List of works by Vesa M Olkkonen

A cytosolic splice variant of Cab45 interacts with Munc18b and impacts on amylase secretion by pancreatic acini

scientific article

A loss-of-function variant in OSBPL1A predisposes to low plasma HDL cholesterol levels and impaired cholesterol efflux capacity.

scientific article published on 11 April 2016

A sec1-related vesicle-transport protein that is expressed predominantly in epithelial cells

scientific journal article

A vertebrate model for the study of lipid binding/transfer protein function: conservation of OSBP-related proteins between zebrafish and human.

scientific article published on 8 December 2013

ABC-cassette transporter 1 (ABCA1) expression in epithelial cells in Chlamydia pneumoniae infection

scientific article published on 21 May 2013

ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.

scientific article

Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrin

scientific article

Active and low-active forms of serum phospholipid transfer protein in a normal Finnish population sample

scientific article published in September 2004

Acyl chain and headgroup specificity of human plasma phospholipid transfer protein

scientific article published on 01 October 1996

Adenovirus mediated overexpression of human phospholipid transfer protein alters plasma HDL levels in mice

scientific article published in June 1998

Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects

scientific article

Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3.

scientific article published on 19 January 2013

Altered hepatic lipid status and apolipoprotein A-I metabolism in mice lacking phospholipid transfer protein.

scientific article published on 22 March 2006

Analysis of the Munc18b-syntaxin binding interface. Use of a mutant Munc18b to dissect the functions of syntaxins 2 and 3

scientific article (publication date: 15 November 2002)

Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid uptake but not on beta-oxidation in myotubes

scientific article published in 2012

Apolipoprotein E activates the low-activity form of human phospholipid transfer protein

scientific article published on 01 May 2005

Assays for interaction between Rab7 and oxysterol binding protein related protein 1L (ORP1L).

scientific article published on January 2005

Association between baseline lipoprotein (a) levels and restenosis after coronary stenting: meta-analysis of 9 cohort studies.

scientific article

Bimolecular fluorescence complementation (BiFC) technique in yeast Saccharomyces cerevisiae and mammalian cells.

scientific article

Biosynthesis and secretion of human plasma phospholipid transfer protein.

scientific article published on October 1998

Cab45b, a Munc18b-interacting partner, regulates exocytosis in pancreatic beta-cells.

scientific article published on June 2009

Caspase-2 and p75 neurotrophin receptor (p75NTR) are involved in the regulation of SREBP and lipid genes in hepatocyte cells

scientific article published on 11 July 2019

Characteristics of oxysterol binding proteins.

scientific article published on January 2008

Cholesterol efflux from macrophage foam cells is enhanced by active phospholipid transfer protein through generation of two types of acceptor particles

scientific article published on 27 September 2007

Cholesterol precursors: more than mere markers of biosynthesis

scientific article published on April 2014

Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity

scientific article published on 5 September 2013

Comparison of dorsocervical with abdominal subcutaneous adipose tissue in patients with and without antiretroviral therapy-associated lipodystrophy.

scientific article

Construction of a transducing virus from double-stranded RNA bacteriophage phi6: establishment of carrier states in host cells

scientific article published on January 1992

Cytoplasmic oxysterol-binding proteins: sterol sensors or transporters?

scientific article published on 17 March 2011

Differentiation of human adipose stromal cells in vitro into insulin-sensitive adipocytes

scientific article published on 29 April 2016

Dissecting the role of the golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface.

scientific article published in July 2000

Distribution of phospholipid transfer protein in human plasma: presence of two forms of phospholipid transfer protein, one catalytically active and the other inactive

scientific article published on 01 October 2000

Dynamic changes in mouse lipoproteins induced by transiently expressed human phospholipid transfer protein (PLTP): importance of PLTP in prebeta-HDL generation

scientific article published in April 2001

Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

scientific article published on 5 September 2012

Egg consumption and risk of bladder cancer: a meta-analysis

scientific article

Endogenous plasma membrane t-SNARE syntaxin 4 is present in rab11 positive endosomal membranes and associates with cortical actin cytoskeleton.

scientific article

Expression of exogenous proteins in mammalian cells with the Semliki Forest virus vector.

scientific article published on January 1994

Expression of heterologous proteins in cultured rat hippocampal neurons using the Semliki Forest virus vector

scientific article published in July 1993

Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice

scientific article published on 03 May 2007

Extendable blocking probe in reverse transcription for analysis of RNA variants with superior selectivity.

scientific article

Fibroblast growth factor-21 (FGF21) regulates low-density lipoprotein receptor (LDLR) levels in cells via the E3-ubiquitin ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting saposin-like protein (Msap)

scientific article

Generation of infectious nucleocapsids by in vitro assembly of the shell protein on to the polymerase complex of the dsRNA bacteriophage phi 6.

scientific article published in April 1991

Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss-induced decrease in liver fat in humans

scientific article published on 27 April 2011

Growth differentiation factor-9 induces Smad2 activation and inhibin B production in cultured human granulosa-luteal cells.

scientific article

HMG-17, a chromosomal non-histone protein, shows developmental regulation during organogenesis.

scientific article published in September 1998

Hepatic gene expression and lipid parameters in complement C3(-/-) mice that do not develop ethanol-induced steatosis

scientific article published on 02 January 2007

Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis

scientific article

Identification of urinary Gc-globulin as a novel biomarker for bladder cancer by two-dimensional fluorescent differential gel electrophoresis (2D-DIGE).

scientific article

Impact of non-alcoholic fatty liver disease on liver volume in humans.

scientific article published on 18 July 2014

Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD.

scientific article published on 21 February 2017

Increased atherosclerotic lesions in LDL receptor deficient mice with hematopoietic nuclear receptor Rev-erbα knock- down

scientific article published on 20 August 2013

Interactions of oxysterols with membranes and proteins

scientific article published on 25 February 2009

Involvement of bicarbonate-induced radical signaling in oxysterol formation and sterol depletion of capacitating mammalian sperm during in vitro fertilization.

scientific article

Isolation of a mouse cDNA encoding Rab23, a small novel GTPase expressed predominantly in the brain

scientific article published on January 1994

Isolation of a murine cDNA clone encoding Rab19, a novel tissue-specific small GTPase

scientific article published on April 1995

Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein

scientific article

Ligand-dependent localization and function of ORP-VAP complexes at membrane contact sites.

scientific article

Macrophage oxysterols and their binding proteins: roles in atherosclerosis

scientific article published on October 2012

Mapping of Ras-related GTP-binding proteins by GTP overlay following two-dimensional gel electrophoresis.

scientific article published on August 1994

Membrane insertion and intracellular transport of yeast syntaxin Sso2p in mammalian cells

scientific article published on 01 December 1994

MicroRNA-192* impairs adipocyte triglyceride storage

scientific article published on 30 December 2015

Modification of the lipidome in RAW264.7 macrophage subjected to stable silencing of oxysterol-binding proteins

scientific article published on 16 May 2012

Molecular cloning and functional expression of cDNA encoding the pig plasma phospholipid transfer protein.

scientific article

Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily.

scientific article published on December 1993

Monoclonal antibodies against core and cellulose-binding domains of Trichoderma reesei cellobiohydrolases I and II and endoglucanase I

scientific article published on 01 September 1991

Monoclonal antibodies to the major structural proteins of bacteriophage phi 6

scientific article published on 01 July 1988

Mouse metanephric kidney as a model system for identifying developmentally regulated genes

scientific article published on November 1997

Munc18-2, a functional partner of syntaxin 3, controls apical membrane trafficking in epithelial cells.

scientific article

Munc18b is a major mediator of insulin exocytosis in rat pancreatic β-cells

scientific article

ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion.

scientific article published on 11 August 2012

ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival

scientific article published on September 2016

OSBP-Related Protein Family in Lipid Transport Over Membrane Contact Sites

scientific article

OSBP-Related Protein Family: Mediators of Lipid Transport and Signaling at Membrane Contact Sites.

scientific article published on 18 November 2015

OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi-late endosome interface

scientific article

OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity.

scientific article

OSBP-related protein 8 (ORP8) interacts with Homo sapiens sperm associated antigen 5 (SPAG5) and mediates oxysterol interference of HepG2 cell cycle.

scientific article published on 11 January 2014

OSBP-related protein 8 (ORP8) regulates plasma and liver tissue lipid levels and interacts with the nucleoporin Nup62

scientific article

OSBP-related protein 8 (ORP8) suppresses ABCA1 expression and cholesterol efflux from macrophages

scientific article

OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism

scientific article published on 12 June 2018

OSBP-related proteins (ORPs) in human adipose depots and cultured adipocytes: evidence for impacts on the adipocyte phenotype

scientific article

OSBP-related proteins: liganding by glycerophospholipids opens new insight into their function

scientific article

OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism

scientific article

Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism

scientific article

Overexpression of OSBP-related protein 2 (ORP2) in CHO cells induces alterations of phospholipid species composition

scientific article published in October 2005

Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis.

scientific article

Overproduction, purification, and characterization of DNA-binding protein P19 of bacteriophage PRD1.

scientific article published in April 1993

Oxidative modification of HDL3 in vitro and its effect on PLTP-mediated phospholipid transfer

scientific article published on 01 March 1998

Oxysterol binding protein induces upregulation of SREBP-1c and enhances hepatic lipogenesis.

scientific article

Oxysterol-binding proteins: functions in cell regulation beyond lipid metabolism.

scientific article

Oxysterol-binding proteins: sterol and phosphoinositide sensors coordinating transport, signaling and metabolism

scientific article published on 02 July 2013

Oxysterols and oxysterol binding proteins: role in lipid metabolism and atherosclerosis.

scientific article

Oxysterols and their cellular effectors

scientific article

PLTP secreted by HepG2 cells resembles the high-activity PLTP form in human plasma

scientific article

PNPLA3 is regulated by glucose in human hepatocytes, and its I148M mutant slows down triglyceride hydrolysis

scientific article

PNPLA3 mediates hepatocyte triacylglycerol remodeling

scientific article

Phospholipid transfer is a prerequisite for PLTP-mediated HDL conversion

scientific article published on 01 December 2000

Plant sterols, cholesterol precursors and oxysterols: Minute concentrations-Major physiological effects

scientific article

Plasma phospholipid transfer protein fused with green fluorescent protein is secreted by HepG2 cells and displays phosphatidylcholine transfer activity

scientific article published on April 2006

Prolonged sleep restriction induces changes in pathways involved in cholesterol metabolism and inflammatory responses

scientific article

Protrudin regulates FAK activation, endothelial cell migration and angiogenesis

scientific article published on 04 April 2022

Quantification of human plasma phospholipid transfer protein (PLTP): relationship between PLTP mass and phospholipid transfer activity

scientific article published on 01 August 2000

Quantitation of the active and low-active forms of human plasma phospholipid transfer protein by ELISA

scientific article published on 16 November 2003

Rab8 regulates ABCA1 cell surface expression and facilitates cholesterol efflux in primary human macrophages

scientific article published on 19 March 2009

Regulation of Angiopoietin-Like Proteins (ANGPTLs) 3 and 8 by Insulin

scientific article published on 23 July 2015

Regulation of exocytotic protein expression and Ca2+-dependent peptide secretion in astrocytes.

scientific article

Role of ORPs in sterol transport from plasma membrane to ER and lipid droplets in mammalian cells.

scientific article published on 6 December 2010

Role of Rab GTPases in membrane traffic

scientific article published on January 1997

Selective targeting of avidin/mannose 6-phosphate receptor chimeras to early or late endosomes

scientific article published on 01 July 2000

Semliki Forest virus as a tool for protein expression in cultured rat hippocampal neurons.

scientific article published in January 1994

Sequence of a Human cDNA Encoding Cab45, a Ca2+-Binding Protein with Six EF-Hand Motifs ⬇️

scientific article published on January 1, 1997

Sequence of a canine cDNA clone encoding a Ran/TC4 GTP-binding protein

scientific article published on October 1992

Short-Term Cooling Increases Plasma ANGPTL3 and ANGPTL8 in Young Healthy Lean Men but Not in Middle-Aged Men with Overweight and Prediabetes

scientific article published on 14 August 2019

Silencing of OSBP-related protein 8 (ORP8) modifies the macrophage transcriptome, nucleoporin p62 distribution, and migration capacity

scientific journal article

Splanchnic balance of free fatty acids, endocannabinoids, and lipids in subjects with nonalcoholic fatty liver disease

scientific article published on 27 June 2010

Sterol binding by OSBP-related protein 1L regulates late endosome motility and function

scientific article published on 6 August 2010

Sterol liganding of OSBP-related proteins (ORPs) regulates the subcellular distribution of ORP-VAPA complexes and their impacts on organelle structure.

scientific article

Structure and phospholipid transfer activity of human PLTP: analysis by molecular modeling and site-directed mutagenesis

scientific article published on 01 June 1999

Subfamily III of mammalian oxysterol-binding protein (OSBP) homologues: the expression and intracellular localization of ORP3, ORP6, and ORP7

scientific article

Syntaxin 2 splice variants exhibit differential expression patterns, biochemical properties and subcellular localizations

scientific journal article

Targeting of OSBP-related protein 3 (ORP3) to endoplasmic reticulum and plasma membrane is controlled by multiple determinants.

scientific article

The OSBP-related protein family in humans

scientific article (publication date: August 2001)

The OSBP-related proteins: a novel protein family involved in vesicle transport, cellular lipid metabolism, and cell signalling.

scientific article

The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue

scientific article published on 09 May 2020

The R-Ras interaction partner ORP3 regulates cell adhesion

scientific article published on 12 February 2008

The Rab GTPase family

scientific article published on 27 April 2001

The Sec1/Munc18 Protein Groove Plays a Conserved Role in Interaction with Sec9p/SNAP-25.

scientific article published on 17 November 2015

The effects of VEGF-A on atherosclerosis, lipoprotein profile, and lipoprotein lipase in hyperlipidaemic mouse models

scientific article

The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket

scientific article

The nucleocapsid of bacteriophage phi 6 penetrates the host cytoplasmic membrane

scientific article published on June 1988

The nucleocapsid of the lipid-containing double-stranded RNA bacteriophage phi 6 contains a protein skeleton consisting of a single polypeptide species

scientific article published on August 1987

The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments

scientific article

The two variants of oxysterol binding protein-related protein-1 display different tissue expression patterns, have different intracellular localization, and are functionally distinct

scientific article

Topology of the major capsid protein P3 of bacteriophage PRD1: analysis using monoclonal antibodies and C-terminally truncated proteins.

scientific article

USF1 deficiency activates brown adipose tissue and improves cardiometabolic health

scientific article

Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307.

scientific article published on 11 January 2017

Vesicular transport and kidney development.

scientific article

When intracellular logistics fails--genetic defects in membrane trafficking.

scientific article published on December 2006

Yeast protein translocation complex: isolation of two genes SEB1 and SEB2 encoding proteins homologous to the Sec61 beta subunit

scientific article

[Plant sterols, cholesterol precursors and oxysterols: small amounts, big effects]

scientific article published on 01 January 2015

[Role of oxysterols in atherosclerotic plaque and lipid metabolism]

scientific article published on 01 January 2005

miR-107 inhibits CDK6 expression, differentiation, and lipid storage in human adipocytes

scientific article published on 24 September 2018

Paulina is supported by:

About Paulina

Help