October 2008

Activated calcineurin ameliorates contraction-induced injury to skeletal muscles of mdx dystrophic mice

scientific article published on 22 June 2006

Acute antibody-directed myostatin inhibition attenuates disuse muscle atrophy and weakness in mice

scientific article published on 26 January 2011

Adaptations in rat skeletal muscle following long-term resistance exercise training.

scientific article

Adipose triacylglycerol lipase deletion alters whole body energy metabolism and impairs exercise performance in mice.

scientific article published on 2 June 2009

Administration of insulin-like growth factor-I improves fatigue resistance of skeletal muscles from dystrophic mdx mice.

scientific article

Ageing prolongs inflammatory marker expression in regenerating rat skeletal muscles after injury

scientific journal article

Alterations in Notch signalling in skeletal muscles from mdx and dko dystrophic mice and patients with Duchenne muscular dystrophy

scientific article published on 17 January 2014

Anabolic agents for improving muscle regeneration and function after injury

scientific article published on July 2008

Analysis of Ca2+ and Sr2+ activation characteristics in skinned muscle fibre preparations with different proportions of myofibrillar isoforms

scientific article published on 01 February 1995

Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice

scientific article published on 15 June 2011

Antibody-directed myostatin inhibition improves diaphragm pathology in young but not adult dystrophic mdx mice

scientific article

Antibody-directed myostatin inhibition in 21-mo-old mice reveals novel roles for myostatin signaling in skeletal muscle structure and function

scientific article published on 12 July 2010

Arginine protects muscle cells from wasting in vitro in an mTORC1-dependent and NO-independent manner

scientific article

Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP

scientific article published in 2024

Beta 2-agonist administration reverses muscle wasting and improves muscle function in aged rats.

scientific article published on 14 November 2003

Beta2-adrenoceptor agonist fenoterol enhances functional repair of regenerating rat skeletal muscle after injury

scientific article

Beta2-agonist administration increases sarcoplasmic reticulum Ca2+-ATPase activity in aged rat skeletal muscle.

scientific article published on 12 October 2004

Bone Geometry Is Altered by Follistatin-Induced Muscle Growth in Young Adult Male Mice

scientific article published on 03 March 2021

Calcineurin-A alpha activation enhances the structure and function of regenerating muscles after myotoxic injury

scientific article published on 02 May 2007

Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness

scientific article

Cellular mechanisms underlying temporal changes in skeletal muscle protein synthesis and breakdown during chronic {beta}-adrenoceptor stimulation in mice

scientific article published on 11 October 2010

Changes in contractile activation characteristics of rat fast and slow skeletal muscle fibres during regeneration

scientific article published on 4 June 2004

Chronic beta-agonist administration affects cardiac function of adult but not old rats, independent of beta-adrenoceptor density.

scientific article

Chronic beta2-adrenoceptor stimulation impairs cardiac relaxation via reduced SR Ca2+-ATPase protein and activity

scientific article

Chronic formoterol administration reduces cardiac mitochondrial protein synthesis and oxidative capacity in mice

scientific article published on 20 November 2010

Citrulline does not prevent skeletal muscle wasting or weakness in limb-casted mice.

scientific article

Comparative evaluation of IGF-I gene transfer and IGF-I protein administration for enhancing skeletal muscle regeneration after injury

scientific article published on 27 July 2006

Continuous testosterone administration prevents skeletal muscle atrophy and enhances resistance to fatigue in orchidectomized male mice

scientific article published on 18 April 2006

Contractile activation characteristics of single permeabilized fibres from levator palpebrae superioris, orbicularis oculi and vastus lateralis muscles from humans

scientific article published in September 1999

Corrigendum: G-CSF does not influence C2C12 myogenesis despite receptor expression in healthy and dystrophic skeletal muscle.

scientific article

Current pharmacotherapies for sarcopenia

scientific article published on 23 May 2019

Cytoskeletal tropomyosin Tm5NM1 is required for normal excitation-contraction coupling in skeletal muscle

scientific article

Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity

scientific article

Deletion of suppressor of cytokine signaling 3 (SOCS3) in muscle stem cells does not alter muscle regeneration in mice after injury

Differential calcineurin signalling activity and regeneration efficacy in diaphragm and limb muscles of dystrophic mdx mice

scientific article

Disruption of muscle renin-angiotensin system in AT1a-/- mice enhances muscle function despite reducing muscle mass but compromises repair after injury

scientific article published on 6 June 2012

Downstream mechanisms of nitric oxide-mediated skeletal muscle glucose uptake during contraction ⬇️

scientific article published on October 13, 2010

Duchenne muscular dystrophy: focus on pharmaceutical and nutritional interventions.

scientific article published on 10 October 2006

Dysfunctional muscle and liver glycogen metabolism in mdx dystrophic mice

scientific article

Early functional muscle regeneration after myotoxic injury in mice is unaffected by nNOS absence

scientific article published on 17 August 2011

Editorial update on emerging drugs for cancer cachexia

scientific article published on 10 January 2012

Effects of leukemia inhibitory factor on rat skeletal muscles are modulated by clenbuterol

scientific article published in February 2002

Elevated expression of activins promotes muscle wasting and cachexia.

scientific article published on 30 December 2013

Emerging drugs for sarcopenia: age-related muscle wasting

scientific article

Emerging drugs for treating skeletal muscle injury and promoting muscle repair

scientific article published on 16 February 2011

Endurance exercise effects on the contractile properties of single, skinned skeletal muscle fibres of young rats

scientific article published on 01 March 1991

Endurance training adaptations modulate the redox-force relationship of rat isolated slow-twitch skeletal muscles.

scientific article published in January 2003

Evaluating an internet weight loss program for diabetes prevention

scientific article published on 29 March 2005

Examination of 'lipotoxicity' in skeletal muscle of high-fat fed and ob/ob mice

scientific article

Excitation-contraction coupling and sarcoplasmic reticulum function in mechanically skinned fibres from fast skeletal muscles of aged mice

scientific article published in August 2002

Expression of the AMP-activated protein kinase beta1 and beta2 subunits in skeletal muscle

scientific journal article

Expression profiling of skeletal muscle following acute and chronic beta2-adrenergic stimulation: implications for hypertrophy, metabolism and circadian rhythm.

scientific article

FHL1 reduces dystrophy in transgenic mice overexpressing FSHD muscular dystrophy region gene 1 (FRG1).

scientific article

Force and power output of diaphragm muscle strips from mdx and control mice after clenbuterol treatment

scientific article published in March 2001

Force and power output of fast and slow skeletal muscles from mdx mice 6-28 months old

scientific article published on 01 September 2001

Force deficits and breakage rates after single lengthening contractions of single fast fibers from unconditioned and conditioned muscles of young and old rats

scientific article published on 28 May 2008

Functional properties of regenerating skeletal muscle following LIF administration

scientific article published on 01 October 2000

Functional β-adrenoceptors are important for early muscle regeneration in mice through effects on myoblast proliferation and differentiation

scientific article

G-CSF does not influence C2C12 myogenesis despite receptor expression in healthy and dystrophic skeletal muscle.

scientific article

Glucose uptake during contraction in isolated skeletal muscles from neuronal nitric oxide synthase μ knockout mice.

scientific article

Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice

scientific article published on 10 September 2019

Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia

scientific article published on 26 June 2013

HSP70 drives myoblast fusion during C2C12 myogenic differentiation

scientific article published on 30 June 2020

Heritable pathologic cardiac hypertrophy in adulthood is preceded by neonatal cardiac growth restriction.

scientific article

Hsp72 preserves muscle function and slows progression of severe muscular dystrophy

scientific journal article

Hydrogen peroxide increases depolarization-induced contraction of mechanically skinned slow twitch fibres from rat skeletal muscles

scientific article published in March 2002

Hydrogen peroxide modulates Ca2+-activation of single permeabilized fibres from fast- and slow-twitch skeletal muscles of rats

scientific article published on 01 January 2000

IGF-I treatment improves the functional properties of fast- and slow-twitch skeletal muscles from dystrophic mice

scientific article published on 01 April 2001

Identification of FHL1 as a therapeutic target for Duchenne muscular dystrophy

scientific article published on 18 September 2013

Impaired skeletal muscle development and function in male, but not female, genomic androgen receptor knockout mice

scientific article published on 7 April 2008

Importance of functional and metabolic impairments in the characterization of the C-26 murine model of cancer cachexia

scientific article

In vivo and in vitro correction of the mdx dystrophin gene nonsense mutation by short-fragment homologous replacement

scientific article published on 01 April 2001

Inhibition of the renin-angiotensin system improves physiological outcomes in mice with mild or severe cancer cachexia

scientific article published on 16 March 2013

Insulin-like growth factor-I analogue protects muscles of dystrophic mdx mice from contraction-mediated damage

scientific article published on 20 June 2008

Intramuscular administration of PEGylated IGF-I improves skeletal muscle regeneration after myotoxic injury

scientific article published on 19 April 2013

Intramuscular beta2-agonist administration enhances early regeneration and functional repair in rat skeletal muscle after myotoxic injury

scientific article published on 24 April 2008

Length-tension relationships are altered in regenerating muscles of the rat after bupivacaine injection

scientific article

Leucine as a treatment for muscle wasting: a critical review

scientific article

Leukemia inhibitory factor ameliorates muscle fiber degeneration in the mdx mouse

scientific article published on 01 November 2000

Low dose formoterol administration improves muscle function in dystrophic mdx mice without increasing fatigue

scientific article published on 28 November 2006

Making fast-twitch dystrophic muscles bigger protects them from contraction injury and attenuates the dystrophic pathology

scientific article

Mitochondrial hydrogen sulfide supplementation improves health in the <i>C. elegans</i> Duchenne muscular dystrophy model

scientific article published on 01 March 2021

Modulation of insulin-like growth factor (IGF)-I and IGF-binding protein interactions enhances skeletal muscle regeneration and ameliorates the dystrophic pathology in mdx mice

scientific article

Muscle-specific overexpression of IGF-I improves E-C coupling in skeletal muscle fibers from dystrophic mdx mice

scientific article published on 7 November 2007

Notexin causes greater myotoxic damage and slower functional repair in mouse skeletal muscles than bupivacaine

scientific article published in November 2006

Novel role for ß-adrenergic signalling in skeletal muscle growth, development and regeneration

scientific article published on 28 September 2009

Optimizing plasmid-based gene transfer for investigating skeletal muscle structure and function

scientific article published on 23 November 2005

Parvalbumin gene transfer impairs skeletal muscle contractility in old mice

scientific article

Physiological characterization of a mouse model of cachexia in colorectal liver metastases

scientific article published on 13 March 2013

Rigor force responses of permeabilized fibres from fast and slow skeletal muscles of aged rats

scientific article published on 01 September 2001

Role of beta-adrenoceptor signaling in skeletal muscle: implications for muscle wasting and disease

scientific article published on April 2008

Role of contraction-induced injury in the mechanisms of muscle damage in muscular dystrophy

scientific article published in August 2004

Separation of fast from slow anabolism by site-specific PEGylation of insulin-like growth factor I (IGF-I).

scientific article

Skeletal muscle glucose uptake during contraction is regulated by nitric oxide and ROS independently of AMPK.

scientific article published on 15 December 2009

Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice.

scientific article published on July 2016

Stimulation of calcineurin Aalpha activity attenuates muscle pathophysiology in mdx dystrophic mice.

scientific article

Systemic administration of IGF-I enhances oxidative status and reduces contraction-induced injury in skeletal muscles of mdx dystrophic mice

scientific article published on 18 April 2006

Systemic administration of beta2-adrenoceptor agonists, formoterol and salmeterol, elicit skeletal muscle hypertrophy in rats at micromolar doses

scientific article published on March 2006

The calcineurin signal transduction pathway is essential for successful muscle regeneration in mdx dystrophic mice.

scientific article published on 16 January 2004

The orphan nuclear receptor, NOR-1, a target of beta-adrenergic signaling, regulates gene expression that controls oxidative metabolism in skeletal muscle

scientific journal article

The orphan nuclear receptor, NOR-1, is a target of beta-adrenergic signaling in skeletal muscle

scientific article

The potential and the pitfalls of beta-adrenoceptor agonists for the management of skeletal muscle wasting

scientific article published on 16 September 2008

The role of beta-adrenoceptor signaling in skeletal muscle: therapeutic implications for muscle wasting disorders

scientific article

Therapeutic approaches for muscle wasting disorders

scientific article published on 8 December 2006

Therapeutic clenbuterol treatment does not alter Ca2+ sensitivity of permeabilized fast muscle fibres from exercise trained or untrained horses

scientific article published in January 2003

Therapeutic potential of PEGylated insulin-like growth factor I for skeletal muscle disease evaluated in two murine models of muscular dystrophy

scientific article published on 15 March 2012

Therapeutic potential of heat shock protein induction for muscular dystrophy and other muscle wasting conditions

scientific article published on 01 January 2018

Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy

scientific article published on 9 April 2008

Tranilast administration reduces fibrosis and improves fatigue resistance in muscles of mdx dystrophic mice

scientific article published on 30 January 2014

Update on emerging drugs for cancer cachexia

scientific article published on December 2009

Update on emerging drugs for sarcopenia - age-related muscle wasting

scientific article published on December 2008

Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size.

scientific article published on 14 March 2016

Whole body deletion of AMP-activated protein kinase {beta}2 reduces muscle AMPK activity and exercise capacity.

scientific article

beta-Adrenoceptor signaling in regenerating skeletal muscle after beta-agonist administration

scientific article published on 10 July 2007

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