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List of works by Dominic J Wells

"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic

scientific article published on 01 January 2018

A New Extensively Characterised Conditionally Immortal Muscle Cell-Line for Investigating Therapeutic Strategies in Muscular Dystrophies ⬇️

scientific article published on September 14, 2011

Adeno-associated virus vector gene transfer and sarcolemmal expression of a 144 kDa micro-dystrophin effectively restores the dystrophin-associated protein complex and inhibits myofibre degeneration in nude/mdx mice

scientific article published in April 2002

Adenoviral vectors for gene transfer of full-length human dystrophin cDNAs

article

Age and sex influence expression of plasmid DNA directly injected into mouse skeletal muscle

scientific article

Altered secondary myogenesis in transgenic animals expressing the neural cell adhesion molecule under the control of a skeletal muscle alpha-actin promoter

scientific article

An IL-7 fusion protein that shows increased thymopoietic ability

scientific article

Analysis of a 70 kb segment of DNA containing the human zeta and alpha-globin genes linked to their regulatory element (HS-40) in transgenic mice

scientific article published on October 1994

Analysis of the human alpha-globin gene cluster in transgenic mice

scientific article published on December 1993

Animal welfare and the 3Rs in European biomedical research ⬇️

scientific article published on 01 December 2011

Animals with Novel Genes.

scientific article published in December 1995

Assessing the welfare of genetically altered mice.

scientific article

Beyond the vertebrates: achieving maximum power during flight in insects and hummingbirds

scientific article published on 01 January 1994

Characterisation of expression of mDMAHP, a homeodomain-encoding gene at the murine DM locus

scientific article published in May 1997

Characterisation of the pathogenic effects of the in vivo expression of an ALS-linked mutation in D-amino acid oxidase: Phenotype and loss of spinal cord motor neurons

scientific article published in December 2017

Characterization of an evolutionarily conserved far-upstream enhancer in the human alpha 2(I) collagen (COL1A2) gene

scientific article published on 28 March 2001

Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome

scientific article published on 9 December 2005

Chronic systemic therapy with low-dose morpholino oligomers ameliorates the pathology and normalizes locomotor behavior in mdx mice

scientific article

Codon and mRNA Sequence Optimization of Microdystrophin Transgenes Improves Expression and Physiological Outcome in Dystrophic mdx Mice Following AAV2/8 Gene Transfer

article

Cold exposure increases running VO(2max) and cost of transport in goats

scientific article published on 01 January 2001

Cooperativity between far upstream enhancer and proximal promoter elements of the human {alpha}2(I) collagen (COL1A2) gene instructs tissue specificity in transgenic mice

scientific article published on 29 October 2004

Designing translationally relevant preclinical studies of new therapeutics

scientific article published on 6 April 2017

Determination of qPCR Reference Genes Suitable for Normalizing Gene Expression in a Canine Model of Duchenne Muscular Dystrophy.

scientific article published on 26 March 2018

Differential expression and secretion of alpha 1 anti-trypsin between direct DNA injection and implantation of transfected myoblast

scientific article published in June 1999

Direct retroviral-mediated transfer of a dystrophin minigene into mdx mouse muscle in vivo

scientific article published on 01 June 1993

Ectopic expression of NCAM in skeletal muscle of transgenic mice results in terminal sprouting at the neuromuscular junction and altered structure but not function

scientific article published on 01 March 2000

Effect of albumin and dextrose concentration on ultrasound and microbubble mediated gene transfection in vivo.

scientific article published on 12 April 2012

Efficiency of in vivo gene transfer using murine retroviral vectors is strain-dependent in mice

scientific article published on 01 September 1995

Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo

scientific article published on December 2009

Enhanced expression of recombinant dystrophin following intramuscular injection of Epstein-Barr virus (EBV)-based mini-chromosome vectors in mdx mice

scientific article published in July 1999

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

scientific article

Expression of opsin genes early in ocular development of humans and mice.

scientific article

Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A.

scientific article published on 19 June 2008

Focus on the Role of D-serine and D-amino Acid Oxidase in Amyotrophic Lateral Sclerosis/Motor Neuron Disease (ALS).

scientific article

Gene doping: possibilities and practicalities

scientific article published on 17 August 2009

Gene doping: the hype and the reality.

scientific article published on 21 April 2008

Gene expression in skeletal muscle in response to stretch and force generation

scientific article published on March 1, 1992

Gene therapy progress and prospects: electroporation and other physical methods.

scientific article

Genetic correction of dystrophin deficiency and skeletal muscle remodeling in adult MDX mouse via transplantation of retroviral producer cells.

scientific article published on August 1997

Genetic engineering in athletes

scientific article published on 7 July 2008

Genetic treatments in muscular dystrophies

scientific article published on October 2007

Genetically modified animals and pharmacological research

scientific article published on January 2010

Heat shock protein 27 overexpression mitigates cytokine-induced islet apoptosis and streptozotocin-induced diabetes

scientific article published on 26 March 2009

Heat shock protein 27 protects against atherogenesis via an estrogen-dependent mechanism: role of selective estrogen receptor beta modulation.

scientific article published on 3 September 2009

Heat shock protein 27 protects the heart against myocardial infarction

scientific article published on 13 July 2004

Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration

scientific article

Histopathological Evaluation of Skeletal Muscle with Specific Reference to Mouse Models of Muscular Dystrophy.

scientific article published on December 2016

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation

scientific article

Identification and validation of quantitative PCR reference genes suitable for normalizing expression in normal and dystrophic cell culture models of myogenesis

scientific article

Identification of a repressor in the first intron of the human alpha2(I) collagen gene (COL1A2).

scientific article published on 8 August 2005

Identification of qPCR reference genes suitable for normalizing gene expression in the mdx mouse model of Duchenne muscular dystrophy

scientific article published in PLoS ONE

Identification of the key regions within the mouse pro-alpha 2(I) collagen gene far-upstream enhancer

scientific article published on 27 December 2001

Improved gene transfer by direct plasmid injection associated with regeneration in mouse skeletal muscle

scientific article published in October 1993

In silico characterisation and chromosomal localisation of human RRH (peropsin)--implications for opsin evolution

scientific article published on 24 January 2003

Independent regulation of the myotonic dystrophy 1 locus genes postnatally and during adult skeletal muscle regeneration

scientific article published in June 2000

Influence of needle gauge on in vivo ultrasound and microbubble-mediated gene transfection.

scientific article published on 7 July 2011

Insertion of two independent enhancers in the long terminal repeat of a self-inactivating vector results in high-titer retroviral vectors with tissue-specific expression

scientific article published on November 1998

Intramuscular injection of plasmid DNA ⬇️

scientific article published on January 1, 1995

Investigating Synthetic Oligonucleotide Targeting of Mir31 in Duchenne Muscular Dystrophy

scientific article

Investigation of a transgenic mouse model of familial dilated cardiomyopathy.

scientific article published on 17 June 2010

Limitations to aerobic performance in mammals: interaction of structure and demand

scientific article published on 01 June 1988

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

scientific article

Measuring clinical effectiveness of medicinal products for the treatment of Duchenne muscular dystrophy

scientific article

Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice

scientific article

Microbubble stability is a major determinant of the efficiency of ultrasound and microbubble mediated in vivo gene transfer.

scientific article

Molecular Mechanism of the E99K Mutation in Cardiac Actin (ACTC Gene) That Causes Apical Hypertrophy in Man and Mouse ⬇️

scientific article published on May 26, 2011

Muscle moment arms and sensitivity analysis of a mouse hindlimb musculoskeletal model

scientific article published in October 2016

Muscular dystrophies due to glycosylation defects: diagnosis and therapeutic strategies

scientific article published on October 2011

Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb

scientific article

Mutated fukutin-related protein (FKRP) localises as wild type in differentiated muscle cells

scientific article published in October 2005

Olfaction variation in mouse husbandry and its implications for refinement and standardization: UK survey of animal scents.

scientific article published on 20 December 2015

Olfactory variation in mouse husbandry and its implications for refinement and standardization: UK survey of non-animal scents

scientific article published on 10 November 2015

Opening the floodgates: clinically applicable hydrodynamic delivery of plasmid DNA to skeletal muscle.

scientific article published in August 2004

Overexpression of heat shock protein 27 reduces cortical damage after cerebral ischemia

scientific article published on 9 December 2009

Peptide-conjugated antisense therapy takes a skip ahead

scientific article published on 01 September 2008

Physiological characterization of muscle strength with variable levels of dystrophin restoration in mdx mice following local antisense therapy.

scientific article

Poloxamer [corrected] 188 has a deleterious effect on dystrophic skeletal muscle function.

scientific article

Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse

scientific article published on 18 July 2012

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression

scientific article published on 23 December 2007

Relocalization of neuronal nitric oxide synthase (nNOS) as a marker for complete restoration of the dystrophin associated protein complex in skeletal muscle

scientific article published in January 2003

Restoration of dystrophin expression using the Sleeping Beauty transposon.

scientific article

Retroviral-mediated gene transfer into murine and human skeletal muscle for the correction of dystrophin deficiency

scientific article published on 01 May 1996

Role of a 5'-enhancer in the transcriptional regulation of the human endothelial cell protein C receptor gene

scientific article published on 20 April 2006

Running energetics in the pronghorn antelope

scientific article published in Nature

Skeletal muscle mitochondria: the aerobic gate?

scientific article published on January 1988

Stable micro-dystrophin gene transfer using an integrating adeno-retroviral hybrid vector ameliorates the dystrophic pathology in mdx mouse muscle.

scientific article

Structure and evolution of the teleost extraretinal rod-like opsin (errlo) and ocular rod opsin (rho) genes: is teleost rho a retrogene?

scientific article published in June 2003

Sustained transgene expression using non-viral enzymatic systems for stable chromosomal integration.

scientific article published on October 2008

The TREAT-NMD advisory committee for therapeutics (TACT): an innovative de-risking model to foster orphan drug development

scientific article

The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus

scientific journal article

The skeletal muscle phenotype of the DE50-MD dog model of Duchenne muscular dystrophy

scientific article published in 2022

The transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice

scientific article

Therapeutic restoration of dystrophin expression in Duchenne muscular dystrophy.

scientific article published on 28 July 2006

Tracking progress: an update on animal models for Duchenne muscular dystrophy.

scientific article

Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window?

scientific article

Transgenic overexpression of LARGE induces α-dystroglycan hyperglycosylation in skeletal and cardiac muscle

scientific article

Translational and regulatory challenges for exon skipping therapies

scientific article published on October 2014

Transplantation of retroviral producer cells for in vivo gene transfer into mouse skeletal muscle

scientific article published on 01 March 1996

Treatments for muscular dystrophy: increased treatment options for Duchenne and related muscular dystropies

scientific article

What is the level of dystrophin expression required for effective therapy of Duchenne muscular dystrophy?

scientific article published on 01 June 2019

Zebrafish melanopsin: isolation, tissue localisation and phylogenetic position

scientific article published on November 2002

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