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List of works by Eric R Prossnitz

A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand

scientific article published on March 2009

A transmembrane intracellular estrogen receptor mediates rapid cell signaling

scientific article

A tyrosine kinase signaling pathway accounts for the majority of phosphatidylinositol 3,4,5-trisphosphate formation in chemoattractant-stimulated human neutrophils

scientific article published in October 1996

Absence of G(i) proteins in the Sf9 insect cell. Characterization of the uncoupled recombinant N-formyl peptide receptor

scientific article published on October 1992

Activated N-formyl peptide receptor and high-affinity IgE receptor occupy common domains for signaling and internalization

scientific article

Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle ⬇️

scientific article published on July 26, 2011

Activation of GPER-1 estradiol receptor downregulates production of testosterone in isolated rat Leydig cells and adult human testis.

scientific article

Activation of mitogen-activated protein kinases by formyl peptide receptors is regulated by the cytoplasmic tail.

scientific article published on August 1998

Adaptor protein-2 interaction with arrestin regulates GPCR recycling and apoptosis

scientific article published on 15 June 2009

Alike but not the same: anatomic heterogeneity of estrogen receptor-mediated vasodilation.

scientific article published on July 2013

Alpha4beta1 integrin affinity changes govern cell adhesion

scientific article published on 3 July 2003

Analysis of free intracellular calcium by flow cytometry: multiparameter and pharmacologic applications

scientific article published on July 2000

Arrestin Variants Display Differential Binding Characteristics for the PhosphorylatedN-Formyl Peptide Receptor Carboxyl Terminus

scientific article published in Journal of Biological Chemistry

Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence

scientific article

Autophagy, Inflammation, and Metabolism (AIM) Center of Biomedical Research Excellence: supporting the next generation of autophagy researchers and fostering international collaborations

scientific article published on 01 January 2018

Binding of low affinity N-formyl peptide receptors to G protein. Characterization of a novel inactive receptor intermediate

scientific article published on May 1995

Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform

Bradykinin stimulates NF-kappaB activation and interleukin 1beta gene expression in cultured human fibroblasts

scientific article

Breast cancer survival, survival disparities, and guideline-based treatment.

scientific article published on 22 March 2018

Cell type- and developmental stage-specific activation of NF-kappaB by fMet-Leu-Phe in myeloid cells.

scientific article published in March 1997

Characterization of a human cDNA that encodes a functional receptor for platelet activating factor

scientific article

Chemokines and chemokine receptors--Keystone Symposium 7-12 January 2003, Breckenridge, CO, USA

scientific article published on 01 March 2003

Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor

scientific article

Cloning and functional characterization of the mouse C3a anaphylatoxin receptor gene

scientific article published on January 1997

Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma

scientific article

Complement Receptor 3 Contributes to the Sexual Dimorphism in Neutrophil Killing of Staphylococcus aureus

scientific article published on 07 August 2020

Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry

scientific article published in August 2005

Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation

scientific article

Deficient homologous desensitization of formyl peptide receptors stably expressed in undifferentiated HL-60 cells

scientific article published on 01 July 2000

Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction

scientific article

Desensitization of N-formylpeptide receptor-mediated activation is dependent upon receptor phosphorylation

scientific article published on June 1997

Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system

scientific article

Determination of a region of the HisJ binding protein involved in the recognition of the membrane complex of the histidine transport system of Salmonella typhimurium

scientific article published in May 1991

Dexras1/AGS-1 Inhibits Signal Transduction from the Gi-coupled Formyl Peptide Receptor to Erk-1/2 MAP Kinases ⬇️

scientific article (publication date: 29 March 2002)

Differential effects of CD20+ B cells and PD-L1+ immune cells on pathologic complete response and outcome: comparison between inflammatory breast cancer and locally advanced breast cancer patients

scientific article

Dilation of epicardial coronary arteries by the G protein-coupled estrogen receptor agonists G-1 and ICI 182,780.

scientific article

Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30

scientific article

Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system

scientific article

Domains of the human neutrophil N-formyl peptide receptor involved in G protein coupling. Mapping with receptor-derived peptides.

scientific article published in January 1994

Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes

scientific article

ERα-targeted endocrine therapy, resistance and the role of GPER

scientific article published on 10 September 2019

Early life stress determines insulin signalling in adulthood

scientific article published on 13 January 2020

Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide

scientific article

Effects of atrazine on estrogen receptor α- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts

scientific article

Emerging roles of GPER in diabetes and atherosclerosis

scientific article

Endometrial cancer: molecular and cellular basis of tumor development, novel biomarkers and therapeutic agents, and innovative research approaches

scientific article published on 16 January 2014

Endothelin-1 but not angiotensin II contributes to functional aging in murine carotid arteries

scientific article published on 5 March 2014

Estrogen and progesterone receptor status and outcome in epithelial ovarian cancers and low malignant potential tumors.

scientific article published on 27 June 2009

Estrogen biology: new insights into GPER function and clinical opportunities

scientific article

Estrogen receptor quantitative measures and breast cancer survival

scientific article published on 19 August 2017

Estrogen signaling through the transmembrane G protein-coupled receptor GPR30.

scientific article published on January 2008

Estrogen-independent activation of estrogen receptors.

scientific article published on 2 May 2011

Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER.

scientific article published on 15 October 2015

Expression and intracellular distribution of the G protein-coupled receptor 30 in rat hippocampal formation.

scientific article published on 5 June 2008

Expression of G Protein-Coupled Receptor-30, a G Protein-Coupled Membrane Estrogen Receptor, in Oxytocin Neurons of the Rat Paraventricular and Supraoptic Nuclei

scientific article published on 13 September 2007

Expression of G protein-coupled receptor 30 in the hamster ovary: differential regulation by gonadotropins and steroid hormones

scientific article published on 19 July 2007

Expression of G protein-coupled receptor 30 in the spinal somatosensory system.

scientific article published on 11 November 2009

Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia

scientific article published on May 2009

FRET detection of cellular alpha4-integrin conformational activation.

scientific article

Female Sex Hormone Receptor Profiling in Uterine Adenosarcomas.

scientific article published on 4 January 2018

Flow cytometry for high-throughput, high-content screening

scientific article

Flow cytometry: A versatile tool for all phases of drug discovery

scientific article published on 01 April 1999

Formaldehyde and photoactivatable cross-linking of the periplasmic binding protein to a membrane component of the histidine transport system of Salmonella typhimurium

scientific article published in December 1988

Full characterization of GPCR monomer-dimer dynamic equilibrium by single molecule imaging ⬇️

scientific article

Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestins

scientific article

Functional heterogeneity of NADPH oxidase-mediated contractions to endothelin with vascular aging

scientific article

G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity.

scientific article published on 24 August 2015

G protein-coupled estrogen receptor protects from atherosclerosis

scientific article

G protein-coupled estrogen receptor regulates mammary tumorigenesis and metastasis

scientific article

G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth

scientific article

G protein-coupled estrogen receptor: a new therapeutic target in stroke and traumatic brain/spinal cord injury?

scientific article published in December 2012

G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells

scientific article published on February 2007

G protein-coupled receptor 30 expression is required for estrogen stimulation of primordial follicle formation in the hamster ovary.

scientific article published on 22 May 2008

G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophils

scientific article published on 25 January 2006

G-Protein-Coupled Estrogen Receptor (GPER) and Sex-Specific Metabolic Homeostasis

scientific article published in January 2017

G-protein-coupled receptor 30 and estrogen receptor-alpha are involved in the proliferative effects induced by atrazine in ovarian cancer cells

scientific article

GPER Mediates Functional Endothelial Aging in Renal Arteries

scientific article published on 14 July 2017

GPER activation protects against epithelial barrier disruption by Staphylococcus aureus α-toxin

scientific article published in Scientific Reports

GPER is required for the age-dependent upregulation of the myocardial endothelin system

scientific article published on 12 February 2016

GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast

scientific article

GPER modulators: Opportunity Nox on the heels of a class Akt.

scientific article published on 8 March 2017

GPER-targeted, 99mTc-labeled, nonsteroidal ligands demonstrate selective tumor imaging and in vivo estrogen binding.

scientific article

GPER/GPR30 Knockout Mice: Effects of GPER on Metabolism

scientific article

GPR30 Expression Is Required for the Mineralocorticoid Receptor–Independent Rapid Vascular Effects of Aldosterone

scientific article published on 17 January 2011

GPR30 and estrogen receptor expression: new insights into hormone dependence of inflammatory breast cancer

scientific article

GPR30 predicts poor survival for ovarian cancer

scientific article

GPR30: A G protein-coupled receptor for estrogen

scientific article

GPR30: a novel indicator of poor survival for endometrial carcinoma

scientific article published on 01 April 2007

GPR30: a novel therapeutic target in estrogen-related disease

scientific article published on 11 February 2008

Gene transcription through activation of G-protein-coupled chemoattractant receptors

article

Glutathione-S-transferase-green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH.

scientific article published in May 2006

HTPS flow cytometry: a novel platform for automated high throughput drug discovery and characterization

scientific article

High-content screening: flow cytometry analysis

scientific article

High-throughput flow cytometry for drug discovery

scientific article published in May 2007

High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands

scientific article published in June 2005

Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs

scientific article

Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity

scientific article published on 14 July 2011

Identification of an N-formyl peptide receptor ligand binding domain by a gain-of-function approach.

scientific article

In vivo effects of a GPR30 antagonist

scientific article

Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1.

scientific article published on 2 July 2011

Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides.

scientific article published on 23 August 2013

Inhibition of chemoattractant N-formyl peptide receptor trafficking by active arrestins

scientific article published in February 2005

Innate Sex Bias of Staphylococcus aureus Skin Infection Is Driven by α-Hemolysin.

scientific article published on 8 December 2017

Insulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer.

scientific article

Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists

scientific article published on 23 August 2005

Internalization of the human N-formyl peptide and C5a chemoattractant receptors occurs via clathrin-independent mechanisms

scientific article published on March 2001

International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators

scientific article published on July 2015

Introduction of D-phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides

scientific article published on 06 January 2014

Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase

scientific article published on 01 March 1995

Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor

scientific article

Ligand-receptor-G-protein molecular assemblies on beads for mechanistic studies and screening by flow cytometry.

scientific article published in November 2003

Linkage effects on binding affinity and activation of GPR30 and estrogen receptors ERalpha/beta with tridentate pyridin-2-yl hydrazine tricarbonyl-Re/(99m)Tc(I) chelates.

scientific article published on November 2006

Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues

scientific article

Lung cancer and hormone replacement therapy

scientific article published in The Lancet

Mechanisms of Estradiol-Induced Insulin Secretion by the G Protein-Coupled Estrogen Receptor GPR30/GPER in Pancreatic β-Cells ⬇️

scientific article published on June 14, 2011

Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes.

scientific article

Mesothelin and GPR30 Staining Among a Spectrum of Pancreatic Epithelial Neoplasms

scientific article published on 01 June 2011

Multiple activation steps of the N-formyl peptide receptor

scientific article published on February 1999

Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors.

scientific article published on August 1993

N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity

scientific article published on 6 November 2002

N-formyl peptide receptors cluster in an active raft-associated state prior to phosphorylation

scientific article published on 9 August 2004

N-formyl peptide receptors internalize but do not recycle in the absence of arrestins

scientific article published on 28 August 2003

New developments in the rapid actions of steroids and their receptors

scientific article published on 05 August 2017

Non-genomic regulation of vascular cell function and growth by estrogen.

scientific article published on 25 March 2009

Non-genomic signaling by steroids

scientific article published on 21 April 2009

Nox1 downregulators: A new class of therapeutics

scientific article published on 10 September 2019

Obesity and survival among a cohort of breast cancer patients is partially mediated by tumor characteristics

scientific article published on 02 October 2019

Obesity, insulin resistance and diabetes: sex differences and role of oestrogen receptors.

scientific article

Obligatory role for GPER in cardiovascular aging and disease.

scientific article

Partial phosphorylation of the N-formyl peptide receptor inhibits G protein association independent of arrestin binding.

scientific article

Peptidyl arginine deiminase from Porphyromonas gingivalis abolishes anaphylatoxin C5a activity

scientific article

Performance of in-line microfluidic mixers in laminar flow for high-throughput flow cytometry

scientific article published on 01 July 2002

Phosphorylation of the N-formyl peptide receptor is required for receptor internalization but not chemotaxis

scientific article

Plug flow cytometry extends analytical capabilities in cell adhesion and receptor pharmacology

scientific article

Post-high-throughput screening analysis: an empirical compound prioritization scheme

scientific article published in August 2005

Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers.

scientific article published on 15 May 2008

Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes

scientific article published on 01 January 2020

Prostanoid-mediated contractions of the carotid artery become Nox2-independent with aging

scientific article published on August 2015

Rapid vasodilation to raloxifene: role of oestrogen receptors and off-target effects

scientific article published on 6 October 2017

Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides

scientific article published on 14 August 2007

Real time analysis of the affinity regulation of alpha 4-integrin. The physiologically activated receptor is intermediate in affinity between resting and Mn(2+) or antibody activation

scientific article

Real-time analysis of G protein-coupled receptor reconstitution in a solubilized system

scientific article published on 17 April 2001

Reconstitution of recombinant N-formyl chemotactic peptide receptor with G protein

scientific article published on April 1993

Reconstitution of the histidine periplasmic transport system in membrane vesicles. Energy coupling and interaction between the binding protein and the membrane complex

scientific article published in March 1989

Regulation of N-Formyl Peptide Receptor Signaling and Trafficking by Arrestin-Src Kinase Interaction

scientific article published on 20 January 2016

Regulation of N-formyl peptide receptor signaling and trafficking by individual carboxyl-terminal serine and threonine residues

scientific article published on May 2006

Regulation of N-formyl peptide-mediated degranulation by receptor phosphorylation

scientific article published in December 2002

Regulation of formyl peptide receptor agonist affinity by reconstitution with arrestins and heterotrimeric G proteins

scientific article

Regulation of vascular smooth muscle tone by adipose-derived contracting factor

scientific article

Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity

scientific article published on 29 January 2009

Role of GPER in estrogen-dependent nitric oxide formation and vasodilation.

scientific article published on 18 May 2017

Role of the intercistronic region in post-transcriptional control of gene expression in the histidine transport operon of Salmonella typhimurium: involvement of REP sequences

scientific article published in January 1988

Roles of G protein-coupled estrogen receptor GPER in metabolic regulation

scientific article published on 18 February 2017

Screening for caspase-3 inhibitors: a new class of potent small-molecule inhibitors of caspase-3.

scientific article published on 20 February 2006

Signal transducing properties of the N-formyl peptide receptor expressed in undifferentiated HL60 cells

scientific article published on 01 November 1993

Signaling, physiological functions and clinical relevance of the G protein-coupled estrogen receptor GPER.

scientific article published on 13 May 2009

Solubilization and display of G protein-coupled receptors on beads for real-time fluorescence and flow cytometric analysis

scientific article published on 01 May 2000

Somatostatin-receptor-targeted alpha-emitting 213Bi is therapeutically more effective than beta(-)-emitting 177Lu in human pancreatic adenocarcinoma cells.

scientific article published on February 2007

Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads

scientific article published on January 2007

Steroid-binding G-protein-coupled receptors: new drug discovery targets for old ligands

scientific article published on July 2006

Strategies for positioning fluorescent probes and crosslinkers on formyl peptide ligands

scientific article published on March 1998

Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30

scientific article

Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides.

scientific article

Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30.

scientific article published on 27 July 2007

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors ⬇️

journal article from 'British Journal of Pharmacology' published in 2021

Techniques: GPCR assembly, pharmacology and screening by flow cytometry.

scientific article

Temporal trends in breast cancer survival by race and ethnicity: A population-based cohort study

scientific article published on 24 October 2019

Testosterone and secondary hypertension: new pieces to the puzzle.

scientific article published on 7 May 2012

The Concise Guide to PHARMACOLOGY 2013/14: overview

scientific article

The G Protein-coupled Estrogen Receptor (GPER) Agonist G-1 Expands the Regulatory T-cell Population Under TH17-polarizing Conditions ⬇️

scientific article published on April 1, 2013

The G protein-coupled estrogen receptor GPER/GPR30 as a regulator of cardiovascular function ⬇️

scientific article published on July 5, 2011

The G protein-coupled receptor GPR30 inhibits human urothelial cell proliferation.

scientific article published on 8 May 2008

The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.

scientific article

The G-protein-coupled estrogen receptor GPER in health and disease

scientific article

The N-formyl peptide receptor: a model for the study of chemoattractant receptor structure and function

scientific article

The R-enantiomer of ketorolac delays mammary tumor development in mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice.

scientific article published on 20 November 2017

The combined presence of CD20 + B cells and PD-L1 + tumor-infiltrating lymphocytes in inflammatory breast cancer is prognostic of improved patient outcome

scientific article published on 01 June 2018

The ins and outs of GPR30: a transmembrane estrogen receptor

scientific article published on 6 March 2008

The rabbit neutrophil N-formyl peptide receptor. cDNA cloning, expression, and structure/function implications.

scientific article published on February 1993

The role of the third intracellular loop of the neutrophil N-formyl peptide receptor in G protein coupling

scientific article published on September 1993

The uncoupled state of the human formyl peptide receptor.

scientific article

Towards a transcriptome-based theranostic platform for unfavorable breast cancer phenotypes

scientific article published on 24 October 2016

Transmembrane signalling by the N-formyl peptide receptor in stably transfected fibroblasts

scientific article

Twenty years of the G protein-coupled estrogen receptor GPER: Historical and personal perspectives.

scientific article published on 24 March 2017

Undifferentiated U937 cells transfected with chemoattractant receptors: a model system to investigate chemotactic mechanisms and receptor structure/function relationships

scientific article published on 01 March 1997

Vasodilation in Response to the GPR30 Agonist G-1 is Not Different From Estradiol in the mRen2.Lewis Female Rat ⬇️

scientific article published on May 1, 2011

Virtual and biomolecular screening converge on a selective agonist for GPR30.

scientific article published on 5 March 2006

What have we learned about GPER function in physiology and disease from knockout mice?

scientific article

cDNA cloning of a novel G protein-coupled receptor with a large extracellular loop structure

scientific journal article

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