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List of works by Craig W. Roberts

A novel microfluidic-based approach to formulate size-tuneable large unilamellar cationic liposomes: Formulation, cellular uptake and biodistribution investigations

scientific article published on 22 August 2019

A protective role for IL-6 during early infection with Toxoplasma gondii

scientific article published in May 1998

Acanthamoeba Activates Macrophages Predominantly through Toll-Like Receptor 4- and MyD88-Dependent Mechanisms To Induce Interleukin-12 (IL-12) and IL-6.

scientific article published on 27 March 2017

Acanthamoeba alternative oxidase genes: identification, characterisation and potential as antimicrobial targets

scientific article published on 21 May 2009

Acanthamoeba castellanii Genotype T4 Stimulates the Production of Interleukin-10 as Well as Proinflammatory Cytokines in THP-1 Cells, Human Peripheral Blood Mononuclear Cells, and Human Monocyte-Derived Macrophages

scientific article published on August 2016

Acanthamoeba proteases contribute to macrophage activation through PAR1 , but not PAR2

scientific article published on 01 February 2019

Accurate determination of adjuvant-associated protein or peptide by ninhydrin assay

scientific article published on 01 January 1995

Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii

scientific article published on 22 September 2016

An Exaggerated Immune Response in Female BALB/c Mice Controls Initial Toxoplasma gondii Multiplication but Increases Mortality and Morbidity Relative to Male Mice

scientific article published in 2021

Antibody responses to Toxoplasma gondii antigen in human peripheral blood lymphocyte-reconstituted severe-combined immunodeficient mice reproduce the immunological status of the lymphocyte donor

article

Biochemical and Immunological Characterization of Toxoplasma gondii Macrophage Migration Inhibitory Factor

scientific article

CD8+ T cells are the major lymphocyte subpopulation involved in the protective immune response to Toxoplasma gondii in mice

scientific article

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii ⬇️

scientific article published on 05 October 2018

Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba

scientific article

Comparative assessment of a DNA and protein Leishmania donovani gamma glutamyl cysteine synthetase vaccine to cross-protect against murine cutaneous leishmaniasis caused by L. major or L. mexicana infection

scientific article published on 28 December 2011

Comparison of the phosphofructokinase and pyruvate kinase activities of Cryptosporidium parvum, Eimeria tenella and Toxoplasma gondii

scientific article published on 01 February 1996

Congenital toxoplasmosis in the Balb/c mouse: prevention of vertical disease transmission and fetal death by vaccination

article

Construction and validation of a polycompetitor construct (SWITCH) for use in competitive RT-PCR to assess tachyzoite-bradyzoite interconversion in Toxoplasma gondii.

scientific article published in November 2001

DNA vaccination against the parasite enzyme gamma-glutamylcysteine synthetase confers protection against Leishmania donovani infection

scientific article published on 26 March 2007

DNA vaccination with the immunodominant tachyzoite surface antigen (SAG-1) protects against adult acquired Toxoplasma gondii infection but does not prevent maternofoetal transmission

scientific article published on June 2003

Delivery of antimicrobials into parasites

scientific article

Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase

scientific article

Detection of cytokine mRNA in the brains of mice with toxoplasmic encephalitis

scientific article published on July 1, 1992

Development of colorimetric microtiter plate assay for assessment of antimicrobials against Acanthamoeba

scientific article published on February 2005

Differential cytotoxicity of phospholipid analogues to pathogenic Acanthamoeba species and mammalian cells

scientific article

Differential modulation of TLR3- and TLR4-mediated dendritic cell maturation and function by progesterone.

scientific article published on 15 September 2010

Drug target identification, validation, characterisation and exploitation for treatment of Acanthamoeba (species) infections

scientific article published on 24 December 2009

Enzymes of energy metabolism in the bradyzoites and tachyzoites of Toxoplasma gondii

scientific article published in March 1996

Evidence for mitochondrial-derived alternative oxidase in the apicomplexan parasite Cryptosporidium parvum: a potential anti-microbial agent target

scientific article published in March 2004

Evolutionary origins of the eukaryotic shikimate pathway: gene fusions, horizontal gene transfer, and endosymbiotic replacements

scientific article published in September 2006

Exploitation of the bilosome platform technology to formulate antibiotics and enhance efficacy of melioidosis treatments

scientific article published on 04 February 2019

Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase

scientific article

How does toxoplasmosis affect the maternal-foetal immune interface and pregnancy?

scientific article published on 19 December 2018

IL-33 receptor (T1/ST2) signalling is necessary to prevent the development of encephalitis in mice infected with Toxoplasma gondii

scientific article published in February 2010

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

scientific article

Immunogenetics of Toxoplasma gondii informs vaccine design

scientific article published on 26 June 2010

Immunological control of Toxoplasma gondii and appropriate vaccine design

scientific article published on January 1996

Immunological control of congenital toxoplasmosis in the murine model.

scientific article

Induced encystment improves resistance to preservation and storage of Acanthamoeba castellanii

scientific article

Influence of genes within the MHC on mortality and brain cyst development in mice infected with Toxoplasma gondii: kinetics of immune regulation in BALB H-2 congenic mice

scientific article published in June 1993

Kinetics of cytokine mRNA production in the brains of mice with progressive toxoplasmic encephalitis

scientific article published on September 1, 1992

MAP kinase phosphatase-2 plays a key role in the control of infection with Toxoplasma gondii by modulating iNOS and arginase-1 activities in mice

scientific article (publication date: August 2013)

Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host.

scientific article

Mechanisms of innate resistance to Toxoplasma gondii infection ⬇️

scientific article published on September 29, 1997

Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii

scientific article published on 14 June 2013

Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds

scientific article published on 10 December 2007

Multi-Omics Studies Demonstrate Toxoplasma gondii-Induced Metabolic Reprogramming of Murine Dendritic Cells

scientific article published on 11 September 2019

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections ⬇️

scientific article published on 14 July 2016

Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway

scientific article

Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo

scientific article published in 2008

Parasites lacking the micronemal protein MIC2 are deficient in surface attachment and host cell egress, but remain virulent in vivo

scientific article

Protein nanovaccine confers robust immunity against Toxoplasma

scientific article published on 5 September 2017

Protozoan Parasites: Familiar Faces, New Directions

scientific article published on 01 September 1998

Publisher Correction: Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer

scientific article published on 28 May 2019

Resistance of Leishmania donovani to sodium stibogluconate is related to the expression of host and parasite gamma-glutamylcysteine synthetase

scientific article published in January 2006

Salicylanilide Inhibitors of Toxoplasma gondii ⬇️

scientific article published on September 26, 2012

Selective inhibition and augmentation of alternative macrophage activation by progesterone.

scientific article published on November 2011

Sequential expression of macrophage anti-microbial/inflammatory and wound healing markers following innate, alternative and classical activation.

scientific article published on 5 January 2010

Sex steroids, pregnancy-associated hormones and immunity to parasitic infection.

scientific article published in October 1996

Sex-associated hormones and immunity to protozoan parasites.

scientific article

Structural and functional studies of histidine biosynthesis in Acanthamoeba spp. demonstrates a novel molecular arrangement and target for antimicrobials

scientific article published in PLoS ONE

Studies ofToxoplasma gondiiandPlasmodium falciparumenoyl acyl carrier protein reductase and implications for the development of antiparasitic agents

scientific article

Studies on a murine model of congenital toxoplasmosis: vertical disease transmission only occurs in BALB/c mice infected for the first time during pregnancy ⬇️

scientific article published on February 1, 1992

Temporal differences in the expression of mRNA for IL-10 and IFN-gamma in the brains and spleens of C57BL/10 mice infected with Toxoplasma gondii

scientific article

The Acanthamoeba shikimate pathway has a unique molecular arrangement and is essential for aromatic amino acid biosynthesis

scientific article published on 11 December 2014

The Toxoplasma gondii plastid replication and repair enzyme complex, PREX.

scientific article published on 30 April 2009

The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target

scientific article

The role of IL-4 in adult acquired and congenital toxoplasmosis

scientific article published in January 1998

The shikimate pathway and its branches in apicomplexan parasites

scientific article

Toll-like receptor-4-mediated macrophage activation is differentially regulated by progesterone via the glucocorticoid and progesterone receptors

scientific article published on 28 March 2008

Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer.

scientific article published on 13 September 2017

Toxoplasma gondii HLA-B*0702-restricted GRA7(20-28) peptide with adjuvants and a universal helper T cell epitope elicits CD8(+) T cells producing interferon-γ and reduces parasite burden in HLA-B*0702 mice

scientific article published on 12 October 2011

Toxoplasma gondii dense granule protein 3 (GRA3) is a type I transmembrane protein that possesses a cytoplasmic dilysine (KKXX) endoplasmic reticulum (ER) retrieval motif

scientific article

Toxoplasma gondii infection reduces serum progesterone levels and adverse effects at the maternal-foetal interface

scientific article published on 18 December 2019

Toxoplasma gondii tachyzoite-bradyzoite interconversion.

scientific article

Toxoplasma gondii-specific immunoglobulin M limits parasite dissemination by preventing host cell invasion. ⬇️

scientific article

Triazine Inhibits Toxoplasma gondii tachyzoites in vitro and in vivo

scientific article published on August 2005

Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.

scientific article

Type I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structure

scientific article

Vaccination with recombinant Leishmania donovani gamma-glutamylcysteine synthetase fusion protein protects against L. donovani infection

scientific article published on 17 April 2010

Vaccines against Toxoplasma gondii: challenges and opportunities

scientific article published on March 2009

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