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List of works by Andreas Ludwig

A cytoplasmic C-terminal fragment of Syndecan-1 is generated by sequential proteolysis and antagonizes Syndecan-1 dependent lung tumor cell migration

scientific article

A disintegrin and metalloproteinase 17 (ADAM17) mediates inflammation-induced shedding of syndecan-1 and -4 by lung epithelial cells

scientific article

A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44

scientific article published on February 2006

A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung metastasis formation

scientific article published on 26 April 2015

A-Disintegrin and Metalloprotease (ADAM) 10 and 17 promote self-renewal of brain tumor sphere forming cells.

scientific article published on 24 July 2012

ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A.

scientific article

ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets

scientific article

ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling

scientific article published on 3 February 2005

ADAM10 cleavage of N-cadherin and regulation of cell–cell adhesion and β-catenin nuclear signalling.

scientific article published in May 2005

ADAM10 inhibition of human CD30 shedding increases specificity of targeted immunotherapy in vitro

scientific article published on January 2007

ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23

scientific article published on 29 October 2006

ADAM10 is expressed in human podocytes and found in urinary vesicles of patients with glomerular kidney diseases

scientific article

ADAM10 is the constitutive functional sheddase of CD44 in human melanoma cells.

scientific article

ADAM10 is the major sheddase responsible for the release of membrane-associated meprin A.

scientific article

ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

scientific article

ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death

scientific article published on 9 February 2007

ADAM10 regulates endothelial permeability and T-Cell transmigration by proteolysis of vascular endothelial cadherin.

scientific article published on 17 April 2008

ADAM8 expression in breast cancer derived brain metastases: Functional implications on MMP-9 expression and transendothelial migration in breast cancer cells

scientific article published on 7 October 2017

Amphiregulin Regulates Phagocytosis-Induced Cell Death in Monocytes via EGFR and the Bcl-2 Protein Family

scientific article published on 03 November 2019

Antagonistic roles of full-length N-cadherin and its soluble BMP cleavage product in neural crest delamination.

scientific article published on 21 December 2006

Breaking up the tie: disintegrin-like metalloproteinases as regulators of cell migration in inflammation and invasion.

scientific article

CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: Limiting steatohepatitis by maintaining intestinal homeostasis

scientific article published on 14 July 2015

Cell surface syndecan-1 contributes to binding and function of macrophage migration inhibitory factor (MIF) on epithelial tumor cells

scientific article published on 04 February 2016

Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)

scientific article

Characterization of CXCL16 and ADAM10 in the normal and transplanted kidney

scientific article published on 14 May 2008

Considerations on inhibition approaches for proinflammatory functions of ADAM proteases.

scientific article published on 26 July 2016

Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skin

scientific article published on 15 March 2007

Contribution of platelet CX(3)CR1 to platelet-monocyte complex formation and vascular recruitment during hyperlipidemia

scientific article

Distinct role of the intracellular C-terminus for subcellular expression, shedding and function of the murine transmembrane chemokine CX3CL1.

scientific article published on 27 March 2010

Downregulation of junctional adhesion molecule-A is involved in the progression of clear cell renal cell carcinoma.

scientific article

Enhanced expression and shedding of the transmembrane chemokine CXCL16 by reactive astrocytes and glioma cells.

scientific article published on June 2005

Etoposide induces apoptosis and upregulation of TACE/ADAM17 and ADAM10 in an in vitro male germ cell line model.

scientific article published on 25 August 2010

Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V

scientific article

Expression levels of the metalloproteinase ADAM8 critically regulate proliferation, migration and malignant signalling events in hepatoma cells

scientific article published on 13 December 2020

Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons

scientific article published on 7 April 2005

FcγRIII (CD16) equips immature 6-sulfo LacNAc-expressing dendritic cells (slanDCs) with a unique capacity to handle IgG-complexed antigens

scientific article published on 4 March 2013

Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases.

scientific article published on 5 February 2017

Glial cross-talk by transmembrane chemokines CX3CL1 and CXCL16.

scientific article published on 05 June 2008

Growth arrest-specific protein 1 is a novel endogenous inhibitor of glomerular cell activation and proliferation

scientific article published on 19 December 2012

Homocysteine up-regulates vascular transmembrane chemokine CXCL16 and induces CXCR6+ lymphocyte recruitment in vitro and in vivo

scientific article published on 11 January 2008

Human renal cancer cells express a novel membrane-bound interleukin-15 that induces, in response to the soluble interleukin-15 receptor alpha chain, epithelial-to-mesenchymal transition

scientific article

Importance of CXC chemokine receptor 2 in the homing of human peripheral blood endothelial progenitor cells to sites of arterial injury

scientific article

Improved synthesis of ADAM10 inhibitor GI254023X.

scientific article

In vitro modulation of induced neutrophil activation by different surfactant preparations

scientific article published on 01 April 1996

In vivo structure/function and expression analysis of the CX3C chemokine fractalkine ⬇️

scientific article published on September 27, 2011

Interaction of vascular smooth muscle cells and monocytes by soluble factors synergistically enhances IL-6 and MCP-1 production

scientific article

Involvement of ADAM10 in axonal outgrowth and myelination of the peripheral nerve.

scientific article published in December 2009

Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis

scientific journal article

L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth

scientific article

Leukocytes require ADAM10 but not ADAM17 for their migration and inflammatory recruitment into the alveolar space

scientific article published on 15 May 2014

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state

scientific article published on 24 August 2014

Lung endothelial ADAM17 regulates the acute inflammatory response to lipopolysaccharide

scientific article published on 24 February 2012

Matrix metalloproteinase 19 processes the laminin 5 gamma 2 chain and induces epithelial cell migration

scientific article

Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.

scientific article

Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis.

scientific article published on 7 February 2015

Novel role of APP cleavage by ADAM10 for breast cancer metastasis

Overexpression of CXCL16 and its receptor CXCR6/Bonzo promotes growth of human schwannomas

scientific article

Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels

scientific article published on 19 March 2012

Platelet-derived CXC chemokines: old players in new games

scientific article (publication date: October 2000)

Protean proteases: at the cutting edge of lung diseases

scientific article published on 8 February 2017

Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases

scientific article published on 3 March 2009

Regulation of nerve growth factor in the heart: the role of the calcineurin-NFAT pathway

scientific article published on 25 December 2008

Requirements for leukocyte transmigration via the transmembrane chemokine CX3CL1.

scientific article published on 18 June 2010

SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.

scientific article

Selenium supplementation induces metalloproteinase-dependent L-selectin shedding from monocytes

scientific article

Sequential processing of the transmembrane chemokines CX3CL1 and CXCL16 by alpha- and gamma-secretases

scientific article published on 24 April 2007

Shear Stress Counteracts Endothelial CX3CL1 Induction and Monocytic Cell Adhesion.

scientific article published on 26 March 2017

Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation

scientific article

Sitagliptin reduces plaque macrophage content and stabilises arteriosclerotic lesions in Apoe (-/-) mice

scientific article published on 18 May 2012

Smooth muscle cells relay acute pulmonary inflammation via distinct ADAM17/ErbB axes.

scientific article published on 16 December 2013

Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes.

scientific article

TACE/ADAM17 is involved in germ cell apoptosis during rat spermatogenesis

scientific article published on 25 May 2010

The CXC chemokine NAP-2 mediates differential heterologous desensitization of neutrophil effector functions elicited by platelet-activating factor

scientific article published on 01 February 2002

The DRF motif of CXCR6 as chemokine receptor adaptation to adhesion

scientific article

The angiotensin-calcineurin-NFAT pathway mediates stretch-induced up-regulation of matrix metalloproteinases-2/-9 in atrial myocytes

scientific article published on 15 January 2009

The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells

scientific article

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion

scientific article

The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer.

scientific article published on 18 September 2008

The metalloproteinase ADAM10 requires its activity to sustain surface expression

scientific article published on 05 May 2020

The metalloproteinase ADAM8 promotes leukocyte recruitment in vitro and in acute lung inflammation.

scientific article published on 8 June 2017

The perioperative time course and clinical significance of the chemokine CXCL16 in patients undergoing cardiac surgery

scientific article

The role of ADAM-mediated shedding in vascular biology.

scientific article published on 03 December 2011

Transmembrane chemokines act as receptors in a novel mechanism termed inverse signaling

scientific article

Tumor necrosis factor alpha activates release of B lymphocyte stimulator by neutrophils infiltrating the rheumatoid joint

scientific article

Tumor-associated MICA is shed by ADAM proteases

scientific article

Tumoural CXCL16 expression is a novel prognostic marker of longer survival times in renal cell cancer patients

scientific article

Whole body and hematopoietic ADAM8 deficiency does not influence advanced atherosclerotic lesion development, despite its association with human plaque progression.

scientific article published on 15 September 2017

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