Search filters

List of works by Patrick M. Kochanek

"Lost in translation?" Noninvasive cerebral monitoring after cardiac arrest

scientific article published on 01 October 2011

2',3'-cAMP, 3'-AMP, 2'-AMP and adenosine inhibit TNF-α and CXCL10 production from activated primary murine microglia via A2A receptors.

scientific article

72-kDa heat shock protein and mRNA expression after controlled cortical impact injury with hypoxemia in rats

scientific article published on March 1998

A critical problem begging for new insight and new therapies

scientific article

A dual role for poly‐ADP‐ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14‐3‐3γ ⬇️

scientific article published on May 1, 2003

A gel-based proteomic comparison of human cerebrospinal fluid between inflicted and non-inflicted pediatric traumatic brain injury

scientific article

A high-throughput screening assay of ascorbate in brain samples

journal article published in 2011

A mitochondrial pathway for biosynthesis of lipid mediators

journal article published in 2014

A model of diffuse traumatic brain injury in the immature rat.

scientific article

A new roadmap for mechanical circulatory support in children

scientific article published on 01 June 2013

A novel multicenter preclinical drug screening and biomarker consortium for experimental traumatic brain injury: operation brain trauma therapy

scientific article published on July 2011

A reappraisal of mouth-to-mouth ventilation during bystander-initiated cardiopulmonary resuscitation

scientific article published on 01 January 1998

A tertiary care center's experience with therapeutic hypothermia after pediatric cardiac arrest.

scientific article published on January 2010

A tribute to Peter J. Safar, MD.

scientific article published in November 2003

Acute CSF interleukin-6 trajectories after TBI: associations with neuroinflammation, polytrauma, and outcome

scientific article published on 31 December 2014

Acute etomidate treatment reduces cognitive deficits and histopathology in rats with traumatic brain injury

scientific article published in August 2003

Acute systemic administration of interleukin-10 suppresses the beneficial effects of moderate hypothermia following traumatic brain injury in rats

scientific article published in May 2002

Adenosine A1 receptor activation as a brake on the microglial response after experimental traumatic brain injury in mice

scientific article

Adenosine A1 receptor gene variants associated with post-traumatic seizures after severe TBI.

scientific article

Adenosine by aortic flush fails to augment the brain preservation effect of mild hypothermia during exsanguination cardiac arrest in dogs - an exploratory study

scientific article published on 01 March 2000

Adenovirus-mediated transfer and expression of beta-gal in injured hippocampus after traumatic brain injury in mice

scientific article published on 01 January 2001

Administration of adenosine receptor agonists or antagonists after controlled cortical impact in mice: effects on function and histopathology

scientific article published in October 2002

Alterations in inducible 72-kDa heat shock protein and the chaperone cofactor BAG-1 in human brain after head injury.

scientific article published in February 2003

An acute inflammatory response to the use of granulocyte colony-stimulating factor to prevent infections in patients with brain injury: what about the brain?

scientific article

Anthraquinone-2-sulfonic acid (AQ2S) is a novel neurotherapeutic agent

scientific article published on 10 January 2013

Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria

journal article published in 2006

Asphyxial cardiac arrest from drowning: giving E-CPR the cold shoulder

scientific article published on 7 January 2015

Assessment of antioxidant reserves and oxidative stress in cerebrospinal fluid after severe traumatic brain injury in infants and children

scientific article

Assessment of the delta opioid agonist DADLE in a rat model of lethal hemorrhage treated by emergency preservation and resuscitation

scientific article

Assessment of the effect of 2-chloroadenosine in normal rat brain using spin-labeled MRI measurement of perfusion

scientific article published in May 2001

Astrocytes are the major source of nerve growth factor upregulation following traumatic brain injury in the rat.

scientific article

Augmented neuronal death in CA3 hippocampus following hyperventilation early after controlled cortical impact.

scientific article published in March 1998

Authors' response to letter to the editor, "Effect of a single dose of propofol and lack of dextrose administration in a child with mitochondrial disease--a case report".

scientific article published on 28 March 2014

Automated detection and characterization of SPIO-labeled cells and capsules using magnetic field perturbations

scientific article

Autophagy in acute brain injury: feast, famine, or folly?

scientific article

Autophagy is Increased after Traumatic Brain Injury in Mice and is Partially Inhibited by the Antioxidant γ-glutamylcysteinyl Ethyl Ester

article

Bakken Lecture: the brain, the heart, and therapeutic hypothermia

scientific article published in April 2009

Bench-to-bedside review: Apoptosis/programmed cell death triggered by traumatic brain injury

scientific article

Biochemical markers of brain injury: could they be used as diagnostic adjuncts in cases of inflicted traumatic brain injury?

scientific article published in July 2004

Blast exposure in rats with body shielding is characterized primarily by diffuse axonal injury

scientific article

Blood brain barrier is impermeable to solutes and permeable to water after experimental pediatric cardiac arrest.

scientific article

Blood-brain barrier integrity in a rat model of emergency preservation and resuscitation.

scientific article published on 8 February 2009

Brain resuscitation in the drowning victim

journal article published in 2012

Brain tissue oxygen monitoring after severe traumatic brain injury in children: relationship to outcome and association with other clinical parameters

scientific article published on 14 September 2012

Brain tissue oxygen monitoring identifies cortical hypoxia and thalamic hyperoxia after experimental cardiac arrest in rats.

scientific article

CSF Bcl-2 and cytochrome C temporal profiles in outcome prediction for adults with severe TBI.

scientific article

Cardiac arrest and therapeutic hypothermia decrease isoform-specific cytochrome P450 drug metabolism.

scientific article published on 25 August 2011

Cardiac arrest in children

scientific article published on July 2010

Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury

scientific article published on 09 January 2019

Caspase-3 mediated neuronal death after traumatic brain injury in rats

scientific article published on 01 February 2000

Caspase-8 expression and proteolysis in human brain after severe head injury.

scientific article published on 8 May 2003

Cerebral blood flow at one year after controlled cortical impact in rats: assessment by magnetic resonance imaging

scientific article published in September 2002

Cerebral blood flow changes after brain injury in human amyloid-beta knock-in mice

scientific article

Cerebral blood flow promotion after prolonged cardiac arrest

scientific article published on 01 August 2000

Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin-labeled MRI.

scientific article published in July 2001

Cerebrospinal Fluid Markers of Macrophage and Lymphocyte Activation After Traumatic Brain Injury in Children

scientific article

Cerebrospinal fluid adenosine concentration and uncoupling of cerebral blood flow and oxidative metabolism after severe head injury in humans

scientific article

Cerebrospinal fluid and plasma nitrite and nitrate concentrations after head injury in humans

article

Cerebrospinal fluid biomarkers versus glasgow coma scale and glasgow outcome scale in pediatric traumatic brain injury: the role of young age and inflicted injury

scientific article

Cerebrospinal fluid levels of high-mobility group box 1 and cytochrome C predict outcome after pediatric traumatic brain injury

scientific article

Cerebrospinal fluid mitochondrial DNA: a novel DAMP in pediatric traumatic brain injury

scientific article

Cerebrospinal fluid procalcitonin and severe traumatic brain injury in children

scientific article published on January 2002

Cerebrovascular response in children following severe traumatic brain injury

scientific article published on 11 May 2011

Changes in expression of amyloid precursor protein and interleukin-1beta after experimental traumatic brain injury in rats

scientific article published in December 2002

Characterization of the effects of adenosine receptor agonists on cerebral blood flow in uninjured and traumatically injured rat brain using continuous arterial spin-labeled magnetic resonance imaging

scientific article

Clinical trials in head injury

scientific article

Cold aortic flush and chest compressions enable good neurologic outcome after 15 mins of ventricular fibrillation in cardiac arrest in pigs

scientific article

Comparison of seven anesthetic agents on outcome after experimental traumatic brain injury in adult, male rats

scientific article published in January 2006

Conventional and functional proteomics using large format two-dimensional gel electrophoresis 24 hours after controlled cortical impact in postnatal day 17 rats

scientific article published in June 2002

Critical mechanisms of secondary damage after inflicted head injury in infants and children

scientific article

Critical time window for intra-arrest cooling with cold saline flush in a dog model of cardiopulmonary resuscitation

scientific article published in June 2006

Cytochrome c, a Biomarker of Apoptosis, is Increased in Cerebrospinal Fluid from Infants with Inflicted Brain Injury from Child Abuse

article

Cytochrome c/cardiolipin relations in mitochondria: a kiss of death

journal article published in 2009

Deciphering of mitochondrial cardiolipin oxidative signaling in cerebral ischemia-reperfusion

journal article published in 2015

Deep hypothermia attenuates microglial proliferation independent of neuronal death after prolonged cardiac arrest in rats.

scientific article published in September 2009

Delayed, spontaneous hypothermia reduces neuronal damage after asphyxial cardiac arrest in rats

scientific article published in October 2000

Developing cooling strategies targeting the heart in adults and children

scientific article published on 01 December 2012

Differences in medical therapy goals for children with severe traumatic brain injury-an international study

scientific article published on October 2013

Disruption of Bax protein prevents neuronal cell death but produces cognitive impairment in mice following traumatic brain injury.

scientific article published on July 2008

Early cerebrovascular response to head injury in immature and mature rats

scientific article

Early neuropathologic effects of mild or moderate hypoxemia after controlled cortical impact injury in rats

scientific article

Early perfusion after controlled cortical impact in rats: quantification by arterial spin-labeled MRI and the influence of spin-lattice relaxation time heterogeneity

scientific article

Early polymorphonuclear leukocyte accumulation correlates with the development of posttraumatic cerebral edema in rats

scientific article published on 01 January 1990

Effect of a single dose of propofol and lack of dextrose administration in a child with mitochondrial disease: a case report

scientific article published on 11 September 2013

Effect of administration of neuromuscular blocking agents in children with severe traumatic brain injury on acute complication rates and outcomes: a secondary analysis from a randomized, controlled trial of therapeutic hypothermia

scientific article published on May 2015

Effect of hyperoxia on resuscitation of experimental combined traumatic brain injury and hemorrhagic shock in mice

scientific article published in March 2013

Effect of hyperventilation on extracellular concentrations of glutamate, lactate, pyruvate, and local cerebral blood flow in patients with severe traumatic brain injury

scientific article published in December 2002

Effect of neutropenia and granulocyte colony stimulating factor-induced neutrophilia on blood-brain barrier permeability and brain edema after traumatic brain injury in rats

scientific article published in November 2000

Effect of short periods of normobaric hyperoxia on local brain tissue oxygenation and cerebrospinal fluid oxidative stress markers in severe traumatic brain injury

scientific article

Effect of traumatic brain injury in mice deficient in intercellular adhesion molecule-1: assessment of histopathologic and functional outcome

scientific article published in April 1999

Effectiveness of Pharmacological Therapies for Intracranial Hypertension in Children With Severe Traumatic Brain Injury--Results From an Automated Data Collection System Time-Synched to Drug Administration

scientific article

Effects of hypothermia on drug disposition, metabolism, and response: A focus of hypothermia-mediated alterations on the cytochrome P450 enzyme system.

scientific article published on September 2007

Effects of neutropenia on edema, histology, and cerebral blood flow after traumatic brain injury in rats

scientific article

Effects of post-injury hypothermia and nerve growth factor infusion on antioxidant enzyme activity in the rat: implications for clinical therapies

scientific article

Electron spin resonance measure of brain antioxidant activity during ischemia/reperfusion

scientific article published in May 1998

Emergency preservation and resuscitation improve survival after 15 minutes of normovolemic cardiac arrest in pigs

scientific article published on 01 December 2007

Emergency preservation and resuscitation with profound hypothermia, oxygen, and glucose allows reliable neurological recovery after 3 h of cardiac arrest from rapid exsanguination in dogs

scientific article

Emerging therapies in traumatic brain injury

scientific article

Endothelin-1 Is Increased in Cerebrospinal Fluid and Associated with Unfavorable Outcomes in Children after Severe Traumatic Brain Injury ⬇️

scientific article published on September 17, 2010

Energy expenditure in children after severe traumatic brain injury

scientific article

Enhanced oxidative stress in iNOS-deficient mice after traumatic brain injury: support for a neuroprotective role of iNOS.

scientific article

Evaluation of autophagy using mouse models of brain injury

scientific article

Excitatory amino acid concentrations in ventricular cerebrospinal fluid after severe traumatic brain injury in infants and children: the role of child abuse

scientific article

Experimental model of pediatric asphyxial cardiopulmonary arrest in rats

scientific article

Expression of the 2′,3′‐cAMP‐adenosine pathway in astrocytes and microglia ⬇️

scientific article published on August 12, 2011

Exsanguination cardiac arrest in rats treated by 60 min, but not 75 min, emergency preservation and delayed resuscitation is associated with intact outcome

scientific article

Extracorporeal versus conventional cardiopulmonary resuscitation after ventricular fibrillation cardiac arrest in rats: a feasibility trial

scientific article published in September 2013

F2-isoprostane and neuron-specific enolase in cerebrospinal fluid after severe traumatic brain injury in infants and children

scientific article published in August 2003

Fever control and application of hypothermia using intravenous cold saline.

scientific article published on January 2012

Finding a faster and safer way to "catch a cold" after cardiac arrest: we may be getting closer

scientific article published on 30 June 2014

Global and Regional Derangements of Cerebral Blood Flow and Diffusion Magnetic Resonance Imaging after Pediatric Cardiac Arrest

scientific article

Global and regional differences in cerebral blood flow after asphyxial versus ventricular fibrillation cardiac arrest in rats using ASL-MRI

scientific article

Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition

scientific article published in January 2012

Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 1: Introduction.

scientific article

HBO: It's not ready for prime time for the treatment of acute central nervous system trauma.

scientific article

Hemorrhagic shock shifts the serum cytokine profile from pro- to anti-inflammatory after experimental traumatic brain injury in mice

scientific article published on August 2014

Histopathologic response of the immature rat to diffuse traumatic brain injury

scientific article published in October 2001

How low can you go? Blood pressure control after intracranial hemorrhage

scientific article

Hypothermia and hemostasis in severe trauma: A new crossroads workshop report

scientific article

Hypothermia and hyperthermia in children after resuscitation from cardiac arrest

scientific article published on July 2000

Hypothermia attenuates the normal increase in interleukin 1 beta RNA and nerve growth factor following traumatic brain injury in the rat

scientific article published on 01 April 1995

Hypothermia decreases cerebrospinal fluid asymmetric dimethylarginine levels in children with traumatic brain injury.

scientific article

Hypothermic therapies targeting brain and spinal cord injury. Introduction

scientific article published in March 2009

IL-1β associations with posttraumatic epilepsy development: a genetics and biomarker cohort study.

scientific article

Identification of inflicted traumatic brain injury in well-appearing infants using serum and cerebrospinal markers: a possible screening tool

scientific article published in February 2006

Identification of poly-ADP-ribosylated mitochondrial proteins after traumatic brain injury

scientific article published on 06 November 2007

Immunohistochemical analysis of histone H3 acetylation and methylation--evidence for altered epigenetic signaling following traumatic brain injury in immature rats

scientific article published on 9 January 2006

Improving outcomes from resuscitation: from hypertension and hemodilution to therapeutic hypothermia to H2.

scientific article

In quest of the optimal cooling device: isn't faster "too fast"?

scientific article

In response to comments on IL-1β associations with posttraumatic epilepsy development: a genetics and biomarker cohort study

scientific article published on 01 August 2014

Increased CSF Concentrations of Myelin Basic Protein After TBI in Infants and Children: Absence of Significant Effect of Therapeutic Hypothermia ⬇️

scientific article published on December 1, 2012

Increased adenosine in cerebrospinal fluid after severe traumatic brain injury in infants and children: association with severity of injury and excitotoxicity

scientific article published in December 2001

Increased adrenomedullin in cerebrospinal fluid after traumatic brain injury in infants and children

scientific article published in September 2001

Increased phosphorylation of protein kinase B and related substrates after traumatic brain injury in humans and rats

scientific article published on 19 October 2005

Increases in bcl-2 protein in cerebrospinal fluid and evidence for programmed cell death in infants and children after severe traumatic brain injury

article

Induced hyperthermia exacerbates neurologic neuronal histologic damage after asphyxial cardiac arrest in rats

scientific article published in February 2003

Inducible nitric oxide synthase expression in cerebrovascular smooth muscle and neutrophils after traumatic brain injury in immature rats

scientific article published on 01 May 1996

Inducible nitric oxide synthase is an endogenous neuroprotectant after traumatic brain injury in rats and mice

scientific article

Induction of profound hypothermia for emergency preservation and resuscitation allows intact survival after cardiac arrest resulting from prolonged lethal hemorrhage and trauma in dogs

scientific article published on 17 April 2006

Induction of the stress response after inflicted and non-inflicted traumatic brain injury in infants and children.

scientific article

Influence of PARP-1 polymorphisms in patients after traumatic brain injury

scientific article

Innate gender-based proclivity in response to cytotoxicity and programmed cell death pathway

scientific article published in July 2004

Interactive roles of CD73 and tissue nonspecific alkaline phosphatase in the renal vascular metabolism of 5'-AMP.

scientific article

Interleukin 6 and apolipoprotein E as predictors of acute brain dysfunction and survival in critical care patients.

scientific article published on January 2014

Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain

scientific article published on 01 January 1996

Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children.

scientific article published in July 1997

Interleukin-8 is increased in cerebrospinal fluid of children with severe head injury

scientific article published on 01 April 2000

Interstitial adenosine, inosine, and hypoxanthine are increased after experimental traumatic brain injury in the rat.

scientific article published in March 1998

Interstitial brain adenosine and xanthine increase during jugular venous oxygen desaturations in humans after traumatic brain injury

scientific article published in February 2001

Intra-mitochondrial poly(ADP-ribosylation) contributes to NAD+ depletion and cell death induced by oxidative stress

scientific article published on 7 March 2003

Intracranial monitoring and continuous data collection

scientific article published on 01 November 2012

Intracranial pressure-monitoring systems in children with traumatic brain injury: combining therapeutic and diagnostic tools

scientific article published on September 2011

Intranuclear localization of apoptosis-inducing factor (AIF) and large scale DNA fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite

scientific article published in July 2002

Intraperitoneal, but not enteric, adenosine administration improves survival after volume-controlled hemorrhagic shock in rats

scientific article

Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing rat brain and in primary cortical neurons in vitro

scientific article

Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury

scientific article published on 13 February 2006

Isoflurane improves long-term neurologic outcome versus fentanyl after traumatic brain injury in rats

scientific article published in December 2000

It might be time to let cooler heads prevail after mild traumatic brain injury or concussion

scientific article

Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury

journal article published in 2012

Long-Term Deficits in Cortical Circuit Function after Asphyxial Cardiac Arrest and Resuscitation in Developing Rats

scientific article

Long-term dysfunction following diffuse traumatic brain injury in the immature rat.

scientific article published in April 2000

MRI assessment of cerebral blood flow after experimental traumatic brain injury combined with hemorrhagic shock in mice

scientific article published on 17 October 2012

Magnetic resonance imaging assessment of macrophage accumulation in mouse brain after experimental traumatic brain injury

scientific article

Magnetic resonance imaging assessment of regional cerebral blood flow after asphyxial cardiac arrest in immature rats

scientific article published on October 2008

Making an IMPACT in traumatic brain injury research

scientific article published on 17 October 2013

Management of pulmonary barotrauma by extracorporeal membrane oxygenation, apnea, and lung rest

scientific article published on 01 May 1988

Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations

journal article published in 2012

Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients

scientific article published in January 2004

Mass critical care for children: implications for adult critical care

scientific article published on 01 December 2011

Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues induced by pro-apoptotic and pro-inflammatory stimuli

journal article published in 2009

Mass-spectrometric characterization of phospholipids and their primary peroxidation products in rat cortical neurons during staurosporine-induced apoptosis

scientific article

Mass-spectrometry based oxidative lipidomics and lipid imaging: applications in traumatic brain injury

journal article published in 2010

Microglial depletion using intrahippocampal injection of liposome-encapsulated clodronate in prolonged hypothermic cardiac arrest in rats.

scientific article

Mild hypothermia alters midazolam pharmacokinetics in normal healthy volunteers.

scientific article

Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest ⬇️

scientific article published on April 1, 2012

Mild hypothermia during hemorrhagic shock in rats improves survival without significant effects on inflammatory responses

scientific article

Mild hypothermia during prolonged cardiopulmonary cerebral resuscitation increases conscious survival in dogs

scientific article published on 01 October 2004

Mild hypothermia improves survival after prolonged, traumatic hemorrhagic shock in pigs

scientific article

Minocycline attenuates brain tissue levels of TNF-α produced by neurons after prolonged hypothermic cardiac arrest in rats

scientific article

Minocycline reduces neuronal death and attenuates microglial response after pediatric asphyxial cardiac arrest

scientific article published on 16 September 2009

Mitochondrial injury after mechanical stretch of cortical neurons in vitro: biomarkers of apoptosis and selective peroxidation of anionic phospholipids

scientific article

Moderate hypothermia may be detrimental after traumatic brain injury in fentanyl-anesthetized rats

scientific article published in April 2003

Moderate hypothermia prevents cardiac arrest-mediated suppression of drug metabolism and induction of interleukin-6 in rats.

scientific article published on January 2009

Morris water maze function and histologic characterization of two age-at-injury experimental models of controlled cortical impact in the immature rat.

scientific article published on 23 October 2012

Motor and cognitive functional deficits following diffuse traumatic brain injury in the immature rat

scientific article published on 01 February 1997

Multiplex Assessment of Cytokine and Chemokine Levels in Cerebrospinal Fluid following Severe Pediatric Traumatic Brain Injury: Effects of Moderate Hypothermia

article

Multiplex assessment of serum biomarker concentrations in well-appearing children with inflicted traumatic brain injury

scientific article published on January 2009

Murine orthostatic response during prolonged vertical studies: effect on cerebral blood flow measured by arterial spin-labeled MRI.

scientific article

Neurological sequelae of 2009 influenza A (H1N1) in children: a case series observed during a pandemic.

scientific article

Neuron-specific enolase and S100B in cerebrospinal fluid after severe traumatic brain injury in infants and children

scientific article published on 01 February 2002

Neuronal NOS-mediated nitration and inactivation of manganese superoxide dismutase in brain after experimental and human brain injury

scientific article published in April 2007

Neutrophil accumulation after traumatic brain injury in rats: comparison of weight drop and controlled cortical impact models

scientific article published in October 1994

Neutrophils do not mediate blood-brain barrier permeability early after controlled cortical impact in rats

scientific article published in July 1999

Nifedipine in the treatment of a child with pulmonary hypertension associated with severe bronchopulmonary dysplasia

scientific article published on 01 April 1986

One-year study of spatial memory performance, brain morphology, and cholinergic markers after moderate controlled cortical impact in rats

scientific article published in February 1999

Optimization of epoxyeicosatrienoic acid syntheses to test their effects on cerebral blood flow in vivo

scientific article published on 01 June 1995

Optimizing oxygenation and ventilation after cardiac arrest in "little adults"

scientific article published on 14 September 2012

Oxidation and cytotoxicity of 6-OHDA are mediated by reactive intermediates of COX-2 overexpressed in PC12 cells.

scientific article published on 18 May 2006

Oxidative lipidomics of apoptosis: quantitative assessment of phospholipid hydroperoxides in cells and tissues

journal article published in 2010

Oxidative lipidomics of programmed cell death

scientific article published in January 2008

Oxidative stress following traumatic brain injury in rats: quantitation of biomarkers and detection of free radical intermediates

scientific article published on 01 November 2000

PCCM 2014

scientific article published on 01 November 2014

Partial liquid ventilation combined with high frequency gas ventilation: clinical breakthrough or two treatments looking for a home?

scientific article published on 01 November 1999

Pass the salt?

scientific article published in July 1998

Patterns of multiorgan dysfunction after pediatric drowning

scientific article

Pediatric Critical Care Medicine reaches another milestone

scientific article published on 01 November 2012

Pediatric Critical Care Medicine: Re-tooling to accommodate growth and success while preserving excellence

scientific article published on 01 January 2011

Pediatric critical care medicine in Chinese--and other developments

scientific article published on 01 April 2002

Pediatric critical care medicine: planning for our research future

scientific article

Pediatric neurointensive care: 2008 update for the Rogers' Textbook of Pediatric Intensive Care

scientific article published in July 2009

Pediatric traumatic brain injury in 2012: the year with new guidelines and common data elements

scientific article

Pediatric traumatic brain injury is inconsistently regionalized in the United States

scientific article published on July 2008

Pediatric traumatic brain injury: beyond the guidelines

scientific article

Pharmacological inhibition of pleckstrin homology domain leucine-rich repeat protein phosphatase is neuroprotective: differential effects on astrocytes

scientific article published on 10 September 2013

Pharmacotherapy of traumatic brain injury: state of the science and the road forward: report of the Department of Defense Neurotrauma Pharmacology Workgroup

scientific article published on January 2014

Phase I randomized clinical trial of N-acetylcysteine in combination with an adjuvant probenecid for treatment of severe traumatic brain injury in children

scientific article

Physiological assessment and control in studies evaluating central nervous system injury: should size matter?

scientific article published in January 2006

Platelet-activating factor antagonists do not attenuate delayed posttraumatic cerebral edema in rats

scientific article

Politics and hypothermia-what might they have in common? Editorial comment on silasi and colbourne, 2011

scientific article published on 01 March 2012

Polynitroxyl albumin and albumin therapy after pediatric asphyxial cardiac arrest: effects on cerebral blood flow and neurologic outcome

scientific article

Polynitroxylated pegylated hemoglobin: a novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice

scientific article published on March 2011

Polynitroxylated-pegylated hemoglobin attenuates fluid requirements and brain edema in combined traumatic brain injury plus hemorrhagic shock in mice

scientific article published on 26 June 2013

Postcardiac arrest syndrome: focus on the brain

scientific article published on December 2009

Probenecid and N-Acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro

scientific article

Progress Amidst Some Anticipated Growing Pains for PCCM

scientific article published on 01 October 2013

Prolonged deep hypothermic circulatory arrest in rats can be achieved without cognitive deficits.

scientific article published on 29 June 2007

Promising strategies to minimize secondary brain injury after head trauma

scientific article

Protective effect of the 20-HETE inhibitor HET0016 on brain damage after temporary focal ischemia

scientific article

Protein nitration and poly-ADP-ribosylation in brain after rapid exsanguination cardiac arrest in a rat model of emergency preservation and resuscitation

scientific article published on 21 July 2008

Proteolysis consistent with activation of caspase-7 after severe traumatic brain injury in humans

scientific article published in November 2006

Publication of Cochrane Reviews in Critical Care Medicine and Pediatric Critical Care Medicine: guiding practice or duplicating the literature?

scientific article published on 01 July 2002

Quantification of poly(ADP-ribose)-modified proteins in cerebrospinal fluid from infants and children after traumatic brain injury.

scientific article published on 28 May 2008

Quinolinic acid in the cerebrospinal fluid of children after traumatic brain injury

scientific article published in March 1999

Quo Vadis 2010? – Carpe Diem: Challenges and Opportunities in Pediatric Traumatic Brain Injury ⬇️

scientific article published on January 1, 2010

Regional brain injury on conventional and diffusion weighted MRI is associated with outcome after pediatric cardiac arrest

scientific article

Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury

scientific article published on 01 July 2002

Relationship between hyperglycemia and outcome in children with severe traumatic brain injury.

scientific article published on January 2012

Relationship of intracranial pressure and cerebral perfusion pressure with outcome in young children after severe traumatic brain injury

scientific article published on 15 September 2010

Relationships between cerebrospinal fluid markers of excitotoxicity, ischemia, and oxidative damage after severe TBI: the impact of gender, age, and hypothermia

scientific article published in February 2004

Repetitive Mild Traumatic Brain Injury in the Developing Brain: Effects on Long-Term Functional Outcome and Neuropathology

scientific article

Resuscitation of traumatic brain injury and hemorrhagic shock with polynitroxylated albumin, hextend, hypertonic saline, and lactated Ringer's: Effects on acute hemodynamics, survival, and neuronal death in mice

scientific article

Risk factors for mortality in children with abusive head trauma.

scientific article

Role of 2',3'-cyclic nucleotide 3'-phosphodiesterase in the renal 2',3'-cAMP-adenosine pathway

scientific article

Role of A1 receptors in renal sympathetic neurotransmission in the mouse kidney.

scientific article

Role of CNPase in the oligodendrocytic extracellular 2',3'-cAMP-adenosine pathway

scientific article published on 06 August 2013

Screening of biochemical and molecular mechanisms of secondary injury and repair in the brain after experimental blast-induced traumatic brain injury in rats

scientific article published on 5 June 2013

Selective early cardiolipin peroxidation after traumatic brain injury: an oxidative lipidomics analysis

journal article published in 2007

Serum D-dimer concentrations are increased after pediatric traumatic brain injury

scientific article published on 20 November 2014

Serum S100B concentrations are increased after closed head injury in children: a preliminary study

scientific article published on November 2002

Serum amyloid A is increased in children with abusive head trauma: a gel-based proteomic analysis

scientific article published on 18 June 2014

Serum biomarkers after traumatic and hypoxemic brain injuries: insight into the biochemical response of the pediatric brain to inflicted brain injury

scientific article published in January 2006

Serum biomarkers of brain injury to classify outcome after pediatric cardiac arrest*.

scientific article published on March 2014

Severe controlled cortical impact in rats: assessment of cerebral edema, blood flow, and contusion volume.

scientific article published on December 1995

Should we add stem cells to the code cart in resuscitation of heatstroke?

scientific article

Socioeconomic factors associated with outcome after cardiac arrest in patients under the age of 65.

scientific article published on 21 May 2015

Soluble adhesion molecules in CSF are increased in children with severe head injury

scientific article

Some historic firsts for Pediatric Critical Care Medicine

scientific article published in October 2001

Specialty neurointensive care--Is it just a name or a way of life?

scientific article published on 01 March 2001

Starving neurons show sex difference in autophagy.

scientific article

Subarachnoid hemorrhage, systemic immune response syndrome, and MODS: is there cross-talk between the injured brain and the extra-cerebral organ systems? Multiple organ dysfunction syndrome

scientific article published in March 1999

Survival without brain damage after clinical death of 60-120 mins in dogs using suspended animation by profound hypothermia

scientific article

Suspended animation can allow survival without brain damage after traumatic exsanguination cardiac arrest of 60 minutes in dogs

scientific article published on 01 December 2004

Systemic hypothermia, but not regional gut hypothermia, improves survival from prolonged hemorrhagic shock in rats

scientific article published in October 2002

Targeting therapeutic hypothermia in neonatal resuscitation and beyond: it is time to phenotype

scientific article published on 23 January 2014

Thalamocortical dysfunction and thalamic injury after asphyxial cardiac arrest in developing rats.

scientific article

The antioxidant enzymes glutathione peroxidase and catalase increase following traumatic brain injury in the rat.

scientific article published in July 1997

The brain in vivo expresses the 2',3'-cAMP-adenosine pathway.

scientific article

The effect of brain temperature on acute inflammation after traumatic brain injury in rats

scientific article published in August 1997

The far-reaching scope of neuroinflammation after traumatic brain injury

scientific article

The incredible career of Peter J. Safar, MD: the Michelangelo of acute medicine

scientific article (publication date: February 2004)

The nuclear splicing factor RNA binding motif 5 promotes caspase activation in human neuronal cells, and increases after traumatic brain injury in mice

scientific article published on 31 March 2015

The potential for bio-mediators and biomarkers in pediatric traumatic brain injury and neurocritical care

scientific article

The simple model versus the super model: translating experimental traumatic brain injury research to the bedside.

scientific article

The utility of near infrared spectroscopy in detecting intracranial hemorrhage in children.

scientific article published on 26 January 2012

Therapeutic Hypothermia on Its 10th Anniversary: Is it Time to Turn the Thermostat Down?

scientific article published in December 2012

Therapeutic hypothermia after cardiac arrest

scientific article published on 01 February 2002

Therapeutic hypothermia for severe traumatic brain injury

scientific article published in June 2003

Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children

scientific article published on February 2009

Therapeutic hypothermia-induced pharmacokinetic alterations on CYP2E1 chlorzoxazone-mediated metabolism in a cardiac arrest rat model

scientific article published in March 2006

Therapeutic hypothermia: applications in pediatric cardiac arrest.

scientific article published on March 2009

Therapeutic hypothermia: the Safar vision

scientific article published on March 2009

Time course analysis of hippocampal nerve growth factor and antioxidant enzyme activity following lateral controlled cortical impact brain injury in the rat.

scientific article

Titrating oxygen during and after cardiopulmonary resuscitation

scientific article published on 01 June 2010

Trajectory analysis of serum biomarker concentrations facilitates outcome prediction after pediatric traumatic and hypoxemic brain injury

scientific article published on 18 September 2010

Transgenic mice that overexpress the anti-apoptotic Bcl-2 protein have improved histological outcome but unchanged behavioral outcome after traumatic brain injury

scientific article published on 19 June 2006

Treatment of traumatic brain injury with moderate hypothermia.

scientific article published in February 1997

Unique brain region-dependent cytokine signatures after prolonged hypothermic cardiac arrest in rats.

scientific article published on 25 November 2014

Unusual peroxidase activity of polynitroxylated pegylated hemoglobin: elimination of H(2)O(2) coupled with intramolecular oxidation of nitroxides

journal article published in 2010

Upregulation of nerve growth factor following cortical trauma.

scientific article published in December 1994

Urinary S100B concentrations are increased after brain injury in children: A preliminary study

scientific article published in November 2006

Variable neuroendocrine-immune dysfunction in individuals with unfavorable outcome after severe traumatic brain injury.

scientific article

Will the next breakthrough for neuroprotection after cardiac arrest come out of thin air?

scientific article published on 01 January 2014

Winning the cold war: Inroads into implementation of mild hypothermia after cardiac arrest in adults from the European Resuscitation Council Hypothermia After Cardiac Arrest Registry Study Group*

scientific article published on 01 April 2007

boc-Aspartyl(OMe)-fluoromethylketone attenuates mitochondrial release of cytochrome c and delays brain tissue loss after traumatic brain injury in rats

scientific article

α-Synuclein levels are elevated in cerebrospinal fluid following traumatic brain injury in infants and children: the effect of therapeutic hypothermia.

scientific article

Paulina is supported by:

About Paulina

Help