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List of works by Josie E. Parker

A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.

scientific article

Azole Affinity of Sterol 14α-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens ⬇️

scientific article published on December 28, 2012

Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).

scientific article

Azole resistance by loss of function of the sterol Δ⁵,⁶-desaturase gene (ERG3) in Candida albicans does not necessarily decrease virulence

scientific article

Characterization of the sterol 14α-demethylases of Fusarium graminearum identifies a novel genus-specific CYP51 function.

scientific article published on 27 February 2013

Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (Sterol 14α-Demethylase) Doxycycline-Regulated Mutant and Screening of the Azole Sensitivity of Aspergillus fumigatus Isoenzymes CYP51A and CYP51B ⬇️

scientific article published on August 23, 2010

Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis.

scientific article

Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus

scientific article published on 11 August 2008

Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy

scientific article (publication date: 2013)

Expression of bacterial levanase in yeast enables simultaneous saccharification and fermentation of grass juice to bioethanol

scientific article published in January 2011

Expression, purification and use of the soluble domain of Lactobacillus paracasei beta-fructosidase to optimise production of bioethanol from grass fructans

scientific article published on 12 February 2010

Expression, purification, and characterization of Aspergillus fumigatus sterol 14-alpha demethylase (CYP51) isoenzymes A and B.

scientific article

Facultative Sterol Uptake in an Ergosterol-Deficient Clinical Isolate of Candida glabrata Harboring a Missense Mutation in ERG11 and Exhibiting Cross-Resistance to Azoles and Amphotericin B ⬇️

scientific article published on May 21, 2012

Heterologous expression of mutated eburicol 14alpha-demethylase (CYP51) proteins of Mycosphaerella graminicola to assess effects on azole fungicide sensitivity and intrinsic protein function

scientific article published on 19 March 2010

Identification and Characterization of Four Azole-Resistant erg3 Mutants of Candida albicans ⬇️

scientific article published on August 23, 2010

In Vitro and In Vivo Efficacy of a Novel and Long Acting Fungicidal Azole, PC1244 on Aspergillus fumigatus Infection.

scientific article published on 12 February 2018

Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals

scientific article published on 29 April 2013

Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola

scientific article published on 27 June 2011

Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris

scientific article published on 12 May 2020

Resistance to antifungals that target CYP51.

scientific article

S279 point mutations in Candida albicans Sterol 14-α demethylase (CYP51) reduce in vitro inhibition by fluconazole.

scientific article published on 17 January 2012

The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme.

scientific article

The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus

scientific article published on 22 January 2020

Two Clinical Isolates of Candida glabrata Exhibiting Reduced Sensitivity to Amphotericin B Both Harbor Mutations in ERG2 ⬇️

scientific article published on October 1, 2012

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