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List of works by Franz Worek

A role for solvents in the toxicity of agricultural organophosphorus pesticides

scientific article published on 16 February 2012

A structure-activity analysis of the variation in oxime efficacy against nerve agents

scientific article published on 22 April 2008

Adsorption of obidoxime onto human serum albumin nanoparticles: drug loading, particle size and drug release

scientific article published in January 2010

Aging mechanism of butyrylcholinesterase inhibited by an N-methyl analogue of tabun: implications of the trigonal-bipyramidal transition state rearrangement for the phosphylation or reactivation of cholinesterases

scientific article published on 8 April 2010

Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine

scientific article published on October 2011

Are we using the right dose? - a tale of mole and gram

scientific article published on 28 June 2008

Assessment of neuromuscular dysfunction during poisoning by organophosphorus compounds

scientific article published on 29 December 2009

Atropine and oxime treatment in lethal soman poisoning of anaesthetized guinea-pigs: HLö 7 dimethanesulfonate versus HI 6 dichloride

scientific article published in January 1993

Atropine maintenance dosage in patients with severe organophosphate pesticide poisoning

scientific article published on 8 July 2011

Blaptica dubia as sentinels for exposure to chemical warfare agents - a pilot study

scientific article published on 14 September 2016

Cardiorespiratory function in nerve agent poisoned and oxime+atropine treated guinea-pigs: effect of pyridostigmine pretreatment ⬇️

scientific article published on January 1, 1995

Central respiratory effects on motor nerve activities after organophosphate exposure in a working heart brainstem preparation of the rat.

scientific article published on 8 July 2011

Chromatographic analysis of toxic phosphylated oximes (POX): a brief overview

scientific article published on October 2010

Chromatographic preparation and kinetic analysis of interactions between tabun enantiomers and acetylcholinesterase

scientific article published on 25 March 2010

Chromatographic resolution, characterisation and quantification of VX enantiomers in hemolysed swine blood samples

scientific article published on 06 August 2008

Comments on "Efficacy of two new asymmetric bispyridinium oximes (K-27 and K-48) in rats exposed to diisopropylfluorophosphate: comparison with pralidoxime, obidoxime, trimedoxime, methoxime, and HI 6".

scientific article published in May 2009

Comparative kinetics of organophosphates and oximes with erythrocyte, muscle and brain acetylcholinesterase

scientific article published on 2 January 2012

Comparative study of oxime-induced reactivation of erythrocyte and muscle AChE from different animal species following inhibition by sarin or paraoxon

scientific article published on 13 February 2010

Comparison of the oxime-induced reactivation of erythrocyte and muscle acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinesterase activity

scientific article published on 21 September 2007

Comparison of the oxime-induced reactivation of rhesus monkey, swine and guinea pig erythrocyte acetylcholinesterase following inhibition by sarin or paraoxon, using a perfusion model for the real-time determination of membrane-bound acetylcholinest

scientific article published on 20 January 2009

Competition radioligand binding assays for the investigation of bispyridinium compound affinities to the human muscarinic acetylcholine receptor subtype 5 (hM(5) ).

scientific article published on 24 February 2012

Correlation between red blood cell acetylcholinesterase activity and neuromuscular transmission in organophosphate poisoning

scientific article published on 2 November 2005

Determination of acetylcholinesterase activity by the Ellman assay: a versatile tool for in vitro research on medical countermeasures against organophosphate poisoning

scientific article published on 13 October 2011

Detoxification of VX and Other V-Type Nerve Agents in Water at 37 °C and pH 7.4 by Substituted Sulfonatocalix[4]arenes

scientific article published on 15 September 2016

Detoxification of nerve agents by a substituted beta-cyclodextrin: application of a modified biological assay

scientific article published in October 2009

Detoxification of tabun at physiological pH mediated by substituted β-cyclodextrin and glucose derivatives containing oxime groups

scientific article published on 11 September 2012

Development and application of procedures for the highly sensitive quantification of cyclosarin enantiomers in hemolysed swine blood samples

scientific article published on 6 September 2007

Development and validation of a sensitive gas chromatography-ammonia chemical ionization mass spectrometry method for the determination of tabun enantiomers in hemolysed blood and plasma of different species

scientific article published on 6 September 2009

Development of a dynamic model for real-time determination of membrane-bound acetylcholinesterase activity upon perfusion with inhibitors and reactivators

scientific article published on 29 April 2006

Development of a high-throughput screening for nerve agent detoxifying materials using a fully-automated robot-assisted biological assay

scientific article published on 2 December 2009

Diagnostic aspects of organophosphate poisoning.

scientific article

Differences between organophosphorus insecticides in human self-poisoning: a prospective cohort study

scientific article

Discovery of a potent non-oxime reactivator of nerve agent inhibited human acetylcholinesterase

scientific article published on 06 August 2018

Effect of MB327 and oximes on rat intestinal smooth muscle function

scientific article published on 18 April 2013

Effects of atropine and soman on the pharmacokinetics of the oxime HLö 7 dimethanesulfonate in anesthetized guinea-pigs

scientific article published in May 1995

Effects of oximes on muscle force and acetylcholinesterase activity in isolated mouse hemidiaphragms exposed to paraoxon

scientific article published on 22 July 2005

Effects of oximes on rate of decarbamylation of human red blood cell AChE measured with two different methods

scientific article

Elimination pathways of cyclosarin (GF) mediated by β-cyclodextrin in vitro: pharmacokinetic and toxicokinetic aspects.

scientific article published on 29 July 2013

Estimation of oxime efficacy in nerve agent poisoning: a kinetic approach

scientific article published on 2 November 2005

Evaluation of 6,6'-dithionicotinic acid as alternative chromogen in a modified Ellman method--comparison in various species

scientific article published on 07 April 2011

Evaluation of functional and structural alterations in muscle tissue after short-term cold storage in a new tissue preservation solution

scientific article published on 14 April 2011

Evaluation of medical countermeasures against organophosphorus compounds: the value of experimental data and computer simulations

scientific article

Evaluation of oxime efficacy in nerve agent poisoning: development of a kinetic-based dynamic model

scientific article

Evaluation of the Test-mate ChE (Cholinesterase) Field Kit in Acute Organophosphorus Poisoning

scientific article published on 01 December 2011

Evaluation of the accuracy of "ChE check mobile" in measurement of acetylcholinesterase in pesticide poisoning

scientific article published on 17 November 2018

Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF).

scientific article published on 09 May 2009

Fourteenth International Medical Chemical Defence Conference 2013 "Translation of experimental research for improved treatment of chemical warfare agents".

scientific article

Functionalized cyclodextrins bearing an alpha nucleophile--a promising way to degrade nerve agents

scientific article

GC-MS and LC-MS analysis of nerve agents in body fluids: intra-laboratory verification test using spiked plasma and urine samples

scientific article published on 24 December 2009

HI 6 human serum albumin nanoparticles--development and transport over an in vitro blood-brain barrier model

scientific article

Highly efficient cyclosarin degradation mediated by a β-cyclodextrin derivative containing an oxime-derived substituent

scientific article published on 22 November 2011

Human parathion poisoning. A toxicokinetic analysis.

scientific article published on January 2003

Identical kinetics of human erythrocyte and muscle acetylcholinesterase with respect to carbamate pre-treatment, residual activity upon soman challenge and spontaneous reactivation after withdrawal of the inhibitors

scientific article

Immobilization of Russian VX skin depots by localized cooling: implications for decontamination and medical countermeasures

scientific article published on 16 June 2011

Improving the promiscuous nerve agent hydrolase activity of a thermostable archaeal lactonase.

scientific article published on 27 July 2010

In Vitro Interaction of Organophosphono- and Organophosphorothioates with Human Acetylcholinesterase

scientific article published on 02 July 2020

In vitro detoxification of cyclosarin (GF) by modified cyclodextrins.

scientific article

In vitro kinetic interactions of DEET, pyridostigmine and organophosphorus pesticides with human cholinesterases

scientific article published on 25 February 2011

In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species

scientific article

In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP).

scientific article published on 22 September 2013

Incorporation of obidoxime into human serum albumin nanoparticles: optimisation of preparation parameters for the development of a stable formulation

scientific article published on January 2010

Influence of cyclic and acyclic cucurbiturils on the degradation pathways of the chemical warfare agent VX

scientific article published on 30 June 2020

Inhibitory potency against human acetylcholinesterase and enzymatic hydrolysis of fluorogenic nerve agent mimics by human paraoxonase 1 and squid diisopropyl fluorophosphatase

scientific article

Innovative Biocatalysts as Tools to Detect and Inactivate Nerve Agents

scientific article published in Scientific Reports

Interaction of bispyridinium compounds with the orthosteric binding site of human α7 and Torpedo californica nicotinic acetylcholine receptors (nAChRs).

scientific article published on 16 June 2011

Interaction of pentylsarin analogues with human acetylcholinesterase: a kinetic study.

scientific article published on 21 February 2009

Interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators: Analysis of reactivation and inhibition kinetics in vitro

article

Intoxication with huperzine A, a potent anticholinesterase found in the fir club moss

scientific article published on 01 January 2000

Investigation of kinetic interactions between approved oximes and human acetylcholinesterase inhibited by pesticide carbamates

scientific article published on 17 August 2013

Kinetic analysis of interactions between alkylene-linked bis-pyridiniumaldoximes and human acetylcholinesterases inhibited by various organophosphorus compounds

scientific article published on 26 May 2010

Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes

scientific article published in December 2004

Kinetic analysis of interactions of amodiaquine with human cholinesterases and organophosphorus compounds

scientific article published on 03 February 2016

Kinetic analysis of interactions of different sarin and tabun analogues with human acetylcholinesterase and oximes: is there a structure-activity relationship?

scientific article published on 25 January 2010

Kinetic analysis of interactions of paraoxon and oximes with human, Rhesus monkey, swine, rabbit, rat and guinea pig acetylcholinesterase

scientific article published on 29 October 2010

Kinetic analysis of reactivation and aging of human acetylcholinesterase inhibited by different phosphoramidates

scientific article published on 16 February 2007

Kinetic analysis of the protection afforded by reversible inhibitors against irreversible inhibition of acetylcholinesterase by highly toxic organophosphorus compounds

scientific article published on 29 April 2006

Kinetic interactions of a homologous series of bispyridinium monooximes (HGG oximes) with native and phosphonylated human acetylcholinesterase

scientific article published on 04 May 2012

Kinetic prerequisites of oximes as effective reactivators of organophosphate-inhibited acetylcholinesterase: a theoretical approach

scientific article published on 31 August 2010

Limitations and challenges in treatment of acute chemical warfare agent poisoning

scientific article

Midazolam is effective to reduce cortical network activity in organotypic cultures during severe cholinergic overstimulation with soman

scientific article published on 27 August 2018

Molar absorption coefficients for the reduced Ellman reagent: reassessment

scientific article published in January 2003

Monitoring of neuromuscular transmission in organophosphate pesticide-poisoned patients

scientific article published on 28 September 2009

Muscle force and acetylcholinesterase activity in mouse hemidiaphragms exposed to paraoxon and treated by oximes in vitro

scientific article published on 10 April 2010

Nanoparticulate transport of oximes over an in vitro blood-brain barrier model

scientific article

New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: evaluation of the detoxification using a half-quantitative enzymatic assay

scientific article published on 29 November 2012

New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (II). In vitro detoxification of cyclosarin (GF): general screening and toxicokinetic aspects of OP scavengers

scientific article published on 29 November 2012

Obidoxime in acute organophosphate poisoning: 1 - clinical effectiveness

scientific article published in September 2009

Obidoxime in acute organophosphate poisoning: 2 - PK/PD relationships

scientific article published in September 2009

Optimized strategies to synthesize β-cyclodextrin-oxime conjugates as a new generation of organophosphate scavengers

scientific article published on 04 March 2011

Organophosphorus compounds and oximes: a critical review

scientific article published on 06 June 2020

Paradox findings may challenge orthodox reasoning in acute organophosphate poisoning

scientific article published on 31 October 2009

Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds

scientific article published on 11 June 2010

Photostability of antidotal oxime HI-6, impact on drug development

scientific article published on 22 February 2012

Poisoning with the S-Alkyl organophosphorus insecticides profenofos and prothiofos.

scientific article

Pralidoxime in acute organophosphorus insecticide poisoning--a randomised controlled trial

scientific article published on 30 June 2009

Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro

scientific article

Predicting outcome using butyrylcholinesterase activity in organophosphorus pesticide self-poisoning.

scientific article published on 28 March 2008

Quantification of pralidoxime (2-PAM) in urine by ion pair chromatography-diode array detection: application to in vivo samples from minipig

scientific article published on 18 November 2011

Reactions of isodimethoate with human red cell acetylcholinesterase

scientific article published on 26 February 2008

Reactivation kinetics of a homologous series of bispyridinium bis-oximes with nerve agent-inhibited human acetylcholinesterase

scientific article published on 22 March 2012

Reactivation kinetics of a series of related bispyridinium oximes with organophosphate-inhibited human acetylcholinesterase--Structure-activity relationships

scientific article published in June 2012

Reactivation of organophosphate-inhibited human acetylcholinesterase by isonitrosoacetone (MINA): a kinetic analysis

scientific article published on 9 September 2011

Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach

scientific article published on October 2010

Reactivation of plasma butyrylcholinesterase by pralidoxime chloride in patients poisoned by WHO class II toxicity organophosphorus insecticides

scientific article published on 19 September 2013

Reactivation of tabun-hAChE investigated by structurally analogous oximes and mutagenesis

scientific article published on 15 September 2009

Red blood cell acetylcholinesterase and plasma butyrylcholinesterase status: important indicators for the treatment of patients poisoned by organophosphorus compounds.

scientific article published on September 2007

Restoration of nerve agent inhibited muscle force production in human intercostal muscle strips with HI 6.

scientific article published on 23 July 2011

Restoration of soman-blocked neuromuscular transmission in human and rat muscle by the bispyridinium non-oxime MB327 in vitro

scientific article published on 13 February 2012

Reversible inhibition of acetylcholinesterase by carbamates or huperzine A increases residual activity of the enzyme upon soman challenge

scientific article published on 29 September 2006

Simulation of cholinesterase status at different scenarios of nerve agent exposure

scientific article published on 07 July 2006

Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies

scientific article published on 30 July 2011

Simultaneous quantification of the organophosphorus pesticides dimethoate and omethoate in porcine plasma and urine by LC-ESI-MS/MS and flow-injection-ESI-MS/MS.

scientific article published on 14 January 2010

Structural requirements for effective oximes--evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes

scientific article

Structure of a prereaction complex between the nerve agent sarin, its biological target acetylcholinesterase, and the antidote HI-6.

scientific article published on 02 May 2016

Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun

scientific article

Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.

scientific article published on 6 March 2009

Tabun scavengers based on hydroxamic acid containing cyclodextrins

scientific article published in April 2013

Testing of antidotes for organophosphorus compounds: experimental procedures and clinical reality

scientific article published in September 2006

The NADPH oxidase inhibitor diphenyleneiodonium is also a potent inhibitor of cholinesterases and the internal Ca(2+) pump

scientific article published on 25 September 2009

The therapeutic use of localized cooling in the treatment of VX poisoning

scientific article published on 17 April 2011

The value of novel oximes for treatment of poisoning by organophosphorus compounds

scientific article published on 17 April 2013

Thirteenth International Medical Chemical Defence Conference 2011 "New developments in the treatment of intoxications by chemical warfare agents with focus on neurotoxic agents"

scientific article published on 12 May 2011

Toxicokinetics of tabun enantiomers in anaesthetized swine after intravenous tabun administration

scientific article published on 25 June 2010

Toxicology of organophosphorus compounds in view of an increasing terrorist threat

scientific article

Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model

scientific article

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