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List of works by Juan Hidalgo

A diet enriched in polyphenols and polyunsaturated fatty acids, LMN diet, induces neurogenesis in the subventricular zone and hippocampus of adult mouse brain

scientific article published in January 2009

A new mouse model to study restoration of interleukin-6 (IL-6) expression in a Cre-dependent manner: microglial IL-6 regulation of experimental autoimmune encephalomyelitis

scientific article published on 15 October 2020

AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise

scientific article

Absence of metallothionein-3 produces changes on MT-1/2 regulation in basal conditions and alters hypothalamic-pituitary-adrenal (HPA) axis

scientific article published on 24 June 2014

Activation of caspase-8 by tumour necrosis factor receptor 1 is necessary for caspase-3 activation and apoptosis in oxygen-glucose deprived cultured cortical cells

scientific article published on 23 June 2009

Active Induction of Experimental Autoimmune Encephalomyelitis (EAE) with MOG35-55 in the Mouse

scientific article published on 01 January 2018

Age-dependent effects of acute and chronic intermittent stresses on serum metallothionein.

scientific article

Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10.

scientific article

Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice.

scientific article published in January 2010

Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis.

scientific article

Analysis of the Cerebral Transcriptome in Mice Subjected to Traumatic Brain Injury: Importance of IL-6

article

Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells

scientific article

Astrocyte-specific deficiency of interleukin-6 and its receptor reveal specific roles in survival, body weight and behavior

scientific article published on 17 October 2012

Astrocyte-targeted expression of IL-6 protects the CNS against a focal brain injury

scientific article

Astrocyte-targeted expression of interleukin-3 and interferon-alpha causes region-specific changes in metallothionein expression in the brain

scientific article published in April 2001

Astrocyte-targeted expression of interleukin-6 protects the central nervous system during neuroglial degeneration induced by 6-aminonicotinamide

scientific article published in August 2003

Astrocytic IL-6 Influences the Clinical Symptoms of EAE in Mice

scientific article published on 17 May 2016

Astrocytic IL-6 mediates locomotor activity, exploration, anxiety, learning and social behavior

scientific article

Brain response to traumatic brain injury in wild-type and interleukin-6 knockout mice: a microarray analysis

scientific article published in January 2005

CXCL12-abundant reticular cells are the major source of IL-6 upon LPS stimulation and thereby regulate hematopoiesis

Catecholaminergic and cholinergic systems of mouse brain are modulated by LMN diet, rich in theobromine, polyphenols and polyunsaturated fatty acids

scientific article

Cd-, Zn-, Cu-binding protein in the elasmobranch Scyliorhinus canicula

scientific article published on 01 January 1985

Changes of metallothionein i + ii proteins in the brain after l-methyl-4-phenylpyridinium administration in mice

scientific article published on 01 January 2000

Characterization of the role of metallothionein-3 in an animal model of Alzheimer's disease

scientific article published on 22 June 2012

Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer's disease

scientific article published on 6 July 2012

Chronic stress reduces serum but not liver metallothionein response to acute stress.

scientific article

Copper modulation as a therapy for Alzheimer's disease?

scientific article

Cyclic GMP phosphodiesterase inhibition alters the glial inflammatory response, reduces oxidative stress and cell death and increases angiogenesis following focal brain injury.

scientific article published on 30 November 2009

Differences between Pregnant and Nulliparous Rats in Basal and Stress Levels of Metallothionein

Different responses to a high-fat diet in IL-6 conditional knock-out mice driven by constitutive GFAP-Cre and Synapsin 1-Cre expression

article

Differential expression of metallothioneins in the CNS of mice with experimental autoimmune encephalomyelitis

scientific article published on 01 January 2001

Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury

scientific article published in December 2005

Distribution of metallothionein I + II and vesicular zinc in the developing central nervous system: correlative study in the rat.

scientific article published on September 1999

Diverging mechanisms for TNF-alpha receptors in normal mouse brains and in functional recovery after injury: From gene to behavior

scientific article published in September 2007

Dogfish metallothionein—I. Purification and characterization and comparison with rat metallothionein

scientific article published on 01 January 1986

Dogfish metallothionein—II. Electrophoretic studies and comparison with rat metallothionein

scientific article published on 01 January 1986

ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development

scientific article published on 14 August 2014

Effect of 2-mercaptoethanol on the electrophoretic behavior of rat and dogfish metallothionein and chromatographic evidence of a naturally occurring metallothionein polymerization

article

Effect of Cd administration on the pituitary-adrenal axis

scientific article

Effect of astrocyte-targeted production of IL-6 on traumatic brain injury and its impact on the cortical transcriptome

article

Effect of dietary zinc deficiency on brain metallothionein-I and -III mRNA levels during stress and inflammation

scientific article published on 01 May 2000

Effect of nitric oxide synthesis inhibition on mouse liver and brain metallothionein expression

scientific article published in December 1998

Effect of stress, adrenalectomy and changes in glutathione metabolism on rat kidney metallothionein content: comparison with liver metallothionein

scientific article published on 01 January 1993

Effect of superoxide dismutase, allopurinol and glucocorticoids on liver and lung metallothionein induction by endotoxin in the rat

scientific article published on 01 January 1993

Effect of zinc, copper and glucocorticoids on metallothionein levels of cultured neurons and astrocytes from rat brain

scientific article published on 01 December 1994

Effects of astrocyte-targeted production of interleukin-6 in the mouse on the host response to nerve injury

article

Endotoxin and intracerebroventricular injection of IL-1 and IL-6 induce rat brain metallothionein-I and -II.

scientific article published in April 1998

Evidence for a high molecular weight cytosolic factor that binds brain and liver metallothionein.

scientific article published in August 1996

Exercise normalises overexpression of TNF-alpha in knockout mice.

scientific article

Exercise-induced liver chemokine CXCL-1 expression is linked to muscle-derived interleukin-6 expression

scientific article published on 4 January 2011

Exercise-induced metallothionein expression in human skeletal muscle fibres

retracted scientific article published on 7 January 2005

Expression of metallothionein-I, -II, and -III in Alzheimer disease and animal models of neuroinflammation

scientific article published in October 2006

Generalization of DNA microarray dispersion properties: microarray equivalent of t-distribution

scientific article

Hypoxic preconditioning induces neuroprotective stanniocalcin-1 in brain via IL-6 signaling

scientific article published in February 2007

IFN-γR -/- mice show an enhanced liver and brain metallothionein I+II response to endotoxin but not to immobilization stress

article

IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease

scientific article published on 02 July 2020

IL-6 deficiency leads to increased emotionality in mice: evidence in transgenic mice carrying a null mutation for IL-6.

scientific article published in December 1998

IL-6 deficiency leads to reduced metallothionein-I+II expression and increased oxidative stress in the brain stem after 6-aminonicotinamide treatment

scientific article

IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling

scientific article published on 01 December 2019

IL-6 regulates exercise and training-induced adaptations in subcutaneous adipose tissue in mice

article

Identification of a signal transducer and activator of transcription (STAT) binding site in the mouse metallothionein-I promoter involved in interleukin-6-induced gene expression

scientific article

Immune and Inflammatory Responses in the Central Nervous System: Modulation by Astrocytes

article

Impaired inflammatory response and increased oxidative stress and neurodegeneration after brain injury in interleukin-6-deficient mice

article

Impaired inflammatory response to glial cell death in genetically metallothionein-I- and -II-deficient mice

scientific article published in March 1999

Increased astrocytic expression of metallothioneins I + II in brainstem of adult rats treated with 6-aminonicotinamide

scientific article published in November 1997

Increased demyelination and axonal damage in metallothionein I+II-deficient mice during experimental autoimmune encephalomyelitis.

scientific article published in January 2003

Induction of atypical EAE mediated by transgenic production of IL-6 in astrocytes in the absence of systemic IL-6.

scientific article published on 16 January 2013

Induction of metallothionein in astrocytes and microglia in the spinal cord from the myelin-deficient jimpy mouse

scientific article published in September 1997

Infection of metallothionein 1+2 knockout mice with Rocky Mountain Laboratory scrapie

Influence of Transgenic Metallothionein-1 on Gliosis, CA1 Neuronal Loss, and Brain Metal Levels of the Tg2576 Mouse Model of Alzheimer's Disease

scientific article published on 26 January 2017

Interactions between metallothionein inducers in rat liver and primary cultures of rat hepatocytes

article

Interferon-gamma regulates oxidative stress during experimental autoimmune encephalomyelitis

scientific article published in September 2002

Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice

scientific article published on 13 May 2013

Interleukin-6 Derived from the Central Nervous System May Influence the Pathogenesis of Experimental Autoimmune Encephalomyelitis in a Cell-Dependent Manner

scientific article published on 31 January 2020

Interleukin-6 and tumor necrosis factor-alpha type 1 receptor deficient mice reveal a role of IL-6 and TNF-alpha on brain metallothionein-I and -III regulation

scientific article published on June 1998

Interleukin-6 deficiency reduces the brain inflammatory response and increases oxidative stress and neurodegeneration after kainic acid-induced seizures.

scientific article

Interleukin-6 deletion in mice driven by aP2-Cre-ERT2 prevents against high-fat diet-induced gain weight and adiposity in female mice

scientific article published in July 2014

Interleukin-6 modifies mRNA expression in mouse skeletal muscle.

scientific article

Interleukin-6 regulates the expression of hypothalamic neuropeptides involved in body weight in a gender-dependent way.

scientific article published in August 2011

Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome

scientific article published on December 2006

Interleukin-6, a major cytokine in the central nervous system

scientific article published on 25 October 2012

LMN diet, rich in polyphenols and polyunsaturated fatty acids, improves mouse cognitive decline associated with aging and Alzheimer's disease

scientific article

Localization of metallothionein-I and -III expression in the CNS of transgenic mice with astrocyte-targeted expression of interleukin 6.

scientific article published on October 1998

M-CSF deficiency leads to reduced metallothioneins I and II expression and increased tissue damage in the brain stem after 6-aminonicotinamide treatment

retracted scientific article published in August 2002

METALLOTHIONEIN INDUCTION BY RESTRAINT STRESS: ROLE OF GLUCOCORTICOIDS AND IL-6

article by Joaquı́n Hernández et al published June 2000 in Cytokine

MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies

scientific article published on 09 December 2013

Metabolic effects of chronic ACTH administration, interaction with response to stress.

scientific article published in January 1986

Metal-saccharide chemistry and biology: saccharide complexes of zinc and their effect on metallothionein synthesis in mice

scientific article published on 01 April 1996

Metallothionein 1+2 protect the CNS during neuroglial degeneration induced by 6-aminonicotinamide

scientific article published on March 2002

Metallothionein Treatment Reduces Proinflammatory Cytokines IL-6 and TNF-α and Apoptotic Cell Death during Experimental Autoimmune Encephalomyelitis (EAE)

article by Milena Penkowa & Juan Hidalgo published July 2001 in Experimental Neurology

Metallothionein and brain inflammation

scientific article published on 16 June 2011

Metallothionein and stress combine to affect multiple organ systems

scientific article

Metallothionein expression and oxidative stress in the brain

scientific article published in January 2002

Metallothionein expression in the central nervous system of multiple sclerosis patients

scientific article published in June 2003

Metallothionein in the central nervous system: Roles in protection, regeneration and cognition

scientific article published on 19 January 2008

Metallothionein in the liver of the small lizard Podarcis muralis

scientific article published on 01 January 1986

Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells

scientific article published in April 2006

Metallothionein prevents neurodegeneration and central nervous system cell death after treatment with gliotoxin 6-aminonicotinamide

scientific article

Metallothionein reduces central nervous system inflammation, neurodegeneration, and cell death following kainic acid-induced epileptic seizures

scientific article published in February 2005

Metallothionein-1+2 Protect the CNS after a Focal Brain Injury

Metallothionein-1+2 deficiency increases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin 6.

scientific article published in April 2002

Metallothionein-I and -III expression in animal models of Alzheimer disease

scientific article published on 4 October 2006

Metallothionein-I induction by stress in specific brain areas

scientific article published on October 1991

Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression

scientific article published in May 2003

Metallothionein-I overexpression decreases brain pathology in transgenic mice with astrocyte-targeted expression of interleukin-6.

scientific article published in March 2003

Metallothionein-I+II induction by zinc and copper in primary cultures of rat microglia

scientific article published in September 1998

Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons.

scientific article

Metallothionein-mediated antioxidant defense system and its response to exercise training are impaired in human type 2 diabetes. Diabetes 2005;54:3089-3094

article

Metallothioneins Are Upregulated in Symptomatic Mice with Astrocyte-Targeted Expression of Tumor Necrosis Factor-α

Metallothioneins I/II are involved in the neuroprotective effect of sildenafil in focal brain injury.

scientific article published on 21 November 2012

Metallothioneins and brain injury: What transgenic mice tell us ⬇️

scientific article published on May 1, 2004

Microglial cell-derived interleukin-6 influences behavior and inflammatory response in the brain following traumatic brain injury

scientific article published on 04 December 2019

Monoamine oxidase-B activity is not involved in the neuroinflammatory response elicited by a focal freeze brain injury

scientific article

Mouse metallothionein-1 and metallothionein-2 are not biologically interchangeable in an animal model of multiple sclerosis, EAE

scientific article published on 01 February 2019

Muscle derived interleukin-6 increases exercise capacity by signaling in osteoblasts

scientific article published on 20 February 2020

Muscle-specific interleukin-6 deletion influences body weight and body fat in a sex-dependent manner

scientific article published on 12 March 2014

Muscular interleukin-6 differentially regulates skeletal muscle adaptation to high-fat diet in a sex-dependent manner

scientific article published on 14 May 2015

Novel roles for metallothionein-I + II (MT-I + II) in defense responses, neurogenesis, and tissue restoration after traumatic brain injury: insights from global gene expression profiling in wild-type and MT-I + II knockout mice

scientific article published in November 2006

Obesity and metabolomics: metallothioneins protect against high-fat diet-induced consequences in metallothionein knockout mice

scientific article published on February 2015

On the blood volume of the Mediterranean dogfish,Scyliorhinus canicula.

scientific article published in April 1991

Ordered transcriptional factor recruitment and epigenetic regulation of tnf-alpha in necrotizing acute pancreatitis

scientific journal article

Overexpression of Metallothionein-1 Modulates the Phenotype of the Tg2576 Mouse Model of Alzheimer's Disease

scientific article published on 19 January 2016

Oxidative and nitrosative stress in acute pancreatitis. Modulation by pentoxifylline and oxypurinol

scientific article published on 8 October 2011

PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] confers MAO-B independent neuroprotection in ER stress-induced cell death

scientific article published on 4 February 2009

PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle.

scientific article published on 11 December 2007

PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in mice.

scientific article published on 28 April 2009

Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions

scientific article published on 7 November 2013

Predictors of blood mercury levels in older urban residents

journal article published in 2006

Primary cortical glial reaction versus secondary thalamic glial response in the excitotoxically injured young brain: astroglial response and metallothionein expression

scientific article

RETRACTED: Interleukin-6 receptor expression in contracting human skeletal muscle: regulating role of IL-6.

retracted scientific article published on 18 April 2005

RETRACTED: Metallothionein I+II expression and their role in experimental autoimmune encephalomyelitis

retracted paper

Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury

scientific article published on 11 March 2008

Restraint stress induced changes in rat liver and serum metallothionein and in Zn metabolism

scientific article published on 01 September 1986

Retraction notice to “M-CSF deficiency leads to reduced metallothioneins I and II expression and increased tissue damage in the brain stem after 6-aminonicotinamide treatment” Exp Neurol 176 (2002) 308–321

scientific article published on 01 September 2013

Retraction: Exercise-induced metallothionein expression in human skeletal muscle fibres ⬇️

scientific article published on August 1, 2011

Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue

scientific article published on 8 January 2014

Role of PGC-1α in exercise and fasting-induced adaptations in mouse liver

scientific article published on 10 August 2011

Role of metallothionein-III following central nervous system damage

scientific article

Role of metallothioneins in peripheral nerve function and regeneration.

scientific article published on June 2003

Role of muscle IL-6 in gender-specific metabolism in mice

scientific article

Roles of the metallothionein family of proteins in the central nervous system

scientific article

Short-term cadmium effects on gill tissue metabolism

Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis

article

Site-specific production of IL-6 in the central nervous system retargets and enhances the inflammatory response in experimental autoimmune encephalomyelitis

scientific article published on 13 July 2009

Skeletal muscle IL-6 and regulation of liver metabolism during high-fat diet and exercise training

scientific article published on 15 May 2016

Skeletal muscle interleukin-6 regulates metabolic factors in iWAT during HFD and exercise training.

scientific article published on 22 June 2015

Specificity and divergence in the neurobiologic effects of different metallothioneins after brain injury

scientific article published on May 2006

Splice variants of mitofusin 2 shape the endoplasmic reticulum and tether it to mitochondria

scientific article published on 22 June 2023

Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice

scientific article published in February 1999

Strongly compromised inflammatory response to brain injury in interleukin-6-deficient mice

scientific article published on 15 February 1999

Systemic and organ specific metabolic variation in metallothionein knockout mice challenged with swimming exercise

Targeted activation of CREB in reactive astrocytes is neuroprotective in focal acute cortical injury

scientific article published on 16 February 2016

The Transcriptional Coactivator Peroxisome Proliferator Activated Receptor (PPAR) Coactivator-1 and the Nuclear Receptor PPAR Control the Expression of Glycerol Kinase and Metabolism Genes Independently of PPAR Activation in Human White Adipocytes

article

The comparison of mouse full metallothionein-1 versus alpha and beta domains and metallothionein-1-to-3 mutation following traumatic brain injury reveals different biological motifs

scientific article published in June 2010

The effect of acute and chronic acth administration on pituitary-adrenal response to acute immobilization stress. Relationship to changes in corticosteroid-binding globulin

article

The effect of cadmium exposure and stress on plasma cortisol, metallothionein levels and oxidative status in rainbow trout (Oncorhynchus mykiss) liver

scholarly article by Lluís Tort et al published May 1996 in Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology

The influence of restraint stress in rats on metallothionein production and corticosterone and glucagon secretion

scientific article published in August 1986

The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in muscle

scientific article published on 13 May 2009

Thioflavin-based molecular probes for application in Alzheimer's disease: from in silico to in vitro models

scientific article

Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain

article

Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells

scientific article

Transgenic expression of interleukin 6 in the central nervous system regulates brain metallothionein-I and -III expression in mice

scientific article published in August 1997

Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat.

scientific article published on 11 September 2009

Transition-metal saccharide chemistry and biology: saccharide complexes of Cu(II) and their effect on in vivo metallothionein synthesis in mice

scientific article published in April 1997

Treatment with metallothionein prevents demyelination and axonal damage and increases oligodendrocyte precursors and tissue repair during experimental autoimmune encephalomyelitis

article published in 2003

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α.

scientific article published on 8 February 2018

Vitamin E-supplemented diets reduce lipid peroxidation but do not alter either pituitary-adrenal, glucose, and lactate responses to immobilization stress or gastric ulceration

scientific article published in January 1990

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