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List of works by David M. Margolis

A Cure for HIV Infection: "Not in My Lifetime" or "Just Around the Corner"?

scientific article

A limited group of class I histone deacetylases acts to repress human immunodeficiency virus type 1 expression

scientific article published on 11 March 2009

A placebo-controlled pilot study of intensification of antiretroviral therapy with mycophenolate mofetil

scientific article published on 26 May 2006

A prospective evaluation of the effect of atazanavir on the QTc interval and QTc dispersion in HIV-positive patients

article

Acceptability of Long-Acting Injectable Cabotegravir (CAB LA) in HIV-Uninfected Individuals: HPTN 077

scientific article published on 12 February 2020

Activation of CD8+T lymphocytes through the T cell receptor turns on CD4 gene expression: Implications for HIV pathogenesis ⬇️

scientific article published on March 17, 1998

Acute HIV-1 infection in the Southeastern United States: a cohort study

scientific article published on 4 September 2012

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

scientific article

An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients

scientific article (publication date: 2013)

Antiretroviral intensification and valproic acid lack sustained effect on residual HIV-1 viremia or resting CD4+ cell infection

scientific article

Antiretroviral therapy initiated during acute HIV infection fails to prevent persistent T-cell activation

scientific article published on April 2013

Assessing the impact of AGS-004, a dendritic cell-based immunotherapy, and vorinostat on persistent HIV-1 Infection

scientific article published on 20 March 2020

Association of HIV neutralizing antibody with lower viral load after treatment interruption in a prospective trial (A5170)

article

Association of HIV neutralizing antibody with lower viral load after treatment interruption in a prospective trial (A5170).

scientific article

Atazanavir for the treatment of human immunodeficiency virus infection

scientific article

Attacking HIV provirus: therapeutic strategies to disrupt persistent infection

scientific article

Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

scientific article published on 01 February 2020

BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

scientific article

Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation.

scientific article published in January 2017

Bispecific antibody-derived molecules to target persistent HIV infection

scientific article published in 2022

Broadly-specific cytotoxic T cells targeting multiple HIV antigens are expanded from HIV+ patients: implications for immunotherapy

scientific article published on 4 November 2014

CD4+ T-cell decline after the interruption of antiretroviral therapy in ACTG A5170 is predicted by differential expression of genes in the ras signaling pathway

scientific article

CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption

scientific article published on 16 March 2020

Cabotegravir is Not Associated with Weight Gain in HIV-uninfected Individuals in HPTN 077.

scientific article published on 24 May 2019

Cellular gene modulation of HIV infected CD4 T cells in response to serial treatment with the histone deacetylase (HDAC) inhibitor vorinostat

scientific article published on 15 April 2020

Change-point models to estimate the limit of detection

scientific article published on 20 June 2013

Chromatin Regulation and the Histone Code in HIV Latency

Clonal sequences recovered from plasma from patients with residual HIV-1 viremia and on intensified antiretroviral therapy are identical to replicating viral RNAs recovered from circulating resting CD4+ T cells

scientific article

Coaxing HIV-1 from resting CD4 T cells: histone deacetylase inhibition allows latent viral expression

scientific article

Combined approaches for HIV cure

scientific article published on May 2013

Compact quadruple therapy with the lamivudine/zidovudine combination tablet plus abacavir and efavirenz, followed by the lamivudine/zidovudine/abacavir triple nucleoside tablet plus efavirenz in treatment-naïve HIV-infected adults

scientific article published in July 2003

Confronting proviral HIV infection

scientific article published on May 2007

Correction for Garrido et al., "Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal Ex Vivo"

scientific article published on 18 May 2020

Correction: The Effect of Raltegravir Intensification on Low-level Residual Viremia in HIV-Infected Patients on Antiretroviral Therapy: A Randomized Controlled Trial.

scientific article published on 4 August 2011

Corrigendum: The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function

scientific article published on 03 October 2016

Countering HIV - Three's the Charm?

scientific article published in January 2018

Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat

scientific article

Cross-sectional detection of acute HIV infection: timing of transmission, inflammation and antiretroviral therapy

scientific article (publication date: 10 May 2011)

Crotonylation sensitizes IAPi-induced disruption of latent HIV by enhancing p100 cleavage into p52

scientific article published on 18 December 2021

Curing HIV: Pharmacologic approaches to target HIV-1 latency

scientific article published on January 2011

Curing HIV: Seeking to Target and Clear Persistent Infection

scientific article published on 26 March 2020

Cyclosporin A Provides No Sustained Immunologic Benefit to Persons with Chronic HIV‐1 Infection Starting Suppressive Antiretroviral Therapy: Results of a Randomized, Controlled Trial of the AIDS Clinical Trials Group A5138

article

Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader

scientific article published on 09 December 2019

Dendritic Cell Immunotherapy for HIV-1 Infection Using Autologous HIV-1 RNA: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

scientific article published on 8 January 2016

Depletion of latent HIV-1 infection in vivo: a proof-of-concept study

scientific article (publication date: August 2005)

Detection of human immunodeficiency virus RNAs in living cells using Spinach RNA aptamers

scientific article published on 30 November 2016

Detection of nonnucleoside reverse-transcriptase inhibitor-resistant HIV-1 after discontinuation of virologically suppressive antiretroviral therapy

scientific article

Determinants of the efficacy of HIV latency-reversing agents and implications for drug and treatment design

article

Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation

scientific article

Dose proportional inhibition of HIV-1 replication by mycophenolic acid and synergistic inhibition in combination with abacavir, didanosine, and tenofovir

scientific article

Dual-Affinity Re-Targeting proteins direct T cell-mediated cytolysis of latently HIV-infected cells

scientific article

Effect of the weaver (wv) mutation on cerebellar neuron differentiation. I. Qualitative observations of neuron behavior in culture

scientific article published in January 1985

Effect of the weaver (wv) mutation on cerebellar neuron differentiation. II. Quantitation of neuron behavior in culture

scientific article published in January 1985

Efficacy of NNRTI-based antiretroviral therapy initiated during acute HIV infection

scientific article published on April 2011

Eliminating Persistent HIV Infection: Getting to the End of the Rainbow

article

Emerging strategies to deplete the HIV reservoir

scientific article

Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection

scientific article

Epigenetic silencing of HIV-1 by the histone H3 lysine 27 methyltransferase enhancer of Zeste 2.

scientific article

Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors

scientific article published on 26 February 2021

Eradicating HIV-1 infection: seeking to clear a persistent pathogen

scientific article

Eradication Therapies for HIV Infection: Time to Begin Again ⬇️

scientific article published on March 11, 2011

Erratum: Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

scientific article published in Nature

Evaluation of EED Inhibitors as a Class of PRC2-Targeted Small Molecules for HIV Latency Reversal

scientific article published on 29 April 2020

Evidence of dysregulation of dendritic cells in primary HIV infection

scientific article published on 6 August 2010

Ex vivo modeling of the effects of mycophenolic acid on HIV infection: considerations for antiviral therapy.

scientific article published on February 2005

Expanded cytotoxic T-cell lymphocytes target the latent HIV reservoir

scientific article published on 13 January 2015

Expanding community engagement in HIV clinical trials: a pilot study using crowdsourcing

scientific article published on 13 April 2020

Expanding the Menu of HIV Prevention Options: A Qualitative Study of Experiences with Long-Acting Injectable Cabotegravir as PrEP in the Context of a Phase II Trial in the United States

scientific article published on 30 December 2017

Expression of latent HIV induced by the potent HDAC inhibitor suberoylanilide hydroxamic acid

scientific article

Expression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors

scientific article published on September 2009

Fixed-dose combination emtricitabine/tenofovir/efavirenz initiated during acute HIV infection; 96-week efficacy and durability.

scientific article published on 20 September 2016

Forcing an enemy into the open

scientific article published on 01 September 2012

Four Weeks of Treatment With Rifaximin Fails to Significantly Alter Microbial Diversity in Rectal Samples of HIV-Infected Immune Non-Responders (ACTG A5286) Which May be Attributed to Rectal Swab Use

scientific article published on 23 September 2019

Framing expectations in early HIV cure research

scientific article

Generation of HIV latency in humanized BLT mice

scientific article published on 19 October 2011

Glucose production pathways by 2H and 13C NMR in patients with HIV-associated lipoatrophy.

scientific article

Gold nanoparticles to improve HIV drug delivery

scientific article published in July 2015

H3K27 Demethylation at the Proviral Promoter Sensitizes Latent HIV to the Effects of Vorinostat in Ex Vivo Cultures of Resting CD4+ T Cells

scientific article published on 3 June 2015

HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal

scientific article published on 17 August 2017

HIV Latency-Reversing Agents Have Diverse Effects on Natural Killer Cell Function

scientific article published on 21 September 2016

HIV Persistence on Antiretroviral Therapy and Barriers to a Cure

article

HIV antibodies for treatment of HIV infection

scientific article published on January 2017

HIV eradication symposium: will the brain be left behind?

scientific article published on 7 March 2015

HIV latency is reversed by ACSS2-driven histone crotonylation

scientific article published on 19 February 2018

HIV reservoirs: what, where and how to target them

scientific article

HIV-1 expression within resting CD4+ T cells after multiple doses of vorinostat

scientific article

HIV-1 infection, response to treatment and establishment of viral latency in a novel humanized T cell-only mouse (TOM) model

scientific article published on 24 October 2013

HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers

scientific article published on 20 August 2018

HIV-Specific T Cell Responses Are Highly Stable on Antiretroviral Therapy

scientific article published on 14 August 2019

HIV-Specific T Cells Generated from Naive T Cells Suppress HIV In Vitro and Recognize Wide Epitope Breadths

scientific article published on 12 April 2018

HIV-Specific, Ex Vivo Expanded T Cell Therapy: Feasibility, Safety, and Efficacy in ART-Suppressed HIV-Infected Individuals

article

HIV/AIDS. Persistence by proliferation?

scientific article published on July 2014

HLA-B*57 elite suppressor and chronic progressor HIV-1 isolates replicate vigorously and cause CD4+ T cell depletion in humanized BLT mice

scientific article published on 03 January 2014

HSV-1 activation of HIV-1 transcription is augmented by a cellular protein that binds near the initiator element

scientific article

Hexamethylbisacetamide and disruption of human immunodeficiency virus type 1 latency in CD4(+) T cells

scientific article published in April 2008

Hexamethylbisacetamide remodels the human immunodeficiency virus type 1 (HIV-1) promoter and induces Tat-independent HIV-1 expression but blunts cell activation

scientific article

Higher macrophage inflammatory protein (MIP)-1alpha and MIP-1beta levels from CD8+ T cells are associated with asymptomatic HIV-1 infection ⬇️

scientific article published on December 2000

Highlights from the 8th International Workshop on HIV Persistence during Therapy, 12-15 December 2017, Miami, FL, USA.

scientific article published in April 2018

Highlights from the Seventh International Workshop on HIV Persistence during Therapy, 8-11 December 2015, Miami, Florida, USA

scientific article

Highlights of the 9th edition of the Conference on HIV Persistence During Therapy, 10-13 December 2019, Miami, USA

scientific article published on 30 April 2020

Histone deacetylase inhibitors and HIV latency ⬇️

scientific article published on January 1, 2011

Hormonal Contraception Use and Cabotegravir Pharmacokinetics in HIV-Uninfected Women Enrolled in HPTN 077

scientific article published on 21 May 2020

How Might We Cure HIV?

scientific article published on March 2014

How Unavoidable Are Analytical Treatment Interruptions in HIV Cure-Related Studies?

scientific article published on 01 July 2019

Immediate antiviral therapy appears to restrict resting CD4+ cell HIV-1 infection without accelerating the decay of latent infection

scientific article

Immunogenicity of AGS-004 Dendritic Cell Therapy in Patients Treated During Acute HIV Infection

scientific article published on 21 June 2017

Impact of biological sex on immune activation and frequency of the latent HIV reservoir during suppressive antiretroviral therapy

scientific article published on 04 June 2020

Improved Killing of HIV-infected Cells Using Three Neutralizing and Non-neutralizing Antibodies

scientific article published on 25 June 2020

Improved measures of quality of life, lipid profile, and lipoatrophy after treatment interruption in HIV-infected patients with immune preservation: results of ACTG 5170

scientific article

In vivo analysis of the effect of panobinostat on cell-associated HIV RNA and DNA levels and latent HIV infection

scientific article

In-vivo administration of histone deacetylase inhibitors does not impair natural killer cell function in HIV+ individuals

scientific article published on 01 March 2019

Inhibition of HIV fusion with multivalent gold nanoparticles

scientific article published on 13 May 2008

Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated

scientific article

Interleukin-15-Stimulated Natural Killer Cells Clear HIV-1-Infected Cells following Latency Reversal

article

Interleukin-7 induces HIV type 1 outgrowth from peripheral resting CD4+ T cells

scientific article published in August 2004

International AIDS Society global scientific strategy: towards an HIV cure 2016.

scientific article published on 11 July 2016

Interrupting antiretroviral treatment in HIV cure research: scientific and ethical considerations

scientific article published on April 2017

Interruption of antiretroviral treatment in HIV-infected patients with preserved immune function is associated with a low rate of clinical progression: a prospective study by AIDS Clinical Trials Group 5170.

scientific article

Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

scientific article

Latency reversal and viral clearance to cure HIV-1.

scientific article

Latent HIV-1 infection of resting CD4⁺ T cells in the humanized Rag2⁻/⁻ γc⁻/⁻ mouse

scientific article published on 19 October 2011

Lipid abnormalities in HIV/hepatitis C virus-coinfected patients

scientific article published in November 2006

Longitudinal dynamics of intact HIV proviral DNA and outgrowth virus frequencies in a cohort of ART-treated individuals

scientific article published on 20 November 2020

Measuring the Inducible, Replication-Competent HIV Reservoir Using an Ultra-Sensitive p24 Readout, the Digital ELISA Viral Outgrowth Assay

scientific article published on 06 August 2020

Mechanisms of HIV latency: an emerging picture of complexity

scientific article published on February 2010

Mitogen-activated protein kinases regulate LSF occupancy at the human immunodeficiency virus type 1 promoter

scientific article published on May 2005

Multi-omics analyses reveal that HIV-1 alters CD4<sup>+</sup> T cell immunometabolism to fuel virus replication

scientific article published on 25 March 2021

New Frontiers in Measuring and Characterizing the HIV Reservoir

scientific article published on 18 December 2019

No effect of raltegravir intensification on viral replication markers in the blood of HIV-1-infected patients receiving antiretroviral therapy

scientific article

Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine

scientific article published in January 2003

P04-45. Characterization of the plasma cell repertoire in acute HIV-1 infection (AHI).

scientific article published on 22 October 2009

Peripheral Vγ9Vδ2 T Cells Are a Novel Reservoir of Latent HIV Infection

scientific article

Persistent HIV infection in newborns: how soon is soon enough?

scientific article published in April 2014

Pharmaceutical approaches to eradication of persistent HIV infection

scientific article

Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors

scientific article published on 15 September 2004

Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection

scientific article

Precise Quantitation of the Latent HIV-1 Reservoir: Implications for Eradication Strategies

scientific article

Predictors of residual viraemia in patients on long-term suppressive antiretroviral therapy

scientific article published on 22 August 2012

Prospects for treatment of latent HIV.

scientific article

Proviral Latency, Persistent Human Immunodeficiency Virus Infection, and the Development of Latency Reversing Agents.

scientific article

Quantification of the Latent HIV-1 Reservoir Using Ultra Deep Sequencing and Primer ID in a Viral Outgrowth Assay

scientific article published on 27 September 2016

Quantitation of replication-competent HIV-1 in populations of resting CD4+ T cells

scientific article

Radiation-free, alternative-donor HCT for Fanconi anemia patients: results from a prospective multi-institutional study.

scientific article

Reactivation of latent HIV-1 in central memory CD4⁺ T cells through TLR-1/2 stimulation

scientific article published on 24 October 2013

Regimen simplification to atazanavir-ritonavir alone as maintenance antiretroviral therapy after sustained virologic suppression

scientific article published on August 2006

Regimen simplification to atazanavir-ritonavir alone as maintenance antiretroviral therapy: final 48-week clinical and virologic outcomes

scientific article published on March 2009

Reply to Cooper et al

scientific article published on 01 March 2008

Rifaximin has a marginal impact on microbial translocation, T-cell activation and inflammation in HIV-positive immune non-responders to antiretroviral therapy - ACTG A5286.

scientific article

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

scientific article published on 22 January 2020

S021-04 OA. A large-scale analysis of immunoglobulin sequences derived from plasmablasts/plasma cells in acute HIV-1 infection subjects

scientific article published on 22 October 2009

SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

scientific article

SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract

scientific article published on 27 May 2020

SMAC mimetic plus triple combination bispecific HIVxCD3 DART® molecules in SHIV.C.CH505-infected, ART-suppressed rhesus macaques

scientific article published on 19 August 2020

Safety and immunogenicity of a heptavalent pneumococcal conjugate vaccine in infants with human immunodeficiency virus type 1 infection

scientific article published in July 2003

Safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in low-risk HIV-uninfected individuals: HPTN 077, a phase 2a randomized controlled trial

article

Selective HDAC inhibition for the disruption of latent HIV-1 infection

scientific article

Selective targeting of the repressive transcription factors YY1 and cMyc to disrupt quiescent human immunodeficiency viruses

scientific article published on 4 September 2012

Sequence evaluation and comparative analysis of novel assays for intact proviral HIV-1 DNA

scientific article published on 23 December 2020

Single-Cell Analysis of Quiescent HIV Infection Reveals Host Transcriptional Profiles that Regulate Proviral Latency

article

Snapshots: chromatin control of viral infection

scientific article

Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α-producing and partially matured phenotype

scientific article

Suppression of human immunodeficiency virus type 1 (HIV-1) viremia with reverse transcriptase and integrase inhibitors, CD4+ T-cell recovery, and viral rebound upon interruption of therapy in a new model for HIV treatment in the humanized Rag2-/-{ga

scientific article published on 03 June 2009

Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

scientific article published on 22 January 2020

Tail-phase safety, tolerability, and pharmacokinetics of long-acting injectable cabotegravir in HIV-uninfected adults: a secondary analysis of the HPTN 077 trial

scientific article published on 01 June 2020

Targeted cytotoxic therapy kills persisting HIV infected cells during ART

scientific article (publication date: 2014)

Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides

scientific article

Ten Years of Screening and Testing for Acute HIV Infection in North Carolina

scientific article

The Control of HIV After Antiretroviral Medication Pause (CHAMP) Study: Posttreatment Controllers Identified From 14 Clinical Studies

scientific article published on 01 November 2018

The HIV-1 latent reservoir is largely sensitive to circulating T cells

scientific article published on 06 October 2020

The RBD Of The Spike Protein Of SARS-Group Coronaviruses Is A Highly Specific Target Of SARS-CoV-2 Antibodies But Not Other Pathogenic Human and Animal Coronavirus Antibodies

scientific article published on 10 May 2020

The Replication-Competent HIV-1 Latent Reservoir is Primarily Established Near the Time of Therapy Initiation: Supplemental Material for Abrahams et al

article

The challenge of finding a cure for HIV infection

scientific article

The differential short- and long-term effects of HIV-1 latency-reversing agents on T cell function

scientific article published on 02 August 2016

The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial

scientific article

The receptor binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

scientific article published on 01 June 2020

The regulation of HIV-1 gene expression: the emerging role of chromatin

scientific article

The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation

scientific article published on 01 October 2019

The use of beta-D-2,6-diaminopurine dioxolane with or without mycophenolate mofetil in drug-resistant HIV infection

scientific article published in October 2007

Therapy for latent HIV-1 infection: the role of histone deacetylase inhibitors

scientific article published on 29 January 2014

Therapy for persistent HIV.

scientific article

Towards an HIV cure: a global scientific strategy

scientific article

Transactivation of the HIV-1 LTR by HSV-1 immediate-early genes

scientific article published on February 1992

Transcriptomic Analysis Implicates the p53 Signaling Pathway in the Establishment of HIV-1 Latency in Central Memory CD4 T Cells in an In Vitro Model.

scientific article

Translational challenges in targeting latent HIV infection and the CNS reservoir problem

scientific article

Treatment for lipoatrophy: facing the real costs

article published in 2007

Treatment with recombinant growth hormone is associated with modest improvement in CD4 lymphocyte reconstitution in HIV-infected persons on antiretroviral therapy: results of ACTG A5174

scientific article

Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells

scientific article published on June 2008

Vorinostat Renders the Replication-Competent Latent Reservoir of Human Immunodeficiency Virus (HIV) Vulnerable to Clearance by CD8 T Cells

scientific article published on 29 July 2017

c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter

scientific article published on August 2007

γδ T cells: an immunotherapeutic approach for HIV cure strategies

article

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