List of works - Quentin Kaas

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

scientific article published on 27 March 2020

A new "era" for cyclotide sequencing.

scientific article

A novel 4/7-conotoxin LvIA from Conus lividus that selectively blocks 3 2 vs. 6/ 3 2 3 nicotinic acetylcholine receptors

scientific article

A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein

scientific article published on 25 July 2019

A systematic approach to document cyclotide distribution in plant species from genomic, transcriptomic, and peptidomic analysis

scientific article published in September 2013

Accurate de novo design of hyperstable constrained peptides

scientific article

Analysis and classification of circular proteins in CyBase

scientific article published in 2010

ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures

scientific article

ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins.

scientific article

ArachnoServer: a database of protein toxins from spiders

scientific article

Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer

scientific article published on 28 August 2017

Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods.

scientific article

Bioinformatics-Aided Venomics

scientific article published on 11 June 2015

Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations

scientific article published on March 3, 2011

Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.

scientific article published on 13 July 2015

Computational Studies of Snake Venom Toxins.

scientific article published on 22 December 2017

Conformational Flexibility Is a Determinant of Permeability for Cyclosporin.

scientific article published on 5 February 2018

ConoServer, a database for conopeptide sequences and structures

scientific article published on 06 December 2007

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

scientific article

Conopeptide characterization and classifications: an analysis using ConoServer

scientific article

Conotoxins: Chemistry and Biology

scientific article published on 21 October 2019

Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat

scientific article

Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain

scientific article

Cyclization of conotoxins to improve their biopharmaceutical properties.

scientific article published on 10 December 2010

Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom

scientific article

Delineation of the Unbinding Pathway of α-Conotoxin ImI from the α7 Nicotinic Acetylcholine Receptor ⬇️

scientific article published on May 18, 2012

Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold

scientific article

Despite a Conserved Cystine Knot Motif, Different Cyclotides Have Different Membrane Binding Modes

scientific article

Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor

scientific article published on 29 April 2013

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

scientific article published on 31 March 2018

Development of efficient docking strategies and structure-activity relationship study of the c-Met type II inhibitors

scientific article published on 11 May 2017

Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus

scientific article published on 15 May 2020

Discovery, synthesis, and structure-activity relationships of conotoxins.

scientific article published on 10 April 2014

Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor

scientific article published on 21 August 2018

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

scientific article published on 18 December 2015

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

scientific article

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3.

scientific article published on 22 February 2013

Engineering of conotoxins for the treatment of pain

scientific article published on December 2011

Enhanced Activity against Multidrug-Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway

scientific article published on 14 February 2020

High-affinity cyclic peptide matriptase inhibitors

scientific article published on 2 April 2013

High-resolution X-ray structure of the unexpectedly stable dimer of the [Lys(-2)-Arg(-1)-des(17-21)]endothelin-1 peptide

scientific article published on 01 December 2004

IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN.

scientific article published on January 2005

IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains

scientific article

IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm

scientific article published on 11 September 2007

IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T cell receptors, MHC, IgSF and MhcSF.

scientific article

IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, T cell receptor and MHC structural data

scientific article

Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis

scientific article

In Silico Design of MDM2-Targeting Peptides from a Naturally Occurring Constrained Peptide

scientific article published on 18 September 2019

Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor

scientific article published on 17 May 2019

KNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007

scientific article

Key residues in the nicotinic acetylcholine receptor β2 subunit contribute to α-conotoxin LvIA binding.

scientific article

Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1.

scientific article

Lysine-rich Cyclotides: A New Subclass of Circular Knotted Proteins from Violaceae

scientific article published on 31 August 2015

Modelling the interactions between animal venom peptides and membrane proteins

scientific article published in August 2017

Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases.

scientific article published on 20 June 2018

Molecular basis for the resistance of an insect chymotrypsin to a potato type II proteinase inhibitor

scientific article

Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor

scientific article published on 07 June 2019

NMR of plant proteins

scientific article published on 31 January 2013

Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR

scientific article published on 31 May 2019

Precursor De13.1 from Conus delessertii defines the novel G gene superfamily.

scientific article published on 20 January 2013

Prediction and characterization of cyclic proteins from sequences in three domains of life

scientific article published on 10 May 2013

Prediction of disulfide dihedral angles using chemical shifts

scientific article published on 05 July 2018

Role of CysI–CysIII Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors.

scientific article published on 17 August 2017

SCORE: predicting the core of protein models

scientific article published in June 2001

Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist

scientific article published on 09 October 2018

Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB

scientific article published on 21 July 2018

Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene

scientific article published on 12 May 2020

Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA

scientific article published on 07 February 2020

The KNOTTIN website and database: a new information system dedicated to the knottin scaffold.

scientific article

The [Lys(-2)-Arg(-1)-des(17-21)]-endothelin-1 peptide retains the specific Arg(-1)-Asp8 salt bridge but reveals discrepancies between NMR data and molecular dynamics simulations.

scientific article

The evolution of Momordica cyclic peptides

scientific article

Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity

scientific article published on 16 September 2013

α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors

scientific article published on 12 June 2017

αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.

scientific article published on 14 April 2017

List of works by Quentin Kaas

A bifunctional asparaginyl endopeptidase efficiently catalyzes both cleavage and cyclization of cyclic trypsin inhibitors

A new "era" for cyclotide sequencing.

A novel 4/7-conotoxin LvIA from Conus lividus that selectively blocks 3 2 vs. 6/ 3 2 3 nicotinic acetylcholine receptors

A suite of kinetically superior AEP ligases can cyclise an intrinsically disordered protein

A systematic approach to document cyclotide distribution in plant species from genomic, transcriptomic, and peptidomic analysis

Accurate de novo design of hyperstable constrained peptides

Analysis and classification of circular proteins in CyBase

ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures

ArachnoServer 3.0: an online resource for automated discovery, analysis and annotation of spider toxins.

ArachnoServer: a database of protein toxins from spiders

Backbone cyclization of analgesic conotoxin GeXIVA facilitates direct folding of the ribbon isomer

Bioactive Compounds Isolated from Neglected Predatory Marine Gastropods.

Bioinformatics-Aided Venomics

Blockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculations

Cloning, synthesis, and characterization of αO-conotoxin GeXIVA, a potent α9α10 nicotinic acetylcholine receptor antagonist.

Computational Studies of Snake Venom Toxins.

Conformational Flexibility Is a Determinant of Permeability for Cyclosporin.

ConoServer, a database for conopeptide sequences and structures

ConoServer: updated content, knowledge, and discovery tools in the conopeptide database

Conopeptide characterization and classifications: an analysis using ConoServer

Conotoxins: Chemistry and Biology

Creating a specialist protein resource network: a meeting report for the protein bioinformatics and community resources retreat

Cyclic analogues of α-conotoxin Vc1.1 inhibit colonic nociceptors and provide analgesia in a mouse model of chronic abdominal pain

Cyclization of conotoxins to improve their biopharmaceutical properties.

Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom

Delineation of the Unbinding Pathway of α-Conotoxin ImI from the α7 Nicotinic Acetylcholine Receptor ⬇️

Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold

Despite a Conserved Cystine Knot Motif, Different Cyclotides Have Different Membrane Binding Modes

Determination of the α-Conotoxin Vc1.1 Binding Site on the α9α10 Nicotinic Acetylcholine Receptor

Development of Novel Melanocortin Receptor Agonists Based on the Cyclic Peptide Framework of Sunflower Trypsin Inhibitor-1.

Development of efficient docking strategies and structure-activity relationship study of the c-Met type II inhibitors

Discovery and mechanistic studies of cytotoxic cyclotides from the medicinal herb Hybanthus enneaspermus

Discovery, synthesis, and structure-activity relationships of conotoxins.

Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor

Efficient backbone cyclization of linear peptides by a recombinant asparaginyl endopeptidase

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3.

Engineering of conotoxins for the treatment of pain

Enhanced Activity against Multidrug-Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway

High-affinity cyclic peptide matriptase inhibitors

High-resolution X-ray structure of the unexpectedly stable dimer of the [Lys(-2)-Arg(-1)-des(17-21)]endothelin-1 peptide

IMGT unique numbering for MHC groove G-DOMAIN and MHC superfamily (MhcSF) G-LIKE-DOMAIN.

IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains

IMGT-Kaleidoscope, the formal IMGT-ONTOLOGY paradigm

IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T cell receptors, MHC, IgSF and MhcSF.

IMGT/3Dstructure-DB and IMGT/StructuralQuery, a database and a tool for immunoglobulin, T cell receptor and MHC structural data

Identification of candidates for cyclotide biosynthesis and cyclisation by expressed sequence tag analysis of Oldenlandia affinis

In Silico Design of MDM2-Targeting Peptides from a Naturally Occurring Constrained Peptide

Insecticidal spider toxins are high affinity positive allosteric modulators of the nicotinic acetylcholine receptor

KNOTTIN: the knottin or inhibitor cystine knot scaffold in 2007

Key residues in the nicotinic acetylcholine receptor β2 subunit contribute to α-conotoxin LvIA binding.

Less is More: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic α-Conotoxin Vc1.1.

Lysine-rich Cyclotides: A New Subclass of Circular Knotted Proteins from Violaceae

Modelling the interactions between animal venom peptides and membrane proteins

Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases.

Molecular basis for the resistance of an insect chymotrypsin to a potato type II proteinase inhibitor

Molecular dynamics simulations of dihydro-β-erythroidine bound to the human α4β2 nicotinic acetylcholine receptor

NMR of plant proteins

Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation - Suggestion of a Binding Mode at the α7 nAChR

Precursor De13.1 from Conus delessertii defines the novel G gene superfamily.

Prediction and characterization of cyclic proteins from sequences in three domains of life

Prediction of disulfide dihedral angles using chemical shifts

Role of CysI–CysIII Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors.

SCORE: predicting the core of protein models

Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist

Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB

Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene

Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA

The KNOTTIN website and database: a new information system dedicated to the knottin scaffold.

The [Lys(-2)-Arg(-1)-des(17-21)]-endothelin-1 peptide retains the specific Arg(-1)-Asp8 salt bridge but reveals discrepancies between NMR data and molecular dynamics simulations.

The evolution of Momordica cyclic peptides

Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity

α-Conotoxin [S9A]TxID Potently Discriminates between α3β4 and α6/α3β4 Nicotinic Acetylcholine Receptors

αO-Conotoxin GeXIVA disulfide bond isomers exhibit differential sensitivity for various nicotinic acetylcholine receptors but retain potency and selectivity for the human α9α10 subtype.