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List of works by Sharad Kumar

A biochemical analysis of the activation of the Drosophila caspase DRONC.

scientific article

A cytochrome c-free fly apoptosome

scientific article published on 07 April 2006

A defect in DNA topoisomerase II activity in ataxia-telangiectasia cells

scientific article published on November 1987

A direct interaction with NEDD1 regulates gamma-tubulin recruitment to the centrosome

scientific article

A novel Apaf-1-independent putative caspase-2 activation complex

scientific article

A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts

scientific article

A poxvirus bidirectional promoter element with early/late and late functions

scientific article published on November 1990

A single cut to pyroptosis

scientific article published on 16 October 2015

A tumor suppressor function for caspase-2

scholarly article

Activity of a fowlpox virus late gene promoter in vaccinia and fowlpox virus recombinants

scientific article published in January 1990

Age-related proteostasis and metabolic alterations in Caspase-2-deficient mice

scientific article

Akt mediates the effect of insulin on epithelial sodium channels by inhibiting Nedd4-2

scientific journal article

All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+

scientific article (publication date: 30 April 1999)

An arginine-histone methyltransferase, CARMER, coordinates ecdysone-mediated apoptosis in Drosophila cells

scientific article published on 19 February 2004

An essential function for the centrosomal protein NEDD1 in zebrafish development.

scientific article

An essential role for the caspase dronc in developmentally programmed cell death in Drosophila

scientific article published in December 2000

An unexpected role for caspase-2 in neuroblastoma.

scientific article published on 21 August 2014

Analysing caspase activation and caspase activity in apoptotic cells.

scientific article published in January 2009

Analyzing the Response of RNAi-Treated Drosophila Cells to Death Stimuli by Quantitative Real-Time Polymerase Chain Reaction

scientific article

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die

scientific article

Apaf-1/cytochrome c apoptosome: an essential initiator of caspase activation or just a sideshow?

scientific article

Apoptosis regulatory gene NEDD2 maps to human chromosome segment 7q34-35, a region frequently affected in haematological neoplasms

scientific article

Apoptosis. A cinderella caspase takes center stage

scientific article published on August 2002

Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation

scientific article published on 22 June 2021

Arrestin-Domain Containing Protein 1 (Arrdc1) Regulates the Protein Cargo and Release of Extracellular Vesicles

scientific article published on 20 August 2018

Autophagy as a pro-death pathway

scientific article

Autophagy in malignant transformation and cancer progression

scientific article

Autophagy, not apoptosis, is essential for midgut cell death in Drosophila

scientific article published on 08 October 2009

Autophagy-dependent cell death

scientific article published on 19 December 2018

Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors

scientific article published on 4 February 2010

Buffy, a Drosophila Bcl-2 protein, has anti-apoptotic and cell cycle inhibitory functions

scientific article

Caspase 2 in apoptosis, the DNA damage response and tumour suppression: enigma no more?

scientific article

Caspase-2 and the oxidative stress response

scientific article published on 23 January 2015

Caspase-2 as a tumour suppressor

scientific article

Caspase-2 deficiency accelerates chemically induced liver cancer in mice

scientific article published on 12 August 2016

Caspase-2 deficiency enhances whole-body carbohydrate utilisation and prevents high-fat diet-induced obesity

scientific article

Caspase-2 deficiency promotes aberrant DNA-damage response and genetic instability

scientific article

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

scientific article published on 01 August 2002

Caspase-2 is required for cell death induced by cytoskeletal disruption

scientific article

Caspase-2 protects against oxidative stress in vivo

scientific article published on 22 December 2014

Caspase-2 protocols

scientific article published on January 2014

Caspase-2-mediated cell death is required for deleting aneuploid cells

scientific article

Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis

scientific article

Caspases Connect Cell-Death Signaling to Organismal Homeostasis

scientific article

Caspases in Developmental Cell Death

scientific article published in August 1999

Caspases in metabolic disease and their therapeutic potential

scientific article published on 9 May 2018

Cell death by autophagy: facts and apparent artefacts ⬇️

scientific article published on November 4, 2011

Characterization of Autophagic Responses in Drosophila melanogaster

scientific article published on 23 November 2016

Characterization of the Drosophila caspase, DAMM.

scientific article published on 3 May 2001

Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells

scientific article

Chimeric caspase molecules with potent cell killing activity in apoptosis-resistant cells.

scientific article

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

scientific article

Comparative analysis of vaccinia virus promoter activity in fowlpox and vaccinia virus recombinants

scientific article published in April 1990

Conversion of procaspase-3 to an autoactivating caspase by fusion to the caspase-2 prodomain

scientific article published on October 1998

Coupling of histone mRNA levels to radioresistant DNA synthesis in ataxia-telangiectasia cells

scientific article published on 01 January 1987

Cp1/cathepsin L is required for autolysosomal clearance in Drosophila

scientific article published on 28 October 2020

Crosstalk between Dpp and Tor signaling coordinates autophagy-dependent midgut degradation

scientific article published on 08 February 2019

Crosstalk between cGAS-STING signaling and cell death

scientific article published on 18 September 2020

Crystallization and preliminary X-ray diffraction studies of the WW4 domain of the Nedd4-2 ubiquitin-protein ligase

scientific article

DECAY, a novel Drosophila caspase related to mammalian caspase-3 and caspase-7.

scientific article published in October 1999

DRG: a novel developmentally regulated GTP-binding protein

scientific article published on November 30, 1992

DRONC, an ecdysone-inducible Drosophila caspase

scientific article

Dasatinib cellular uptake and efflux in chronic myeloid leukemia cells: therapeutic implications

scientific article

Death to flies: Drosophila as a model system to study programmed cell death

scientific article

Debcl, a proapoptotic Bcl-2 homologue, is a component of the Drosophila melanogaster cell death machinery.

scientific article

Deletion of Nedd4-2 results in progressive kidney disease in mice

scientific article published on September 2017

Developmentally programmed cell death in Drosophila

scientific article published on 27 June 2013

Dietary sodium modulates nephropathy in Nedd4-2-deficient mice

scientific article published on 04 December 2019

Dimerization and autoprocessing of the Nedd2 (caspase-2) precursor requires both the prodomain and the carboxyl-terminal regions

scientific article published on March 1998

Distinct promoter regions regulate spatial and temporal expression of the Drosophila caspase dronc

scientific article published in December 2003

Distinct requirements of Autophagy-related genes in programmed cell death

scientific article

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

scientific article

Dpp regulates autophagy-dependent midgut removal and signals to block ecdysone production

scientific article published on 29 June 2018

Drosophila Ndfip is a novel regulator of Notch signaling

scientific article

Drosophila caspase DRONC is required for specific developmental cell death pathways and stress-induced apoptosis

scientific article

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis.

scientific article published on 29 November 2013

Ecdysone controlled cell and tissue deletion

scientific article published on 19 November 2019

Ecdysone receptor directly binds the promoter of the Drosophila caspase dronc, regulating its expression in specific tissues

scientific article

Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex

scientific article

Ecdysone-mediated programmed cell death in Drosophila

scientific article

Ecdysone-mediated up-regulation of the effector caspase DRICE is required for hormone-dependent apoptosis in Drosophila cells.

scientific article

Enhancing DNA vaccine potency by coadministration of DNA encoding antiapoptotic proteins

scientific article

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.

scientific article

Expression of DRG during murine embryonic development

scientific article

Fat, sex and caspase-2.

scientific article published on 3 March 2016

Functional activation of Nedd2/ICH-1 (caspase-2) is an early process in apoptosis

scientific article published on May 1997

GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2

scientific journal article

Genetic background and tumour susceptibility in mouse models

scientific article published on 26 April 2013

Global ubiquitinome profiling identifies NEDD4 as a regulator of Profilin 1 and actin remodelling in neural crest cells

scientific article published on 19 April 2022

Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes.

scientific article published on 17 April 2009

Hedgehog and Wingless signaling are not essential for autophagy-dependent cell death

scientific article published on 26 October 2018

Heteronuclear Ribonucleoproteins C1 and C2, Components of the Spliceosome, Are Specific Targets of Interleukin 1β-converting Enzyme-like Proteases in Apoptosis

scientific article published in Journal of Biological Chemistry

ICE-like proteases in apoptosis ⬇️

scientific article published on May 1, 1995

Identification of a developmentally regulated gene in the mouse central nervous system which encodes a novel proline rich protein

scientific article (publication date: 20 October 1992)

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

scientific article (publication date: 30 June 1992)

Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4

scientific article

Immunostaining Using an Antibody against Active Caspase-3 to Detect Apoptotic Cells in Drosophila

scientific article published in June 2015

Impaired antioxidant defence and accumulation of oxidative stress in caspase-2-deficient mice

scientific article

Impaired haematopoietic stem cell differentiation and enhanced skewing towards myeloid progenitors in aged caspase-2-deficient mice

scientific article published on December 2016

Inhibition of apoptosis by the expression of antisense Nedd2.

scientific article published on July 1995

Insect Caspases

scholarly article published 2013

Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation

scientific article

K-29 linked ubiquitination of Arrdc4 regulates its function in extracellular vesicle biogenesis

scientific article published on 01 February 2022

Larval midgut destruction in Drosophila: not dependent on caspases but suppressed by the loss of autophagy.

scientific article published on 11 January 2010

Learning, memory and long-term potentiation are altered in Nedd4 heterozygous mice

scientific article published on 25 January 2016

Loss of caspase-2 augments lymphomagenesis and enhances genomic instability in Atm-deficient mice.

scientific article

Mammalian HECT ubiquitin-protein ligases: Biological and pathophysiological aspects ⬇️

scientific article published on March 29, 2013

Mapping of a major early/late gene of fowlpox virus

scientific article published on February 1990

Methods and protocols for studying cell death in Drosophila

scientific article

Molecular definitions of autophagy and related processes.

scientific article published on 08 June 2017

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

scientific article (publication date: 2012)

Molecular determinants of the subcellular localization of the Drosophila Bcl-2 homologues DEBCL and BUFFY.

scientific article published on 5 January 2007

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

scientific article

N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein

scientific journal article

N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking

scientific article

NEDD1: function in microtubule nucleation, spindle assembly and beyond

scientific article published on September 2006

NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins

scientific article

NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity

scientific article

NEDD4-2-dependent control of Na+ homeostasis and renal disease

scientific article published on 6 November 2017

NEDD4: The founding member of a family of ubiquitin-protein ligases

scientific article published on 17 December 2014

Na(+)-H(+) exchange in salivary secretory cells is controlled by an intracellular Na(+) receptor

scientific article

Na+ and K+ transport in Nitrosomonas europaea and Nitrobacter agilis

scientific article published on 01 June 1984

Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells

scientific article published on 13 January 2014

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia

scientific article published on 2 January 2012

Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis

scientific article published on 19 October 2010

Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver

scientific article published on 6 April 2016

Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development

scientific journal article

Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

scientific article

Nedd4 controls animal growth by regulating IGF-1 signaling

scientific article

Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins

scientific article published on 25 September 2008

Nedd4 mediates control of an epithelial Na+ channel in salivary duct cells by cytosolic Na+

scientific article

Nedd4-2 (NEDD4L) controls intracellular Na(+)-mediated activity of voltage-gated sodium channels in primary cortical neurons

scientific article

Nedd4-2 functionally interacts with ClC-5: involvement in constitutive albumin endocytosis in proximal tubule cells

scientific article

Nedd4-WW domain-binding protein 5 (Ndfip1) is associated with neuronal survival after acute cortical brain injury.

scientific article

Nedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions

scientific article

New insights into apoptosome structure and function

scientific article published on 15 May 2018

Old, new and emerging functions of caspases

scientific article

Patch-clamp studies on epithelial sodium channels in salivary duct cells

scientific article

Peripubertal high-fat diet promotes c-Myc stabilization in mammary gland epithelium

scientific article published on 29 June 2020

Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion

scientific article published on 21 July 2020

Phosphorylation by Aurora B kinase regulates caspase-2 activity and function

scientific article published on 18 August 2020

Physiological Functions of Nedd4-2: Lessons from Knockout Mouse Models

scientific article published on 29 June 2018

Prevalence of ocular signs and subclinical vitamin A deficiency and its determinants among rural pre-school children in India

scientific article

Prodomain-dependent nuclear localization of the caspase-2 (Nedd2) precursor. A novel function for a caspase prodomain

scientific article published on September 1998

Prodomains--adaptors--oligomerization: the pursuit of caspase activation in apoptosis.

scientific article

Putative functions of caspase-2 ⬇️

scientific article published on December 15, 2009

Rearrangements of T-cell receptor beta-chain genes in human leukaemias

scientific article

Recombinant caspase-3 expressed in Pichia pastoris is fully activated and kinetically indistinguishable from the native enzyme.

scientific article published in September 1997

Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins

scientific article

Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2.

scientific article

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

scientific article

Regulation of the divalent metal ion transporter via membrane budding.

scientific article published on 21 June 2016

Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11.

scientific article

Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein

scientific journal article

Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by serum- and glucocorticoid-regulated kinase-1.

scientific article published on 7 May 2008

Regulation of the voltage-gated K(+) channels KCNQ2/3 and KCNQ3/5 by ubiquitination. Novel role for Nedd4-2

scientific journal article

Relationship between growth arrest and autophagy in midgut programmed cell death in Drosophila

scientific article

Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension

scientific article

Respiratory distress and perinatal lethality in Nedd4-2-deficient mice

scientific article

Retromer regulates the lysosomal clearance of MAPT/tau

scientific article published on 22 September 2020

Ribophagy: new receptor discovered

scholarly article by Donna Denton published in July 2018

Role of Bcl-2 family of proteins in malignancy

scientific article

Role of multiple cellular proteases in the execution of programmed cell death.

scientific article published on November 1995

Role of prodomain in importin-mediated nuclear localization and activation of caspase-2

scientific journal article

STRICA, a novel Drosophila melanogaster caspase with an unusual serine/threonine-rich prodomain, interacts with DIAP1 and DIAP2.

scientific article

Sex-specific alterations in glucose homeostasis and metabolic parameters during ageing of caspase-2-deficient mice

scientific article published on 29 February 2016

Short-term intense Bcr-Abl kinase inhibition with nilotinib is adequate to trigger cell death in BCR-ABL(+) cells

scientific article published on 5 March 2009

Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition

scientific article published on 17 January 2006

Structure of the Drosophila Apoptosome at 6.9 Å Resolution

scientific article

Studying Apoptosis in Drosophila

scientific article

Subtle gait abnormalities in Nedd4 heterozygous mice

scientific article published on 23 November 2013

TRIM21 Is Targeted for Chaperone-Mediated Autophagy during Salmonella Typhimurium Infection

scientific article published on 18 September 2020

Targeted disruption of caspase genes in mice: what they tell us about the functions of individual caspases in apoptosis.

scientific article

Terminal Deoxynucleotidyl Transferase (TdT)-Mediated dUTP Nick-End Labeling (TUNEL) for Detection of Apoptotic Cells in Drosophila

scientific article published in June 2015

The Apoptosis-inducing Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Analog E21R Functions through Specific Regions of the Heterodimeric GM-CSF Receptor and Requires Interleukin-1β-converting Enzyme-like Proteases

scientific article published in Journal of Biological Chemistry

The Drosophila ZNRF1/2 homologue, detour, interacts with HOPS complex and regulates autophagy

scientific article published in 2024

The Drosophila melanogaster Apaf-1 homologue ARK is required for most, but not all, programmed cell death ⬇️

scientific article

The Nedd4-2/Ndfip1 axis is a negative regulator of IgE-mediated mast cell activation

scientific article published on 27 October 2016

The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel

scientific article

The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism

scientific article published on 20 March 2009

The apical caspase dronc governs programmed and unprogrammed cell death in Drosophila

scientific article published in December 2004

The apoptotic cysteine protease CPP32.

scientific article published on March 1997

The biochemical mechanism of caspase-2 activation

scientific article published on November 2004

The histone deacetylase SIRT2 stabilizes Myc oncoproteins

scientific article

The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels

scholarly article

The role of cytochrome c in caspase activation in Drosophila melanogaster cells

scientific article

The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd

scientific article

The two cytochrome c species, DC3 and DC4, are not required for caspase activation and apoptosis in Drosophila cells

scientific article

The ubiquitin ligase NEDD4-2/NEDD4L regulates both sodium homeostasis and fibrotic signaling to prevent end-stage renal disease

scientific article published on 14 April 2021

The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties

scientific article

The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels

scientific article

The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities

scientific article published on 22 November 2005

Ticket to a bubble ride: Cargo sorting into exosomes and extracellular vesicles

scientific article published on 26 February 2019

Transcriptional control of the core cell-death machinery

scientific article published on April 2004

Transcriptome profiling of caspase-2 deficient EμMyc and Th-MYCN mouse tumors identifies distinct putative roles for caspase-2 in neuronal differentiation and immune signaling

scientific article published on 22 January 2019

UTX coordinates steroid hormone-mediated autophagy and cell death

scientific article published on January 2013

Ubiquitination and the Regulation of Membrane Proteins

scientific article published on January 2017

Using Synthetic Peptide Substrates to Measure Drosophila Caspase Activity

scientific article published in July 2015

Using the vital dye acridine orange to detect dying cells in Drosophila

scientific article published in June 2015

cDNA Cloning, Expression Analysis, and Mapping of the MouseNedd4Gene

article

cDNA cloning, expression analysis, and mapping of the mouse Nedd4 gene.

scientific article

dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes

scientific article published on August 2008

mGrb10 interacts with Nedd4

scientific journal article

p53 accumulation following cytokinesis failure in the absence of caspase-2

scholarly article by Yoon Lim published in November 2018

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