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List of works by Anthony Maxwell

A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight into the Mechanism of Inhibition

scientific article

A biochemical analysis of the interaction of DNA gyrase with the bacteriophage Mu, pSC101 and pBR322 strong gyrase sites: the role of DNA sequence in modulating gyrase supercoiling and biological activity

scientific article published in October 2003

A common origin for the bacterial toxin-antitoxin systems parD and ccd, suggested by analyses of toxin/target and toxin/antitoxin interactions

scientific article published in 2012

A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase

scientific article

A fluoroquinolone resistance protein from Mycobacterium tuberculosis that mimics DNA.

scientific article

A high-throughput assay for DNA topoisomerases and other enzymes, based on DNA triplex formation.

scientific article

A model for the mechanism of strand passage by DNA gyrase

scientific article

A monoclonal antibody that inhibits mycobacterial DNA gyrase by a novel mechanism.

scientific article

A mutation in Escherichia coli DNA gyrase conferring quinolone resistance results in sensitivity to drugs targeting eukaryotic topoisomerase II

scientific article

A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance

scientific article published on 10 March 2018

A novel decatenation assay for DNA topoisomerases using a singly-linked catenated substrate

scientific article published on 01 October 2020

A rapid high-resolution method for resolving DNA topoisomers.

scientific article published on 16 January 2018

A single point mutation in the DNA gyrase A protein greatly reduces binding of fluoroquinolones to the gyrase-DNA complex

scientific article published on January 1993

A strand-passage conformation of DNA gyrase is required to allow the bacterial toxin, CcdB, to access its binding site

scientific article published on 8 September 2006

Antibiotic-resistant bacteria in the guts of insects feeding on plants: prospects for discovering plant-derived antibiotics

scientific article published in December 2017

Application of a novel microtitre plate-based assay for the discovery of new inhibitors of DNA gyrase and DNA topoisomerase VI

scientific article

Arabidopsis SPO11-2 functions with SPO11-1 in meiotic recombination

scientific article published in October 2006

Arabidopsis thaliana DNA gyrase is targeted to chloroplasts and mitochondria

scholarly article

Arabidopsis thaliana GYRB3 does not encode a DNA gyrase subunit

scientific article (publication date: 26 March 2010)

BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis

scientific article published on 30 November 2007

Base-pair resolution analysis of the effect of supercoiling on DNA flexibility and major groove recognition by triplex-forming oligonucleotides

scientific article published on 16 February 2021

Characterization of a mitochondrially targeted single-stranded DNA-binding protein in Arabidopsis thaliana.

scientific article published on 3 March 2005

Clerocidin, a terpenoid antibiotic, inhibits bacterial DNA gyrase ⬇️

scientific article published on 01 March 1993

Cloning of the DNA gyrase genes under tac promoter control: overproduction of the gyrase A and B proteins

scientific article published in September 1990

Co-operativity and enzymatic activity in polymer-activated enzymes

scientific article published on 01 July 1986

Conformational Changes in DNA Gyrase Revealed by Limited Proteolysis ⬇️

scientific article published on August 28, 1998

Coupling ATP hydrolysis to DNA strand passage in type IIA DNA topoisomerases.

scientific article

Coupling of the biosynthesis and export of the DNA gyrase inhibitor simocyclinone in Streptomyces antibioticus.

scientific article

Crystal structure of an N-terminal fragment of the DNA gyrase B protein.

scientific article

Crystal structure of the breakage-reunion domain of DNA gyrase

scientific article

Crystallization and preliminary X-ray analysis of a complex formed between the antibiotic simocyclinone D8 and the DNA breakage-reunion domain of Escherichia coli DNA gyrase.

scientific article published on 30 July 2009

Crystallization of Inhibitor Complexes of an N-Terminal 24 kDa Fragment of the DNA Gyrase B Protein

scientific article published on 01 August 1994

DNA G-segment bending is not the sole determinant of topology simplification by type II DNA topoisomerases. ⬇️

scientific article published on 21 August 2014

DNA Gyrase Is the Target for the Quinolone Drug Ciprofloxacin in Arabidopsis thaliana.

scientific article published on 09 December 2015

DNA Topoisomerases

scientific article published on 01 August 2009

DNA cleavage is not required for the binding of quinolone drugs to the DNA gyrase-DNA complex

scientific article

DNA gyrase as a drug target

scientific article

DNA gyrase can cleave short DNA fragments in the presence of quinolone drugs

scientific article published on July 1997

DNA gyrase can supercoil DNA circles as small as 174 base pairs

scientific article published on June 1989

DNA gyrase from the albicidin producer Xanthomonas albilineans has multiple-antibiotic-resistance and unusual enzymatic properties

scientific article published on 11 February 2008

DNA gyrase requires DNA for effective two-site coordination of divalent metal ions: further insight into the mechanism of enzyme action.

scientific article

DNA gyrase: structure and function.

scientific article

DNA supercoiling by DNA gyrase. A static head analysis

scientific article published on January 1988

DNA topoisomerase I and DNA gyrase as targets for TB therapy

scientific article

DNA topology: topoisomerases keep it simple

scientific article published on December 1997

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

scientific article published in February 2018

Dissection of the bacteriophage Mu strong gyrase site (SGS): significance of the SGS right arm in Mu biology and DNA gyrase mechanism

scientific article published on January 2006

Domain Structure of Escherichia coli DNA Gyrase As Revealed by Differential Scanning Calorimetry

scientific article published on 01 June 1994

Energy coupling in DNA gyrase: a thermodynamic limit to the extent of DNA supercoiling

scientific article published on 01 October 1992

Energy coupling in type II topoisomerases: why do they hydrolyze ATP?

scientific article published on 20 June 2007

Enterococcus innesii sp. nov., isolated from the wax moth Galleria mellonella

scholarly article published in 2021

Enzymes that keep DNA under control: Meeting: DNA enzymes: structures and mechanisms

scientific article published in April 2001

Escherichia coli cells resistant to the DNA gyrase inhibitor, ciprofloxacin, overproduce a 60 kD protein homologous to GroEL.

scientific article published in March 1990

Evidence for a conformational change in the DNA gyrase-DNA complex from hydroxyl radical footprinting

scientific article published on May 1994

Evidence for the role of DNA strand passage in the mechanism of action of microcin B17 on DNA gyrase

scientific article

Exploiting Nucleotide Thiophosphates To Probe Mechanistic Aspects ofEscherichia coliDNA Gyrase†

scientific article published on 01 May 1997

Exploiting bacterial DNA gyrase as a drug target: current state and perspectives.

scientific article

Fragments of the bacterial toxin microcin B17 as gyrase poisons

scientific article

Galleria mellonella (greater wax moth) larvae as a model for antibiotic susceptibility testing and acute toxicity trials

scientific article

High-throughput assays for DNA gyrase and other topoisomerases

scientific article published on 26 August 2006

High-throughput microtitre plate-based assay for DNA topoisomerases

scientific article

Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by Gram-negative and Gram-positive type II DNA topoisomerases

scientific article published on 30 August 2007

How do type II topoisomerases use ATP hydrolysis to simplify DNA topology beyond equilibrium? Investigating the relaxation reaction of nonsupercoiling type II topoisomerases

scientific article

Hydrolysis of ATP at Only One GyrB Subunit Is Sufficient to Promote Supercoiling by DNA Gyrase

scientific article published in Journal of Biological Chemistry

Identification of a residue involved in transition-state stabilization in the ATPase reaction of DNA gyrase

scientific article published in July 1998

Identification of four GyrA residues involved in the DNA breakage-reunion reaction of DNA gyrase

scientific article published in April 2002

Identifying the catalytic residue of the ATPase reaction of DNA gyrase

scientific article published on December 1993

Imidazopyrazinones (IPYs): Non-Quinolone Bacterial Topoisomerase Inhibitors Showing Partial Cross-Resistance with Quinolones.

scientific article published on 29 March 2018

Immunogold localization of GyrA and GyrB proteins in Escherichia coli.

scientific article

Increased sensitivity to quinolone antibacterials can be engineered in human topoisomerase IIα by selective mutagenesis

scientific article published on 01 July 2000

Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics.

scientific article

Interaction between DNA gyrase and quinolones: effects of alanine mutations at GyrA subunit residues Ser(83) and Asp(87).

scientific article

Interference between Triplex and Protein Binding to Distal Sites on Supercoiled DNA. ⬇️

scientific article published on 17 January 2017

Lead selection and characterization of antitubercular compounds using the Nested Chemical Library

scientific article published on 28 February 2015

Locking the DNA gate of DNA gyrase: investigating the effects on DNA cleavage and ATP hydrolysis.

scientific article

Mapping DNA Topoisomerase Binding and Cleavage Genome Wide Using Next-Generation Sequencing Techniques

scientific article published on 13 January 2020

Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB.

scientific article published on 26 October 2009

Mass Spectrometry Reveals That the Antibiotic Simocyclinone D8 Binds to DNA Gyrase in a “Bent-Over” Conformation: Evidence of Positive Cooperativity in Binding

article

Mechanistic aspects of DNA topoisomerases.

scientific article published on January 1986

Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase.

scientific article published on February 1996

Modular Structure of the Full-Length DNA Gyrase B Subunit Revealed by Small-Angle X-Ray Scattering

scientific article published on 01 March 2007

Multiple modes of Escherichia coli DNA gyrase activity revealed by force and torque

scientific article published on 4 March 2007

Mycobacterium fluoroquinolone resistance protein B, a novel small GTPase, is involved in the regulation of DNA gyrase and drug resistance ⬇️

scientific article published on December 28, 2012

Neutron and light-scattering studies of DNA gyrase and its complex with DNA.

scientific article published in January 1990

Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins

scientific article published on February 1991

Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90.

scientific article

Nucleotide binding to DNA gyrase causes loss of DNA wrap

scientific article published in March 2004

Nucleotide binding to the 43-kilodalton N-terminal fragment of the DNA gyrase B protein.

scientific article

Overexpression and purification of bacterial DNA gyrase.

scientific article

Oxytetracycline reduces the diversity of tetracycline-resistance genes in the Galleria mellonella gut microbiome

article

Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis

scientific article published on 10 June 2016

Preliminary crystallographic analysis of the ATP-hydrolysing domain of the Escherichia coli DNA gyrase B protein

scientific article published in January 1991

Preliminary crystallographic analysis of the breakage-reunion domain of the Escherichia coli DNA gyrase A protein

scientific article published in October 1990

Probing the Binding of Coumarins and Cyclothialidines to DNA Gyrase†

scientific article published on 01 February 1999

Probing the limits of the DNA breakage-reunion domain of the Escherichia coli DNA gyrase A protein.

scientific article published in February 1991

Probing the role of the ATP-operated clamp in the strand-passage reaction of DNA gyrase

scientific article published on December 1996

Probing the two-gate mechanism of DNA gyrase using cysteine cross-linking.

scientific article

Protein gates in DMA topoisomerase II

scientific article published on 01 February 1996

Quinolone-DNA interaction: sequence-dependent binding to single-stranded DNA reflects the interaction within the gyrase-DNA complex

scientific article

Quinolone-binding pocket of DNA gyrase: role of GyrB.

scientific article published on June 2002

Quinolone-resistant gyrase mutants demonstrate decreased susceptibility to triclosan.

scientific article published in October 2017

Quinolones: Mechanism, Lethality and Their Contributions to Antibiotic Resistance

scientific article published on 01 December 2020

Rotational diffusion of short DNA fragments in polyacrylamide gels: An electric birefringence study

scientific article published on 01 November 1986

SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone.

scientific article published on 8 April 2015

Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action

scientific article published on March 2005

Single-molecule imaging of DNA gyrase activity in living Escherichia coli

scientific article published on 01 January 2019

Small DNA circles as probes of DNA topology

scientific article published on April 2013

Small-angle X-ray scattering reveals the solution structure of the full-length DNA gyrase a subunit.

scientific article

Structural and biochemical analysis of the pentapeptide repeat protein EfsQnr, a potent DNA gyrase inhibitor

scientific article

Structural insights into simocyclinone as an antibiotic, effector ligand, and substrate

scientific article

Structure of the DNA gyrase-DNA complex as revealed by transient electric dichroism

scientific article published on 01 February 1987

Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis

scientific article

Structures of the TetR-like simocyclinone efflux pump repressor, SimR, and the mechanism of ligand-mediated derepression

scientific article

Synthesis of full length and truncated microcin B17 analogues as DNA gyrase poisons.

scientific article published in March 2014

Temperature-sensitive suppressor mutations of the Escherichia coli DNA gyrase B protein

scientific article published on May 2000

The 24 kDa N-terminal sub-domain of the DNA gyrase B protein binds coumarin drugs

scientific article published on 01 May 1994

The 43-kilodalton N-terminal fragment of the DNA gyrase B protein hydrolyzes ATP and binds coumarin drugs

scientific article published in March 1993

The ATP-binding site of type II topoisomerases as a target for antibacterial drugs

scientific article (publication date: 2003)

The ATP-operated clamp of human DNA topoisomerase IIalpha: hyperstimulation of ATPase by "piggy-back" binding

scientific article

The C-terminal domain of the Escherichia coli DNA gyrase A subunit is a DNA-binding protein

scientific article published on April 1991

The DNA Dependence of the ATPase Activity of Human DNA Topoisomerase IIα

scientific article published in Journal of Biological Chemistry

The DNA Gyrase-Quinolone Complex

scientific article published in Journal of Biological Chemistry

The DNA dependence of the ATPase activity of DNA gyrase

scientific article published in Journal of Biological Chemistry

The Effects of Metal Ions on the Structure and Stability of the DNA Gyrase B Protein

scientific article published on 30 September 2005

The Interaction of Coumarin Antibiotics with Fragments of the DNA Gyrase B Protein†

scientific article published on 01 April 1996

The N-Terminal Domain of Human Topoisomerase IIα Is a DNA-Dependent ATPase†

scientific article published on 01 December 1998

The Origins of Specificity in the Microcin-Processing Protease TldD/E.

scientific article

The SalGI restriction endonuclease. Enzyme specificity

scientific article published on April 1982

The SalGI restriction endonuclease. Mechanism of DNA cleavage

scientific article published on April 1982

The SalGI restriction endonuclease. Purification and properties

scientific article published on April 1982

The action of the bacterial toxin microcin B17. Insight into the cleavage-religation reaction of DNA gyrase

scientific article

The action of the bacterial toxin, microcin B17, on DNA gyrase

scientific article

The additional 165 amino acids in the B protein of Escherichia coli DNA gyrase have an important role in DNA binding

scientific article published on July 2000

The ancestral role of ATP hydrolysis in type II topoisomerases: prevention of DNA double-strand breaks

scientific article

The antibiotic microcin B17 is a DNA gyrase poison: characterisation of the mode of inhibition

scientific article published in April 2001

The cleavage of DNA at phosphorothioate internucleotidic linkages by DNA gyrase

scientific article published on July 1992

The complex of DNA gyrase and quinolone drugs on DNA forms a barrier to the T7 DNA polymerase replication complex.

scientific article

The complex of DNA gyrase and quinolone drugs with DNA forms a barrier to transcription by RNA polymerase.

scientific article

The dimer state of GyrB is an active form: implications for the initial complex assembly and processive strand passage ⬇️

scientific article published on July 10, 2011

The interaction of the F plasmid killer protein, CcdB, with DNA gyrase: induction of DNA cleavage and blocking of transcription 1 1J. Karn

scientific article published in November 1997

The key DNA-binding residues in the C-terminal domain of Mycobacterium tuberculosis DNA gyrase A subunit (GyrA).

scientific article published on 11 October 2006

The molecular basis of quinolone action

scientific article published on October 1, 1992

The naphthoquinone diospyrin is an inhibitor of DNA gyrase with a novel mechanism of action.

scientific article published on 28 December 2012

The nature of inhibition of DNA gyrase by the coumarins and the cyclothialidines revealed by X-ray crystallography

scientific article

The phytotoxin albicidin is a novel inhibitor of DNA gyrase.

scientific article published on 30 October 2006

The role of ATP in the reactions of type II DNA topoisomerases

scientific article published on April 2010

The role of Ca²⁺ in the activity of Mycobacterium tuberculosis DNA gyrase.

scientific article published on 27 July 2012

The role of GyrB in the DNA cleavage-religation reaction of DNA gyrase: a proposed two metal-ion mechanism

scientific article published in April 2002

The role of monovalent cations in the ATPase reaction of DNA gyrase

scientific article

Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase

scientific article

Thioredoxin can influence gene expression by affecting gyrase activity.

scientific article published on 24 August 2004

Topoisomerase VI is a chirally-selective, preferential DNA decatenase

scientific article published on 25 January 2022

Topoisomerases. In one gate, out the other

scientific article published on November 1994

Topology simplification: Important biological phenomenon or evolutionary relic?

scientific article published on 09 July 2016

Tryptic fragments of the Escherichia coli DNA gyrase A protein.

scientific article published in November 1989

Use of a rapid throughput in vivo screen to investigate inhibitors of eukaryotic topoisomerase II enzymes

scientific article

Use of divalent metal ions in the DNA cleavage reaction of topoisomerase IV ⬇️

scientific article published on February 7, 2011

gyrB mutations which confer coumarin resistance also affect DNA supercoiling and ATP hydrolysis by Escherichia coli DNA gyrase.

scientific article

gyrB-225, a mutation of DNA gyrase that compensates for topoisomerase I deficiency: investigation of its low activity and quinolone hypersensitivity

scientific article published in June 2001

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