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List of works by David J. Timson

<i>Escherichia coli</i>Modulator of Drug Activity B (MdaB) Has Different Enzymological Properties to Eukaryote Quinone Oxidoreductases

scientific article published in 2019

A Dynamic Core in Human NQO1 Controls the Functional and Stability Effects of Ligand Binding and Their Communication across the Enzyme Dimer

scientific article published on 12 November 2019

A calcium-dependent interaction between calmodulin and the calponin homology domain of human IQGAP1.

scientific article published on 4 September 2012

A galactokinase-like protein from the liver fluke Fasciola hepatica

scientific article published on 21 July 2018

A ligand predication tool based on modeling and reasoning with imprecise probabilistic knowledge

scientific article published on 23 September 2009

A mysterious family of calcium-binding proteins from parasitic worms

scientific article published on August 2016

A novel calmodulin-like protein from the liver fluke, Fasciola hepatica

scientific article published on 19 June 2012

A plasma membrane Ca(2+)-ATPase (PMCA) from the liver fluke, Fasciola hepatica.

scientific article

A universal measure of chaotropicity and kosmotropicity.

scientific article

Altered cofactor binding affects stability and activity of human UDP-galactose 4′-epimerase: Implications for type III galactosemia ⬇️

scientific article published on May 18, 2012

Analysis of UDP-galactose 4'-epimerase mutations associated with the intermediate form of type III galactosaemia

scientific article

Antioxidant properties and global metabolite screening of the probiotic yeast Saccharomyces cerevisiae var. boulardii

scientific article published on 21 November 2016

Antiproton induced DNA damage: proton like in flight, carbon-ion like near rest.

scientific article published on January 2013

Artemisinins act through at least two targets in a yeast model

scientific article published on 17 December 2010

Binding of serum albumin to the anthelmintic drugs albendazole, triclabendazole and their sulphoxides

scientific article published on 3 March 2010

Biochemical analysis of the interactions of IQGAP1 C-terminal domain with CDC42

scientific article published in March 2012

Biochemical characterisation of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) from the liver fluke, Fasciola hepatica

scientific article published on 22 February 2014

Calmodulin disruption impacts growth and motility in juvenile liver fluke

scientific article published on 27 January 2016

Calmodulins from Schistosoma mansoni: Biochemical analysis and interaction with IQ-motifs from voltage-gated calcium channels

scientific article published on 17 May 2018

Cancer-associated variants of human NQO1: impacts on inhibitor binding and cooperativity

scientific article published on 06 September 2019

Catalytic mechanism of mevalonate kinase revisited, a QM/MM study

scientific article published on 01 February 2019

Chaotropicity: a key factor in product tolerance of biofuel-producing microorganisms.

scientific article published on 02 April 2015

Characterisation of eppin function: expression and activity in the lung

scientific article published on 13 July 2017

Characterisation of two calmodulin-like proteins from the liver fluke, Fasciola hepatica

scientific article

Characterization of Calcium-Binding Proteins from Parasitic Worms

scientific article published on 01 January 2019

Characterization of the Saccharomyces cerevisiae galactose mutarotase/UDP-galactose 4-epimerase protein, Gal10p.

scientific article published on 24 January 2007

Citrate synthase from the liver fluke Fasciola hepatica

scientific article published on 14 March 2013

Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family: Differences in ion and drug binding properties

scientific article published on 5 November 2014

Comparison of dynamics of wildtype and V94M human UDP-galactose 4-epimerase-A computational perspective on severe epimerase-deficiency galactosemia.

scientific article published on 31 May 2013

Conformational dynamics is key to understanding loss-of-function of NQO1 cancer-associated polymorphisms and its correction by pharmacological ligands

scientific article published on 3 February 2016

Coumarin-based inhibitors of human NAD(P)H:quinone oxidoreductase-1. Identification, structure-activity, off-target effects and in vitro human pancreatic cancer toxicity.

scientific article published on 14 November 2007

DNA damage by low-energy ions

scientific article published on August 2009

Damage to plasmid DNA induced by low energy carbon ions

scientific article published on 25 May 2007

Destressing Yeast for Higher Biofuel Yields: Can Excess Chaotropicity Be Mitigated?

scientific article published on 17 August 2020

Detection and localisation of protein-protein interactions in Saccharomyces cerevisiae using a split-GFP method

scientific article published on 26 January 2008

Development and implementation of split-GFP-based bimolecular fluorescence complementation (BiFC) assays in yeast

scientific article published in June 2008

Development of a novel mass spectrometric technique for studying DNA damage

scientific article published in August 2009

Dicoumarol: A Drug which Hits at Least Two Very Different Targets in Vitamin K Metabolism

scientific article

Different specificities of two aldehyde dehydrogenases from Saccharomyces cerevisiae var. boulardii

scientific article

Differential expression of liver fluke β-tubulin isotypes at selected life cycle stages

scientific article published on 24 October 2013

Dynamic origins of substrate promiscuity in bacterial galactokinases

scientific article published on 17 October 2019

Effects of alcohols and compatible solutes on the activity of β-galactosidase.

scientific article published on 30 December 2012

Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution

scientific article

Evidence for chaotropicity/kosmotropicity offset in a yeast growth model

scientific article published on 26 September 2019

Expression, purification and crystallization of a novel metagenome-derived salicylaldehyde dehydrogenase from Alpine soil

scientific article published on 28 March 2022

FAD binding overcomes defects in activity and stability displayed by cancer-associated variants of human NQO1.

scientific article published on 29 August 2014

Fasciola hepatica calcium-binding protein FhCaBP2: structure of the dynein light chain-like domain

scientific article

Fasciola hepatica expresses multiple alpha- and beta-tubulin isotypes.

scientific article published on 14 February 2008

FhCaBP1 (FH22): A Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

scientific article

FhCaBP2: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains

scientific article published on 8 July 2015

FhCaBP3: a Fasciola hepatica calcium binding protein with EF-hand and dynein light chain domains.

scientific article

FhCaBP4: a Fasciola hepatica calcium-binding protein with EF-hand and dynein light chain domains.

scientific article published on 8 July 2012

Fine tuning the myosin motor: the role of the essential light chain in striated muscle myosin.

scientific article published on July 2003

Fragmentation of neutral amino acids and small peptides by intense, femtosecond laser pulses.

scientific article

Fructose 1,6-phosphatase: getting the message across

scientific article published on 06 March 2019

Functional analysis of disease-causing mutations in human UDP-galactose 4-epimerase

scientific article

Functional analysis of disease‐causing mutations in human galactokinase ⬇️

scientific article published on April 1, 2003

Functional domains of an NAD + -dependent DNA ligase 1 1Edited by A. R. Fersht

scientific article published on 01 January 1999

Functional domains of the human epididymal protease inhibitor, eppin

scientific article

Galactokinase promiscuity: a question of flexibility?

scientific article published on February 2016

Glycerol enhances fungal germination at the water-activity limit for life

scientific article

Hydrophobic substances induce water stress in microbial cells.

scientific article

IQ motif selectivity in human IQGAP1: binding of myosin essential light chain and S100B

scientific article published on 28 June 2008

IQ-motif peptides as novel anti-microbial agents

scientific article published on 10 December 2012

IQ-motif selectivity in human IQGAP2 and IQGAP3: binding of calmodulin and myosin essential light chain

scientific article

IQGAP1 Interaction with RHO Family Proteins Revisited: KINETIC AND EQUILIBRIUM EVIDENCE FOR MULTIPLE DISTINCT BINDING SITES.

scientific article published on 4 November 2016

Identification and characterisation of human aldose 1-epimerase

scientific article

Improving the Activity and Stability of Human Galactokinase for Therapeutic and Biotechnological Applications.

scientific article

In Silico Analysis of the Effects of Point Mutations on α-Globin: Implications for α-Thalassemia

scientific article published on 18 May 2020

In Silico Prediction of the Effects of Mutations in the Human Mevalonate Kinase Gene: Towards a Predictive Framework for Mevalonate Kinase Deficiency.

scientific article published on 29 September 2015

In silico identification and biochemical characterization of novel inhibitors of NQO1

scientific article published on 29 September 2006

In silico prediction of the effects of mutations in the human UDP-galactose 4'-epimerase gene: towards a predictive framework for type III galactosemia

scientific article published in May 2013

In silico prediction of the effects of mutations in the human triose phosphate isomerase gene: Towards a predictive framework for TPI deficiency

scientific article published on 21 March 2017

In vivo and in vitro function of human UDP-galactose 4'-epimerase variants.

scientific article

Increased promiscuity of human galactokinase following alteration of a single amino acid residue distant from the active site.

scientific article

Insight into the mechanism of galactokinase: Role of a critical glutamate residue and helix/coil transitions

scientific article published on 24 October 2016

Interaction of prothrombin with a phospholipid surface: evidence for a membrane-induced conformational change

article

Interactions between the budding yeast IQGAP homologue Iqg1p and its targets revealed by a split-EGFP bimolecular fluorescence complementation assay.

scientific article published on 16 July 2008

Is there a common water-activity limit for the three domains of life?

scientific article published on 12 December 2014

Kinetic analysis of yeast galactokinase: implications for transcriptional activation of the GAL genes

scientific article published in April 2002

LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway.

scientific article published on 24 July 2017

LIAD-fs scheme for studies of ultrafast laser interactions with gas phase biomolecules.

scientific article

Liver fluke β-tubulin isotype 2 binds albendazole and is thus a probable target of this drug

scientific article published on 31 July 2010

Mechanistic studies on human N-acetylgalactosamine kinase

scientific article published in June 2010

Metabolic Enzymes of Helminth Parasites: Potential as Drug Targets

scientific article published on January 2016

Misfolding of galactose 1-phosphate uridylyltransferase can result in type I galactosemia.

scientific article published on 11 April 2013

Modulating Mobility: a Paradigm for Protein Engineering?

scientific article

Modulation of the mobility of a key region in human galactokinase: Impacts on catalysis and stability

article

Molecular structure of Saccharomyces cerevisiae Gal1p, a bifunctional galactokinase and transcriptional inducer

scientific article published on 22 August 2005

Molecular structure of human galactokinase: implications for type II galactosemia

scientific article

Molecular structure of human galactose mutarotase

scientific article

Multiplication of microbes below 0.690 water activity: implications for terrestrial and extraterrestrial life ⬇️

scientific article

Myosin Va and spermine synthase: partners in exosome transport

scientific article published on 30 April 2019

N-acetylgalactosamine Kinase: A Naturally Promiscuous Small Molecule Kinase

scientific article published on 08 October 2011

NAD(P)H quinone oxidoreductase (NQO1): an enzyme which needs just enough mobility, in just the right places

article

NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms

scientific article published on 12 May 2019

Natural (and Unnatural) Small Molecules as Pharmacological Chaperones and Inhibitors in Cancer.

scientific article

Natural Small Molecules as Stabilizers and Activators of Cancer-Associated NQO1 Polymorphisms

scientific article published on January 2016

Negative Cooperativity in NAD(P)H Quinone Oxidoreductase 1 (NQO1)

scientific article published on 20 September 2019

New model for the interaction of IQGAP1 with CDC42 and RAC1.

scientific article published on 16 June 2017

Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity

scientific article published on 13 February 2020

Nucleotide sequence, heterologous expression and novel purification of DNA ligase from Bacillus stearothermophilus(1).

scientific article published in July 1999

Phosphorylation Mechanism of N-Acetyl-l-glutamate Kinase, a QM/MM Study

scientific article published on 21 March 2019

Phosphorylation Mechanism of Phosphomevalonate Kinase: Implications for Rational Engineering of Isoprenoid Biosynthetic Pathway Enzymes

scientific article published on 27 September 2016

Pilot Evaluation of Two Fasciola hepatica Biomarkers for Supporting Triclabendazole (TCBZ) Efficacy Diagnostics

scientific article published on 30 July 2020

Plume characteristics and dynamics of UV and IR laser-desorbed oligonucleotides ⬇️

scientific article published on March 19, 2012

Purple sweet potato colour--a potential therapy for galactosemia?

scientific article

Reaction Mechanism of Isopentenyl Phosphate Kinase: A QM/MM Study.

scientific article published on 20 November 2017

Role of Arg228 in the phosphorylation of galactokinase: the mechanism of GHMP kinases by quantum mechanics/molecular mechanics studies

scientific article

Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism.

scientific article published on 14 March 2017

Split-EGFP screens for the detection and localisation of protein-protein interactions in living yeast cells

scientific article

Structural and molecular biology of type I galactosemia: disease-associated mutations

scientific article published on 30 September 2011

Structure of the adenylation domain of an NAD+-dependent DNA ligase

scientific article

The 67 kDa laminin receptor: structure, function and role in disease

scientific article

The Catalytic Cycle of the Antioxidant and Cancer-Associated Human NQO1 Enzyme: Hydride Transfer, Conformational Dynamics and Functional Cooperativity

scientific article published on 20 August 2020

The GAL genetic switch: visualisation of the interacting proteins by split-EGFP bimolecular fluorescence complementation

scientific article published on 7 February 2011

The Mechanism of Action of Praziquantel: Can New Drugs Exploit Similar Mechanisms?

scientific article published on 01 January 2020

The N-terminus of A1-type myosin essential light chains binds actin and modulates myosin motor function

scientific article

The Schistosoma mansoni tegumental allergen protein, SmTAL1: Binding to an IQ-motif from a voltage-gated ion channel and effects of praziquantel

scientific article published on 13 January 2020

The biology of habitat dominance; can microbes behave as weeds?

scientific article

The contribution of key hydrophobic residues in ecotin to enzyme-inhibitor complex stability

scientific article published in December 2009

The interaction of IQGAPs with calmodulin-like proteins

scientific article published on April 2011

The mechanism of action of praziquantel: six hypotheses

scientific article published on 01 January 2018

The metastability of human UDP-galactose 4'-epimerase (GALE) is increased by variants associated with type III galactosemia but decreased by substrate and cofactor binding.

scientific article

The molecular basis of galactosemia - Past, present and future

scientific article published on 02 July 2015

The molecular dynamics of Trypanosoma brucei UDP-galactose 4'-epimerase: a drug target for African sleeping sickness

scientific article

The role of the active site residues in human galactokinase: implications for the mechanisms of GHMP kinases.

scientific article

The roles and applications of chaotropes and kosmotropes in industrial fermentation processes

scientific article published on 08 June 2020

The rôle of the proline-rich region in A1-type myosin essential light chains: implications for information transmission in the actomyosin complex

scientific article

The structural and molecular biology of type I galactosemia: Enzymology of galactose 1-phosphate uridylyltransferase

scientific article published on 25 July 2011

The structural and molecular biology of type III galactosemia.

scientific article

The structural and molecular biology of type IV galactosemia

scientific article published on 09 November 2020

The tegumental allergen-like proteins of Schistosoma mansoni: a biochemical study of SmTAL4-TAL13.

scientific article published on 14 February 2018

The two common polymorphic forms of human NRH-quinone oxidoreductase 2 (NQO2) have different biochemical properties

scientific article published on 12 March 2014

TheSaccharomyces cerevisiaequinone oxidoreductase Lot6p: stability, inhibition and cooperativity

scientific article published on 19 June 2014

Therapies for galactosemia: a patent landscape

scientific article published on 21 April 2020

Triose phosphate isomerase from the blood fluke Schistosoma mansoni: biochemical characterisation of a potential drug and vaccine target

scientific article

Type IV galactosemia

scientific article published on 21 November 2018

UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase- 6 (pp-GalNAc-T6): Role in Cancer and Prospects as a Drug Target.

scientific article published on 22 September 2016

UDP-galactose 4'-epimerase from the liver fluke, Fasciola hepatica: biochemical characterization of the enzyme and identification of inhibitors.

scientific article

Water-mediated network in the resistance mechanism of fosfomycin

scientific article published on 01 August 2018

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