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List of works by Matthew D. Hirschey

A Class of Reactive Acyl-CoA Species Reveals the Non-enzymatic Origins of Protein Acylation

scientific article published on April 2017

A Prob(e)able Route to Lysine Acylation

scientific article

A cell non-autonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism

scientific article published on 26 November 2020

Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload

scientific article published on 16 May 2018

Acetate metabolism and aging: An emerging connection

scientific article published on 15 May 2010

Acetylation of mitochondrial proteins

scientific article published on January 2009

Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver

scientific article

Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-Like Effect in Caenorhabditis elegans.

scientific article published in November 2016

Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

scientific article (publication date: December 2010)

Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation.

scientific article published on 14 August 2017

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article

Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.

scientific article

Dysregulated metabolism contributes to oncogenesis

scientific article

Effect of aerobic training on the host systemic milieu in patients with solid tumours: an exploratory correlative study.

scientific article published on 13 January 2015

Ethanol metabolism modifies hepatic protein acylation in mice

scientific article (publication date: 2013)

From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect in Caenorhabditis elegans

scientific article

Generating mammalian sirtuin tools for protein-interaction analysis.

scientific article published on January 2013

HINT2 and fatty liver disease: mitochondrial protein hyperacetylation gives a hint?

scientific article published on May 2013

Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression

scientific article

High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet

scientific article published on 20 March 2015

Imaging Escherichia coli using functionalized core/shell CdSe/CdS quantum dots

scientific article

In Vivo Determination of Mitochondrial Function Using Luciferase-Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant-Induced Dysfunction

scientific article published on August 2016

Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH

scientific article published on 9 February 2016

Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation

scientific article

Long-chain Acylcarnitines Reduce Lung Function by Inhibiting Pulmonary Surfactant

scientific article

Loss of sirtuin 4 leads to elevated glucose- and leucine-stimulated insulin levels and accelerated age-induced insulin resistance in multiple murine genetic backgrounds.

scientific article published on 19 July 2017

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

scientific article

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

scientific journal article

Measurement of fatty acid oxidation rates in animal tissues and cell lines

scientific article

Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight

scientific article published on 17 October 2017

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.

scientific article

Metabolic control by sirtuins and other enzymes that sense NAD+, NADH, or their ratio

scientific article

Mitochondria, energetics, epigenetics, and cellular responses to stress

scientific article

Mitochondrial acetylome analysis in a mouse model of alcohol-induced liver injury utilizing SIRT3 knockout mice

scientific article

Mitochondrial protein acetylation regulates metabolism ⬇️

scientific article published on January 1, 2012

Mitochondrial sirtuins

scientific article published on 07 January 2010

Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.

scientific article

Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases

scientific article

Old Enzymes, New Tricks: Sirtuins Are NAD+-Dependent De-acylases ⬇️

scientific article published on November 17, 2011

Oxygen flux analysis to understand the biological function of sirtuins

scientific article published on January 2013

Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure

scientific article

Progressive mitochondrial protein lysine acetylation and heart failure in a model of Friedreich's ataxia cardiomyopathy

scientific article

Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats

scientific article published on June 2016

Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases

scientific article

SIRT3 Directs Carbon Traffic in Muscle to Promote Glucose Control

scientific article published on September 2015

SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production

scientific article

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

scientific article

SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism

scientific article

SIRT3 regulates progression and development of diseases of aging

scientific article

SIRT3 weighs heavily in the metabolic balance: a new role for SIRT3 in metabolic syndrome

scientific article published on 4 May 2012

SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion

scientific article

Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site

scientific article published on 11 October 2013

Sirtuin 5 is required for mouse survival in response to cardiac pressure overload

scientific article published on 2 October 2017

Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

scientific article published on 20 September 2010

Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production

scientific article

SnapShot: Mammalian Sirtuins.

scientific article

Statin therapy inhibits fatty acid synthase via dynamic protein modifications

scientific article published on 10 May 2022

Targeting sirtuins for the treatment of diabetes

scientific article

Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism.

scientific article published on 2 December 2012

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