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List of works by Dominic J Wells

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Exon skipping and dystrophin restoration in patients with Duchenne muscular dystrophy after systemic phosphorodiamidate morpholino oligomer treatment: an open-label, phase 2, dose-escalation study

scientific article
Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

scientific article
Gene therapy progress and prospects: electroporation and other physical methods.

scientific article
Gene expression in skeletal muscle in response to stretch and force generation

scientific article published on March 1, 1992
Codon and mRNA Sequence Optimization of Microdystrophin Transgenes Improves Expression and Physiological Outcome in Dystrophic mdx Mice Following AAV2/8 Gene Transfer

article
Chronic systemic therapy with low-dose morpholino oligomers ameliorates the pathology and normalizes locomotor behavior in mdx mice

scientific article
Improved gene transfer by direct plasmid injection associated with regeneration in mouse skeletal muscle

scientific article published in October 1993
Muscular dystrophies due to glycosylation defects: diagnosis and therapeutic strategies

scientific article published on October 2011
Protective effects of heat shock protein 27 in a model of ALS occur in the early stages of disease progression

scientific article published on 23 December 2007
Extracellular release of the atheroprotective heat shock protein 27 is mediated by estrogen and competitively inhibits acLDL binding to scavenger receptor-A.

scientific article published on 19 June 2008
Heat shock protein 27 protects the heart against myocardial infarction

scientific article published on 13 July 2004
Zebrafish melanopsin: isolation, tissue localisation and phylogenetic position

scientific article published on November 2002
Investigation of a transgenic mouse model of familial dilated cardiomyopathy.

scientific article published on 17 June 2010
Adeno-associated virus vector gene transfer and sarcolemmal expression of a 144 kDa micro-dystrophin effectively restores the dystrophin-associated protein complex and inhibits myofibre degeneration in nude/mdx mice

scientific article published in April 2002
Analysis of the human alpha-globin gene cluster in transgenic mice

scientific article published on December 1993
Expression of opsin genes early in ocular development of humans and mice.

scientific article
Molecular Mechanism of the E99K Mutation in Cardiac Actin (ACTC Gene) That Causes Apical Hypertrophy in Man and Mouse

scientific article published on May 26, 2011
Characterization of the role of gamma2 R531G mutation in AMP-activated protein kinase in cardiac hypertrophy and Wolff-Parkinson-White syndrome

scientific article published on 9 December 2005
Physiological characterization of muscle strength with variable levels of dystrophin restoration in mdx mice following local antisense therapy.

scientific article
Hsp27 overexpression in the R6/2 mouse model of Huntington's disease: chronic neurodegeneration does not induce Hsp27 activation

scientific article
Microbubble stability is a major determinant of the efficiency of ultrasound and microbubble mediated in vivo gene transfer.

scientific article
Direct retroviral-mediated transfer of a dystrophin minigene into mdx mouse muscle in vivo

scientific article published on 01 June 1993
Heat shock protein 27 shows a distinctive widespread spatial and temporal pattern of induction in CNS glial and neuronal cells compared to heat shock protein 70 and caspase 3 following kainate administration

scientific article
Running energetics in the pronghorn antelope

scientific article published in Nature
Analysis of a 70 kb segment of DNA containing the human zeta and alpha-globin genes linked to their regulatory element (HS-40) in transgenic mice

scientific article published on October 1994
Relocalization of neuronal nitric oxide synthase (nNOS) as a marker for complete restoration of the dystrophin associated protein complex in skeletal muscle

scientific article published in January 2003
Age and sex influence expression of plasmid DNA directly injected into mouse skeletal muscle

scientific article
Heat shock protein 27 protects against atherogenesis via an estrogen-dependent mechanism: role of selective estrogen receptor beta modulation.

scientific article published on 3 September 2009
Gene doping: the hype and the reality.

scientific article published on 21 April 2008
Overexpression of heat shock protein 27 reduces cortical damage after cerebral ischemia

scientific article published on 9 December 2009
Metformin treatment has no beneficial effect in a dose-response survival study in the SOD1(G93A) mouse model of ALS and is harmful in female mice

scientific article
Genetic treatments in muscular dystrophies

scientific article published on October 2007
Translational and regulatory challenges for exon skipping therapies

scientific article published on October 2014
Electroporation and ultrasound enhanced non-viral gene delivery in vitro and in vivo

scientific article published on December 2009
Altered secondary myogenesis in transgenic animals expressing the neural cell adhesion molecule under the control of a skeletal muscle alpha-actin promoter

scientific article
Characterization of an evolutionarily conserved far-upstream enhancer in the human alpha 2(I) collagen (COL1A2) gene

scientific article published on 28 March 2001
Transgenic overexpression of LARGE induces α-dystroglycan hyperglycosylation in skeletal and cardiac muscle

scientific article
Structure and evolution of the teleost extraretinal rod-like opsin (errlo) and ocular rod opsin (rho) genes: is teleost rho a retrogene?

scientific article published in June 2003
Measuring clinical effectiveness of medicinal products for the treatment of Duchenne muscular dystrophy

scientific article
Characterisation of expression of mDMAHP, a homeodomain-encoding gene at the murine DM locus

scientific article published in May 1997
Preventing phosphorylation of dystroglycan ameliorates the dystrophic phenotype in mdx mouse

scientific article published on 18 July 2012
Identification and validation of quantitative PCR reference genes suitable for normalizing expression in normal and dystrophic cell culture models of myogenesis

scientific article
An IL-7 fusion protein that shows increased thymopoietic ability

scientific article
Genetic correction of dystrophin deficiency and skeletal muscle remodeling in adult MDX mouse via transplantation of retroviral producer cells.

scientific article published on August 1997
The human ClC-4 protein, a member of the CLC chloride channel/transporter family, is localized to the endoplasmic reticulum by its N-terminus

scientific journal article
The transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice

scientific article
Muscle moment arms and sensitivity analysis of a mouse hindlimb musculoskeletal model

scientific article published in October 2016
Transplantation of retroviral producer cells for in vivo gene transfer into mouse skeletal muscle

scientific article published on 01 March 1996
Mutated fukutin-related protein (FKRP) localises as wild type in differentiated muscle cells

scientific article published in October 2005
Musculoskeletal Geometry, Muscle Architecture and Functional Specialisations of the Mouse Hindlimb

scientific article

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