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List of works by Raffaella Giavazzi

45th annual meeting of the Italian Cancer Society. Bergamo, 9-12 November 2003.

scientific article

A comparative analysis of oncofetal fibronectin and tenascin-C incorporation in tumour vessels using human recombinant SIP format antibodies

article

A complex of α6 integrin and E-cadherin drives liver metastasis of colorectal cancer cells through hepatic angiopoietin-like 6

scientific article

A human acute lymphoblastic leukemia line with the T(4;11) translocation as a model of minimal residual disease in SCID mice

scientific article

A ligand-free, soluble urokinase receptor is present in the ascitic fluid from patients with ovarian cancer.

scientific article

A murine ovarian tumor with unique metastasizing capacity

scientific article published on 01 June 1981

A proteomic approach for the identification of vascular markers of liver metastasis

scientific article

Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia.

scientific article

An HSP90-mimic peptide revealed by fingerprinting the pool of antibodies from ovarian cancer patients

scientific article published in November 2004

An in vivo model of somatic cell gene therapy for human severe combined immunodeficiency

scientific article

Angiogenesis inhibitors: implications for combination with conventional therapies

scientific article published on January 2010

Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development

scientific article published on 14 September 2006

Antiangiogenic activity of aplidine, a new agent of marine origin

scientific article published on June 2004

Antiangiogenic activity of trabectedin in myxoid liposarcoma: Involvement of host TIMP-1 and TIMP-2 and tumor thrombospondin-1

scientific article published on 19 June 2014

Antiangiogenic and antitumor activity of IDN 5390, a new taxane derivative

scientific article published on April 2002

Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator

scientific article published on July 2004

Anticancer therapy with angiogenesis inhibitors.

scientific article

Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent

scientific article

Antitumor activity of taxol (NSC-125973) in human ovarian carcinomas growing in the peritoneal cavity of nude mice

scientific article published on February 1993

Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4.

scientific article published on January 2003

Batimastat, a synthetic inhibitor of matrix metalloproteinases, potentiates the antitumor activity of cisplatin in ovarian carcinoma xenografts ⬇️

scientific article published on April 1, 1998

Bevacizumab-Induced Inhibition of Angiogenesis Promotes a More Homogeneous Intratumoral Distribution of Paclitaxel, Improving the Antitumor Response.

scientific article published on 22 October 2015

Bioavailability of VEGF in tumor-shed vesicles depends on vesicle burst induced by acidic pH.

scientific article

Blood coagulation changes in nude mice bearing human colon carcinomas

scientific article published on 01 January 1992

Cediranib combined with chemotherapy reduces tumor dissemination and prolongs the survival of mice bearing patient-derived ovarian cancer xenografts with different responsiveness to cisplatin

scientific article published on 17 July 2015

Characterization of novel clonal murine endothelial cell lines with an extended life span

scientific article published on May 2000

Characterization of tumor lines derived from spontaneous metastases of a transplanted murine sarcoma

scientific article published on 01 January 1981

Chemotherapy counteracts metastatic dissemination induced by antiangiogenic treatment in mice

scientific article

Circulating plasma vascular endothelial growth factor in mice bearing human ovarian carcinoma xenograft correlates with tumor progression and response to therapy

scientific article published on 01 May 2005

Cisplatin plus paclitaxel and maintenance of bevacizumab on tumour progression, dissemination, and survival of ovarian carcinoma xenograft models

scientific article

Combination therapy in cancer: effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics

scientific article

Comparative analysis of the membrane proteome of closely related metastatic and nonmetastatic tumor cells

scientific article

Comparative study on the metastatic behavior of human tumors in nude, beige/nude/xid and severe combined immunodeficient mice

scientific article published on 01 January 1993

Comparison of paclitaxel and docetaxel activity on human ovarian carcinoma xenografts

scientific article published on 01 January 1994

Contribution of tumor endothelial cells to drug resistance: anti-angiogenic tyrosine kinase inhibitors act as p-glycoprotein antagonists

scientific article published on 7 April 2017

Correction: Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle

scientific article published on June 2016

Correlation between the in vitro interaction of tumor cells with an organ environment and metastatic behavior in vivo

scientific article published on 01 January 1987

Correlation of Tumor Growth Inhibitory Activity of Macrophages Exposed to Adriamycin and Adriamycin Sensitivity of the Target Tumor Cells234

scientific article published on 01 August 1984

Cytokine-mediated tumor-endothelial cell interaction in metastasis

scientific article published on January 1996

Cytokines and cell adhesion molecules in tumor-endothelial cell interaction and metastasis.

scientific article published on July 1994

Determination of paclitaxel distribution in solid tumors by nano-particle assisted laser desorption ionization mass spectrometry imaging

scientific article (publication date: 2013)

Differential expression of a sialoglycoprotein with an approximate molecular weight of 900,000 on metastatic human colon carcinoma cells growing in culture and in tumor tissues

scientific article published on May 1988

Differential vascular expression and regulation of oncofetal tenascin-C and fibronectin variants in renal cell carcinoma (RCC): implications for an individualized angiogenesis-related targeted drug delivery

scientific article published on 11 November 2011

Distinct role of fibroblast growth factor-2 and vascular endothelial growth factor on tumor growth and angiogenesis

scientific article published on June 2003

Distribution of mono-, di, and tri-O-acetylated sialic acids in normal and neoplastic colon.

scientific article published in January 1988

Divergent effects of macrophage toxins on growth of primary tumors and lung metastases in mice

scientific article published on 01 May 1980

Driving p53 response to Bax activation greatly enhances sensitivity to taxol by inducing massive apoptosis.

scientific article

Dual targeting of tumor and endothelial cells by gonadotropin-releasing hormone agonists to reduce melanoma angiogenesis

scientific article published on 4 August 2010

E-3810 is a potent dual inhibitor of VEGFR and FGFR that exerts antitumor activity in multiple preclinical models

scientific article published on 6 January 2011

Ecteinascidin-743, a new marine natural product with potent antitumor activity on human ovarian carcinoma xenografts

scientific article published on 01 August 1998

Effect of Interleukin-1-beta on Metastasis Formation in Different Tumor Systems

scientific article published on 01 January 1991

Effect of alltrans-retinoic acid (ATRA) on the adhesive and motility properties of acute promyelocytic leukemia cells

scientific article published on 01 January 1997

Endothelial cell migration and invasiveness are induced by a soluble factor produced by murine endothelioma cells transformed by polyoma virus middle T oncogene

scientific article published on August 1993

Endothelin-1 induces an angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo.

scientific article published on November 2000

Enhancement of Metastatic Potential of Murine and Human Melanoma Cells by Laminin Receptor Peptide G: Attachment of Cancer Cells to Subendothelial Matrix as a Pathway for Hematogenous Metastasis

scientific article published on 01 February 1993

Establishment of human acute myelogenous leukemia lines secreting interleukin-1β in SCID mice

scientific article published on 01 April 1995

Experimental nude mouse model of human colorectal cancer liver metastases

scientific article published on 01 December 1986

Expression levels of vascular endothelial growth factor, matrix metalloproteinases 2 and 9 and tissue inhibitor of metalloproteinases 1 and 2 in the plasma of patients with ovarian carcinoma

scientific article published on 01 September 2003

Expression of beta-tubulin isotypes in human ovarian carcinoma xenografts and in a sub-panel of human cancer cell lines from the NCI-Anticancer Drug Screen: correlation with sensitivity to microtubule active agents

scientific article published on 01 September 2001

Expression of cell surface P-glycoprotein by an adriamycin-resistant murine fibrosarcoma.

scientific article

Expression of the 67 kD laminin receptor in human ovarian carcinomas as defined by a monoclonal antibody, MLuC5.

scientific article published on August 1996

Expression of the soluble vascular endothelial growth factor receptor-1 in cutaneous melanoma: role in tumour progression.

scientific article published on May 2011

Fibroblast growth factor-2 binding to the thrombospondin-1 type III repeats, a novel antiangiogenic domain

scientific article

Flavone acetic acid pharmacokinetics in nude mice

scientific article

Gemtuzumab ozogamicin (Mylotarg) has therapeutic activity against CD33 acute lymphoblastic leukaemias in vitro and in vivo.

scientific article published in February 2005

Gene expression correlating with response to paclitaxel in ovarian carcinoma xenografts

article

Glycerophosphoinositols inhibit the ability of tumour cells to invade the extracellular matrix

scientific article published in February 2005

Growth advantage and vascularization induced by basic fibroblast growth factor overexpression in endometrial HEC-1-B cells: an export-dependent mechanism of action.

scientific article

Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice

scientific article published in August 1986

Growth and metastatic behavior of human tumor cells implanted into nude and beige nude mice

scientific article published on 01 April 1987

Growth potential of human colorectal carcinomas in nude mice: association with the preoperative serum concentration of carcinoembryonic antigen in patients

scientific article published on 01 March 1988

Heterogeneity of paclitaxel distribution in different tumor models assessed by MALDI mass spectrometry imaging

scientific article published on 21 December 2016

High antitumour activity of ET743 against human tumour xenografts from melanoma, non-small-cell lung and ovarian cancer

scientific article

Human immunodeficiency virus-1 (HIV-1)-Tat protein promotes migration of acquired immunodeficiency syndrome-related lymphoma cells and enhances their adhesion to endothelial cells

scientific article published on September 1999

IDN 5390: a new concept in taxane development

scientific article

IDN5109, a taxane with oral bioavailability and potent antitumor activity.

scientific article

IL-1alpha gene-transfected human melanoma cells increase tumor-cell adhesion to endothelial cells and their retention in the lung of nude mice

scientific article published on September 1996

Identification of a functional role for the protease-activated receptor-1 in hypoxic breast cancer cells

scientific article

Identification of novel vascular markers through gene expression profiling of tumor-derived endothelium

scientific article

Identification of thrombin-like activity in ovarian cancer associated ascites and modulation of multiple cytokine networks

scientific article published on 11 August 2011

Impact of VEGF-dependent tumour micro-environment on EDB fibronectin expression by subcutaneous human tumour xenografts in nude mice

scientific article published in December 2009

Impact of fibroblast growth factor-2 on tumor microvascular architecture. A tridimensional morphometric study ⬇️

scientific article published on June 1, 1998

In vivo measurement of vascular modulation in experimental tumors using a fluorescent contrast agent

scientific article published on 12 April 2008

In vivo protein biotinylation for identification of organ-specific antigens accessible from the vasculature

scientific article published on 23 March 2005

Inactivating STAT3: bad for tumor, good for muscle

scientific article published in January 2015

Inhibition of Angiogenesis and Murine Hemangioma Growth by Batimastat, a Synthetic Inhibitor of Matrix Metalloproteinases

scientific article published on 01 February 1995

Inhibition of SIRT2 potentiates the anti-motility activity of taxanes: implications for antineoplastic combination therapies.

scientific article

Inhibition of matrix metalloproteinases by over‐expression of tissue inhibitor of metalloproteinase‐2 inhibits the growth of experimental hemangiomas

scientific article published on 01 January 2001

Inhibition of the metastatic spread and growth of B16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor

scientific article published on 01 August 1994

Interleukin 1 receptor antagonist inhibits the augmentation of metastasis induced by interleukin 1 or lipopolysaccharide in a human melanoma/nude mouse system.

scientific article published on October 1993

Interleukin 1-induced augmentation of experimental metastases from a human melanoma in nude mice

scientific article published on August 1990

Interleukin-1β regulates the migratory potential of MDAMB231 breast cancer cells through the hypoxia-inducible factor-1α.

scientific article published on 26 August 2010

Intraperitoneal and subcutaneous xenografts of human ovarian carcinoma in nude mice and their potential in experimental therapy

scientific article published on 01 September 1989

Intratumor heterogeneity and its impact on drug distribution and sensitivity

scientific article published on 14 May 2014

Isolation and characterization of human tumor-derived capillary endothelial cells: role of oncofetal fibronectin

scientific article published on 01 January 1998

Isolation and preliminary characterization of an Adriamycin-resistant murine fibrosarcoma cell line.

scientific article published on May 1983

Laminin inhibits the adhesion of a murine tumor of macrophage origin

scientific article published on 01 August 1982

Malignant behavior and resistance to cisplatin of human ovarian carcinoma xenografts established from the same patient at different stages of the disease.

scientific article

Matrix metalloproteinase inhibition: a review of anti-tumour activity

scientific article published on December 1995

Matrix metalloproteinases (MMP9 and MMP2) induce the release of vascular endothelial growth factor (VEGF) by ovarian carcinoma cells: implications for ascites formation.

scientific article published in September 2003

Membrane fluidity affects tumor-cell motility, invasion and lung-colonizing potential

scientific article published on 01 October 1989

Mesothelial cells induce the motility of human ovarian carcinoma cells

scientific article published on 01 January 1999

Metabolism of tumour-derived urokinase receptor and receptor fragments in cancer patients and xenografted mice.

scientific article published in February 2004

Metastasizing capacity of tumour cells from spontaneous metastases of transplanted murine tumours

scientific article

Metastatic behavior of an adriamycin-resistant murine tumor

scientific article published on November 1983

Metastatic potential of metastases, tumor cell heterogeneity, and therapeutic implications.

scientific article

Modulation of tumor angiogenesis by conditional expression of fibroblast growth factor-2 affects early but not established tumors.

scientific article

Molecular characterisation of a panel of human ovarian carcinoma xenografts

scientific article published on 01 August 1998

Mononuclear phagocyte adherence in the presence of laminin. A possible marker of cellular differentiation

scientific article published in July 1983

Natural cytotoxic activity in human lungs

scientific article published in February 1982

Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds

scientific article

Organ distribution of experimental metastases of a human colorectal carcinoma injected in nude mice

scientific article published on 01 January 1989

Organ-specific growth of a murine lymphoma of spontaneous origin in nude mice

scientific article published on 01 September 1991

Orthotopic Model of Ovarian Cancer

scientific article published on January 2016

Outbreaks of hyperkeratotic dermatitis of athymic nude mice in northern Italy

scientific article

PO-15 - Antiangiogenic small molecule ligands of FGF2 derived from the endogenous inhibitor thrombospondin-1.

scientific article

PO-44 - Tissue factor pathway inhibitor-2 (TFPI-2) is cleaved by PRSS3: implication for tumor endothelial cells migration.

scientific article

Paclitaxel (Taxol(R)) inhibits motility of paclitaxel-resistant human ovarian carcinoma cells

scientific article published on 01 October 1996

Paclitaxel enhances therapeutic efficacy of the F8-IL2 immunocytokine to EDA-fibronectin-positive metastatic human melanoma xenografts

scientific article

Patient-Derived Ovarian Tumor Xenografts Recapitulate Human Clinicopathology and Genetic Alterations

scientific article published on 10 October 2014

Pharmacokinetics and antineoplastic activity of galectin-1-targeting OTX008 in combination with sunitinib.

scientific article published on 24 August 2013

Phenotypic and functional characteristics of tumour-derived microvascular endothelial cells

scientific article published on 01 January 1999

Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.

scientific article

Posttranscriptional stimulation of endothelial cell matrix metalloproteinases 2 and 1 by endothelioma cells.

scientific article published on August 2000

Potential antagonism of tubulin-binding anticancer agents in combination therapies.

scientific article

Preclinical development of metalloproteasis inhibitors in cancer therapy.

scientific article

Procoagulant activity of sarcoma sublines with different metastatic potential

scientific article published on April 1981

Prostaglandin and thromboxane synthesis by M5076 ovarian reticulosarcoma during growth: effects of a thromboxane synthetase inhibitor

scientific article published on February 1987

Protease-activated receptor-1 (PAR-1) promotes the motility of human melanomas and is associated to their metastatic phenotype

scientific article

Regulator of G-protein signaling 5 (RGS5) protein: a novel marker of cancer vasculature elicited and sustained by the tumor's proangiogenic microenvironment

scientific article published in December 2011

Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts ⬇️

scientific article published on March 1, 1988

Retention of vital dyes correlates inversely with the multidrug-resistant phenotype of adriamycin-selected murine fibrosarcoma variants

scientific article published on September 1990

Retroviral vector-mediated gene transfer into human primary myogenic cells leads to expression in muscle fibers in vivo

scientific article published in December 1993

Role of beta 1 integrins in tumor cell adhesion to cultured human endothelial cells

scientific article published on 01 November 1991

Sequence dependent antitumour efficacy of the vascular disrupting agent ZD6126 in combination with paclitaxel.

scientific article published on 11 September 2007

Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells

scientific article published on February 2002

Small molecules in anti-angiogenic therapy.

scientific article

Soluble intercellular adhesion molecule 1 is released by human melanoma cells and is associated with tumor growth in nude mice

scientific article published on May 1992

Soluble intercellular adhesion molecule—1 (ICAM-1) is released into the serum and ascites of human ovarian carcinoma patients and in nude mice bearing tumour xenografts

scientific article published on 01 January 1994

Soluble stroma-related biomarkers of pancreatic cancer.

scientific article

Solution state conformation and degradation of cyclopeptides containing an NGR motif

scientific article published in January 2005

Sunitinib prevents cachexia and prolongs survival of mice bearing renal cancer by restraining STAT3 and MuRF-1 activation in muscle.

scientific article published on February 2015

Syngeneic Murine Metastasis Models: B16 Melanoma

scientific article published on 01 January 2001

Syngeneic Murine Metastasis Models: B16 Melanoma

scientific article published on 01 January 2014

Targeting angiogenesis with compounds from the extracellular matrix

scientific article published on 17 August 2011

The 140-kilodalton antiangiogenic fragment of thrombospondin-1 binds to basic fibroblast growth factor

scientific article published on 01 April 1997

The adhesion molecule NCAM promotes ovarian cancer progression via FGFR signalling

scientific article

The biological basis for antiangiogenic therapy

scientific article published on 01 October 2000

The combination of the tyrosine kinase receptor inhibitor SU6668 with paclitaxel affects ascites formation and tumor spread in ovarian carcinoma xenografts growing orthotopically

scientific article published in August 2003

The combination of yondelis and cisplatin is synergistic against human tumor xenografts

scientific article published in September 2003

The effects of vandetanib on paclitaxel tumor distribution and antitumor activity in a xenograft model of human ovarian carcinoma

scientific article

The heparin binding 25 kDa fragment of thrombospondin-1 promotes angiogenesis and modulates gelatinase and TIMP-2 production in endothelial cells

scientific article published on 01 September 2000

The immunocytokine F8-IL2 improves the therapeutic performance of sunitinib in a mouse model of renal cell carcinoma

scientific article published on 28 October 2010

The metalloproteinase inhibitor batimastat (BB-94) causes cell cycle phase perturbations in ovarian cancer cells

scientific article published on 01 May 1999

The tyrosine kinase inhibitor E-3810 combined with paclitaxel inhibits the growth of advanced-stage triple-negative breast cancer xenografts

scientific article

The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis

scientific article published on March 2006

Thrombospondin 1 as a scavenger for matrix-associated fibroblast growth factor 2

scientific article published on 28 August 2003

Thrombospondin induces glomerular mesangial cell adhesion and migration

scientific article published in November 1992

Thrombospondin modulates basic fibroblast growth factor activities on endothelial cells ⬇️

scientific article published on January 1, 1992

Thrombospondin-1 inhibits Kaposi's sarcoma (KS) cell and HIV-1 Tat-induced angiogenesis and is poorly expressed in KS lesions

article

Thrombospondin-1 is part of a Slug-independent motility and metastatic program in cutaneous melanoma, in association with VEGFR-1 and FGF-2.

scientific article published on 13 October 2014

Thrombospondin-1/HIV-1 Tat protein interaction: modulation of the biological activity of extracellular Tat

article

Transfer of the ADA gene into human ADA-deficient T lymphocytes reconstitutes specific immune functions

scientific article published on September 1992

Transfer of the HSV-tk gene into donor peripheral blood lymphocytes for in vivo modulation of donor anti-tumor immunity after allogeneic bone marrow transplantation

scientific article published in June 1995

Trypsinogen 4 boosts tumor endothelial cells migration through proteolysis of tissue factor pathway inhibitor-2.

scientific article published on 22 July 2015

Tumor delivery of chemotherapy combined with inhibitors of angiogenesis and vascular targeting agents

scientific article published on October 2013

Tumor progression and metastatic dissemination in ovarian cancer after dose-dense or conventional paclitaxel and cisplatin plus bevacizumab

scientific article published on 07 August 2018

Tumor-derived suppressor factors (TDSFs) in normal and neoplastic colon and rectum

scientific article

Tumor-host interaction in the optimization of paclitaxel-based combination therapies with vascular targeting compounds

scientific article published on December 2007

Tumour levels of O6-alkylguanine-DNA-alkyltransferase and sensitivity to BCNU of human xenografts.

scientific article published in November 1992

Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host

scientific article published in January 1981

Vascular disrupting activity of tubulin-binding 1,5-diaryl-1H-imidazoles

scientific article

Vascular endothelial growth factor c promotes ovarian carcinoma progression through paracrine and autocrine mechanisms.

scientific article

Vascular endothelial growth factor stimulates organ-specific host matrix metalloproteinase-9 expression and ovarian cancer invasion

scientific article published in April 2008

Vascular endothelium summary statement III: Cancer prevention and control

scientific article published on 21 November 2006

Vascular-targeting activity of ZD6126, a novel tubulin-binding agent.

scientific article published in April 2003

p73 overexpression increases VEGF and reduces thrombospondin-1 production: implications for tumor angiogenesis

scientific article published on 01 November 2001

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