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List of works by Geir Slupphaug

22 DNA repair and cancer

A Combined Nuclear and Nucleolar Localization Motif in Activation-Induced Cytidine Deaminase (AID) Controls Immunoglobulin Class Switching

scientific article published on 23 November 2012

A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA

scientific article

A robust, sensitive assay for genomic uracil determination by LC/MS/MS reveals lower levels than previously reported

scientific article published on 3 June 2013

AID expression in B-cell lymphomas causes accumulation of genomic uracil and a distinct AID mutational signature.

scientific article

Aerobic interval training reduces inducible ventricular arrhythmias in diabetic mice after myocardial infarction

scientific article published on 26 June 2015

AlkB demethylases flip out in different ways

scientific article published on 06 September 2008

Alkylation damage in DNA and RNA--repair mechanisms and medical significance

scientific article published in November 2004

An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells

scientific article

Analysis of uracil-DNA glycosylases from the murine Ung gene reveals differential expression in tissues and in embryonic development and a subcellular sorting pattern that differs from the human homologues

scientific journal article

Antibody cross-linking and target elution protocols used for immunoprecipitation significantly modulate signal-to noise ratio in downstream 2D-PAGE analysis

scientific article

Atrial myocyte function and Ca2+ handling is associated with inborn aerobic capacity

scientific article

B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil

scientific article

Backbone (1)H, (13)C and (15)N chemical shift assignment of full-length human uracil DNA glycosylase UNG2.

scientific article

Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.

scientific article

Base excision repair of DNA in mammalian cells

scientific article

Cell cycle regulation and in vitro hybrid arrest analysis of the major human uracil-DNA glycosylase

scientific article

Cell cycle regulation and subcellular localization of the major human uracil-DNA glycosylase

scientific article

Cell cycle regulation of human DNA repair and chromatin remodeling genes

scientific article

Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA.

scientific article

Changes in cellular signaling proteins in extracts from A549, H460, and U2OS cells treated with cisplatin or docetaxel

scientific article published on 18 March 2017

Characterization of the proteome and lipidome profiles of human lung cells after low dose and chronic exposure to multiwalled carbon nanotubes

scientific article

Characterization of the uracil-DNA glycosylase activity of Epstein-Barr virus BKRF3 and its role in lytic viral DNA replication

scientific article published on 15 November 2006

Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase.

scientific article

Consensus sequences for good and poor removal of uracil from double stranded DNA by uracil-DNA glycosylase

scientific article published on May 1993

Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis

scientific article

Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA

scientific article

DNA glycosylases in the base excision repair of DNA

scientific article published on July 1997

DNA-uracil and human pathology

scientific article published on 18 May 2007

Divergent ß-hairpins determine double-strand versus single-strand substrate recognition of human AlkB-homologues 2 and 3

scientific article

Eating behavior and glucagon-like peptide-1-producing cells in interposed ileum and pancreatic islets in rats subjected to ileal interposition associated with sleeve gastrectomy

scientific article published in January 2013

Enhanced base excision repair capacity in carotid atherosclerosis may protect nuclear DNA but not mitochondrial DNA.

scientific article published on 2 July 2016

Error-free versus mutagenic processing of genomic uracil--relevance to cancer

scientific article

Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase

scientific article

Expression of O6-methylguanine-DNA methyltransferase and uracil-DNA glycosylase in human placentae from smokers and non-smokers

scientific article published on 01 October 1992

Fading correction for fluorescence quantitation in confocal microscopy

scientific article published on March 1996

Genomic uracil and human disease

scientific article

Glucocorticoids inhibit the production of IL6 from monocytes, endothelial cells and fibroblasts

scientific article published on November 1990

HDACi mediate UNG2 depletion, dysregulated genomic uracil and altered expression of oncoproteins and tumor suppressors in B- and T-cell lines

scientific article published on 07 April 2020

Hexyl aminolevulinate and light induces posttranslational modifications of proteins in different cell pathways

Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage

scientific article

Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA

scientific article

Human Uracil-DNA Glycosylase

Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA

scientific article (publication date: 20 February 2003)

Human immunodeficiency virus type 1 Vpr modulates cellular expression of UNG2 via a negative transcriptional effect

scientific article published on 22 July 2009

Human mitochondrial uracil-DNA glycosylase preform (UNG1) is processed to two forms one of which is resistant to inhibition by AP sites

scientific article published on November 1998

Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination

scientific article published on 7 September 2003

Identification of a novel in vivo virus-targeted phosphorylation site in interferon regulatory factor-3 (IRF3)

scientific article

Identification of a novel, widespread, and functionally important PCNA-binding motif

scientific article

Immunocytochemical localization of myrosinase in Brassica napus L

scientific article published on 01 January 1990

LEUCINE-272-ALANINE URACIL-DNA GLYCOSYLASE BOUND TO ABASIC SITE-CONTAINING DNA

scholarly article published 6 May 1999

Low Incorporation of dUMP by Some Thermostable DNA Polymerases May Limit Their Use in PCR Amplifications

scientific article published in 1993

Modulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cells

scientific article

Monoclonal B-cell hyperplasia and leukocyte imbalance precede development of B-cell malignancies in uracil-DNA glycosylase deficient mice

scientific article published on 19 September 2005

NEIL1 Is the Major DNA Glycosylase that Processes 5-Hydroxyuracil in the Proximity of a DNA Single-Strand Break

scientific article published in 2007

NEIL3-Dependent Regulation of Cardiac Fibroblast Proliferation Prevents Myocardial Rupture

scientific article published on January 2017

Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice

scientific article published on 22 June 2016

Novel UCHL1 mutations reveal new insights into ubiquitin processing

scientific article published on 22 December 2016

Novel UCHL1 mutations reveal new insights into ubiquitin processing.

scientific article

Novel activities of human uracil DNA N-glycosylase for cytosine-derived products of oxidative DNA damage

scientific journal article

Novel aspects of macromolecular repair and relationship to human disease

scientific article published on 24 February 2004

Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene

scientific article

Nuclear and mitochondrial splice forms of human uracil-DNA glycosylase contain a complex nuclear localisation signal and a strong classical mitochondrial localisation signal, respectively

scientific article published on October 1998

Off-target responses in the HeLa proteome subsequent to transient plasmid-mediated transfection

scientific article published on 5 November 2014

On-column trypsinization allows for re-use of matrix in modified multiplexed inhibitor beads assay

scientific article published on 3 February 2017

Opposite-base dependent excision of 5-formyluracil from DNA by hSMUG1.

scientific article

Partial characterisation of gelatinolytic activities in herring (Clupea harengus) and sardine (Sardina pilchardus) possibly involved in post-mortem autolysis of ventral muscle

article published in 2010

Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways

scientific article published on 30 March 2011

Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins

scientific article published on 8 January 2016

Post-replicative base excision repair in replication foci

scientific article

Preface

Properties and functions of human uracil-DNA glycosylase from the UNG gene

scientific article

Properties of a Recombinant Human Uracil-DNA Glycosylase from the UNG Gene and Evidence that UNG Encodes the Major Uracil-DNA Glycosylase

article

Protein phosphatase 2A holoenzyme is targeted to peroxisomes by piggybacking and positively affects peroxisomal β-oxidation

scientific article published on 08 December 2014

Proteome alterations associated with transformation of multiple myeloma to secondary plasma cell leukemia

scientific article published on 27 December 2016

Pso p27, a SERPINB3/B4-derived protein, is most likely a common autoantigen in chronic inflammatory diseases

scientific article published on 15 November 2016

Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates

scientific article published on 9 June 2015

Psoriasis pathogenesis — Pso p27 is generated from SCCA1 with chymase

scholarly article by Hilde Lysvand published in May 2014

Purification, Characterization and Partial Amino Acid Sequencing of β-thioglucosidase from Brassica napus L

article by Atle Bones & Geir Slupphaug published August 1989 in The Journal of Plant Physiology

RNA base damage and repair

scientific article published on December 2007

Repair of U/G and U/A in DNA by UNG2-associated repair complexes takes place predominantly by short-patch repair both in proliferating and growth-arrested cells

scientific article published on 12 October 2004

Strikingly different properties of uracil-DNA glycosylases UNG2 and SMUG1 may explain divergent roles in processing of genomic uracil

scientific article

Structural basis for the removal and exclusion of uracil from DNA

article published in 1996

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

scientific article published on 16 December 2015

The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA.

scientific article

The interacting pathways for prevention and repair of oxidative DNA damage

scientific article published on October 2003

The rate of base excision repair of uracil is controlled by the initiating glycosylase

scientific article

Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair.

scientific article published in September 2004

UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation

scientific article

Uracil DNA N-glycosylase promotes assembly of human centromere protein A

scientific article (publication date: 2011)

Uracil in DNA and its processing by different DNA glycosylases

scientific article

Uracil in DNA--general mutagen, but normal intermediate in acquired immunity

scientific article

Uracil in DNA--occurrence, consequences and repair

scientific article

Uracil-DNA glycosylase (UNG)-deficient mice reveal a primary role of the enzyme during DNA replication

scientific article

Uracil-DNA glycosylase in base excision repair and adaptive immunity: species differences between man and mouse.

scientific article

Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects

scientific article

Uracil-DNA glycosylases SMUG1 and UNG2 coordinate the initial steps of base excision repair by distinct mechanisms

scientific article

XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage

scientific article

Xenopus CENP-A assembly into chromatin requires base excision repair proteins

scientific article published in July 2005

[DNA repair enzymes and their genes]

scientific article published on 01 May 1998

hUNG2 is the major repair enzyme for removal of uracil from U:A matches, U:G mismatches, and U in single-stranded DNA, with hSMUG1 as a broad specificity backup

scientific article

mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored

scientific article

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