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List of works by Ian G. Ganley

A comparative map of macroautophagy and mitophagy in the vertebrate eye

scientific article published on 20 February 2019

A functional role for the GCC185 golgin in mannose 6-phosphate receptor recycling

scientific article

A syntaxin 10-SNARE complex distinguishes two distinct transport routes from endosomes to the trans-Golgi in human cells

scientific article

ATG5 Promotes Death Signaling in Response to the Cyclic Depsipeptides Coibamide A and Apratoxin A.

scientific article published in March 2018

Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity

scientific article published on 27 October 2020

Autophagosome maturation and lysosomal fusion

scientific article published on January 2013

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

scientific article

Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells

scientific article

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

scientific article published on 22 May 2019

Clues to neuro-degeneration in Niemann-Pick type C disease from global gene expression profiling

scientific article published on 20 December 2006

Coibamide A induces mTOR-independent autophagy and cell death in human glioblastoma cells

scientific article

DGAT1 activity synchronises with mitophagy to protect cells from metabolic rewiring by iron  depletion

scientific article published on 12 April 2022

Determination of Cellular Phosphatidylinositol-3-phosphate (PI3P) Levels Using a Fluorescently Labelled Selective PI3P Binding Domain (PX).

scientific article published on August 2016

Determination of VPS34/PIK3C3 Activity in vitro Utilising 32P-γATP.

scientific article published on August 2016

Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest

scientific article

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.

scientific article published on January 2013

GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling

scientific article published on 9 July 2015

Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1

scientific article published on 12 November 2021

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells

scientific article published on 8 February 2016

Investigating Mitophagy and Mitochondrial Morphology In Vivo Using mito-QC: A Comprehensive Guide

scientific article published on 01 January 2019

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

scientific article

Life in lights: Tracking mitochondrial delivery to lysosomes in vivo

scientific article published on 7 October 2016

Loss of iron triggers PINK1/Parkin-independent mitophagy

scientific article

MTOR, PIK3C3, and autophagy: Signaling the beginning from the end.

scientific article

Mammalian mitophagy - from in vitro molecules to in vivo models.

scientific article published on 19 November 2017

Organelle Turnover: A USP30 Safety Catch Restrains the Trigger for Mitophagy and Pexophagy

scientific article published on 01 August 2018

Outstanding Questions in Mitophagy: What We Do and Do Not Know

scientific article published on 09 July 2019

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy

scientific article

Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy

scientific article published in Journal of Biological Chemistry

Phosphorylation of Parkin at serine 65 is essential for its activation

scientific article published on 07 November 2018

Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading

scientific article published on 17 May 2019

RUTBC1 protein, a Rab9A effector that activates GTP hydrolysis by Rab32 and Rab33B proteins

scientific article

RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36

scientific journal article

Rab9 GTPase regulates late endosome size and requires effector interaction for its stability

scientific article

Role of autophagy in histone deacetylase inhibitor-induced apoptotic and nonapoptotic cell death

scientific article published on 9 April 2012

Self-assembly is important for TIP47 function in mannose 6-phosphate receptor transport

scientific article (publication date: 2003)

Semi-automated quantitation of mitophagy in cells and tissues

scientific article published on 13 December 2019

Thapsigargin distinguishes membrane fusion in the late stages of endocytosis and autophagy

article

The ULK1 complex: sensing nutrient signals for autophagy activation.

scientific article published on 07 January 2013

The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets

scientific article published on 01 February 2020

The mammalian ULK1 complex and autophagy initiation.

scientific article published on 12 December 2017

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

scientific article published on 8 September 2017

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

scientific article

mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival

scientific article

mito-QC illuminates mitophagy and mitochondrial architecture in vivo

scientific article

p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia

scientific article published on 3 October 2013

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