List of works - Donald S. Backos

19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity

scientific article

2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways.

scientific article published on 13 June 2011

4-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity

scientific article published on 06 July 2020

A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation

scientific article published on April 2017

A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization ⬇️

scientific article

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells

scientific article published on 15 June 2016

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells.

scientific article published on 8 January 2016

AIMing towards improved antitumor efficacy.

scientific article

Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration

scientific article

Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons

scientific article published on 2 March 2007

Characterization and Optimization of the Novel Transient Receptor Potential Melastatin 2 Antagonist tatM2NX

scientific article published on 26 November 2019

Characterizing Sirtuin 3 Deacetylase Affinity for Aldehyde Dehydrogenase 2.

scientific article

Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.

scientific article published on 14 August 2017

Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2.

scientific article published on 13 December 2012

Compensatory Expression of Nur77 and Nurr1 Regulates NF-B-Dependent Inflammatory Signaling in Astrocytes

scholarly article by Katriana A Popichak et al published October 2018 in Molecular Pharmacology

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

scientific article published on 19 December 2016

Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55

scientific article published on 08 April 2019

Development of potent pyrazolopyrimidinone-based WEE1 inhibitors with limited single-agent cytotoxicity for cancer therapy.

scientific article

Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells

scientific article

Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter

scientific article published on 8 April 2017

Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors

scientific article published on 25 October 2016

Identification and characterization of novel mutations implicated in congenital fibrinogen disorders

scientific article published on 02 July 2018

Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol

scientific article

Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activation

scientific article published on 5 March 2013

Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis

scientific article published on 17 July 2013

Independent functions of hsp90 in neurotransmitter release and in the continuous synaptic cycling of AMPA receptors.

scientific article published on May 2004

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH

scientific article published on 9 February 2016

Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4

scientific article published on 10 August 2018

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

scientific article

Manipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicity

scientific article

Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation

scientific article

NMDA receptor-dependent activation of the small GTPase Rab5 drives the removal of synaptic AMPA receptors during hippocampal LTD.

scientific article published in January 2005

Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes

scientific article published on 24 July 2017

Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease

scientific article

Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.

scientific article

Post-Translational Oxidative Modification and Inactivation of Mitochondrial Complex I in Epileptogenesis ⬇️

scientific article published on August 15, 2012

Posttranslational modification and regulation of glutamate-cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal

scientific article

ROCK and Rho: Promising therapeutic targets to ameliorate pulmonary fibrosis.

scientific article

Redox modulation of NQO1.

scientific article published on 3 January 2018

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

scientific article

Selective Targeting of RSK Isoforms in Cancer

scientific article

Statin therapy inhibits fatty acid synthase via dynamic protein modifications

scientific article published on 10 May 2022

Strategies and Approaches of Targeting STAT3 for Cancer Treatment.

scientific article published on 5 January 2016

Structure-Based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors

scientific article published on 31 December 2015

Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study

scientific article published on 12 January 2020

Targeting WEE1 Kinase in Cancer

scientific article

The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism.

scientific article

The role of glutathione in brain tumor drug resistance ⬇️

scientific article published on November 28, 2011

List of works by Donald S. Backos

19-substituted benzoquinone ansamycin heat shock protein-90 inhibitors: biological activity and decreased off-target toxicity

2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways.

4-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity

A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation

A Novel Di-Leucine Motif at the N-Terminus of Human Organic Solute Transporter Beta Is Essential for Protein Association and Membrane Localization ⬇️

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells

A WEE1 Inhibitor Analog of AZD1775 Maintains Synergy with Cisplatin and Demonstrates Reduced Single-Agent Cytotoxicity in Medulloblastoma Cells.

AIMing towards improved antitumor efficacy.

Allosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration

Brain-derived neurotrophic factor regulates the expression and synaptic delivery of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits in hippocampal neurons

Characterization and Optimization of the Novel Transient Receptor Potential Melastatin 2 Antagonist tatM2NX

Characterizing Sirtuin 3 Deacetylase Affinity for Aldehyde Dehydrogenase 2.

Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.

Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2.

Compensatory Expression of Nur77 and Nurr1 Regulates NF-B-Dependent Inflammatory Signaling in Astrocytes

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55

Development of potent pyrazolopyrimidinone-based WEE1 inhibitors with limited single-agent cytotoxicity for cancer therapy.

Diindolylmethane analogs bind NR4A1 and are NR4A1 antagonists in colon cancer cells

Dimeric isoxazolyl-1,4-dihydropyridines have enhanced binding at the multi-drug resistance transporter

Evaluation of quantitative assays for the identification of direct signal transducer and activator of transcription 3 (STAT3) inhibitors

Identification and characterization of novel mutations implicated in congenital fibrinogen disorders

Identification of 5' AMP-activated kinase as a target of reactive aldehydes during chronic ingestion of high concentrations of ethanol

Identification of functionally relevant lysine residues that modulate human farnesoid X receptor activation

Increased carbonylation of the lipid phosphatase PTEN contributes to Akt2 activation in a murine model of early alcohol-induced steatosis

Independent functions of hsp90 in neurotransmitter release and in the continuous synaptic cycling of AMPA receptors.

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH

Isoxazolo[3,4-d]pyridazinones positively modulate the metabotropic glutamate subtypes 2 and 4

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

Manipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicity

Motor protein-dependent transport of AMPA receptors into spines during long-term potentiation

NMDA receptor-dependent activation of the small GTPase Rab5 drives the removal of synaptic AMPA receptors during hippocampal LTD.

Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes

Oxidative Stress and the ER Stress Response in a Murine Model for Early-Stage Alcoholic Liver Disease

Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function.

Post-Translational Oxidative Modification and Inactivation of Mitochondrial Complex I in Epileptogenesis ⬇️

Posttranslational modification and regulation of glutamate-cysteine ligase by the α,β-unsaturated aldehyde 4-hydroxy-2-nonenal

ROCK and Rho: Promising therapeutic targets to ameliorate pulmonary fibrosis.

Redox modulation of NQO1.

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

Selective Targeting of RSK Isoforms in Cancer

Statin therapy inhibits fatty acid synthase via dynamic protein modifications

Strategies and Approaches of Targeting STAT3 for Cancer Treatment.

Structure-Based Screen Identification of a Mammalian Ste20-like Kinase 4 (MST4) Inhibitor with Therapeutic Potential for Pituitary Tumors

Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study

Targeting WEE1 Kinase in Cancer

The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism.

The role of glutathione in brain tumor drug resistance ⬇️