List of works - Hyun Kyu Song

A cytosine modification mechanism revealed by the structure of a ternary complex of deoxycytidylate hydroxymethylase from bacteriophage T4 with its cofactor and substrate

scientific article published on 24 January 2019

A degradation signal recognition in prokaryotes

scientific article published on 18 April 2008

A facile method to prepare large quantities of active caspase-3 overexpressed by auto-induction in the C41(DE3) strain.

scientific article published on 14 June 2016

A host dTMP-bound structure of T4 phage dCMP hydroxymethylase mutant using an X-ray free electron laser

scientific article published on 08 November 2019

A key lysine residue in the AXH domain of ataxin-1 is essential for its ubiquitylation

scientific article published on 29 January 2015

A novel conformation of the LC3-interacting region motif revealed by the structure of a complex between LC3B and RavZ.

scientific article published on 28 June 2017

A role for a menthone reductase in resistance against microbial pathogens in plants.

scientific article

A thermostable xylose isomerase from Thermus caldophilus: biochemical characterization, crystallization and preliminary X-ray analysis

scientific article published on 01 January 1999

ACCORD: an assessment tool to determine the orientation of homodimeric coiled-coils.

scientific article published on 07 March 2017

Aminopeptidases trim Xaa-Pro proteins, initiating their degradation by the Pro/N-degron pathway

scientific article published on 18 October 2021

Backbone resonances assignment of 19 kDa CD1 domain of human mitotic checkpoint serine/threonine-protein kinase, Bub1.

scientific article

Biochemical and structural characterization of 5'-methylthioadenosine nucleosidases from Arabidopsis thaliana

scientific article published on 26 February 2009

Change in single cystathionine β-synthase domain-containing protein from a bent to flat conformation upon adenosine monophosphate binding

scientific article

Crystal Structure of a Coiled-Coil Domain from Human ROCK I

scientific article

Crystal structure of 5'-methylthioadenosine nucleosidase from Arabidopsis thaliana at 1.5-A resolution

scientific article published in November 2006

Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family

scientific article published in August 2000

Crystal structure of PRY-SPRY domain of human TRIM72

scientific article

Crystal structure of Pyrococcus furiosus PF2050, a member of the DUF2666 protein family

scientific article

Crystal structure of a 16 kDa double-headed Bowman-Birk trypsin inhibitor from barley seeds at 1.9 A resolution

scientific article

Crystal structure of carboxylesterase from Pseudomonas fluorescens, an α/β hydrolase with broad substrate specificity ⬇️

scientific article published on December 15, 1997

Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex

scientific article

Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates

scientific article published on 25 July 2022

Crystal structure of the Bowman-Birk inhibitor from barley seeds in ternary complex with porcine trypsin

scientific article published in October 2004

Crystal structure of the FERM domain of focal adhesion kinase.

scientific article

Crystal structure of the single cystathionine β-synthase domain-containing protein CBSX1 from Arabidopsis thaliana

scientific article

Crystal structure of ubiquitin-like small archaeal modifier protein 1 (SAMP1) from Haloferax volcanii

scientific article

Crystallization and preliminary X-ray analysis of Saccharomyces cerevisiae Ypd1p, a key intermediate in phosphorelay signal transduction

scientific article published on 01 June 1999

Crystallization and preliminary X-ray analysis of a complex between the Bowman-Birk trypsin inhibitor from barley and porcine pancreatic trypsin

scientific article published on 01 June 1999

Crystallization and preliminary X-ray analysis of the C-terminal fragment of Ski7 from Saccharomyces cerevisiae

scientific article

Crystallization and preliminary X-ray crystallographic analysis of DNA polymerase from Thermus aquaticus

scientific article published in November 1995

Crystallization and preliminary X-ray crystallographic analysis of Escherichia coli CyaY, a structural homologue of human frataxin.

scientific article

Crystallization and preliminary X-ray crystallographic analysis of chitinase from barley seeds

scientific article published on 01 September 1993

Crystallization and preliminary X-ray crystallographic analysis of deoxycytidylate hydroxymethylase from bacteriophage T4.

scientific article published on May 1999

Crystallization and preliminary X-ray crystallographic analysis of the protease inhibitor ecotin in complex with chymotrypsin

scientific article published on 01 May 1999

Crystallization and preliminary X-ray crystallographic study of ribosome-inactivating protein from barley seeds

scientific article published in November 1994

Crystallization and preliminary X-ray diffraction analysis of Saccharomyces cerevisiae Ygr203p, a homologue of Acr2 arsenate reductase

scientific article published on June 2000

Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing

scientific article published on October 2010

Differential in vitro and cellular effects of iron chelators for hypoxia inducible factor hydroxylases.

scientific article published in April 2013

Direct recognition of the C-terminal polylysine residues of nonstop protein by Ltn1, an E3 ubiquitin ligase

scientific article published on 08 October 2014

Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

scientific article published on 28 March 2019

Expansion of the clinicopathological and mutational spectrum of Perry syndrome

scientific article published on 22 January 2014

Expression, purification and biochemical characterization of the N-terminal regions of human TIG3 and HRASLS3 proteins

scientific article

Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY).

scientific article

Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain

scientific article (publication date: 11 April 2003)

In vivo fluorescence imaging for cancer diagnosis using receptor-targeted epidermal growth factor-based nanoprobe

scientific article published on 30 August 2013

Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners

scientific article

Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter

scientific article published in Nature Communications

Insights into eukaryotic multistep phosphorelay signal transduction revealed by the crystal structure of Ypd1p from Saccharomyces cerevisiae

scientific article

Insights into the molecular evolution of HslU ATPase through biochemical and mutational analyses

scientific article published in 2014

Insulin activates EGFR by stimulating its interaction with IGF-1R in low-EGFR-expressing TNBC cells.

scientific article

Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV

scientific article (publication date: 2003)

Kunitz-type soybean trypsin inhibitor revisited: refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator

scientific article

LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy

scientific article published on 17 March 2022

MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling

scientific journal article

MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

scientific article published on 21 February 2019

MTRAQ-based quantitative analysis combined with peptide fractionation based on cysteinyl peptide enrichment

scientific article published on 10 March 2015

Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant

scientific article published on 28 November 2019

Mitochondrial ATP synthase activity is impaired by suppressed O-GlcNAcylation in Alzheimer's disease.

scientific article published on 10 September 2015

Mutational studies on HslU and its docking mode with HslV

scientific article

Nucleoside diphosphate kinase from the hyperthermophilic archaeon Methanococcus jannaschii: overexpression, crystallization and preliminary X-ray crystallographic analysis

scientific article published on 01 November 2000

Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes

scientific article (publication date: May 2003)

PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells

scientific article

Preliminary X-ray crystallographic analysis of Bowman-Birk trypsin inhibitor from barley seeds

scientific article published on 01 May 1998

Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors

scientific article

Purification, crystallization and preliminary X-ray diffraction analysis of a cystathionine beta-synthase domain-containing protein, CDCP2, from Arabidopsis thaliana

scientific article published on 20 August 2008

Real-time imaging of NF-AT nucleocytoplasmic shuttling with a photoswitchable fluorescence protein in live cells

scientific article

Renal protective effects of toll-like receptor 4 signaling blockade in type 2 diabetic mice.

scientific article published on 8 April 2013

Ring-shaped architecture of RecR: implications for its role in homologous recombinational DNA repair.

scientific article

SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity

scientific article published in 2024

Single Cystathionine -Synthase Domain-Containing Proteins Modulate Development by Regulating the Thioredoxin System in Arabidopsis

scientific article

Structural and Biochemical Analyses of the Eukaryotic Heat Shock Locus V (HslV) from Trypanosoma brucei

scientific article

Structural and Biochemical Study of the Mono-ADP-Ribosyltransferase Domain of SdeA, a Ubiquitylating/Deubiquitylating Enzyme from Legionella pneumophila

scientific article published on 02 June 2018

Structural basis for dual specificity of yeast N-terminal amidase in the N-end rule pathway

scientific article published on 17 October 2016

Structural basis for recognition of autophagic receptor NDP52 by the sugar receptor galectin-8

scientific article

Structural basis for the N-degron specificity of ClpS1 from Arabidopsis thaliana

scientific article published on 23 December 2020

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases

scientific article

Structural basis of SspB-tail recognition by the zinc binding domain of ClpX

scientific article

Structural basis of degradation signal recognition by SspB, a specificity-enhancing factor for the ClpXP proteolytic machine

scientific article

Structural insights into the conformational diversity of ClpP from Bacillus subtilis

scientific article

Structure biology of selective autophagy receptors.

scientific article

Structure of the autophagic E2 enzyme Atg10 ⬇️

scientific article published on September 18, 2012

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

scientific article

Swapping of interaction partners with ATG5 for autophagosome maturation

scientific article published on March 2015

The C-terminal region of ATG101 bridges ULK1 and PtdIns3K complex in autophagy initiation

scientific article published on 16 August 2018

The quaternary arrangement of HslU and HslV in a cocrystal: a response to Wang, Yale

scientific article published in September 2001

The recombination-associated protein RdgC adopts a novel toroidal architecture for DNA binding.

scientific article

Tumoral acidic extracellular pH targeting of pH-responsive MPEG-poly(beta-amino ester) block copolymer micelles for cancer therapy

scientific article

Tyrosyltyrosylcysteine-Directed Synthesis of Chiral Cobalt Oxide Nanoparticles and Peptide Conformation Analysis

scientific article published on 17 December 2020

UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy

scientific article published on 29 March 2021

Use of the LC3B-fusion technique for biochemical and structural studies of proteins involved in the N-degron pathway

scientific article published on 09 January 2020

eIF4A3 Phosphorylation by CDKs Affects NMD during the Cell Cycle

scientific article published on 01 February 2019

eIF4AIII enhances translation of nuclear cap-binding complex-bound mRNAs by promoting disruption of secondary structures in 5'UTR.

scientific article

pH-dependent regulation of SQSTM1/p62 during autophagy

scientific article published on 12 October 2018

List of works by Hyun Kyu Song

A cytosine modification mechanism revealed by the structure of a ternary complex of deoxycytidylate hydroxymethylase from bacteriophage T4 with its cofactor and substrate

A degradation signal recognition in prokaryotes

A facile method to prepare large quantities of active caspase-3 overexpressed by auto-induction in the C41(DE3) strain.

A host dTMP-bound structure of T4 phage dCMP hydroxymethylase mutant using an X-ray free electron laser

A key lysine residue in the AXH domain of ataxin-1 is essential for its ubiquitylation

A novel conformation of the LC3-interacting region motif revealed by the structure of a complex between LC3B and RavZ.

A role for a menthone reductase in resistance against microbial pathogens in plants.

A thermostable xylose isomerase from Thermus caldophilus: biochemical characterization, crystallization and preliminary X-ray analysis

ACCORD: an assessment tool to determine the orientation of homodimeric coiled-coils.

Aminopeptidases trim Xaa-Pro proteins, initiating their degradation by the Pro/N-degron pathway

Backbone resonances assignment of 19 kDa CD1 domain of human mitotic checkpoint serine/threonine-protein kinase, Bub1.

Biochemical and structural characterization of 5'-methylthioadenosine nucleosidases from Arabidopsis thaliana

Change in single cystathionine β-synthase domain-containing protein from a bent to flat conformation upon adenosine monophosphate binding

Crystal Structure of a Coiled-Coil Domain from Human ROCK I

Crystal structure of 5'-methylthioadenosine nucleosidase from Arabidopsis thaliana at 1.5-A resolution

Crystal structure of Escherichia coli CyaY protein reveals a previously unidentified fold for the evolutionarily conserved frataxin family

Crystal structure of PRY-SPRY domain of human TRIM72

Crystal structure of Pyrococcus furiosus PF2050, a member of the DUF2666 protein family

Crystal structure of a 16 kDa double-headed Bowman-Birk trypsin inhibitor from barley seeds at 1.9 A resolution

Crystal structure of carboxylesterase from Pseudomonas fluorescens, an α/β hydrolase with broad substrate specificity ⬇️

Crystal structure of deoxycytidylate hydroxymethylase from bacteriophage T4, a component of the deoxyribonucleoside triphosphate-synthesizing complex

Crystal structure of the Ate1 arginyl-tRNA-protein transferase and arginylation of N-degron substrates

Crystal structure of the Bowman-Birk inhibitor from barley seeds in ternary complex with porcine trypsin

Crystal structure of the FERM domain of focal adhesion kinase.

Crystal structure of the single cystathionine β-synthase domain-containing protein CBSX1 from Arabidopsis thaliana

Crystal structure of ubiquitin-like small archaeal modifier protein 1 (SAMP1) from Haloferax volcanii

Crystallization and preliminary X-ray analysis of Saccharomyces cerevisiae Ypd1p, a key intermediate in phosphorelay signal transduction

Crystallization and preliminary X-ray analysis of a complex between the Bowman-Birk trypsin inhibitor from barley and porcine pancreatic trypsin

Crystallization and preliminary X-ray analysis of the C-terminal fragment of Ski7 from Saccharomyces cerevisiae

Crystallization and preliminary X-ray crystallographic analysis of DNA polymerase from Thermus aquaticus

Crystallization and preliminary X-ray crystallographic analysis of Escherichia coli CyaY, a structural homologue of human frataxin.

Crystallization and preliminary X-ray crystallographic analysis of chitinase from barley seeds

Crystallization and preliminary X-ray crystallographic analysis of deoxycytidylate hydroxymethylase from bacteriophage T4.

Crystallization and preliminary X-ray crystallographic analysis of the protease inhibitor ecotin in complex with chymotrypsin

Crystallization and preliminary X-ray crystallographic study of ribosome-inactivating protein from barley seeds

Crystallization and preliminary X-ray diffraction analysis of Saccharomyces cerevisiae Ygr203p, a homologue of Acr2 arsenate reductase

Dab1 binds to Fe65 and diminishes the effect of Fe65 or LRP1 on APP processing

Differential in vitro and cellular effects of iron chelators for hypoxia inducible factor hydroxylases.

Direct recognition of the C-terminal polylysine residues of nonstop protein by Ltn1, an E3 ubiquitin ligase

Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

Expansion of the clinicopathological and mutational spectrum of Perry syndrome

Expression, purification and biochemical characterization of the N-terminal regions of human TIG3 and HRASLS3 proteins

Functional interactions of HslV (ClpQ) with the ATPase HslU (ClpY).

Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain

In vivo fluorescence imaging for cancer diagnosis using receptor-targeted epidermal growth factor-based nanoprobe

Insights into autophagosome maturation revealed by the structures of ATG5 with its interacting partners

Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter

Insights into eukaryotic multistep phosphorelay signal transduction revealed by the crystal structure of Ypd1p from Saccharomyces cerevisiae

Insights into the molecular evolution of HslU ATPase through biochemical and mutational analyses

Insulin activates EGFR by stimulating its interaction with IGF-1R in low-EGFR-expressing TNBC cells.

Isolation and characterization of the prokaryotic proteasome homolog HslVU (ClpQY) from Thermotoga maritima and the crystal structure of HslV

Kunitz-type soybean trypsin inhibitor revisited: refined structure of its complex with porcine trypsin reveals an insight into the interaction between a homologous inhibitor from Erythrina caffra and tissue-type plasminogen activator

LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy

MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling

MST1 Negatively Regulates TNFα-Induced NF-κB Signaling through Modulating LUBAC Activity

MTRAQ-based quantitative analysis combined with peptide fractionation based on cysteinyl peptide enrichment

Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant

Mitochondrial ATP synthase activity is impaired by suppressed O-GlcNAcylation in Alzheimer's disease.

Mutational studies on HslU and its docking mode with HslV

Nucleoside diphosphate kinase from the hyperthermophilic archaeon Methanococcus jannaschii: overexpression, crystallization and preliminary X-ray crystallographic analysis

Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes

PEA-15 facilitates EGFR dephosphorylation via ERK sequestration at increased ER-PM contacts in TNBC cells

Preliminary X-ray crystallographic analysis of Bowman-Birk trypsin inhibitor from barley seeds

Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors

Purification, crystallization and preliminary X-ray diffraction analysis of a cystathionine beta-synthase domain-containing protein, CDCP2, from Arabidopsis thaliana

Real-time imaging of NF-AT nucleocytoplasmic shuttling with a photoswitchable fluorescence protein in live cells

Renal protective effects of toll-like receptor 4 signaling blockade in type 2 diabetic mice.

Ring-shaped architecture of RecR: implications for its role in homologous recombinational DNA repair.

SIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity

Single Cystathionine -Synthase Domain-Containing Proteins Modulate Development by Regulating the Thioredoxin System in Arabidopsis

Structural and Biochemical Analyses of the Eukaryotic Heat Shock Locus V (HslV) from Trypanosoma brucei

Structural and Biochemical Study of the Mono-ADP-Ribosyltransferase Domain of SdeA, a Ubiquitylating/Deubiquitylating Enzyme from Legionella pneumophila

Structural basis for dual specificity of yeast N-terminal amidase in the N-end rule pathway

Structural basis for recognition of autophagic receptor NDP52 by the sugar receptor galectin-8

Structural basis for the N-degron specificity of ClpS1 from Arabidopsis thaliana

Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases

Structural basis of SspB-tail recognition by the zinc binding domain of ClpX

Structural basis of degradation signal recognition by SspB, a specificity-enhancing factor for the ClpXP proteolytic machine

Structural insights into the conformational diversity of ClpP from Bacillus subtilis