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Authors whose works are in public domain in at least one jurisdiction

List of works by Dominic J Wells

1-50 of 101 results

Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

scientific article

Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

scientific article

Gene therapy progress and prospects: electroporation and other physical methods.

scientific article

Gene expression in skeletal muscle in response to stretch and force generation

scientific article published on March 1, 1992

Codon and mRNA Sequence Optimization of Microdystrophin Transgenes Improves Expression and Physiological Outcome in Dystrophic mdx Mice Following AAV2/8 Gene Transfer

article

Chronic systemic therapy with low-dose morpholino oligomers ameliorates the pathology and normalizes locomotor behavior in mdx mice

scientific article

Improved gene transfer by direct plasmid injection associated with regeneration in mouse skeletal muscle

scientific article published in October 1993

Muscular dystrophies due to glycosylation defects: diagnosis and therapeutic strategies

scientific article published on October 2011

Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression

scientific article published on 23 December 2007

Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A.

scientific article published on 19 June 2008

Heat shock protein 27 protects the heart against myocardial infarction

scientific article published on 13 July 2004

Zebrafish melanopsin: isolation, tissue localisation and phylogenetic position

scientific article published on November 2002

Investigation of a transgenic mouse model of familial dilated cardiomyopathy.

scientific article published on 17 June 2010

Adeno-associated virus vector gene transfer and sarcolemmal expression of a 144 kDa micro-dystrophin effectively restores the dystrophin-associated protein complex and inhibits myofibre degeneration in nude/mdx mice

scientific article published in April 2002

Analysis of the human alpha-globin gene cluster in transgenic mice

scientific article published on December 1993

Expression of opsin genes early in ocular development of humans and mice.

scientific article

Molecular Mechanism of the E99K Mutation in Cardiac Actin (ACTC Gene) That Causes Apical Hypertrophy in Man and Mouse

scientific article published on May 26, 2011

Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome

scientific article published on 9 December 2005

Physiological characterization of muscle strength with variable levels of dystrophin restoration in mdx mice following local antisense therapy.

scientific article

Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation

scientific article

Microbubble stability is a major determinant of the efficiency of ultrasound and microbubble mediated in vivo gene transfer.

scientific article

Direct retroviral-mediated transfer of a dystrophin minigene into mdx mouse muscle in vivo

scientific article published on 01 June 1993

Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration

scientific article

Running energetics in the pronghorn antelope

scientific article published in Nature

Analysis of a 70 kb segment of DNA containing the human zeta and alpha-globin genes linked to their regulatory element (HS-40) in transgenic mice

scientific article published on October 1994

Relocalization of neuronal nitric oxide synthase (nNOS) as a marker for complete restoration of the dystrophin associated protein complex in skeletal muscle

scientific article published in January 2003

Age and sex influence expression of plasmid DNA directly injected into mouse skeletal muscle

scientific article

Heat shock protein 27 protects against atherogenesis via an estrogen-dependent mechanism: role of selective estrogen receptor beta modulation.

scientific article published on 3 September 2009

Gene doping: the hype and the reality.

scientific article published on 21 April 2008

Overexpression of heat shock protein 27 reduces cortical damage after cerebral ischemia

scientific article published on 9 December 2009

Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice

scientific article

Genetic treatments in muscular dystrophies

scientific article published on October 2007

Translational and regulatory challenges for exon skipping therapies

scientific article published on October 2014

Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo

scientific article published on December 2009

Altered secondary myogenesis in transgenic animals expressing the neural cell adhesion molecule under the control of a skeletal muscle alpha-actin promoter

scientific article

Characterization of an evolutionarily conserved far-upstream enhancer in the human alpha 2(I) collagen (COL1A2) gene

scientific article published on 28 March 2001

Transgenic overexpression of LARGE induces α-dystroglycan hyperglycosylation in skeletal and cardiac muscle

scientific article

Structure and evolution of the teleost extraretinal rod-like opsin (errlo) and ocular rod opsin (rho) genes: is teleost rho a retrogene?

scientific article published in June 2003

Measuring clinical effectiveness of medicinal products for the treatment of Duchenne muscular dystrophy

scientific article

Characterisation of expression of mDMAHP, a homeodomain-encoding gene at the murine DM locus

scientific article published in May 1997

Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse

scientific article published on 18 July 2012

Identification and validation of quantitative PCR reference genes suitable for normalizing expression in normal and dystrophic cell culture models of myogenesis

scientific article

An IL-7 fusion protein that shows increased thymopoietic ability

scientific article

Genetic correction of dystrophin deficiency and skeletal muscle remodeling in adult MDX mouse via transplantation of retroviral producer cells.

scientific article published on August 1997

The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus

scientific journal article

The transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice

scientific article

Muscle moment arms and sensitivity analysis of a mouse hindlimb musculoskeletal model

scientific article published in October 2016

Transplantation of retroviral producer cells for in vivo gene transfer into mouse skeletal muscle

scientific article published on 01 March 1996

Mutated fukutin-related protein (FKRP) localises as wild type in differentiated muscle cells

scientific article published in October 2005

Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb

scientific article