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List of works by Stephen Muench

A Tribute to Stephen Allan Baldwin

scientific article published on 22 June 2015

A cryo-EM grid preparation device for time-resolved structural studies

scientific article published on 05 September 2019

A method for detergent-free isolation of membrane proteins in their local lipid environment. ⬇️

scientific article

A reconstitution method for integral membrane proteins in hybrid lipid-polymer vesicles for enhanced functional durability ⬇️

scientific article published on 31 January 2018

ALOX12 in human toxoplasmosis

scientific article

An introduction to sample preparation and imaging by cryo-electron microscopy for structural biology ⬇️

scientific article published on 27 February 2016

Approaches to altering particle distributions in cryo-electron microscopy sample preparation ⬇️

scientific article published on 18 May 2018

Archazolid A binds to the equatorial region of the c-ring of the vacuolar H+-ATPase

scientific article published on 30 September 2010

Artificial membranes for membrane protein purification, functionality and structure studies ⬇️

scientific article

AtSPX1 affects the AtPHR1 -DNA binding equilibrium by binding monomeric AtPHR1 in solution ⬇️

scientific article published on 8 September 2017

CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii ⬇️

scientific article published on 05 October 2018

Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3

Characterization of the flexibility of the peripheral stalk of prokaryotic rotary A-ATPases by atomistic simulations ⬇️

scientific article published on 14 May 2016

Cloning, purification and preliminary crystallographic analysis of the Bacillus subtilis GTPase YphC-GDP complex ⬇️

scientific article published on 12 April 2006

Conformational changes during human P2X7 receptor activation examined by structural modelling and cysteine-based cross-linking studies ⬇️

scientific article published on 26 December 2016

Corrigendum to 'Methods to account for movement and flexibility in cryo-EM data processing' [Methods 100 (2016) 35-41]. ⬇️

scientific article

Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from Salmonella

scientific article published on 23 June 2020

Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states ⬇️

scientific article published on 18 June 2018

Cryo-electron microscopy of the vacuolar ATPase motor reveals its mechanical and regulatory complexity

scientific article (publication date: 6 March 2009)

Crystallization and preliminary X-ray crystallographic studies on the class II cholesterol oxidase from Burkholderia cepacia containing bound flavin

scientific article published on 23 November 2002

Delivery of antimicrobials into parasites

scientific article

Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase

scientific article

Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides

scientific article

Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo-electron microscopy

scientific article published on 28 August 2019

Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay

scientific article published on 13 December 2013

Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human ⬇️

scientific article published on 6 June 2015

Durable proteo-hybrid vesicles for the extended functional lifetime of membrane proteins in bionanotechnology ⬇️

scientific article

Durable vesicles for reconstitution of membrane proteins in biotechnology ⬇️

scientific article published on February 2017

Editorial ⬇️

scientific article published on 06 April 2016

Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM. ⬇️

scientific article published on 6 February 2018

Everyone needs good neighbours - the intricate relationship between the acetylcholine-receptor channel and its membrane environment ⬇️

scientific article published on 29 June 2017

Expression, purification and crystallization of the Plasmodium falciparum enoyl reductase

scientific article published on 27 June 2003

Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase

scientific article

Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes ⬇️

scientific article published on 24 February 2016

Flexibility within the rotor and stators of the vacuolar H+-ATPase ⬇️

scientific article

Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

scientific article published on 23 November 2020

Identification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl Reductase

scientific article

Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans

scientific article

In situ formation of magnetopolymersomes via electroporation for MRI. ⬇️

scientific article

LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM

scientific article published on 28 June 2019

Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host.

scientific article

Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium ⬇️

scientific article

Methods to account for movement and flexibility in cryo-EM data processing. ⬇️

scientific article

Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii

scientific article published on 14 June 2013

Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds

scientific article published on 10 December 2007

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections ⬇️

scientific article published on 14 July 2016

No Longer Hidden Secrets of Proton Pumping: The Resolution Revolution Enlightens V-ATPases ⬇️

scientific article published in March 2018

Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkers ⬇️

scientific article

Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway

scientific article

Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo

scientific article published in 2008

PA1b inhibitor binding to subunits c and e of the vacuolar ATPase reveals its insecticidal mechanism ⬇️

scientific article

Pi sensing and signalling: from prokaryotic to eukaryotic cells ⬇️

scientific article published on June 2016

Replace, reuse, recycle: improving the sustainable use of phosphorus by plants ⬇️

scientific article

Rotating with the brakes on and other unresolved features of the vacuolar ATPase ⬇️

scientific article

Sample deposition onto cryo-EM grids: from sprays to jets and back

scientific article published on 25 March 2020

Spherical-supported membranes as platforms for screening against membrane protein targets. ⬇️

scientific article published on 12 March 2018

Spiroindolone that inhibits PfATPase4 is a potent, cidal inhibitor of Toxoplasma gondii tachyzoites in vitro and in vivo

scientific article published on 23 December 2013

Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy

scientific article published on 15 December 2020

Structural divergence of the rotary ATPases

scientific article published on 22 March 2011

Structure of the protective nematode protease complex H-gal-GP and its conservation across roundworm parasites

scientific article published on 09 April 2020

Structure of the vacuolar H+-ATPase rotary motor reveals new mechanistic insights ⬇️

scientific article published on 5 February 2015

Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists ⬇️

scientific article

Studies ofToxoplasma gondiiandPlasmodium falciparumenoyl acyl carrier protein reductase and implications for the development of antiparasitic agents

scientific article

Styrene maleic acid recovers proteins from mammalian cells and tissues while avoiding significant cell death

scientific article published on 25 November 2019

Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies ⬇️

scientific article published on 04 December 2018

Subunit positioning and stator filament stiffness in regulation and power transmission in the V1 motor of the Manduca sexta V-ATPase ⬇️

scientific article

T. gondii RP promoters & knockdown reveal molecular pathways associated with proliferation and cell-cycle arrest

scientific article (publication date: 2010)

TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p ⬇️

scientific article published on 16 October 2017

The Acanthamoeba shikimate pathway has a unique molecular arrangement and is essential for aromatic amino acid biosynthesis

scientific article published on 11 December 2014

The Growing Role of Electron Microscopy in Anti-parasitic Drug Discovery ⬇️

scientific article published on 9 November 2017

The Vacuolar ATPase - A Nano-scale Motor That Drives Cell Biology.

scientific article published in January 2018

The active form of quinol-dependent nitric oxide reductase from Neisseria meningitidis is a dimer

scientific article published on 21 March 2020

The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target

scientific article

The changing landscape of membrane protein structural biology through developments in electron microscopy ⬇️

scientific article

The conservation of phosphate-binding residues among PHT1 transporters suggests that distinct transport affinities are unlikely to result from differences in the phosphate-binding site ⬇️

scientific article published on October 2016

The essential GTPase YphC displays a major domain rearrangement associated with nucleotide binding

scientific article

The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM

scientific article published on 01 March 2019

The potential use of single-particle electron microscopy as a tool for structure-based inhibitor design. ⬇️

scientific article published on 20 April 2017

The use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy. ⬇️

scientific article

The varied functions of aluminium-activated malate transporters-much more than aluminium resistance ⬇️

scientific article

Triclosan inhibits the growth of Plasmodium falciparum and Toxoplasma gondii by inhibition of apicomplexan Fab I.

scientific article

Type I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structure

scientific article

Understanding the apparent stator-rotor connections in the rotary ATPase family using coarse-grained computer modeling ⬇️

scientific article published on 11 November 2014

Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure. ⬇️

scientific article

X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery. ⬇️

scientific article published on 20 February 2018

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