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List of works by Miles D. Houslay

'Crosstalk': a pivotal role for protein kinase C in modulating relationships between signal transduction pathways ⬇️

scientific article published on January 1, 1991

1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, beta-arrestin and RACK1

scientific article

5-Hydroxytryptamine is a substrate for both species of monoamine oxidase in beef heart mitochondria

scientific article published on September 1976

5-Hydroxytryptamine receptors mediating vasoconstriction in pulmonary arteries from control and pulmonary hypertensive rats

scientific article published on November 1996

5′-Nucleotidase is activated upon cholesterol-depletion of liver plasma membranes

scientific article published on 01 June 1983

A RSK(y) relationship with promiscuous PKA.

scientific article published on 22 August 2006

A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity

scientific article published on 20 May 2010

A kinetic evaluation of monoamine oxidase activity in rat liver mitochondrial outer membranes

scientific article published on June 1974

A kinetic method for the detection of inhibitory contaminants in radioactive substrates

scientific article published in August 1977

A mnemonical or negative-co-operativity model for the activation of adenylate cyclase by a common G-protein-coupled calcitonin-gene-related neuropeptide (CGRP)/amylin receptor.

scientific article published on July 1993

A model for the selective mode of action of the irreversible monoamine oxidase inhibitors clorgyline and deprenyl, based on studies of their ability to activate a Ca2+-Mg2+ ATPase in defined lipid environments ⬇️

scientific article published on November 1, 1977

A novel role for a Drosophila homologue of cGMP-specific phosphodiesterase in the active transport of cGMP

scientific article published on January 2006

A peripheral and an intrinsic enzyme constitute the cyclic AMP phosphodiesterase activity of rat liver plasma membranes

scientific article published on May 1980

A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells

scientific article

A role for protein kinase C-mediated phosphorylation in eliciting glucagon desensitization in rat hepatocytes

scientific article published on April 1995

A scanning peptide array approach uncovers association sites within the JNK/beta arrestin signalling complex

scientific article

A simple method for sequencing small DNAs by introducing precise overlapping ends into restriction digestion fragments

scientific article published on August 1998

A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway

scientific article

Abolition of the expression of inhibitory guanine nucleotide regulatory protein Gi activity in diabetes

scientific article published in Nature

Acidic phospholipid species inhibit adenylate cyclase activity in rat liver plasma membranes

scientific article published on April 1986

Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocytic cells

scientific article published on April 2000

Activation and phosphorylation of the 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase by cyclic AMP-dependent protein kinase

scientific article published on May 1989

Activation of two signal-transduction systems in hepatocytes by glucagon

scientific article published in Nature

Adaptation in cyclic AMP signalling processes: A central role for cyclic AMP phosphodiesterases ⬇️

scientific article published on April 1, 1998

Adenosine 3',5'-cyclic monophosphate (cAMP)-dependent inhibition of IL-5 from human T lymphocytes is not mediated by the cAMP-dependent protein kinase A.

scientific article published in August 2001

Adenylate cyclase and a fatty acid spin probe detect changes in plasma membrane lipid phase separations induced by dietary manipulation of the cholesterol:phospholipid ratio

scientific article published on 01 April 1985

Adenylate cyclase is inhibited upon depletion of plasma-membrane cholesterol

scientific article

Adipocyte plasma-membrane Gi and Gs in insulinopenic diabetic patients

scientific article published on November 1989

Allotopic properties of human brain monoamine oxidase

scientific article published in December 1973

Alterations in G-protein expression and the hormonal regulation of adenylate cyclase in the adipocytes of obese (fa/fa) Zucker rats

scientific article published on May 1991

Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity.

scientific article

Altered Expression of PDE1 and PDE4 Cyclic Nucleotide Phosphodiesterase Isoforms in 7-oxo-prostacyclin-preconditioned Rat Heart

article

Altered G-protein expression and adenylate cyclase activity in platelets of non-insulin-dependent diabetic (NIDDM) male subjects

scientific article published on February 1991

Alternative splicing of cAMP-specific phosphodiesterase mRNA transcripts. Characterization of a novel tissue-specific isoform, RNPDE4A8.

scientific article published in January 1996

Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: 'designer' changes in Vmax, stability and membrane association.

scientific article

Amine competition for oxidation by rat liver mitochondrial monoamine oxidase

scientific article published on March 1975

Amphoptericin B has very different effects on the glucagon- and fluoride-stimulated adenylate cyclase activities of rat liver plasma membranes

scientific article published on 01 October 1979

An assessment of the ability of insulin-stimulated cyclic AMP phosphodiesterase to decrease hepatocyte intracellular cyclic AMP concentrations

scientific article published on August 1984

An insulin mediator preparation serves to stimulate the cyclic GMP activated cyclic AMP phosphodiesterase rather than other purified insulin-activated cyclic AMP phosphodiesterases

scientific article published on 01 October 1988

Analysis of mammalian ras effector function.

scientific article

Analysis of the adenylate cyclase signalling system, and alterations induced by culture with insulin, in a novel SV40-DNA-immortalized hepatocyte cell line (P9 cells).

scientific article published on June 1994

Annular lipids determine the ATPase activity of a calcium transport protein complexed with dipalmitoyllecithin

scientific article published on September 1976

Antisense technology reveals distinct roles for protein kinase C isoforms during 3T3-F442A preadipocyte differentiation

scientific article published on November 1997

Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes

scientific article

Arrestin times for developing antipsychotics and beta-blockers

scientific article

Arresting times for PTEN ⬇️

scientific article published on July 6, 2011

Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2

scientific journal article

Behavioral phenotypes of Disc1 missense mutations in mice

scientific article

Binding to GDP-agarose identifies a novel 60kDa substrate for the insulin receptor tyrosyl kinase in mouse NIH-3T3 cells expressing high concentrations of the human insulin receptor

scientific article published on February 1989

Bombesin stimulation of inositol 1,4,5-trisphosphate generation and intracellular calcium release is amplified in a cell line overexpressing the N-ras proto-oncogene

scientific article published on June 1989

Cell signalling: Dual control of adenylate cyclase ⬇️

scientific article published on May 12, 1983

Challenge of hepatocytes by glucagon triggers a rapid modulation of adenylate cyclase activity in isolated membranes

scientific article published on July 1983

Challenge of human Jurkat T-cells with the adenylate cyclase activator forskolin elicits major changes in cAMP phosphodiesterase (PDE) expression by up-regulating PDE3 and inducing PDE4D1 and PDE4D2 splice variants as well as down-regulating a novel

scientific article published on January 1997

Changes in the form of Arrhenius plots of the activity of glucagon-stimulated adenylate cyclase and other hamster liver plasma-membrane enzymes occurring on hibernation

scientific article published on September 1978

Changes in the phosphorylation state of the inhibitory guanine-nucleotide-binding protein Gi-2 in hepatocytes from lean (Fa/Fa) and obese (fa/fa) Zucker rats

scientific article published on September 1990

Characterization of five different proteins produced by alternatively spliced mRNAs from the human cAMP-specific phosphodiesterase PDE4D gene ⬇️

scientific article published on December 1, 1997

Characterization of the phosphorylated form of the insulin-stimulated cyclic AMP phosphodiesterase from rat liver plasma membranes

scientific article published on June 1981

Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)

scientific article

Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase

scientific article

Chimeric constructs show that the unique N-terminal domain of the cyclic AMP phosphodiesterase RD1 (RNPDE4A1A; rPDE-IVA1) can confer membrane association upon the normally cytosolic protein chloramphenicol acetyltransferase

scientific article published on June 1995

Cholera toxin mediated activation of adenylate cyclase in intact rat hepatocytes

scientific article published on 01 August 1979

Cholera toxin requires oxidized nicotinamide-adenine dinucleotide to activate adenylate cyclase in purified rat liver plasma membranes

scientific article published on March 1977

Cholesterol is excluded from the phospholipid annulus surrounding an active calcium transport protein

scientific article

Chronic effects of somatotropin treatment on response of subcutaneous adipose tissue lipolysis to acutely acting factors in vivo and in vitro

scientific article

Co-transfection with protein kinase D confers phorbol-ester-mediated inhibition on glucagon-stimulated cAMP accumulation in COS cells transfected to overexpress glucagon receptors

scientific article published on September 1997

Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract

scientific article

Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells

scientific article published on 29 November 2006

Compartmentalization of cyclic AMP phosphodiesterases, signalling 'crosstalk', desensitization and the phosphorylation of Gi-2 add cell specific personalization to the control of the levels of the second messenger cyclic AMP.

scientific article

Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory.

scientific article published on August 2016

Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2.

scientific article

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway

scientific article published on 15 December 2005

Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP.

scientific article

Constitutive activation of the G-protein subunit Galphas within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression.

scientific article published on 28 January 2008

Coupling of the Glucagon Receptor to Adenylate Cyclase ⬇️

scientific article published on October 1, 1979

Creating a potential diagnostic for prostate cancer risk stratification (InformMDx™) by translating novel scientific discoveries concerning cAMP degrading phosphodiesterase-4D7 (PDE4D7)

scientific article published on 25 January 2019

Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase a signaling pathways at the level of a protein kinase B/beta-arrestin/cAMP phosphodiesterase 4 complex

scientific article published on 19 January 2010

Cyclic AMP controls mTOR through regulation of the dynamic interaction between Rheb and phosphodiesterase 4D.

scientific article published on 13 September 2010

Cyclic AMP phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a vascular endothelial cadherin (VE-Cad)-based signaling complex and controls cAMP-mediated vascular permeability

scientific article published on 23 August 2010

Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoter

scientific article

Cyclic nucleotide phosphodiesterases in Drosophila melanogaster.

scientific article published on May 2005

DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling

scientific article

DISC1 regulates N-methyl-D-aspartate receptor dynamics: abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness

scientific article published on 06 September 2018

DISC1-dependent switch from progenitor proliferation to migration in the developing cortex

scientific journal article

Derivation of endothelial cells from human embryonic stem cells by directed differentiation: analysis of microRNA and angiogenesis in vitro and in vivo

scientific article

Desensitization of atriopeptin stimulated accumulation and extrusion of cyclic GMP from a kidney epithelial cell line (MDCK).

scientific article published on February 1991

Detergents modify the form of Arrhenius plots of 5'-nucleotidase activity

scientific article

Determination of G-protein levels, ADP-ribosylation by cholera and pertussis toxins and the regulation of adenylyl cyclase activity in liver plasma membranes from lean and genetically diabetic (db/db)

article

Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H NMR and identification of the membrane association domain using chimeric constructs

scientific article

Development of lipid metabolism in ovine preadipocytes in vitro

article

Development of rolipram-sensitive, cyclic AMP phosphodiesterase (PDE4) in rat primary neuronal cultures

scientific article

Developmental changes in the form of the Arrhenius plots of rat liver plasma membrane adenylate cyclase and 5'-nucleotidase activities

scientific article published in March 1982

Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (Gi) on adipocyte adenylate cyclase activity

scientific article published on March 1990

Diabetes induces selective alterations in the expression of protein kinase C isoforms in hepatocytes

scientific article published on 01 July 1993

Diabetes-induced alterations in the expression, functioning and phosphorylation state of the inhibitory guanine nucleotide regulatory protein Gi-2 in hepatocytes

scientific article published on October 1990

Diabetes-induced changes in guanine-nucleotide-regulatory-protein mRNA detected using synthetic oligonucleotide probes

scientific article

Dietary linoleic acid-induced changes in respiratory beta-adrenergic receptor function and the form of arrhenius plots of isoprenaline- and prostaglandin E2-stimulated adenylate cyclase activity in a model for atopy

scientific article published in February 1994

Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers

scientific article published on 26 March 2004

Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains

scientific article published on 27 December 2014

Dimethylnitrosamine inhibits the glucagon-stimulated adenylate cyclase activity of rat liver plasma membranes and decreases plasma membrane fluidity

scientific article published on 01 June 1984

Discriminative stimulus effects of the type-4 phosphodiesterase inhibitor rolipram in rats

scientific article published in November 2001

Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness

scientific article published on 06 September 2007

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

scientific journal article

Disrupting specific PDZ domain-mediated interactions for therapeutic benefit

scientific article published on September 2009

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

scientific article published on 18 February 2011

Does insulin exert certain of its actions through a distinct species of guanine nucleotide regulatory protein? ⬇️

scientific article published on October 1, 1984

Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during beta2-adrenoceptor and prostanoid receptor cAMP signaling

scientific article published on 13 September 2007

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.

scholarly article

ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions

scientific article (publication date: 2 June 2000)

Editorial

Effects of lactation on the signal transduction systems regulating lipolysis in sheep subcutaneous and omental adipose tissue

scientific article published on May 1995

Effects of transformation by p21N-ras upon the inositol phospholipid and adenylate cyclase signaling pathways in NIH 3T3 cells

scientific article published on January 1988

Effects of Δ9-tetrahydrocannabinol on glucagon receptor coupling to adenylate cyclase in rat liver plasma membranes

scientific article published on 01 August 1986

Elevated membrane cholesterol concentrations inhibit glucagon-stimulated adenylate cyclase

scientific article published on February 1983

Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).

scientific article published on 13 April 2011

Engineered deletion of the unique N-terminal domain of the cyclic AMP-specific phosphodiesterase RD1 prevents plasma membrane association and the attainment of enhanced thermostability without altering its sensitivity to inhibition by rolipram

scientific article

Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model

scientific article published on May 2014

Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells

scientific article published on December 2010

Eukaryotic translation initiation factor 3, subunit a, regulates the extracellular signal-regulated kinase pathway

scientific journal article

Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D

scientific article

Exchange of partners in glucagon receptor-adenylate cyclase complexes. Physical evidence for the independent, mobile receptor model

scientific article published on June 1977

Exposure of mitochondrial outer membranes to neuraminidase selectively destroys monoamine oxidase A activity

article

Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene

scientific article published on June 2004

Extracellular calcium modulates insulin's action on enzymes controlling cyclic AMP metabolism in intact hepatocytes

scientific article

Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases

scientific article published on 3 June 2004

Forskolin and ethanol both perturb the structure of liver plasma membranes and activate adenylate cyclase activity.

scientific article published on May 1983

G-protein linked receptors: a family probed by molecular cloning and mutagenesis procedures

scientific article published on June 1, 1992

G-proteins in essential hypertension: a study of human platelet plasma membranes.

scientific article

G-proteins in experimental hypertension: a study of spontaneously hypertensive rat myocardial and renal cortical plasma membranes

scientific article published on 01 April 1993

Genetically acquired diabetes: adipocyte guanine nucleotide regulatory protein expression and adenylate cyclase regulation

scientific article published on February 1991

Genomic organisation of the human cyclic AMP-specific phosphodiesterase PDE4C gene and its chromosomal localisation to 19p13.1, between RAB3A and JUND.

scientific article

Glucagon desensitization of adenylate cyclase and stimulation of inositol phospholipid metabolism does not involve the inhibitory guanine nucleotide regulatory protein Gi, which is inactivated upon challenge of hepatocytes with glucagon

scientific article published on April 1989

Glucagon stimulates adenylate cyclase through GR2 glucagon receptors: a process which can be attenuated by glucagon stimulating inositol phospholipid metabolism through GR1 glucagon receptors

scientific article published in February 1987

Glucagon, vasopressin and angiotensin all elicit a rapid, transient increase in hepatocyte protein kinase C activity

scientific article published on April 1992

Glucagon-stimulated adenylate cyclase detects a selective perturbation of the inner half of the liver plasma-membrane bilayer achieved by the local anaesthetic prilocaine

scientific article published on July 1980

Growth hormone and phorbol esters require specific protein kinase C isoforms to activate mitogen-activated protein kinases in 3T3-F442A cells

scientific article published on May 1997

Growth hormone decreases the response to anti-lipolytic agonists and decreases the levels of Gi2 in rat adipocytes

scientific article published on January 1994

Growth hormone-dependent differentiation of 3T3-F442A preadipocytes requires Janus kinase/signal transducer and activator of transcription but not mitogen-activated protein kinase or p70 S6 kinase signaling.

scientific article

Guanine nucleotide regulatory proteins in insulin's action and in diabetes

scientific article

Guanine nucleotides can activate the insulin-stimulated phosphodiesterase in liver plasma membranes

scientific article published on 01 April 1983

Guanine-nucleotide-binding proteins expressed in rat white adipose tissue. Identification of both mRNAs and proteins corresponding to Gi1, Gi2 and Gi3.

scientific article published on September 1989

Guanine-nucleotide-binding proteins in diabetes and insulin-resistant states

scientific article published on January 1990

Guanosine 5'-triphosphate and guanosine 5'-[beta gamma-imido]triphosphate effect a collision coupling mechanism between the glucagon receptor and catalytic unit of adenylate cyclase

scientific article published on March 1980

Hard Times for Oncogenic BRAF-Expressing Melanoma Cells

Helix-1 of the cAMP-specific phosphodiesterase PDE4A1 regulates its phospholipase-D-dependent redistribution in response to release of Ca2+.

scientific article

Heterogeneity of cyclic nucleotide phosphodiesterases in liver endoplasmic reticulum

scientific article

Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis.

scientific article published on 24 July 2014

High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules

scientific article

Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change

scientific article

Hypertension linked to PDE3A activation

Hypoxia-induced remodelling of PDE4 isoform expression and cAMP handling in human pulmonary artery smooth muscle cells

scientific article published on 3 February 2006

Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene

scientific article (publication date: June 2005)

Identification and characterization of both the cytosolic and particulate forms of cyclic GMP-stimulated cyclic AMP phosphodiesterase from rat liver

scientific article published on March 1986

Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells.

scientific article

Identification and characterization of the human homologue of the short PDE4A cAMP-specific phosphodiesterase RD1 (PDE4A1) by analysis of the human HSPDE4A gene locus located at chromosome 19p13.2

scientific article

Identification and characterization of the type-IVA cyclic AMP-specific phosphodiesterase RD1 as a membrane-bound protein expressed in cerebellum

scientific article published on March 1995

Identification and selective inhibition of four distinct soluble forms of cyclic nucleotide phosphodiesterase activity from kidney

scientific article published on 01 July 1990

Identification of two splice variant forms of type-IVB cyclic AMP phosphodiesterase, DPD (rPDE-IVB1) and PDE-4 (rPDE-IVB2) in brain: selective localization in membrane and cytosolic compartments and differential expression in various brain regions

scientific article published on December 1994

Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

scientific article

In addition to the SH3 binding region, multiple regions within the N-terminal noncatalytic portion of the cAMP-specific phosphodiesterase, PDE4A5, contribute to its intracellular targeting

scientific article

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10).

scientific article published on 5 August 2008

In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region

scientific article published on September 2005

Induction of Ca2+/calmodulin-stimulated cyclic AMP phosphodiesterase (PDE1) activity in Chinese hamster ovary cells (CHO) by phorbol 12-myristate 13-acetate and by the selective overexpression of protein kinase C isoforms

scientific article published on September 1995

Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species

scientific article published in January 2010

Inhibition of beef plasma amine oxidase by clorgyline

scientific article published on 01 February 1975

Insulin activates a rat liver peripheral plasma-membrane cyclic AMP phosphodiesterase by a phosphorylation mechanism

scientific article published on 01 October 1980

Insulin activates the plasma-membrane and dense-vesicle cyclic AMP phosphodiesterase in hepatocytes by distinct routes

scientific article published on October 1983

Insulin affects the ability of Gi to be ADP-ribosylated but does not elicit its phosphorylation in intact hepatocytes

scientific article published on 01 November 1989

Insulin alters the target size of the peripheral cyclic AMP phosphodiesterase but not the integral cyclic GMP-stimulated cyclic AMP phosphodiesterase in liver plasma membranes

scientific article

Insulin and glucagon attenuate the ability of cholera toxin to activate adenylate cyclase in intact hepatocytes

scientific article published on April 1988

Insulin and glucagon regulate the activation of two distinct membrane-bound cyclic AMP phosphodiesterases in hepatocytes

scientific article published on July 1983

Insulin and vasopressin elicit inhibition of cholera-toxin-stimulated adenylate cyclase activity in both hepatocytes and the P9 immortalized hepatocyte cell line through an action involving protein kinase C.

scientific article

Insulin controls intracellular cyclic AMP concentrations in hepatocytes by activating specific cyclic AMP phosphodiesterases: phosphorylation of the peripheral plasma membrane enzyme

scientific article published on 01 January 1984

Insulin controls the cyclic AMP-dependent phosphorylation of integral and peripheral proteins associated with the rat liver plasma membrane

article

Insulin exerts actions through a distinct species of guanine nucleotide regulatory protein: inhibition of adenylate cyclase

scientific article published on August 1983

Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes

scientific article published on June 1985

Insulin inhibits the phosphorylation of alpha-Gi-2 in intact hepatocytes

scientific article published on June 1995

Insulin stimulates a novel GTPase activity in human platelets

scientific article

Insulin stimulates the tyrosyl phosphorylation and activation of the 52 kDa peripheral plasma-membrane cyclic AMP phosphodiesterase in intact hepatocytes

scientific article published on August 1989

Insulin trigger, cyclic AMP-dependent activation and phosphorylation of a plasma membrane cyclic AMP phosphodiesterase

scientific article published on August 1980

Insulin, glucagon and the receptor-mediated control of cyclic AMP concentrations in liver. Twenty-second Colworth medal lecture.

scientific article

Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.

scientific article published on April 2011

Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function

scientific article published on 7 June 2011

Interaction of caspase-3 with the cyclic GMP binding cyclic GMP specific phosphodiesterase (PDE5a1).

scientific article published in March 2003

Interaction of the human insulin receptor with the ras oncogene product p21.

scientific article published on June 1987

Intracellular compartmentalization of PDE4 cyclic AMP-specific phosphodiesterases.

scientific article

Intracellular localization of the PDE4A cAMP-specific phosphodiesterase splice variant RD1 (RNPDE4A1A) in stably transfected human thyroid carcinoma FTC cell lines

scientific article published on January 1997

Intracellular targeting of phosphodiesterase-4 underpins compartmentalized cAMP signaling

scientific article published on January 2006

Investigation of extracellular signal-regulated kinase 2 mitogen-activated protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases

scientific article published in January 2005

Investigation of the alkenyldiarylmethane non-nucleoside reverse transcriptase inhibitors as potential cAMP phosphodiesterase-4B2 inhibitors

scientific article

Is an early calcium flux necessary to stimulate lymphocytes?

scientific article

Is the receptor-mediated endocytosis of cholera toxin A pre-requisite for its activation of adenylate cyclase in intact rat hepatocytes?

scientific article published on June 1981

Islet-activating protein blocks glucagon desensitization in intact hepatocytes

scientific article published on August 1984

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.

scientific article published on August 2007

Keynote review: phosphodiesterase-4 as a therapeutic target

scientific article

Lentivirus-mediated reprogramming of somatic cells in the absence of transgenic transcription factors

scientific article

Lipid phase transitions control β-hydroxybutyrate dehydrogenase activity in defined-lipid protein complexes

scientific article published on 01 March 1975

Lipid substitution of mitochondrial monoamine oxidase can lead to the abolition of clorgyline selective inhibition without alteration in the A/B ratio assessed by substrate utilisation

scientific article published on 01 December 1980

Localization of the gene for the human serotonin 5-HT2Breceptor to chromosome 2

article

Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)

scientific article

Low level cyclic adenosine 3',5'-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists

scientific article published on 01 August 1996

Lysolecithin is a selective reversible inhibitor of mitochondrial monoamine oxidase

scientific article published on 01 January 1978

Lysophosphatidylcholines can modulate the activity of the glucagon-stimulated adenylate cyclase from rat liver plasma membranes

scientific article published on January 1979

MEK1 binds directly to betaarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization

scientific article published on 19 January 2009

MEK1 binds directly to βarrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization

scientific article published in Journal of Biological Chemistry

Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays

scientific article

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5

scientific article

Mdm2 directs the ubiquitination of β-arrestin-sequestered cAMP phosphodiesterase-4D5.

scientific article published in August 2009

Mechanism of glucagon activation of adenylate cyclase in the presence of Mn2+.

scientific article published on May 1983

Membrane phosphorylation: a crucial role in the action of insulin, EGF, and pp60src?

scientific article published on January 1981

Membrane-mediated responses to 12-O-tetradecanoylphorbol-13-acetate in human skin fibroblasts

article

Metabolism of aldehydes in brain

scientific article

Metformin treatment of lean and obese Zucker rats modulates the ability of glucagon and insulin to regulate hepatocyte adenylate cyclase activity

scientific article published on 01 July 1989

Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression

scientific article published on 9 May 2014

Mixed substrate experiments with human brain monoamine oxidase

scientific article published in July 1974

Mobile receptor and collision coupling mechanisms for the activation of adenylate cyclase by glucagon

scientific article published on 01 January 1981

Modulation of adenosine signalling in sheep adipose tissue by growth hormone

scientific article published on 01 February 1995

Molecular basis of insulin receptor function

scientific article

Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1)

scientific article (publication date: September 1994)

Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform

scientific article

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3 ⬇️

scientific article published on December 1, 1997

Molecular cloning of a novel splice variant of human type IVA (PDE-IVA) cyclic AMP phosphodiesterase and localization of the gene to the p13.2-q12 region of human chromosome 19 [corrected]

scientific article

Molecular genetic approaches. III. Determination of protein sequence motifs involved in protein targeting by use of coupled transcription-translation systems

scientific article

Multi-site phosphorylation of the inhibitory guanine nucleotide regulatory protein Gi-2 occurs in intact rat hepatocytes

scientific article

Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) Zucker rats: loss of functional Gi and abnormal Gs function

scientific article

Multiple forms of monoamine oxidase: fact and artefact

scientific article published on August 1976

Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems

scientific article

Mutations of beta-arrestin 2 that limit self-association also interfere with interactions with the beta2-adrenoceptor and the ERK1/2 MAPKs: implications for beta2-adrenoceptor signalling via the ERK1/2 MAPKs

scientific article

N6-(Phenylisopropyl)adenosine prevents glucagon both blocking insulin's activation of the plasma-membrane cyclic AMP phosphodiesterase and uncoupling hormonal stimulation of adenylate cyclase activity in hepatocytes

scientific article published on August 1984

Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA).

scientific article

Noradrenergic activity differentially regulates the expression of rolipram-sensitive, high-affinity cyclic AMP phosphodiesterase (PDE4) in rat brain

scientific article

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

scientific article

Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process

scientific article published in October 2003

Okadaic acid identifies a phosphorylation/dephosphorylation cycle controlling the inhibitory guanine-nucleotide-binding regulatory protein Gi2

scientific article published on March 1991

On the possible role of biliverdin stimulation of cyclic AMP levels as a trigger for liver regeneration in the rat

scientific article published on 01 June 1984

Oxidative stress employs phosphatidyl inositol 3-kinase and ERK signalling pathways to activate cAMP phosphodiesterase-4D3 (PDE4D3) through multi-site phosphorylation at Ser239 and Ser579.

scientific article published on August 2006

Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α.

scientific article published on November 2011

PDE4 associates with different scaffolding proteins: modulating interactions as treatment for certain diseases.

scientific article published on January 2008

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

scientific article

PDE4-regulated cAMP degradation controls the assembly of integrin-dependent actin adhesion structures and REF52 cell migration

scientific article published on May 2004

PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6).

scientific article

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases

scientific article

PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding

scientific article published on 7 August 2014

Peptide mapping of cyclic nucleotide phosphodiesterases.

scientific article published in January 1984

Peptide mapping of multiple forms of cyclic nucleotide phosphodiesterase.

scientific article published in December 1982

Perturbations of liver plasma membranes induced by Ca2+ are detected using a fatty acid spin label and adenylate cyclase as membrane probes.

scientific article published in March 1983

Phenobarbital selectively modulates the glucagon-stimulated activity of adenylate cyclase by depressing the lipid phase separation occurring in the outer half of the bilayer of liver plasma membranes

scientific article published on September 1981

Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK).

scientific article published in November 2001

Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes.

scientific article

Phosphodiesterase inhibitors: factors that influence potency, selectivity, and action

scientific article published on January 2011

Phosphodiesterase isoforms in the pulmonary arterial circulation of the rat: changes in pulmonary hypertension

scientific article published on 01 November 1997

Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.

scientific article published on March 2006

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

scientific journal article

Phosphorylation of Gi in intact cells

scientific article published on 01 January 1990

Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase

scientific article

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

scientific article published in May 2011

Phosphorylation of calmodulin on Tyr99 selectively attenuates the action of calmodulin antagonists on type-I cyclic nucleotide phosphodiesterase activity

scientific article published on May 1994

Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases

scientific article

Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni.

scientific article published on March 1986

Protein kinase A type I and type II define distinct intracellular signaling compartments

scientific article published on 28 August 2008

Protein kinase C isoform expression during differentiation of 3T3-F442A preadipocytes

scientific article published on May 1997

Protein kinase C isoforms play differential roles in the regulation of adipocyte differentiation

scientific article published on August 1998

Proteolysis of cyclic AMP phosphodiesterase-II attenuates its ability to be inhibited by compounds which exert positive inotropic actions in cardiac tissue

scientific article published on December 1987

Proteolytic activation and solubilization of endoplasmic-reticulum cyclic AMP phosphodiesterase activity

scientific article published on July 1983

Purification and properties of the insulin-stimulated cyclic AMP phosphodiesterase from rat liver plasma membranes

scientific article

Purification, characterization and analysis of rolipram inhibition of a human type-IVA cyclic AMP-specific phosphodiesterase expressed in yeast

scientific article published on December 1994

Putting the lid on phosphodiesterase 4

Quinidine and melittin both decrease the fluidity of liver plasma membranes and both inhibit hormone-stimulated adenylate cyclase activity

scientific article published on 01 May 1987

RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta2-adrenergic receptor to activation of ERK in HEK293B2 cells.

scientific article published on 19 July 2005

Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.

scientific article published on February 1996

Rat liver mitochondrial monoamine oxidase. A change in the reaction mechanism on solubilization

scientific article

Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase

scientific article

Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice

scholarly article by Line M. Grønning published in June 2006

Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein

scientific article published in September 2008

Regulation of adenylate cyclase (EC 4.6.1.1) activity by its lipid environment

article published in 1985

Regulation of cardiac adenylate cyclase activity in rodent models of obesity

scientific article published on April 1992

Regulation of hepatocyte adenylate cyclase by amylin and CGRP: a single receptor displaying apparent negative cooperatively towards CGRP and simple saturation kinetics for amylin, a requirement for phosphodiesterase inhibition to observe elevated he

scientific article published on January 1994

Regulation of intracellular cyclic AMP concentrations in hepatocytes involves the integrated activation and desensitization of adenylyl cyclase coupled with the action and activation of specific isoforms of cyclic AMP phosphodiesterase

scientific article published on February 1, 1992

Regulation of the GTP-binding protein-based antilipolytic system of sheep adipocytes by growth hormone

scientific article published on 01 September 1998

Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.

scientific article

Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values

scientific article published on January 1988

Resolution of soluble cyclic nucleotide phosphodiesterase isoenzymes, from liver and hepatocytes, identifies a novel IBMX-insensitive form

scientific article published in November 1989

Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.

scientific article

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK.

scientific article published on 28 April 2010

Selective regulation of cyclic nucleotide phosphodiesterase PDE3A isoforms

scientific article

Sleep deprivation impairs cAMP signalling in the hippocampus

scientific article

Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes

scientific journal article

Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells

scientific journal article

Specific antibodies and the selective inhibitor ICI 118233 demonstrate that the hormonally stimulated 'dense-vesicle' and peripheral-plasma-membrane cyclic AMP phosphodiesterases display distinct tissue distributions in the rat

scientific article published on December 1987

Stimulation of p70S6 kinase via a growth hormone-controlled phosphatidylinositol 3-kinase pathway leads to the activation of a PDE4A cyclic AMP-specific phosphodiesterase in 3T3-F442A preadipocytes ⬇️

scientific article published on March 31, 1998

Strategies for identifying functionally active domains upon cell surface receptors

scientific article

Streptozotocin-induced diabetes elicits the phosphorylation of hepatocyte Gi2 alpha at the protein kinase C site but not at the protein kinase A-controlled site

scientific article published on April 1996

Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors

scientific article

Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases

scientific article published on October 2000

Subcellular localization and hormone sensitivity of adipocyte cyclic AMP phosphodiesterase ⬇️

scientific article published on September 1989

Submitochondrial localization and asymmetric disposition of two peripheral cyclic nucleotide phosphodiesterases

scientific article published on October 1982

Surgically Induced Cryptorchidism-Related Degenerative Changes in Spermatogonia Are Associated with Loss of Cyclic Adenosine Monophosphate-Dependent Phosphodiesterases Type 4 in Abdominal Testes of Rats

scientific article published on 01 June 2001

TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid

scientific article (publication date: 2 August 2002)

TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling

scientific article published in October 2004

Tailoring cAMP-signalling responses through isoform multiplicity

scientific article published on June 1997

Targeting of cyclic AMP degradation to beta 2-adrenergic receptors by beta-arrestins

scientific article

The N-terminal alternately spliced regions of PDE4A cAMP-specific phosphodiesterases determine intracellular targeting and regulation of catalytic activity

scientific article published on 01 November 1996

The RACK1 scaffold protein: a dynamic cog in cell response mechanisms

scientific article

The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes

scientific article published on April 1986

The action of the local anaesthetic, benzyl alcohol and the monoamine oxidase inhibitor, clorgyline on the beta-hydroxybutyrate dehydrogenase activity of adult and weanling rat brain mitochondria

scientific article published on November 1978

The activity of 5'-nucleotidase in liver plasma membranes is affected by the increase in bilayer fluidity achieved by anionic drugs but not by cationic drugs.

scientific article published in February 1982

The activity of dopamine-stimulated adenylate cyclase from rat brain stratum is modulated by temperature and the bilayer-fluidizing agent, benzyl alcohol

scientific article published on July 1982

The activity of glucagon-stimulated adenylate cyclase from rat liver plasma membranes is modulated by the fluidity of its lipid environment

scientific article published on July 1978

The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells

scientific article

The cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3

scientific article

The cyclic nucleotides

scientific article published on 01 January 2011

The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase.

scientific article published in July 2004

The effect of tris buffers on rat liver mitochondrial monoamine oxidase

scientific article published on July 1977

The effect of vinblastine on the glucagon, basal and GTP-stimulated states of the adenylate cyclase from rat liver plasma membranes

scientific article published on March 1980

The effects of p21N-ras expression in NIH-3T3 cells upon cyclic AMP metabolism

scientific article published on September 1989

The glucagon receptor of rat liver plasma membrane can couple to adenylate cyclase without activating it.

scientific article

The increase in bilayer fluidity of rat liver plasma membranes achieved by the local anesthetic benzyl alcohol affects the activity of intrinsic membrane enzymes

scientific article published in Journal of Biological Chemistry

The insulin receptor tyrosyl kinase phosphorylates holomeric forms of the guanine nucleotide regulatory proteins Gi and Go.

scientific article published in February 1987

The insulin- and glucagon-stimulated 'dense-vesicle' high-affinity cyclic AMP phosphodiesterase from rat liver. Purification, characterization and inhibitor sensitivity

scientific article

The insulin-stimulated cyclic AMP phosphodiesterase binds to a single class of protein sites on the liver plasma membrane

scientific article published in September 1981

The lipid environment of the glucagon receptor regulates adenylate cyclase activity

scientific article

The lipid fluidity of rat liver membrane subfractions

scientific article published on September 1983

The local anaesthetic and bilayer fluidising agent, benzyl alcohol decreases the thermostability of the integral membrane protein adenylate cyclase

scientific article published in April 1982

The local anaesthetic benzyl alcohol attenuates the alpha 2-adrenoceptor-mediated inhibition of human platelet adenylate cyclase activity when stimulated by prostaglandin E1, but not that stimulated by forskolin

scientific article published on December 1989

The long and short of vascular smooth muscle phosphodiesterase-4 as a putative therapeutic target

scientific article

The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and antidepressant actions

scientific article published on January 1998

The nature of the electrophoretically separable multiple forms of rat liver monoamine oxidase

scientific article published on September 1973

The novel long PDE4A10 cyclic AMP phosphodiesterase shows a pattern of expression within brain that is distinct from the long PDE4A5 and short PDE4A1 isoforms

scientific article published in December 2001

The phorbol ester TPA inhibits cyclic AMP phosphodiesterase activity in intact hepatocytes

scientific article published on 01 November 1986

The phorbol ester TPA prevents the expression of both glucagon desensitisation and the glucagon-mediated block of insulin stimulation of the peripheral plasma membrane cyclic AMP phosphodiesterase in rat hepatocytes

scientific article published on 01 August 1985

The phorbol ester, TPA inhibits glucagon-stimulated adenylate cyclase activity

scientific article published on 01 May 1984

The phospholipid headgroup specificity of an ATP-dependent calcium pump

scientific article published on November 1978

The psychiatric disease risk factors DISC1 and TNIK interact to regulate synapse composition and function.

scientific article

The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism

scientific article published on April 1987

The reaction pathway of membrane-bound rat liver mitochondrial monoamine oxidase

scientific article

The role of Gi and the membrane-fluidizing agent benzyl alcohol in modulating the hysteretic activation of human platelet adenylate cyclase by guanylyl 5'-imidodiphosphate

scientific article published on May 1993

The role of N-ras p21 in the coupling of growth factor receptors to inositol phospholipid turnover.

scientific article published in February 1987

The role of polybasic compounds in determining the tyrosyl phosphorylation of calmodulin by the human insulin receptor

scientific article published on 01 November 1993

The selective effects of charged local anaesthetics on the glucagon- and fluoride-stimulated adenylate cyclase activity of rat-liver plasma membranes

scientific article published in January 1980

The temperature dependence of adenylate cyclase activity solubilised using various Lubrol detergents

scientific article published on 01 September 1979

The thermodependence of the activity of integral enzymes in liver plasma membranes

scientific article published on 01 June 1982

The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins

scientific article published on 18 September 2003

The use of selective inhibitors and computer modelling to evaluate the role of specific high affinity cyclic AMP phosphodiesterases in the hormonal regulation of hepatocyte intracellular cyclic AMP concentrations

scientific article

Thermotropic lipid phase separations in human platelet and rat liver plasma membranes

scientific article published on 01 January 1983

Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets

scientific article published on August 1986

Tosyl-lysyl chloromethylketone detects conformational changes in the catalytic unit of adenylate cyclase induced by receptor and G-protein stimulation

scientific article published in October 1988

Treatment of intact hepatocytes with either the phorbol ester TPA or glucagon elicits the phosphorylation and functional inactivation of the inhibitory guanine nucleotide regulatory protein Gi.

scientific article

Treatment of intact hepatocytes with synthetic diacyl glycerols mimics the ability of glucagon to cause the desensitization of adenylate cyclase

scientific article published on 01 September 1991

Treatment of intact hepatocytes with the calcium ionophore A23187 perturbs both the synthesis and the degradation of the second messenger cyclic AMP. Actions on adenylate cyclase and cyclic AMP phosphodiesterase activities

scientific article published in July 1988

Treatment of streptozotocin-diabetic rats with metformin restores the ability of insulin to inhibit adenylate cyclase activity and demonstrates that insulin does not exert this action through the inhibitory guanine nucleotide regulatory protein Gi.

scientific article

Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and beta1 integrin and for tumor cell proliferation and migration

scientific article

UCR1 and UCR2 domains unique to the cAMP-specific phosphodiesterase family form a discrete module via electrostatic interactions

scientific article published in April 2000

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

scientific article published on 26 October 2009

Upregulation of cAMP-specific PDE-4 activity following ligation of the TCR complex on thymocytes is blocked by selective inhibitors of protein kinase C and tyrosyl kinases

scientific article published on 01 January 1998

Use of an activation-specific probe to show that Rap1A and Rap1B display different sensitivities to activation by forskolin in rat1 cells

scientific journal article

[69] Isolation and characterization of insulin-stimulated, high-affinity cAMP phosphodiesterases from rat liver

scientific article published on 01 January 1988

beta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to Gi

scientific journal article

cAMP synthesis and degradation by phagosomes regulate actin assembly and fusion events: consequences for mycobacteria

scientific article published in September 2006

cAMP-Specific phosphodiesterase-4 enzymes in the cardiovascular system: a molecular toolbox for generating compartmentalized cAMP signaling

scientific article published on April 2007

cAMP-specific phosphodiesterase HSPDE4D3 mutants which mimic activation and changes in rolipram inhibition triggered by protein kinase A phosphorylation of Ser-54: generation of a molecular model.

scientific article published on July 1998

cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling.

scientific article published on November 2007

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.

scientific article published on 19 June 2010

p62 (SQSTM1) forms part of a novel, reversible aggregate containing a specific conformer of the cAMP degrading phosphodiesterase, PDE4A4 ⬇️

scientific article published on November 16, 2010

p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway

scientific article

β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation.

scientific article

β-Arrestin-recruited phosphodiesterase-4 desensitizes the AKAP79/PKA-mediated switching of β2-adrenoceptor signalling to activation of ERK

article

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