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List of works by David Melzer

A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses

scientific article published on 6 October 2006

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity

scientific article

A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects.

scientific article published on 02 August 2007

A common variant of the p16(INK4a) genetic region is associated with physical function in older people

scientific article

A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine

scientific article published on 20 May 2008

A genome-wide association search for type 2 diabetes genes in African Americans

scientific article published on 4 January 2012

A genome-wide association study identifies protein quantitative trait loci (pQTLs)

scientific article

A genome-wide association study of depressive symptoms

scientific journal article

A genome-wide association study reveals variants in ARL15 that influence adiponectin levels

scientific article

A meta-analysis of gene expression signatures of blood pressure and hypertension

scientific article (publication date: March 2015)

A reference panel of 64,976 haplotypes for genotype imputation

scientific article

A whole-blood transcriptome meta-analysis identifies gene expression signatures of cigarette smoking

scientific article

Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology

scientific article published on 01 January 2020

Access to medium secure psychiatric care in England and Wales. 1: A national survey of admission assessments

article

Access to medium secure psychiatric care in England and Wales. 2: A qualitative study of admission decision-making

article

Access to medium secure psychiatric care in England and Wales. 3: The clinical needs of assessed patients

article

Adjusting for unmeasured confounding in non-randomised longitudinal studies: a methodological review

scientific article

Advancing age is associated with gene expression changes resembling mTOR inhibition: evidence from two human populations

scientific article published on 16 July 2012

Aftercare of depressed inpatients--service delivery and unmet needs

scientific article published in March 2003

Age-related impairments of mobility associated with cobalt and other heavy metals: data from NHANES 1999-2004.

scientific article

Aging children of long-lived parents experience slower cognitive decline.

scientific article

Albumin:creatinine ratio predicts mortality after stroke: analysis of the Third National Health and Nutrition Examination Survey.

scientific article published on December 2010

Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association

scientific article

An evaluation of a respite care unit for elderly people with dementia: framework and some results

scientific article published on 01 January 1990

An interleukin-18 polymorphism is associated with reduced serum concentrations and better physical functioning in older people

scientific article published on January 2007

Another explanation for apparent epistasis

scientific article published in Nature

Any versus long-term prescribing of high risk medications in older people using 2012 Beers Criteria: results from three cross-sectional samples of primary care records for 2003/4, 2007/8 and 2011/12. ⬇️

scientific article published on 5 November 2015

Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies

scientific article published on 23 December 2011

Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey

scientific article

Association of Bisphenol A With Diabetes and Other Abnormalities—Reply

scientific article published in The Journal of the American Medical Association

Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults

scientific article (publication date: 17 September 2008)

Association of urinary bisphenol a concentration with heart disease: evidence from NHANES 2003/06

scientific article

Associations between PFOA, PFOS and changes in the expression of genes involved in cholesterol metabolism in humans

scientific article published on 24 April 2013

Associations between socioeconomic status and environmental toxicant concentrations in adults in the USA: NHANES 2001-2010.

scientific article

Baby boomers nearing retirement: the healthiest generation?

scientific article

Bisphenol A and Adult Disease: Making Sense of Fragmentary Data and Competing Inferences

Bisphenol A exposure is associated with in vivo estrogenic gene expression in adults

scientific article

Bisphenol A modulates the metabolic regulator oestrogen-related receptor-α in T-cells

scientific article published on 2 March 2014

Blood Pressure Trajectories in the 20 Years Before Death.

scientific article

CARERS AND THE MONITORING OF PSYCHOGERIATRIC COMMUNITY TEAMS

CCAAT-enhancer-binding protein-beta expression in vivo is associated with muscle strength

scientific article

COVID-19 severity is predicted by earlier evidence of accelerated aging

scientific article published on 11 July 2020

Cell Specific eQTL Analysis without Sorting Cells

scientific article published on 8 May 2015

Cell specific eQTL analysis without sorting cells

Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants

scientific article

Changes in CEBPB expression in circulating leukocytes following eccentric elbow-flexion exercise

scientific article

Changes in splicing factor expression are associated with advancing age in man.

scientific article published on 06 June 2013

Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans.

scientific article published on 30 June 2016

Chronological and Functional Ageing

Circulating beta-carotene levels and type 2 diabetes-cause or effect?

scientific article published on 07 August 2009

Clinical Outcomes of CADASIL-Associated NOTCH3 Mutations in 451,424 European Ancestry Community Volunteers

Closing the gaps--enhancing the regulation of genetic tests using responsive regulation

scientific article published on 01 January 2007

Cognitive impairment in elderly people: population based estimate of the future in England, Scotland, and Wales

scientific article

Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank

scientific article published in the British Medical Journal

Common genetic variation in the gene encoding interleukin-1-receptor antagonist (IL-1RA) is associated with altered circulating IL-1RA levels

article

Common health predictors of early retirement: findings from the English Longitudinal Study of Ageing

scientific article published in January 2011

Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people

scientific article published on 12 May 2009

Common mental disorder symptom counts in populations: are there distinct case groups above epidemiological cut-offs?

scientific article published in October 2002

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI

scientific article

Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study

scientific article published on 29 January 2009

Community care for patients with schizophrenia one year after hospital discharge.

scientific article

Comparison of senescence-associated miRNAs in primary skin and lung fibroblasts

scientific article

Comprehensive treatment for long-term mentally ill patients in UK

Computer-assisted diagnosis of focal liver lesions on CT images evaluation of the Perceptron algorithm

scientific article published in September 2005

Correction: Urinary Bisphenol A Concentration and Angiography-Defined Coronary Artery Stenosis.

scientific article published on 9 November 2012

DNA methylation of lipid-related genes affects blood lipid levels

scientific article published on 12 January 2015

DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

scientific article published on 12 December 2016

DNA methylation-based measures of biological age: meta-analysis predicting time to death

scientific article

Daily bisphenol A excretion and associations with sex hormone concentrations: results from the InCHIANTI adult population study

scientific article

Decline in Common Mental Disorder prevalence in men during the sixth decade of life. Evidence from the National Psychiatric Morbidity Survey

scientific article published in January 2004

Developing quality indicators for older adults: transfer from the USA to the UK is feasible

scientific article published on August 2004

Diversion from custody

scientific article published in January 1993

Donepezil for dementia due to Alzheimer's disease

scientific article (published 2003-07-21)

Economic inequalities in burden of illness, diagnosis and treatment of five long-term conditions in England: panel study. ⬇️

scientific article

Educational Differences in the Prevalence of Mobility Disability in Old Age: The Dynamics of Incidence, Mortality, and Recovery

article

Educational differences in the dynamics of disability incidence, recovery and mortality: Findings from the MRC Cognitive Function and Ageing Study (MRC CFAS)

article

Effects of the diabetes linked TCF7L2 polymorphism in a representative older population

scientific article

Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms

scientific article

Epidemiology of balance and dizziness in a national population: findings from the English Longitudinal Study of Ageing

scientific article published on 12 February 2008

Epidemiology of balance and dizziness in a national population: findings from the English Longitudinal Study of Ageing

scholarly article by K. N. Stevens et al published 13 November 2008 in Age and Ageing

Epigenetic Signatures of Cigarette Smoking

scientific article

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article published in May 2010

Estrogen replacement therapy: new options, continuing concerns

scientific article published in The Journal of the American Medical Association

Events in Early Life are Associated with Female Reproductive Ageing: A UK Biobank Study

scientific article published on 20 April 2016

Factors explaining the use of psychiatric services by general practices

scientific article

Filaggrin gene mutations are associated with asthma and eczema in later life

scientific article published on 29 August 2008

Framingham Stroke Risk Profile and poor cognitive function: a population-based study

scientific article

Gene expression markers of age-related inflammation in two human cohorts

scientific article

Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons

scientific article

Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes

scientific article published on 14 October 2008

Genetic determinants of serum testosterone concentrations in men.

scientific article

Genetic polymorphisms and human aging: association studies deliver

scientific article published on April 2008

Genetic tests for common diseases: new insights, old concerns

scientific article

Genetic variation and human aging: progress and prospects

scientific article published on March 2007

Genetic variation associated with circulating monocyte count in the eMERGE Network

scientific article published on 12 January 2013

Genetics and medicalisation

scientific article published on April 2002

Genome-wide Association Study of Parental Life Span

scientific article

Genomics and successful aging: grounds for renewed optimism?

scientific article published on 27 March 2012

High urinary tungsten concentration is associated with stroke in the National Health and Nutrition Examination Survey 1999-2010.

scientific article

Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing

scientific article

Human genetic variations: Beacons on the pathways to successful ageing

scientific article published on 04 July 2009

Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants

scientific article published on 23 March 2016

Human longevity: 25 genetic loci associated in 389,166 UK biobank participants

scientific article published on 6 December 2017

Identifying likely causal connections between gene expression levels using a Mendelian randomization approach

article

Imputation of variants from the 1000 Genomes Project modestly improves known associations and can identify low-frequency variant-phenotype associations undetected by HapMap based imputation

scientific article

Incapacidade funcional entre as mulheres idosas no Brasil

Income and the midlife peak in common mental disorder prevalence

scientific article published on 10 December 2010

Interleukin-18 polymorphism and physical functioning in older people: a replication study and meta-analysis

scientific article

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

scientific article published on 14 March 2012

Leukocyte CCR2 expression is associated with mini-mental state examination score in older adults

scientific article

Local population differences and the needs of people with cognitive impairment

Local population differences and the needs of people with cognitive impairment

scientific article published on 01 September 1997

Longer lived parents: protective associations with cancer incidence and overall mortality

scientific article published on 16 May 2013

Longer-Lived Parents and Cardiovascular Outcomes

scientific article published on 01 August 2016

Low prevalence of depression and anxiety is linked to statutory retirement ages rather than personal work exit: a national survey

scientific article published on 2 May 2006

Medication received by patients with depression following the acute episode: adequacy and relation to outcome

scientific article published on 01 February 1999

Mental health and the timing of men's retirement

scientific article published on 13 April 2006

Mental health. Talk--don't inject

scientific article published in December 1992

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

scientific article

MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice.

scientific article published on 17 March 2017

Middle-aged and mobility-limited: prevalence of disability and symptom attributions in a national survey

scientific article published on October 2006

Mobility disability in the middle-aged: cross-sectional associations in the English Longitudinal Study of Ageing

article

Moderate alcohol consumption in later life: time for a trial?

scientific article published in June 2009

Moderate alcohol consumption in older adults is associated with better cognition and well-being than abstinence

scientific article published on 12 March 2007

Much more medicine for the oldest old: trends in UK electronic clinical records ⬇️

scientific article

Multiple loci are associated with white blood cell phenotypes

scientific article

National mortality rates from chronic liver disease and consumption of alcohol and pig meat

scientific article published on 29 June 2009

Need for and receipt of hip and knee replacement—a national population survey

article by N. Steel et al published 21 April 2006 in Rheumatology

Neighborhood Deprivation, Individual Socioeconomic Status, and Frailty in Older Adults

scientific article published on 15 September 2009

Neighborhood deprivation, individual socioeconomic status, and cognitive function in older people: analyses from the English Longitudinal Study of Ageing

scientific article published on 24 December 2007

Neighbourhood deprivation and dental service use: a cross-sectional analysis of older people in England

article

Neighbourhood deprivation and incident mobility disability in older adults

scientific article published on 16 May 2008

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

scientific article

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

scientific article

Obesity in Older People With and Without Conditions Associated With Weight Loss: Follow-up of 955,000 Primary Care Patients

scientific article

Obesity, physical function, and mortality in older adults.

scientific article

Outcomes of Treated Hypertension at Age 80 and Older: Cohort Analysis of 79,376 Individuals

scientific article

Patent protection for medical technologies: why some and not others? ⬇️

scientific article published on February 14, 1998

Patient characteristics predicting failure to receive indicated care for type 2 diabetes ⬇️

scientific article published on 3 December 2014

Paying for health services: A public health view

article

Performance tests and disability: developing an objective index of mobility-related limitation in older populations

scientific article published in May 2002

Peripheral Blood Transcriptomic Signatures of Fasting Glucose and Insulin Concentrations

scientific article

Personal paper: New drug treatment for Alzheimer's disease: lessons for healthcare policy ⬇️

scientific article published on March 7, 1998

Personality profile of the children of long-lived parents

scientific article published on 18 February 2013

Pharmacogenetics and public policy: expert views in Europe and North America

Pharmacogenetics: policy needs for personal prescribing

Pharmacogenetics: policy needs for personal prescribing

scientific article published on 01 January 2005

Physical activity in middle-aged adults reduces risks of functional impairment independent of its effect on weight

scientific article published in November 2007

Polymorphisms in LMNA and near a SERPINA gene cluster are associated with cognitive function in older people.

scientific article

Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes

scientific article

Predictors of Extraordinary Survival in the Iowa Established Populations for Epidemiologic Study of the Elderly: Cohort Follow-Up to “Extinction” ⬇️

scientific article published on June 7, 2011

Prevalence and distribution of hip and knee joint replacements and hip implants in older Americans by the end of life

scientific article published in February 2003

Problem behavior in the last year of life: prevalence, risks, and care receipt in older Americans

scientific article

Profile of disability in elderly people: estimates from a longitudinal population study.

scientific article published on April 1999

Proton-Pump Inhibitors and Fragility Fractures in Vulnerable Older Patients.

scientific article published on March 2017

Proton-Pump Inhibitors and Long-Term Risk of Community-Acquired Pneumonia in Older Adults

scientific article published on 20 April 2018

Psychosis in the community and in prisons: a report from the British National Survey of psychiatric morbidity

scientific article

Racial disparities in receipt of hip and knee joint replacements are not explained by need: the Health and Retirement Study 1998-2004.

scientific article published in June 2008

Red blood cell distribution width: Genetic evidence for aging pathways in 116,666 volunteers.

scientific article published on 28 September 2017

Red cell distribution width and common disease onsets in 240,477 healthy volunteers followed for up to 9 years

scientific article published in PLoS ONE

Reductions in disability prevalence among the highest income groups of older Brazilians

article

Regulatory options for pharmacogenetics

Relationship Between Urinary Nitrate Excretion and Blood Pressure in the InChianti Cohort.

scientific article published on 19 April 2017

Reply

article published in 2007

Reply to WG Thompson.

scientific article published on September 2017

Report from the second cytomegalovirus and immunosenescence workshop

scientific article published on 28 October 2011

Response letter to Shil and colleagues.

scientific article

Responsiveness of the index of mobility limitation: comparison with gait speed alone in the longitudinal aging study amsterdam

scientific article published in August 2003

Retirement and mental health: analysis of the Australian national survey of mental health and well-being

scientific article published on 19 September 2005

Safety and Effectiveness of Statins for Prevention of Recurrent Myocardial Infarction in 12 156 Typical Older Patients: A Quasi-Experimental Study

scientific article published on 04 May 2016

Self reported receipt of care consistent with 32 quality indicators: national population survey of adults aged 50 or more in England

scientific article published on 13 August 2008

Self-reported quality of care for older adults from 2004 to 2011: a cohort study ⬇️

scientific article

Seropositivity to cytomegalovirus, inflammation, all-cause and cardiovascular disease-related mortality in the United States

scientific article

Serum leptin and risk of cognitive decline in elderly italians.

scientific article

Severe mental illness in prisoners: a persistent problem that needs a concerted and long term response

scientific article published on October 1998

Sex differences in the prevalence of mobility disability in old age:the dynamics of incidence, recovery, and mortality

article

Small molecule modulation of splicing factor expression is associated with rescue from cellular senescence.

scientific article published on 17 October 2017

Smoking cessation and transition into retirement: analyses from the English Longitudinal Study of Ageing

scientific article published on 28 September 2007

Social inequalities and the common mental disorders: a systematic review of the evidence

scientific article

Social position and the common mental disorders with disability: estimates from the National Psychiatric Survey of Great Britain

scientific article published in May 2003

Socio-demographic correlates of mobility disability in older Brazilians: results of the first national survey

article

Socioeconomic status and the expectation of disability in old age: estimates for England

scientific article

Splicing factor 3B1 hypomethylation is associated with altered SF3B1 transcript expression in older humans

scientific article published on 23 January 2014

Systematic identification of trans eQTLs as putative drivers of known disease associations

scientific article (publication date: October 2013)

The 9p21 myocardial infarction risk allele increases risk of peripheral artery disease in older people

scientific article published on 23 June 2009

The European IVD Directive and Genetic Testing

article published in 2010

The Triangulation WIthin a STudy (TWIST) framework for causal inference within pharmacogenetic research

scientific article published in 2021

The VEGFA165b isoform is dysregulated in senescent endothelial cells and may be associated with prevalent and incident coronary heart disease

scientific article published on 12 January 2018

The apolipoprotein E e4 polymorphism is strongly associated with poor mobility performance test results but not self-reported limitation in older people

scientific article published in October 2005

The coronary artery disease-associated 9p21 variant and later life 20-year survival to cohort extinction

scientific article

The current landscape for direct-to-consumer genetic testing: legal, ethical, and policy issues

scientific article published on January 2008

The distribution of the common mental disorders: social inequalities in Europe

scientific article

The dynamics of quality: a national panel study of evidence-based standards ⬇️

scientific article

The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians

scientific article published on 5 June 2006

The genetics of human ageing

scientific article published on 05 November 2019

The mental health of early retirees-- national interview survey in Britain

scientific article published in February 2005

The outcome of targeting community mental health services: evidence from the West Lambeth schizophrenia cohort

scientific article published on March 1994

The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies

scientific article published on 03 August 2009

The predictive validity for mortality of the index of mobility-related limitation--results from the EPESE study

scientific article published on November 2003

The role of waist circumference in predicting disability in periretirement age adults

scientific article published on 01 February 2006

The transcriptional landscape of age in human peripheral blood

scientific article

The value of England and Wales congenital malformation notification scheme data for epidemiology: male genital tract malformations

scientific article

Towards a gene expression biomarker set for human biological age.

scientific article

Trends in service use and treatment for mental disorders in adults throughout Great Britain

scientific article published in November 2004

Uric acid measurement improves prediction of cardiovascular mortality in later life.

scientific article

Urinary bisphenol A concentration and risk of future coronary artery disease in apparently healthy men and women

scientific article published on 21 February 2012

Urinary bisphenol a concentration and angiography-defined coronary artery stenosis

scientific article

Variation in Thresholds for Reporting Mobility Disability Between National Population Subgroups and Studies

article

Variation in prescribing of hypnotics, anxiolytics and antidepressants between 61 general practices.

scientific article

Vitamin D and Risk of Cognitive Decline in Elderly Persons

Vitamin D and cognitive function

scientific article published on January 2012

Vitamin D and cognitive impairment in the elderly U.S. population.

scientific article

Vitamin D and risk of cognitive decline in elderly persons

scientific article

WHAT BECOMES OF PEOPLE WITH DEMENTIA REFERRED TO COMMUNITY PSYCHOGERIATRIC TEAMS?

scholarly article by SUSAN BEDFORD et al published December 1996 in International Journal of Geriatric Psychiatry

Was John Reid right? Smoking, class, and pleasure: a population-based cohort study in England

scientific article published on 2 March 2007

What Level of Alcohol Consumption Is Hazardous for Older People? Functioning and Mortality in U.S. and English National Cohorts

article

What determines access to medium secure psychiatric provision?

Whole blood gene expression and interleukin-6 levels

scientific article

Whole-genome sequencing to understand the genetic architecture of common gene expression and biomarker phenotypes

scientific article

[Disability among elderly women in Brazil]

scientific article published on 30 June 2005

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