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List of works by Jun Zhou

A novel microtubule-modulating agent EM011 inhibits angiogenesis by repressing the HIF-1α axis and disrupting cell polarity and migration

scientific article

A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering

scientific article

Accurate Quantification of Disease Markers in Human Serum Using Iron Oxide Nanoparticle-linked Immunosorbent Assay

scientific article published on 15 June 2016

Altering microtubule stability affects microtubule clearance and nuclear extrusion during erythropoiesis

scientific article published on 04 April 2019

Apoptosis signal-regulating kinase 1 exhibits oncogenic activity in pancreatic cancer

scientific article published on 17 September 2016

BTat, a trans-acting regulatory protein, contributes to bovine immunodeficiency virus-induced apoptosis

scientific article

CEP70 Protein Interacts with γ-Tubulin to Localize at the Centrosome and Is Critical for Mitotic Spindle Assembly ⬇️

scientific article published on July 27, 2011

CYLD - a deubiquitylase that acts to fine-tune microtubule properties and functions

scientific article

CYLD Regulates Noscapine Activity in Acute Lymphoblastic Leukemia via a Microtubule-Dependent Mechanism.

scientific article

CYLD coordinates with EB1 to regulate microtubule dynamics and cell migration

scientific article published on 21 January 2014

CYLD deficiency promotes pancreatic cancer development by causing mitotic defects

scientific article published on 26 October 2018

CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.

scientific article

CYLD negatively regulates Hippo signaling by limiting Hpo phosphorylation in Drosophila

scientific article published on 6 September 2014

CYLD regulates RhoA activity by modulating LARG ubiquitination

scientific article

CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation

scientific article published on 27 January 2014

Cep70 contributes to angiogenesis by modulating microtubule rearrangement and stimulating cell polarization and migration

scientific article published on 15 April 2012

Cep70 overexpression stimulates pancreatic cancer by inducing centrosome abnormality and microtubule disorganization.

scientific article published on 19 February 2016

Cep70 promotes microtubule assembly in vitro by increasing microtubule elongation

scientific article published on 16 March 2012

Cep70 regulates microtubule stability by interacting with HDAC6.

scientific article

Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabetic complications

scientific article published on 14 November 2018

Ciliopathies: Does HDAC6 Represent a New Therapeutic Target?

scientific article

Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.

scientific article published on 6 August 2015

Deregulated ALG-2/HEBP2 axis alters microtubule dynamics and mitotic spindle behavior to stimulate cancer development

scientific article published on 22 December 2016

Dimethylenastron suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5.

scientific article

Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection

scientific article published in 2023

Diverse roles of HDAC6 in viral infection: Implications for antiviral therapy

scientific article published on 23 April 2016

Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis

scientific article

EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A

scientific article

Ectopic expression of the microtubule-dependent motor protein Eg5 promotes pancreatic tumourigenesis

scientific article published on 01 June 2010

End-binding protein 1 stimulates paclitaxel sensitivity in breast cancer by promoting its actions toward microtubule assembly and stability

scientific article

Endoplasmic reticulum stress, a novel significant mechanism responsible for DEHP-induced increased distance between seminiferous tubule of mouse testis

scientific article published on 15 April 2019

Fully synthetic self-adjuvanting MUC1-fibroblast stimulating lipopeptide 1 conjugates as potential cancer vaccines

scientific article published on 17 August 2016

Functional interplay between cylindromatosis and histone deacetylase 6 in ciliary homeostasis revealed by phenotypic analysis of double knockout mice.

scientific article published on 25 March 2016

HDAC6 deacetylase activity is critical for lipopolysaccharide-induced activation of macrophages

scientific article

HDAC6 regulates neuroblastoma cell migration and may play a role in the invasion process

scientific article published on January 2014

Histone deacetylase 6 and cytoplasmic linker protein 170 function together to regulate the motility of pancreatic cancer cells

scientific article published on 29 January 2014

Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells

scientific article

IFP35 is involved in the antiviral function of interferon by association with the viral tas transactivator of bovine foamy virus

scientific article published on 27 February 2008

Identification of a cytoplasmic linker protein as a potential target for neovascularization

scientific article published on 21 January 2014

Identification of novel microtubule-binding proteins by taxol-mediated microtubule stabilization and mass spectrometry analysis.

scientific article

Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach ⬇️

scientific article published on July 12, 2012

Inhibition of farnesyltransferase reduces angiogenesis by interrupting endothelial cell migration

scientific article published on 22 February 2012

Inhibition of protein deacetylation by trichostatin A impairs microtubule-kinetochore attachment

scientific article published in October 2008

Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells

scientific article

Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability

scientific article

Microtubule stabilization by Mdp3 is partially attributed to its modulation of HDAC6 in addition to its association with tubulin and microtubules

scientific article

Microtubule-Binding Proteins as Promising Biomarkers of Paclitaxel Sensitivity in Cancer Chemotherapy

scientific article

Microtubule-associated deacetylase HDAC6 promotes angiogenesis by regulating cell migration in an EB1-dependent manner.

scientific article published on 25 February 2011

Microtubule-associated protein Mdp3 promotes breast cancer growth and metastasis

scientific article

Microtubule-binding protein CLIP-170 is a mediator of paclitaxel sensitivity

scientific article published on 17 January 2012

Microtubule-dependent retrograde transport of bovine immunodeficiency virus

scientific article

Mixed-lineage leukemia protein 2 suppresses ciliary assembly by the modulation of actin dynamics and vesicle transport

scientific article published on 25 June 2019

Modulation of Eg5 activity contributes to mitotic spindle checkpoint activation and Tat-mediated apoptosis in CD4-positive T-lymphocytes

scientific article published on 28 March 2014

Modulation of multidrug resistance in cancer cells by the E3 ubiquitin ligase seven-in-absentia homologue 1

scientific article published on 01 March 2008

Modulation of the stability and activities of HIV-1 Tat by its ubiquitination and carboxyl-terminal region

scientific article

New HDAC6-mediated deacetylation sites of tubulin in the mouse brain identified by quantitative mass spectrometry

scientific article

Non-toxic melanoma therapy by a novel tubulin-binding agent

scientific article

O-GlcNAc transferase regulates centriole behavior and intraflagellar transport to promote ciliogenesis

scientific article published on 30 June 2020

Oncogenic function of microtubule end-binding protein 1 in breast cancer

scientific article published in February 2010

Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice.

scientific article published in February 2015

PO(2)-dependent differential regulation of multidrug resistance 1 gene expression by the c-Jun NH2-terminal kinase pathway

scientific article published on 23 April 2007

Parkin deficiency contributes to pancreatic tumorigenesis by inducing spindle multipolarity and misorientation.

scientific article published on 7 March 2013

Parkin regulates Eg5 expression by Hsp70 ubiquitination-dependent inactivation of c-Jun NH2-terminal kinase

scientific article

Parkin regulates paclitaxel sensitivity in breast cancer via a microtubule-dependent mechanism

scientific article

Parkin ubiquitinates Drp1 for proteasome-dependent degradation: implication of dysregulated mitochondrial dynamics in Parkinson disease

scientific article

Phosphoregulation of the dimerization and functions of end-binding protein 1

scientific article (publication date: 23 July 2014)

Proteomic Profiling and Functional Characterization of Multiple Post-Translational Modifications of Tubulin

scientific article published on 17 July 2015

Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity.

scientific article

Proto-Oncogenic Src Phosphorylates EB1 to Regulate the Microtubule-Focal Adhesion Crosstalk and Stimulate Cell Migration

scientific article published on 12 September 2016

Reactive oxygen species-induced actin glutathionylation controls actin dynamics in neutrophils

scientific article published on 15 November 2012

Regulation of Tat acetylation and transactivation activity by the microtubule-associated deacetylase HDAC6.

scientific article

Regulation of microtubule assembly and stability by the transactivator of transcription protein of Jembrana disease virus

scientific article

Regulation of tumor angiogenesis by the microtubule-binding protein CLIP-170.

scientific article published on 03 April 2013

Regulation of vascular endothelial cell polarization and migration by Hsp70/Hsp90-organizing protein

scientific article

Reversal of P-glycoprotein-mediated multidrug resistance in cancer cells by the c-Jun NH2-terminal kinase

scientific article published on January 2006

STAT3 association with microtubules and its activation are independent of HDAC6 activity

scientific article

Synthesis and Biological Evaluations of Cytotoxic and Antiangiogenic Triterpenoids-Jacaranone Conjugates

scientific article published on 2 May 2016

Tat acetylation regulates its actions on microtubule dynamics and apoptosis in T lymphocytes

article

The Multifaceted Roles of Primary Cilia in the Regulation of Stem Cell Properties and Functions

scientific article published on 11 November 2016

The Noscapine Chronicle: A Pharmaco-Historic Biography of the Opiate Alkaloid Family and its Clinical Applications

scientific article

The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration.

scientific article published on 24 January 2008

Tumour suppressor CYLD is a negative regulator of the mitotic kinase Aurora-B.

scientific article published in August 2010

Validating the mitotic kinesin Eg5 as a therapeutic target in pancreatic cancer cells and tumor xenografts using a specific inhibitor.

scientific article

Validation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cells

scientific article

p53 and p21 determine the sensitivity of noscapine-induced apoptosis in colon cancer cells

scientific article published on April 2007

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