List of works - Damian Yap

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

article

ASPP1 and ASPP2 are new transcriptional targets of E2F

scientific article

Atrophin controls developmental signaling pathways via interactions with Trithorax-like

scientific article

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

scientific article published on 23 February 2017

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

scientific article published on 17 February 2017

Clonal genotype and population structure inference from single-cell tumor sequencing.

scientific article

Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer

scientific article published on 16 May 2016

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

scientific article published on 26 November 2014

Engineered in-vitro cell line mixtures and robust evaluation of computational methods for clonal decomposition and longitudinal dynamics in cancer.

scientific article published on 18 October 2017

Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study

scientific article

Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.

scientific article

Ligation of CD40 potentiates Fas-mediated activation of the cysteine protease CPP32, cleavage of its death substrate PARP, and apoptosis in Ramos-Burkitt lymphoma B cells

scientific article

Mdm2 Inhibits the Apoptotic Function of p53 Mainly by Targeting It for Degradation

scientific article published in Journal of Biological Chemistry

Mll5 is required for normal spermatogenesis

scientific article (publication date: 2011)

Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage

scientific article published on January 2002

Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation

scientific article published on 03 May 2019

PyClone: statistical inference of clonal population structure in cancer.

scientific article

Ser392 phosphorylation regulates the oncogenic function of mutant p53.

scientific article published on July 2004

Solution NMR structure and histone binding of the PHD domain of human MLL5.

scientific article

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

scientific article

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

scientific article published on 29 December 2010

TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data

scientific article

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

scientific article (publication date: 4 April 2012)

The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors

scientific article

The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent

scientific article

Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro

scientific journal article

List of works by Damian Yap

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

ASPP1 and ASPP2 are new transcriptional targets of E2F

Atrophin controls developmental signaling pathways via interactions with Trithorax-like

CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

Clonal genotype and population structure inference from single-cell tumor sequencing.

Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer

Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution.

Engineered in-vitro cell line mixtures and robust evaluation of computational methods for clonal decomposition and longitudinal dynamics in cancer.

Histological Transformation and Progression in Follicular Lymphoma: A Clonal Evolution Study

Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.

Ligation of CD40 potentiates Fas-mediated activation of the cysteine protease CPP32, cleavage of its death substrate PARP, and apoptosis in Ramos-Burkitt lymphoma B cells

Mdm2 Inhibits the Apoptotic Function of p53 Mainly by Targeting It for Degradation

Mll5 is required for normal spermatogenesis

Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage

Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation

PyClone: statistical inference of clonal population structure in cancer.

Ser392 phosphorylation regulates the oncogenic function of mutant p53.

Solution NMR structure and histone binding of the PHD domain of human MLL5.

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

TITAN: inference of copy number architectures in clonal cell populations from tumor whole-genome sequence data

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

The oncogenic roles of DICER1 RNase IIIb domain mutations in ovarian Sertoli-Leydig cell tumors

The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent

Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro