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List of works by Omar Abdel-Wahab

2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels.

scientific article published on 09 July 2012

A mathematical framework to determine the temporal sequence of somatic genetic events in cancer

scientific article

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.

scientific article

ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine

scientific article published on 21 September 2021

ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression

scientific article

ASXL2 is essential for haematopoiesis and acts as a haploinsufficient tumour suppressor in leukemia.

scientific article

Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q

scientific article

Activating mutations in CSF1R and additional receptor tyrosine kinases in histiocytic neoplasms

scientific article published on 25 November 2019

Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis

scientific article published on 24 October 2012

BRAF-mutant hematopoietic malignancies

scientific article published in September 2014

Clinical and pathologic impact of select chromatin-modulating tumor suppressors in clear cell renal cell carcinoma

scientific article published on 27 September 2012

Clinical effect of point mutations in myelodysplastic syndromes

scientific article

Clinical implications of novel mutations in epigenetic modifiers in AML.

scientific article published on 29 October 2011

Collaborating constitutive and somatic genetic events in myeloid malignancies: ASXL1 mutations in patients with germline GATA2 mutations

scientific article published on February 2014

Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms ⬇️

scientific article published on April 1, 2011

Consensus guidelines for the diagnosis and clinical management of Erdheim-Chester disease

scientific article (publication date: 24 July 2014)

Current pre-clinical and clinical advances in the BCR-ABL1-positive and -negative chronic myeloproliferative neoplasms

scientific article published on May 2014

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

scientific article published on March 2014

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia

scientific article

DNA methylation disruption reshapes the hematopoietic differentiation landscape

scientific article published on 23 March 2020

DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms ⬇️

scientific article published on April 26, 2011

Data from Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

Data from Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

Ddx18 is essential for cell-cycle progression in zebrafish hematopoietic cells and is mutated in human AML.

scientific article

Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo

scientific article

Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera

scientific article published on 28 June 2010

Detection of an NRAS mutation in Erdheim-Chester disease.

scientific article published in August 2013

Diagnosis and classification of hematologic malignancies on the basis of genetics.

scientific article

Disordered epigenetic regulation in the pathophysiology of myeloproliferative neoplasms

scientific article published on March 2012

ETV6-ABL1-positive "chronic myeloid leukemia": clinical and molecular response to tyrosine kinase inhibition.

scientific article published on 29 December 2010

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

scientific article published on May 2013

Efficacy of intermittent combined RAF and MEK inhibition in a patient with concurrent BRAF- and NRAS-mutant malignancies

scientific article published on 3 March 2014

Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis

scientific article

Emerging therapeutic paradigms to target the dysregulated Janus kinase/signal transducer and activator of transcription pathway in hematological malignancies

scientific article

Epigenetic alterations in hematopoietic malignancies

scientific article published on 27 September 2012

FISHing for TET2: Utility of FISH for TET2 deletions detection in clinical samples

scientific article published on 13 September 2011

Femoral bone marrow aspiration in live mice

scientific article published on 5 July 2014

Focus on the epigenome in the myeloproliferative neoplasms

scientific article published on January 2013

Frequent ASXL2 mutations in acute myeloid leukemia patients with t(8;21)/RUNX1-RUNX1T1 chromosomal translocations.

scientific article

Functional evidence for derivation of systemic histiocytic neoplasms from hematopoietic stem/progenitor cells

scientific article published on 31 May 2017

GM-CSF-dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia.

scientific article

Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome

scientific article

Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias

scientific article

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

scientific article

Genetics of the myeloproliferative neoplasms

scientific article published on March 2011

Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations

scientific article published on 11 August 2017

Genomic and functional analysis of leukemic transformation of myeloproliferative neoplasms.

scientific article

HDL and Glut1 inhibition reverse a hypermetabolic state in mouse models of myeloproliferative disorders.

scientific article published on 14 January 2013

HSP90 is a therapeutic target in JAK2-dependent myeloproliferative neoplasms in mice and humans

scientific article

Hematopoietic stem cell origin of BRAFV600E mutations in hairy cell leukemia

scientific article

Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapy

scientific article published on September 2012

How do messenger RNA splicing alterations drive myelodysplasia?

scientific article

IDH mutation impairs histone demethylation and results in a block to cell differentiation

scientific article (publication date: 15 February 2012)

IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis.

scientific article

Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene

article published in the Proceedings of the National Academy of Sciences of the United States of America

Importance of genetics in the clinical management of chronic myelomonocytic leukemia

scientific article published on 20 May 2013

Interpreting new molecular genetics in myelodysplastic syndromes

scientific article published on January 2012

JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response

scientific article

JAK2V617F-mediated phosphorylation of PRMT5 downregulates its methyltransferase activity and promotes myeloproliferation

scientific article published on February 2011

Janus kinase-2 inhibition induces durable tolerance to alloantigen by human dendritic cell-stimulated T cells yet preserves immunity to recall antigen

scientific article published on 13 September 2011

Kinase-impaired BTK mutations are susceptible to clinical-stage BTK and IKZF1/3 degrader NX-2127

scientific article published on 01 February 2024

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

scientific article (publication date: 14 December 2010)

Loss of the tumor suppressor BAP1 causes myeloid transformation

scientific article published on 09 August 2012

Metabolism and the leukemic stem cell.

scientific article

Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition

scientific article published on 12 April 2021

Modeling CBL activating mutations in vivo

scientific article published in April 2017

Modulation of splicing catalysis for therapeutic targeting of leukemia with mutations in genes encoding spliceosomal proteins

scientific article published on 02 May 2016

Molecular analysis of patients with polycythemia vera or essential thrombocythemia receiving pegylated interferon α-2a

scientific article published on 19 June 2013

Molecular genetics of acute myeloid leukemia: clinical implications and opportunities for integrating genomics into clinical practice

scientific article published on 01 April 2012

Muscarinic acetylcholine receptor regulates self-renewal of early erythroid progenitors

scientific article published on 01 September 2019

Mutational analysis of therapy-related myelodysplastic syndromes and acute myelogenous leukemia ⬇️

scientific article published on January 24, 2013

Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy

scientific article

Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia.

scientific article

Mutations with epigenetic effects in myeloproliferative neoplasms and recent progress in treatment: Proceedings from the 5th International Post-ASH Symposium

scientific article published on 4 March 2011

Myelodysplastic syndromes are induced by histone methylation–altering ASXL1 mutations

scientific journal article

Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies

scientific article published on 06 August 2018

Oncogenic splicing regulated by phase separation

scientific article published on 27 July 2020

PHF6 mutations in adult acute myeloid leukemia

scientific article published on 29 October 2010

PTEN isoforms with dual and opposing function

scientific article published on 01 November 2019

Partial loss of genes might open therapeutic window

scientific article published on 17 March 2017

Primary myelofibrosis: update on definition, pathogenesis, and treatment.

scientific article published on January 2009

Prognostic relevance of integrated genetic profiling in acute myeloid leukemia

scientific article

Progression of RAS-mutant leukemia during RAF inhibitor treatment

scientific article published on 7 November 2012

Proposed criteria for response assessment in patients treated in clinical trials for myeloproliferative neoplasms in blast phase (MPN-BP): formal recommendations from the post-myeloproliferative neoplasm acute myeloid leukemia consortium

scientific article published on 28 August 2012

Recent advances in the treatment of acute myeloid leukemia.

scientific article

Recent discoveries in molecular characterization of acute myeloid leukemia

scientific article published on June 2014

Recurrent RAS and PIK3CA mutations in Erdheim-Chester disease

scientific article

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

scientific article

Refining the prognostic importance of the diversity of FLT3 internal tandem duplications

scientific article published on 14 August 2012

Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression.

scientific article published on March 2013

Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML.

scientific article published on 2 June 2017

Role of TET2 and ASXL1 mutations in the pathogenesis of myeloproliferative neoplasms

scientific article published on 21 August 2012

Safety, efficacy and biological predictors of response to sequential azacitidine and lenalidomide for elderly patients with acute myeloid leukemia

scientific article

Selective activity of the histone deacetylase inhibitor AR-42 against leukemia stem cells: a novel potential strategy in acute myelogenous leukemia

scientific article published on 16 June 2014

Sequential azacitidine plus lenalidomide combination for elderly patients with untreated acute myeloid leukemia ⬇️

scientific article published on December 14, 2012

Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia ⬇️

scientific article published on 02 May 2013

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.

scientific article

Somatic alterations and dysregulation of epigenetic modifiers in cancers.

scientific article

Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes

scientific article published in 2022

Somatic mutations and cell identity linked by Genotyping of Transcriptomes

scientific article published on 03 July 2019

Supplementary Figure from Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

Supplementary Figure from Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation

Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations

article

TET family proteins and their role in stem cell differentiation and transformation.

scientific article published on September 2011

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

scientific journal article

The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics

scientific article published on 09 October 2012

The JAK2V617F oncogene requires expression of inducible phosphofructokinase/fructose-bisphosphatase 3 for cell growth and increased metabolic activity

scientific article published on 23 August 2011

The Notch/Hes1 pathway sustains NF-κB activation through CYLD repression in T cell leukemia.

scientific article

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

scientific article

The importance of subclonal genetic events in MDS.

scientific article published in November 2013

The most commonly reported variant in ASXL1 (c.1934dupG;p.Gly646TrpfsX12) is not a somatic alteration

scientific article published in July 2010

The mutational landscape of paroxysmal nocturnal hemoglobinuria revealed: new insights into clonal dominance

scientific article

The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.

scientific article published on 21 December 2012

The role of mutations in epigenetic regulators in myeloid malignancies

scientific article

The spliceosome as an indicted conspirator in myeloid malignancies

scientific article published on October 2011

Toll-like receptor alterations in myelodysplastic syndrome

scientific article

Translocation t(11;17) in de novo myelodysplastic syndrome not associated with acute myeloid or acute promyelocytic leukemia

scientific article published on 7 November 2012

Unraveling the genetic underpinnings of myeloproliferative neoplasms and understanding their effect on disease course and response to therapy: proceedings from the 6th International Post-ASH Symposium

scientific article published on 28 March 2012

Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes

scientific article

Warfarin-induced skin necrosis in a patient with heparin-induced thrombocytopenia: two diseases or one?

scientific article

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